Dr. Gupta: New ways to survive cardiac arrest Sep 22, 2009
But you might also ask your doctor about getting your C-reactive protein, or CRP, checked. It is a marker for inflammation, a powerful risk factor for heart disease. (CNN -- Health)
Diabetes Medications Don't Lower Inflammation Sep 17, 2009
As for markers of inflammation, the researchers found reductions in inflammation (as measured through levels of C-reactive protein, IL-6 and tumor necrosis factor receptor 2) for all of the groups ... For example, C-reactive protein levels went down in the placebo group by 19 percent, in the metformin group by 16 percent and the metformin and insulin group by 20 percent. (MEDLINEplus)
Metabolic Syndrome May Raise Risk of Peripheral Artery Disease Sep 10, 2009
The study also found that women with metabolic syndrome and PAD had higher levels of two markers of inflammation -- high sensitivity C-reactive protein and soluble intercellular adhesion molecule-1. The study appears in the Sept. 8 issue of Circulation: Journal of the American Heart Association. (Atlanta Journal-Constitution -- Health)
Fluvastatin in Patients Undergoing Vascular Surgery Sep 3, 2009
Lipid, interleukin-6, and C-reactive protein levels were measured at the time of randomization and before surgery ... Levels of total cholesterol, low-density lipoprotein cholesterol, interleukin-6, and C-reactive protein were significantly decreased in the fluvastatin group but were unchanged in the placebo group. (New England Journal of Medicine)
Heart group urges daily limit on added sugar Aug 26, 2009
Although added sugar is not directly linked to heart disease, it is associated with risk factors such as obesity, high blood pressure, high levels of triglycerides, and high levels of C-reactive protein, which has been linked to oxidative stress and inflammation, says Linda Van Horn, a registered dietitian and chair of the 's Nutrition Committee. In contrast, foods with naturally occurring sugars deliver nutrients while still satisfying our craving for sweetness. (CNN -- Health)
Marriage cuts men's risk of health problems Aug 23, 2009
In the University of Arizona study, boffins reviewed blood samples from 1,715 volunteers aged 57 to 85 to measure the level of C-reactive protein (CRP), which is produced by the liver in response to inflammation. CRP has been linked in previous studies to heart disease, depression and even stroke. (India Times, India -- Health/Science)
Fatigue Related To Radiotherapy May Be Caused By Inflammation Aug 21, 2009
In a new finding, the researchers noted that increases in serum markers of cytokine activity, specifically IL-1 receptor antagonist and C-reactive protein, were also linked with fatigue. "This study suggests that exposure to radiation is releasing these inflammatory cytokines and that may be contributing to fatigue," said Bower. (Science Daily)
Infection Associated with Prosthetic Joints Aug 20, 2009
Her leukocyte count is 8000 per cubic millimeter, and the C-reactive protein (CRP) level is 15. 5. (New England Journal of Medicine)
Quitting Smoking Causes Quick Drop in Inflammation Aug 18, 2009
To investigate, they performed blood tests for several markers of inflammation, including C-reactive protein (CRP), tumor necrosis factor (TNF), and other substances, in 36 women participating in a smoking cessation program. The women were tested four times over 6 to 7 weeks. (MEDLINEplus)
Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study Aug 15, 2009
The outcome measures were the Lequesne Algofunctional Index (LAI) for joint pain and movement as well as biomarkers of inflammation (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]). Results. (Nutrition Journal)
Amazonian Tribe Sheds Light On Causes Of Heart Disease In Developed Countries Aug 12, 2009
According to the study, the Tsimane also have unusually high levels of C-reactive protein, increasingly used in clinical settings to evaluate risk for cardiovascular disease. Yet, despite these risk factors for heart attacks, the researchers found that the high levels of C-reactive protein were unrelated to risk of peripheral arterial disease (the hardening of plaque in the arteries). (Science Daily)
Sex Hormone Protein May Predict Type 2 Diabetes Aug 7, 2009
"In direct comparison, it significantly outperformed some newer risk predictors such as HbA1c (glycated hemoglobin) and C-reactive protein.". The researchers also used genetic data to confirm that SHBG may play a causal role in the development of type 2 diabetes. (MEDLINEplus)
Depression and inflammation linked to pain in rheumatoid arthritis patients Aug 5, 2009
Researchers at Nagoya City University and Nagoya University Graduate Schools of Medicine in Japan studied the interrelationship between levels of depression symptoms, C-reactive protein (CRP) level, and pain, confirming a significant positive association between depressive symptoms and CRP level in RA. A second study by researchers at the University of British Columbia in Canada further explored depression in spouses of persons with RA, finding that higher levels of spouse depression predicted... (EurekAlert!)
