Personalized Medicine Jun 23, 2008
For example, a woman who has a mutation in her BRCA1 gene, a gene implicated in hereditary breast cancer, would learn she has an increased chance of developing the disease and could be screened more frequently and earlier. Since the earlier breast cancer is detected, the better the likelihood of being cured, close monitoring of such predisposed women could make a dramatic reduction in overall breast cancer deaths. (Suite101.com)
Mammogram Screening Day In Langford Jun 19, 2008
Genetic alterations (changes)-Specific alterations in certain genes (BRCA1, BRCA2, and others) increase the risk of breast cancer. These alterations are rare; they are estimated to account for no more than 10 percent of all breast cancers. (Marshall County Journal, SD)
Answers on cancer and genetics Jun 16, 2008
That's why my daughter, Gabrielle, shared the story of her BRCA1 mutation and the preventive double mastectomy she had six months ago to reduce her risk of getting breast cancer. Many asked questions that Dr. Georgia Wiesner, director of the Center for Human Genetics at University Hospitals, answered. (Cleveland.com)
KU Cancer Center director to speak at Relay For Life Jun 5, 2008
His laboratory was instrumental in demonstrating the role of BRCA1 in the growth control of normal and malignant cells and in how loss of BRCA1 function contributes to the development of breast cancer. Dr. Jensen was born in Gardner and earned his bachelor's degree in biology from Pittsburg State University. (Abilene Recorder Chronicle)
Cancer-blocking chemo not being offered Jun 3, 2008
Studies in 25,000 women have shown clear benefit for those with family risk, but it is less clear if it is effective for women carrying the specific high risk genes BRCA1 and BRCA2, because of the nature of the tumour types. The study questioned 23 specialists on their attitude towards the therapy and found nine "barriers" to offering the therapy. (Sydney Morning Herald)
Breast Cancer Gene Risk May Be Overstated Jun 2, 2008
Many women fear that breast cancer is inevitable if they are found to carry mutations in the genes BRCA1 and BRCA2 ... Some 181 carried mutations in either BRCA1 or BRCA2 genes, the team found ... Rather, it simply asserts greater variation in breast cancer risk among carriers of BRCA1 and BRCA2 which does not inherently say anything about overall risk (e. (Yahoo News -- Cancer)
Breast Cancer Rates Projected To Soar May 30, 2008
Professor Gareth Evans led the study of 1,442 women who carried the high-risk genes BRCA1 and BRCA2, on behalf of the Manchester-based Genesis Breast Cancer Prevention Centre. Around one in 500 people are said to carry the gene mutations which give women an 85-90% risk of breast cancer. (Sky News)
New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers May 28, 2008
15, 2007) Although defects in the "breast cancer gene," BRCA1, have long been known to increase the risk for breast cancer, exactly how the defects lead to tumor growth has remained a mystery. Now scientists. (Science Daily)
Personal Health: Red flags for hereditary cancers May 28, 2008
You might be familiar with the BRCA1 and BRCA2 mutations that are strongly linked to breast and ovarian cancer in women and somewhat less strongly to breast and prostate cancer in men. A woman with a BRCA mutation faces a 56 to 87 percent chance of contracting breast cancer and a 10 to 40 percent chance of ovarian cancer. (International Herald Tribune)
Cancer test a genetic crystal ball for Jewish women May 25, 2008
They plan to do that by offering adult Jewish women in Ontario, with no known family history of breast or ovarian cancer, the blood test to screen for three specific mutations of the BRCA1 and BRCA2 genes, beginning this Thursday ... One in 44 Ashkenazi Jewish people carry the mutation, he noted; in the general population, an estimated one in 400 individuals carries a mutation in BRCA1 or BRCA2 ... Ms. Neumin has since tested positive for a mutation of the BRCA1 gene that she inherited from her... (Globe and Mail -- Business)
Researchers Pinpoint How Smoking Causes Cancer May 15, 2008
ScienceDaily (May 14, 2008) Oregon Health & Science University Cancer Institute researchers have pinpointed the protein that can lead to genetic changes that cause lung cancer. Researchers discovered that the production of a protein called FANCD2 is slowed when lung cells are exposed to cigarette smoke. (Science Daily)
Previously Unseen Switch Regulates Breast Cancer Response To Estrogen May 11, 2008
