Obesity, Insulin Level Impact Prostate Cancer Survival Oct 7, 2008
Information on body mass index (BMI) was available for all of these men, while information on C-peptide concentration (a marker of insulin levels in the blood) was available for 827 men ... Men with the highest C-peptide concentrations also had more than double the risk of dying from their cancer compared with men with the lowest levels, the study found ... Finally, men who had a BMI of more than 25 and high C-peptide concentrations had quadruple the risk of dying from their cancer compared with... (MEDLINEplus)
Obesity linked to prostate cancer deaths Oct 6, 2008
The researchers looked at each subject's body mass index (BMI), C-peptide concentrations a marker of insulin secretion and whether or not they died of prostate cancer ... They also found that those with the highest C-peptide concentrations also had a significantly greater risk of prostate-cancer mortality compared with men with the lowest concentrations. (Globe and Mail)
Can Diet Alone Control Type 2 Diabetes? No Evidence Yet Jul 17, 2008
In another study 12 months of dietary advice led to significant reductions in many diabetes related factors, such as insulin resistance, fasting C-peptide, fasting proinsulin, fasting blood glucose, fasting triglycerides, and fasting cholesterol and PAI-1. "These two studies give grounds for believing that dietary advice alone could play an important role in reducing type 2 diabetes, but we do need more well-designed, long-term studies before we can work out the best advice to give," says Nield. (Science Daily)
Pill effective against gestational diabetes May 8, 2008
The test of 23,316 women in nine countries found having "mild" gestational diabetes, which usually is not treated, increased the risk for having a higher-weight baby and or a baby with high C-peptide levels, which measures the likelihood of diabetes. For example, the risk of delivering a child whose weight was in the 90th percentile was 5 percent among the women with the lowest glucose levels, and at least 20 percent among women whose levels were highest. (Scientific American)
Hyperglycemia and Adverse Pregnancy Outcomes May 8, 2008
Primary outcomes were birth weight above the 90th percentile for gestational age, primary cesarean delivery, clinically diagnosed neonatal hypoglycemia, and cord-blood serum C-peptide level above the 90th percentile ... 44), respectively; for cord-blood serum C-peptide level above the 90th percentile, 1 ... Conclusions Our results indicate strong, continuous associations of maternal glucose levels below those diagnostic of diabetes with increased birth weight and increased cord-blood serum... (New England Journal of Medicine)
Exenatide and Rare Adverse Events May 2, 2008
1 Islet-graft dysfunction with preserved C-peptide levels was observed after approximately 1 year. After the patient had provided written informed consent, off-label use of exenatide (Byetta, Amylin Pharmaceuticals). (New England Journal of Medicine)
Fewer Steps Per Day Send Disease Markers Up Mar 19, 2008
The team found that when healthy men cut their daily activity, their insulin levels spiked dramatically, as did levels of blood factors such as C-peptide and triglycerides -- suggesting an increased risk of diabetes and heart disease. "It is amazing that only two weeks of reduced stepping can induce numerous metabolic abnormalities," said the one of the study's authors, Dr. Rikke Krogh-Madsen, from the Centre of Inflammation and Metabolism in Copenhagen. (Health-Finder)
Breast cancer, blood sugar and body fat Mar 18, 2008
The study was a designed to explore the relationship between body mass index (BMI), the hormones involved in metabolism (leptin and adiponectin), some of those involved in controlling blood-sugar levels (C-peptide and glycated haemoglobin) and breast cancer risk among women in northern Sweden ... They also compared the levels of chemicals involved in regulating blood sugar: C-peptide and glycated haemoglobin ... Overall, the researchers found that BMI, leptin, adiponectin, C-peptide and glycated... (NHS Choices)
Diamyd Medical: Diamyd Announces Completion of Type 1 Diabetes Vaccine Trial with Long Term Efficacy Demonstrated at 30 Months Jan 21, 2008
As reported by professor Ludvigsson, the Phase IIb study with the Diamyd therapeutic diabetes vaccine met its primary endpoint regarding preservation of beta cell function as measured by C-peptide, a marker for the body s natural insulin production. As previously reported, the clear positive effect of Diamyd on preservation of beta cell function is also accompanied by a significant and specific immune response, an additional important factor in evaluating the effectiveness of the therapy since... (BusinessWire)
Once-irrelevant Compound May Have Medical Role In Preventing Diabetes Complications Jan 17, 2008
In the article, C&EN Senior Editor Celia Henry Arnaud notes that scientists previously believed that the compound, called C-peptide, had little biological activity and was a useless byproduct of insulin production. In recent years, however, researchers have seen beneficial effects of C-peptide in patients with type 1 diabetes, including improved kidney function, nerve function, and blood flow ... Clinical studies on the compound, so far inconclusive, may determine if C-peptide can help prevent... (Science Daily)