Innovation in preventing heart disease Jul 28, 2009
What the Massachusetts General Hospital research fails to acknowledge is that the predictive value of the test for C-reactive protein is at least as good as that of LDL cholesterol, and that it has repeatedly been shown that adults with elevated C-reactive protein and normal cholesterol levels are at significantly increased risk of a cardiac event. A recent 18,000-person clinical trial has shown that giving a statin to people with this laboratory profile can cut in half the risk of heart attack,... (Boston Globe -- Editorial)
Human Cells Secrete Cancer-killing Protein Jul 28, 2009
The research implicates C-reactive protein (CRP) as a potential. (Sep. (Science Daily)
Scoop: Nurse says Jackson lost 5 pounds a day Jul 27, 2009
The C-reactive protein test. Nothing there (The test is a general marker of inflammation throughout the body, and can rule out things like coronary heart disease and cardiovascular disease). (MSNBC -- Gossip)
R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent Jul 24, 2009
blood measurements of C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR). Efficacy Results Treatment N of Pts ACR 20 ACR 50 ACR 70 DAS28<2. (PR Newswire)
Diagnosing Rheumatoid Arthritis Jul 22, 2009
Much like the ESR test, the C-reactive protein (CRP) measures the degree of inflammation, sometimes one will be raised when the other isn t.. Rheumatoid Factor (RF). (Suite101.com)
Hildreth: Why does the brain wear out first? Jul 16, 2009
That is why a periodic examination including blood tests that include a serum C-reactive protein and homocysteine blood levels are important. An MRI x-ray study of the brain can give some feedback as to the amount of brain cell destruction that has been going on, although there may not be a direct relationship at any one time as to the amount of tissue destruction noted and the symptoms of dementia. (Green Valley News & Sun, AZ)
Mysteries of the heart Jul 15, 2009
The test is for C-reactive protein, a measurement of inflammation in the arteries ... In November, a Brigham team led by Dr. Paul Ridker published a study showing that in patients with normal cholesterol but high levels of C-reactive protein the use of a statin drug - which also lowers cholesterol - could reduce the incidence of heart attacks, strokes, and deaths ... The researchers obtained blood samples and tested for C-reactive protein and other potential heart-disease markers. (Boston Globe)
Study Demonstrates the Anti-Inflammatory Properties of Pine Bark Extract on Inflammatory Mediators COX-2 and 5-LOX Jul 15, 2009
One arthritis study showed a significant reduction of inflammatory marker C-reactive protein. Pycnogenol(R) has been shown to inhibit inflammation in several dysmenorrhoea studies and also a reduction in skin inflammation related to sunburn and acne. (PR Newswire)
XOMA Announces Positive Results From U.S. Phase 1 Trial of XOMA 052 in Type 2 Diabetes Jul 15, 2009
Further, a multiple dose regimen of XOMA 052 showed clinically meaningful reductions in glycosylated hemoglobin, HbA1c, and high sensitivity C-reactive protein, hsCRP, compared to a single dose regimen. Generally, a more consistent response was seen across patients in the multiple dose regimen compared to single dose regimen. (Primezone Releases)
Current Search For Heart Disease Treatment May Not Be Fruitful Jul 8, 2009
Their research suggests that C-reactive protein, an enticing target for scientists working on new treatments for coronary heart disease, may not have a role in causing the disease, even though it is a predictive marker ... There is strong interest in measuring levels of C-reactive protein in a patient's blood, because it is a marker of inflammation ... Previously, scientists had not known whether C-reactive protein causes coronary heart disease, even though a number of studies over the past 12... (Science Daily)
Study Supports Wider Use of Statins Jul 2, 2009
It supports the findings of the JUPITER trial, reported last year, which noted 54 percent fewer heart attacks and 48 percent fewer strokes among people taking a statin who had normal cholesterol levels but high levels of C-reactive protein, a marker of inflammation, said Dr. Antonio M. Gotto, Jr., dean of Weill Cornell Medical College, a member of the international team reporting on the meta-analysis in the BMJ online. The analysis shows that "the more risk factors you have, the more aggressive... (MEDLINEplus)
C-Reactive Protein Doesn't Cause Heart Disease Jul 2, 2009