Also, the methylation appears in exactly the same spot where another protein called BRCA1 adds a different kind of regulatory marking, and may block BRCA1's restrictive effects on the estrogen receptor. Women who inherit a mutation in the gene that encodes BRCA1 have up to an 80 percent lifetime risk of developing breast cancer, several times the risk of those who don't have it, according to the National Cancer Institute ... BRCA1 mutations are estimated to account for about a third of all... (Science Daily)
Book Review: Masha Gessen's 'Blood Matters' May 10, 2008
Eleven years after her mother died of breast cancer, Masha Gessen, a Moscow-based journalist and the author of the fine family memoir "Ester and Ruzya: How My Grandmothers Survived Hitler's War and Stalin's Peace," tested positive for a BRCA1 mutation, which disproportionately afflicts Ashkenazi Jews and significantly increases the risk of dying young. (Of the women who carry a BRCA1 mutation, as many as 85 percent will eventually develop breast cancer, and as many as 50 percent will develop... (International Herald Tribune -- Arts)
Some doctors still cautious of gene tests May 6, 2008
At the same time, states have adopted a patchwork of protections, and steadily growing use of two of the best-proven tests for the BRCA1 and BRCA2 gene mutations linked to breast and ovarian cancer suggests that lingering concern hasnt been a huge deterrent for people with strong family histories of disease ... All three shared their mothers BRCA1 mutation. (MSNBC -- Health)
Second breast cancer may be greater than thought for high-risk women without BRCA mutations May 5, 2008
New York, NY A preliminary analysis of ongoing research suggests that high-risk women with breast cancer who do not have a BRCA1/2 mutation may face a greater chance for developing a second breast cancer than previously thought ... The increased risk of developing breast cancer is already understood for women with the disease who test positive for a BRCA1 or 2 mutation ... The registry participants had a least a 10 percent probability of carrying a BRCA1/2 mutation based on personal or family... (EurekAlert!)
Simultaneous Breast-Ovary Surgery Feasible May 2, 2008
NEW YORK (Reuters Health) - Women who are carriers of BRCA1/2 gene mutations that put them high risk for cancer may opt to undergo mastectomy and ovary removal as a cancer prevention strategy ... Women with BRCA1 or BRCA2 mutations are known to be at greatly increased risk of both breast and ovarian cancer, Dr. Funda Meric-Bernstam and colleagues point out. (MEDLINEplus)
Read more... Apr 22, 2008
D., of Georgetown University to identify environmental agents that cause DNA damage to BRCA1 defective breast cells, triggering the development of cancerous tumors. A Komen for the Cure grant is supporting the work of Amy Trenthan-Dietz, Ph. (PNN Online)
Some doubt genome's value as health tool Apr 21, 2008
Testing for the BRCA1 gene, for example, can tell a woman whether her risk for breast or ovarian cancer is dramatically elevated ... She might not realize that she could still be carrying a high-risk mutation in BRCA1, which SNP scans do not test for. (Boston Globe)
New Technologies Offer More Accurate Means Of Diagnosis And Monitoring Cancer Apr 21, 2008
23, 2006) Women with mutations in the BRCA1 or BRCA2 genes can significantly reduce their risk of certain types of cancer by having their ovaries removed, according to a study in the July 12 issue of. (Apr. (Science Daily)
States Crack Down On Online Gene Tests Apr 19, 2008
For example, 23andMe tests for some gene variants involved in mildly raising breast cancer risk, but not genes called BRCA1 and BRCA2 that vastly raise breast cancer risk. Harvard Medical School's Mark Daley says if you found out that you had genes that slightly reduced the risk of cancer, but didn't check for the real cancer-causing gene like BRCA1, "you get a potentially dangerously misleading answer.". (Forbes -- Business)
Breast cancer risk amplified by additional genes in combo with BRCA mutation Apr 17, 2008
Researchers at the University of Pennsylvania School of Medicine join an international consortium of research groups that looked at more than 10,000 women carrying a BRCA1 or BRCA2 mutation for breast-cancer risk. These results suggest that knowledge of a BRCA1 or BRCA2 mutation is necessary, but not sufficient, to fully understand cancer risk in women who carry these mutations, says co-author and head of the North American coalition Timothy R. Rebbeck, PhD, Professor of Epidemiology at Penn... (EurekAlert!)
Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors Apr 17, 2008
Berlin, Germany: The first study to investigate the effects of chemotherapy on metastatic breast cancer in women with the BRCA1 or BRCA2 gene mutation has shown that standard chemotherapy works better in these patients than in women without the BRCA1/2 mutation. The authors of a study presented today (Thursday) at the 6th European Breast Cancer Conference (EBCC-6) in Berlin found that women with BRCA2-associated breast cancer had a significantly higher response rate, a longer time without the... (EurekAlert!)
Hereditary Breast Cancer: Some Women Choose Mastectomy Over Lifetime Surveillance Apr 16, 2008
Women with mutations in the BRCA1 or BRCA2 genes have an estimated lifetime risk of developing breast cancer of about 85 ... The surveillance strategy does not prevent breast cancer, and especially in BRCA1 carriers, who mostly have fast growing tumours, 25-30% of carriers are diagnosed when the tumour is already more than 2cm in diameter. (Science Daily)
Coordinated prophylactic surgical management for women with hereditary breast-ovarian cancer syndrome Apr 15, 2008
Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. (BioMed Central)
New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit Apr 14, 2008
On the basis of these and related studies, a clinical trial will soon be initiated specifically targeting patients with genetic defects in mismatch repair genes such as BRCA1 and 2, which are associated with susceptibility for breast and ovarian cancer. To review the poster and see more detailed information about the study, please go to. (PR Newswire)
Looping Genes May Hold A Key To Understanding Breast Cancer Apr 11, 2008
Dr Brown and Dr Juliet French at UQ, together with their colleagues at The University of Oxford, studied the BRCA1 gene and found that it exists in a looped formation. "Our studies suggest that BRCA1 looks a bit like a bow when the gene is switched off, and that part of this 'bow' disappears when the gene is switched on," Dr Brown said ... She said ongoing studies would identify the specific DNA sequences and DNA binding molecules involved in BRCA1 gene looping. (Science Daily)
Eating Soy Foods In Puberty Protects Against Breast Cancer, Evidence Now Suggests Apr 10, 2008
Other associated research has found that the genes that genistein appears to activate in developing mammary glands are well known --- BRCA1, p53, and PTEN tumor suppressors, Hilakivi-Clarke says ... "In pregnancy, BRCA1 is also up-regulated, perhaps in order to control the fate of stem cells, allowing them to make more cells for milk production, for example, but not more of themselves.". (Science Daily)
Five Years Later, Patient On Vaccine Trial Still Free Of Ovarian Cancer Apr 8, 2008
2, 2008) Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer. . (Science Daily)
'Pretty' author defies breast cancer destiny Apr 1, 2008
Mutations in a gene called BRCA1 dramatically increase a woman's risk of cancer ... Average woman: 12%With BRCA1 mutations: 56% to 84 ... 5%With BRCA1 mutations: 39% to 44. (USA Today)
Defying destiny: One woman's cancer story Mar 29, 2008
On that morning in 2004, Queller called the lab from her desk at Gilmore Girls and was told by a gruff voice that shed tested positive for the BRCA1 mutation. Translation: She had up to an 87 percent chance of getting breast cancer by age 70, and up to a 44 percent chance of ovarian cancer, too. (MSNBC -- Health)
MRI's High False Positive Rate Has Little Impact On Women's Choice Of Preventive Mastectomy Mar 28, 2008
The researchers from the Hereditary Cancer Clinic at Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, followed 196 women with a BRCA1 or BRCA2 mutation, aged between 21 and 68 for an average of two years (a range of between one and nine years). Once the women had discovered that they carried a BRCA mutation (which gives a lifetime risk of breast cancer of up to 85 per cent and for ovarian cancer of up to 60 per cent) they made six-monthly visits to hospital to be examined... (Science Daily)
Cancer victim's family walks for awareness Mar 27, 2008