Diamyd Medical: Diamyd Files US IND for Phase III Trial with Diabetes Vaccine Dec 21, 2007
Based upon previous discussions with the FDA, meal-stimulated C-peptide, as a correlate for the patient s own insulin production, will be the primary endpoint. Insulin requirement and glycemic endpoints will also be measured and results will be evaluated after 15 months. (BusinessWire)
Keeping Insulin in Check Important in Breast Cancer Dec 14, 2007
At study enrollment and over several years or until death, researchers analyzed blood levels of C-peptide -- a marker of how much insulin the body is producing. They found that women with the highest C-peptide levels at the time of breast cancer diagnosis had almost twice the risk of death compared to women with lower C-peptide levels ... For women with invasive breast cancer -- meaning the cancer has spread throughout the breast tissue or to surrounding tissues -- the risk of death was three... (MEDLINEplus)
Obesity And Metabolism: Weight Gain And The Growing Risk Of Cancer Dec 11, 2007
Fasting C-peptide levels and breast cancer death in women with breast cancer: The Health, Eating, Activity and Lifestyle (HEAL) Study. Women with invasive breast cancer and high blood levels of C-peptide (a marker of insulin secretion) face a risk of death nearly three times higher than women with lower blood levels of C-peptide, according to findings from the Health, Eating, Activity and Lifestyle (HEAL) Study, a long-term observational study of breast cancer patients ... While previous... (Science Daily)
Obesity, Diabetes Linked to Cancers Dec 11, 2007
They measured blood levels of C-peptide, a marker of insulin secretion, in women in a long-term study of breast cancer. Over an eight-year period, the women in the highest third of C-peptide levels had twice the risk of dying from breast cancer, compared to women in the bottom third, the researchers said ... The researchers matched 264 men diagnosed with the cancer with a group of 264 cancer-free men, measuring C-peptide levels in both groups. (MEDLINEplus)
African-American Men Face Disadvantages Versus Caucasian Men In Prostate Cancer Survival Nov 29, 2007
From each participant's blood sample, the researchers compared PSA levels with the amounts of HbA1c, C-peptide, leptin and adiponectin -- naturally occurring blood-borne molecules that have a biological role in metabolism, insulin activity, or the function of fat cells. Among African-Americans, PSA levels were 50 percent lower among men with higher levels of C-peptide, a biomarker that reliably indicates an increase in insulin ... PSA levels also declined somewhat among obese Caucasian men with... (Science Daily)
Year End Report for Diamyd Medical AB, Fiscal Year 2006/2007 Oct 26, 2007
On average, the 35 patients that received Diamyd experienced only half the decline in meal-stimulated insulin secretion, as measured by meal-stimulated C-peptide levels, compared to placebo ... Previously it was reported that the most efficacous dose (20 g) significantly improved both meal-stimulated C-peptide levels and HbA1c at two years after treatment. (BusinessWire)
Takeda's Investigational DPP-4 Inhibitor Demonstrated Efficacy in Reducing Glucose Levels in Early Phase Study Jun 24, 2007
Secondary efficacy endpoints included change in mean 4-hour postprandial insulin levels; fasting plasma levels of C-peptide, fructosamine, and glycosylated hemoglobin (A1C); and incidence of hyperglycemia (blood glucose is greater than or equal to 200 mg/dL) ... There were no statistically significant differences in mean 4-hour postprandial insulin concentrations, hyperglycemia, or mean C-peptide concentrations in the alogliptin or placebo groups. (PR Newswire)
Insulin made from stem cells in research first May 26, 2007
Larry Denner of the University of Texas, who worked on the study, says his team had addressed this issue because the cells also produced a compound called C-peptide, which is not found in the culture medium - the broth used to nourish cells in the lab. "It is a part of the insulin precursor protein and is only present when cells produce insulin. So the state-of-the-art criteria for insulin production is the demonstration of the presence of C-peptide," Dr Denner said in an email. (ABC News Online, Australia -- World)
Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus Apr 12, 2007
03); C-peptide secretion was enhanced (P=0. 05), and there were reductions in the ratio of proinsulin to insulin (P=0. (New England Journal of Medicine)
Islet Transplantation Mar 1, 2007
Please for full text and personal services. Since this article has no abstract, we have provided an extract of the first 100 words of the and any section headings. (New England Journal of Medicine)
JDRF forms partnership with MacroGenics Jan 4, 2007
The patients who received hOKT3-gamma-1 (Ala-Ala) had improved C-peptide responses following a mixed meal tolerance test, reduced hemoglobin A1c (HbA1c) levels, and lower insulin requirements for at least two years following the initial treatment compared to the control population. C-peptide responses measure a patient's residual beta cell function and ability to produce insulin. (EurekAlert! -- Business News)