Starting in 2001, Dolan, a divorced mother of two, had mammograms and ultrasounds regularly because of a family history of cancer and a positive test for a mutation in the BRCA1 cancer gene. On her doctor's advice, she opted for a prophylactic hysterectomy in April 2005 to further reduce her risk. (Springfield Sun, PA)
Identical Genes from Parents May Raise Cancer Risk Mar 27, 2008
Unlike many currently available genetic tests -- such as those for the BRCA1 and 2 genes thought to play a role in breast cancer -- these anticipated tests could be applicable to everybody, not just people at high risk for a particular malignancy. Similarly, the new findings suggest that more than 5 percent of all cancers are linked to heredity, the researchers said. (MEDLINEplus)
Breast MRI scans 'commonly wrong' Mar 26, 2008
Researchers at the Hereditary Cancer Clinic at Nijmegen Medical Centre followed 196 women with the BRCA1 or BRCA2 gene mutation which has been linked to breast cancer. On their first visit, they were asked whether they had a preference for ongoing surveillance in the form of scans, or whether they would rather have their breasts removed as a precaution. (BBC News -- Health)
Breast cancer gene carriers' risk 'amplified' by additional genes Mar 25, 2008
The study brings together results from international research groups looking at a total of more than 10,000 women carrying a BRCA1 or BRCA2 mutation. Dr Lesley Walker, Cancer Research UK's director of cancer information, said: "It's important to remember that the prevalence of this combination of gene faults is rare in the general population. But advances like this will add to our ability to identify those most at risk for clinical monitoring, detecting the disease earlier in those who develop... (News-Medical.net)
Read this before buying a home testing kit Mar 25, 2008
MYTH: Anyone who wants to find out their risk of developing breast and ovarian cancer should get the BRCA1/2 genetic test. FACT: A BRCA gene test does not test for cancer itself only for mutations, or changes, in the BRCA1 or BRCA2 genes that may increase the chance of developing certain cancers over a lifetime ... Ethnic background known to have a high frequency of a BRCA1/2 mutation. (Atlanta Journal-Constitution -- Health)
After cancer, alife resculpted Mar 24, 2008
Its just that with my family history my mother died of ovarian cancer at 48; her sister died of breast cancer at 39; and Id tested positive for the BRCA1 gene mutation, which increased my chances of developing both diseases my doctor had been abundantly clear that if I was ever diagnosed with , my safest option would be to have a bilateral mastectomy. But losing my breasts isnt what frightened me. (MSNBC -- Health)
Family Discussion Plays Role in Breast Cancer Awareness Mar 23, 2008
Genetic testing looks for BRCA1 and BRCA2, two genes in which mutations greatly increase the risk of breast cancer ... "In this study, we evaluated the impact of socio-cultural variables on knowledge and attitudes about BRCA1/2 counseling and testing. We hope to use this information to better understand why there's a difference in testing uptake among black and white women," she said. (Health-Finder)
Family discussions about cancer impact upon genetic test decisions Mar 22, 2008
Participants were asked about their cancer history, whether they felt they were at risk, the extent to which they had discussed the disease with their doctors and families, and how much they knew about counselling and testing for the genes BRCA1 and BRCA2, which are responsible for around one quarter of hereditary breast cancer cases. Dr Kristi Graves, a clinical psychologist in the Cancer Control programme at the Lombardi Comprehensive Cancer Centre, revealed that there was no difference in... (Cancer Research UK - News & Resources)
Water: More crop per drop Mar 20, 2008
He compares the early buzz on genes associated with drought tolerance to the discovery of the first gene associated with breast cancer BRCA1. People celebrated an imminent end to the disease, and then they found a second and a third and a fourth and a fifth gene, and they realized it was more complicated. (Nature News Service)
Better Regulation Of Home Genetic Tests Needed, Researchers Urge Mar 17, 2008
For example, direct marketing of the BRCA1 and 2 familial breast cancer tests to women at low risk was criticised for causing unfounded anxiety and unnecessary preventive surgery. False reassurance from tests for common diseases could also result in effective prevention measures, such as controlling weight and exercising, being ignored. (Science Daily)
Severe Psychological Stress May Be Linked To Breast Cancer Mar 10, 2008
The study, led by biochemist Christopher Mueller, found that the stress hormone hydrocortisone may repress the activity of a tumour-suppressing gene known as BRCA1 that is related to breast cancer ... BRCA1 is a tumour-suppressing gene involved in a range of key cellular processes, including the repair of damaged DNA and the regulation of cell death ... In researching the effects of various hormones on cultured mouse mammary cells, Mueller found that continuous exposure to hydrocortisone was... (Science Daily)
New Genetic Marker For Breast Cancer Identified Mar 5, 2008
29, 2007) Men with mutations in the BRCA1 or BRCA2 genes are at greater risk of breast cancer than the general population. Male breast cancer accounts for less than 1 percent of all breast cancers in the U.S.. (Science Daily)
Jan Aitken reveals why she chose to have double mastectomy Mar 2, 2008
The BRCA1 result came back in 2001 and the BRCA2 result came back in 2006 - four years after Lila's death. Both were negative but now there are four more genes that I am to be tested for. (Mirror.co.uk)
Potential New Drug Targets Against Hormone-dependent Breast Cancer Identified Mar 1, 2008
More recently, the healthy form of the BRCA1 tumor-suppressor gene was found to quiet the aromatase gene performing its duty in keeping breast cancer risk low. "Maintaining this BRCA1-aromatase relationship in a healthy balance may help to keep patients free of hormone-dependent breast cancer," Dr. Dannenberg explains ... "It appears that PGE2 binds to these receptors and that this causes a downregulation of BRCA1," Dr. Subbaramaiah says. (Science Daily)
North-East pioneers new drug for cancer Feb 28, 2008
Dr Ruth Plummer, a senior lecturer in medical oncology and the chief investigator on the trial, said: "People who inherit faults in the BRCA1 or BRCA2 genes have a 50 to 80 per cent chance of developing cancer."Currently, women with hereditary forms of breast and ovarian cancer are treated in the same way as every other woman who develops the disease ... Mutations in the BRCA1 or BRCA2 genes are responsible for about five per cent of the 44,000 cases of breast cancer diagnosed annually in the... (The Northern Echo)
Breast Cancer Gene Carriers Need Dual Screening Feb 28, 2008
NEW YORK (Reuters Health) - Among women with BRCA1 gene mutations, which are known to increase the risk of breast cancer, annual screening with both mammography and MRI is associated with better survival when compared with screening with either method alone, new research indicates ... The findings were based on data from 22 studies that included 8,139 women who carried the BRCA1 gene ... "For women who carry BRCA1 gene mutations, adding annual MRI to annual mammography has a clear benefit in... (MEDLINEplus)
Sexual Satisfaction Feb 27, 2008
"In the past," Kaplan notes, "virtually all testing was done in medical laboratories for diagnostic purposes, such as searching for the mutations in the BRCA1 gene that are related to breast cancer." Today, however, prenatal sex tests have come down in price to $300 or less, cheap enough to sell directly to would-be parents. And instead of waiting the "10 to 16 weeks needed for traditional medical tests, such as ultrasound," you can now find out at just five to seven weeks whether you're... (Slate)
• Accuracy of gender test kits in question Feb 24, 2008
In the past, virtually all testing was done in medical laboratories for diagnostic purposes, such as searching for the mutations in the BRCA1 gene that are related to breast cancer. But the development of faster and cheaper machines to sequence specific genes quickly gave entrepreneurs an opportunity. (Q13.com, WA)
Personalized Medicine Can Cut Breast Cancer Risk Feb 20, 2008
"A growing body of evidence has documented the benefits of preventive measures for high-risk women including those with mutations in the BRCA1 and BRCA2 genes," said Funmi Olopade, MD, the Walter L Palmer Distinguished Service professor of medicine and director of the Cancer Risk Clinic at the University of Chicago Medical Center ... "More than ten years after BRCA1 and BRCA2 were identified as major breast and ovarian cancer susceptibility genes," Olopade added, "primary care providers should... (Science Daily)
Benefit Of Cancer Prevention Surgery Differs Between Women With BRCA1 And BRCA2 Mutations Feb 15, 2008
14, 2008) The surgical removal of the ovaries has been widely adopted as a cancer-risk-reducing strategy for women with either BRCA1 or BRCA2 mutations. A new multicenter study led by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) is the first prospective examination of the impact of this procedure in which BRCA2 mutation carriers were analyzed separately from BRCA1 mutation carriers ... All previous studies evaluating this approach have only examined BRCA1 and BRCA2 mutation... (Science Daily)
Ovary Removal Protects Some High-Risk Women Feb 14, 2008
BRCA2 carriers get twice the reduction in breast cancer risk that BRCA1 carriers do, study finds ... TUESDAY, Feb. 12 (HealthDay News) -- Women who carry the BRCA1 or BRCA2 mutations that raise the risk for both breast and ovarian cancer should weigh a new finding that suggests having your ovaries removed provides greater protection against breast cancer if you have the BRCA2 mutation ... "There have been studies that looked at BRCA1 and 2 together, but not 2 alone," Kauff noted. (MEDLINEplus)
Study reveals why certain ovarian cancers develop resistance to platinum-based chemotherapy Feb 11, 2008
While these findings are based on the study of ovarian-cancer cells from women with inherited mutations in the BRCA2 gene, they also may help explain the mechanics of cisplatin resistance in ovarian-cancer patients with BRCA1-gene mutations ... Because BRCA1 and BRCA2 have similar functions in terms of DNA repair, we may be able to generalize these findings for women with either mutation, said Taniguchi, an assistant member of the Hutchinson Centers Human Biology and Public Health Sciences... (EurekAlert!)
Radical surgery to curb cancer Feb 4, 2008
Most are among a minority of people diagnosed through genetic testing with a mutation in the BRCA1 and BRCA2 genes, which carries a high risk of getting both breast and ovarian cancer ... The mutation in the BRCA1 and BRCA2 genes also carried lifetime risk of between 30 to 40 per cent for ovarian cancer ... In one case, Sheidow Park sisters Terry Friebe, 40, and Karyle, 43, both had the risk-reducing surgery after being diagnosed in the past three years as carriers of the BRCA1 mutation. (Advertiser Adelaide)
BRCA1 Mutation Linked To Breast Cancer Stem Cells Feb 2, 2008
1, 2008) A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer ... Researchers from the University of Michigan Comprehensive Cancer Center found that BRCA1 plays a role in regulating breast stem cells, the small number of cells that might develop into cancers ... The study, in mice and in human breast cancer cells, found that BRCA1 is involved in the stem cells differentiating into other breast tissue cells. (Science Daily)
New Pathway Provides More Clues About BRCA1 Role In Breast Cancer Jan 19, 2008
The discovery also could lead to more effective therapies for women with and without mutated copies of the BRCA1 gene, according to a study led by Duke University Medical Center researchers. "Since it was discovered in 1994, BRCA1 and its role in preventing and causing cancer has been intensely studied, and our research represents an important piece of the puzzle," said Craig Bennett, Ph ... "This study has identified an important mechanism by which BRCA1 comes into play when DNA -- the basis... (Science Daily)
Biological Link Between BRCA1 and Breast Cancer Detailed Jan 19, 2008
THURSDAY, Jan. 17 (HealthDay News) -- A newly discovered role played by the breast cancer gene BRCA1 in repairing damaged DNA may help explain why women who inherit a mutated version of the gene are more likely to develop breast and ovarian cancer ... "Since it was discovered in 1994, BRCA1 and its role in preventing and causing cancer has been intensely studied, and our research represents an important piece of the puzzle," lead investigator Craig Bennett, a researcher in Duke's Department of... (MEDLINEplus)
Breast Cancer Gene Testing Less Likely Among Blacks Jan 19, 2008
NEW YORK (Reuters Health) - African American women are generally less likely than white women to pursue genetic testing for BRCA1 or BRCA2, the gene mutations associated with an increased risk of break cancer, researchers report ... Evans and associates examined race and the timing of breast cancer diagnosis and the frequency of BRCA1/2 genetic testing among women attending the UNC Cancer Genetics Service ... Among 768 women diagnosed with breast cancer who were offered BRCA1/2 testing, the... (MEDLINEplus)
Should Children Be Permitted To Get Genetic Testing For BRCA 1/2 Mutations? Jan 18, 2008
21, 2006) BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular and pancreatic cancers, according to a study in. (Nov. (Science Daily)
Breast Cancer Gene Risk May Be Overstated Jan 10, 2008
Many women fear that breast cancer is inevitable if they are found to carry mutations in the genes BRCA1 and BRCA2 ... Some 181 carried mutations in either BRCA1 or BRCA2 genes, the team found ... Rather, it simply asserts greater variation in breast cancer risk among carriers of BRCA1 and BRCA2 which does not inherently say anything about overall risk (e. (Yahoo News -- Cancer)
Breast Cancer Risk Varies Significantly Among BRCA1 And BRCA2 Carriers Jan 10, 2008
9, 2008) There is a broad variation in the risk of developing breast cancer among people who carry the BRCA1 and BRCA2 gene mutation, according to a new article ... " BRCA1 and BRCA2 are gene mutations that predispose carriers to breast cancer. The magnitude of the risk of breast cancer in BRCA1 and BRCA2 carriers is critical for guiding decisions concerning cancer prevention options. The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively... (Science Daily)
Breast cancer gene may not be only determinant of disease, study shows Jan 9, 2008
So a woman who knows she has a BRCA1 or BRCA2 mutation still cannot know precisely what her risk of breast cancer is, the researchers reported in the Journal of the American Medical Association ... They found that 5 percent of those with cancer in one breast had a BRCA1 or BRCA2 mutation and 15 percent of those with cancer in both breasts did ... And 58 percent of those with BRCA1 or BRCA2 mutations had a mother, sister, or other close relative with the disease, the researchers said. (Boston Globe)
Breast-Cancer Genes May Pose Lower Risk Jan 9, 2008
Researchers didn't use the commercial test, but did independently test patients for mutations to BRCA1 and BRCA2 genes ... Currently, BRCA1 and 2 testing is recommended for women with families already affected by cancer, rather than as a population-screening tool for women worried about breast cancer but not at risk. (Wall Street Journal)
BRCA Mutations Don't Raise Breast Cancer Risk Equally Jan 9, 2008
TUESDAY, Jan. 8 (HealthDay News) -- Not all carriers of the BRCA1 and BRCA2 genetic mutations show the same risk for developing breast cancer ... It is known that the BRCA1 and BRCA2 gene mutations raise a woman's risk for developing breast cancer, so the degree of that risk is critical in helping a woman make choices about prevention ... "People have studied BRCA1 and 2 separately, but, other than that, there's the sense that if you're a carrier, you have a certain risk, and it's a high risk,... (Health-Finder)
Breast Cancer Gene Might Extend Ovarian Cancer Survival Jan 3, 2008
THURSDAY, Jan. 3 (HealthDay News) -- Ashkenazi Jewish women with ovarian cancer live significantly longer if they carry specific mutations of the BRCA1 or BRCA2 genes known to raise risks for breast cancer. After five years of following a group of Ashkenazi Jewish women with ovarian cancer, researchers reported that women with the BRCA1 or 2 mutations were 29 percent less likely to die from the disease ... The Israel-based research team compared five-year survival between 213 Ashkenazi ovarian... (Health-Finder)