com - C-Reactive Protein Doesnause Heart Disease ... C-Reactive Protein Doesnause Heart Disease ... C-reactive protein (CRP), a target for studies of treatment for coronary heart disease, is not in fact directly involved in causing it, as once thought, said the research published in the Journal of the American Medical Association. (Newsmax)
Newer Blood Tests May Not Improve Heart Risk Assessment Jul 2, 2009
TUESDAY, June 30 (HealthDay News) -- Newer biomarkers of cardiac risk, such as inflammation-linked C-reactive protein (CRP), add little or no predictive power to older, established factors such as smoking, obesity, high cholesterol and physical activity, two major studies find. The newer blood-borne markers have been touted as a better way of assessing heart risk, but recent studies have suggested otherwise. (MEDLINEplus)
Lap-band weight-loss surgery can reverse metabolic syndrome in obese teens Jul 2, 2009
Metabolic syndrome is defined as a cluster of risk factors -- high blood pressure; low levels of HDL or "good" cholesterol; excessive abdominal fat; and elevated levels of blood sugar, C-reactive protein and triglycerides -- that increase a person's chances of developing cardiovascular disease or diabetes later in life ... Six months after surgery, they noted a significant drop in participants' BMI, waist circumference, and blood levels of C-reactive protein. (EurekAlert!)
Study suggests C-reactive protein doesn't cause heart disease Jul 1, 2009
Researchers conclude C-reactive protein probably not the cause of heart disease ... High levels of C-reactive protein (CRP) in the blood probably don't cause hardening of the arteries or heart disease, according to the largest study of its kind to focus on the long-suspected culprit ... A large study in London showed that C-reactive protein does not cause heart disease or heart attacks. (CNN -- Health)
Report on protein test to predict heart attack sounds cautious note Jul 1, 2009
General research does not directly contradict a landmark study from Brigham and Women s Hospital last year - which was highly supportive of testing for C-reactive protein - but sounds a more cautious note on expanding its use ... C-reactive protein is a measurement of inflammation in the arteries designed to predict whether patients are prone to dangerous blood clots ... For example, in a 2004 study, European researchers said C-reactive protein was only a moderate predictor of risk. (Boston Globe)
Sleep duration is associated with variations in levels of inflammatory markers in women Jul 1, 2009
The study found that both interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) levels varied with sleep duration in women following multiple adjustments for a number of confounding factors. Compared with women who reported sleeping seven hours on an average weekday, IL-6 levels were significantly lower in women who reported sleeping eight hours. (EurekAlert!)
Mild and bitter Jun 30, 2009
Two years ago he and his colleagues published a study in which they showed that those teenagers who were better at doing so had a lower concentration of C-reactive protein, a substance made in response to inflammation and associated with an elevated risk of diabetes and cardiovascular disease. Dr Wrosch thus concludes that it is healthy to give up overly ambitious goals. (The Economist)
J&J unit wins $1.67 billion verdict vs Abbott Labs Jun 30, 2009
Prochymal significantly decreased systemic inflammation in patients when compared to those receiving placebo, as determined by C-reactive protein (CRP). Despite the reduction in inflammation, pulmonary function in patients receiving Prochymal was not significantly improved compared. (Fresno Bee -- Business)
Inflammation Markers Linked More With Fatal Than Nonfatal Cardiovascular Events In Elderly Jun 29, 2009
They examined if three inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen were each more strongly massociated with fatal cardiovascular events than with non-fatal cardiovascular events in the period of over three years in which the patients in the trial were monitored. Using several statistical models, the researchers found that in this group of elderly patients increased levels of all three inflammatory markers, and in particular IL-6, were more strongly... (Science Daily)
Prostate Cancer Test Improves Prediction Of Disease Course Jun 24, 2009
14, 2006) Increased levels of two markers of inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), are significantly associated with prostate cancer incidence and mortality almost a decade prior to. (Jan. (Science Daily)
Can Alzheimer's Be Cured? Jun 24, 2009
The core of our program is to teach people about the growing links between cardiovascular markers (blood pressure, blood sugar, body weight and BMI, blood , C-reactive protein) and brain health. A population study from Finland has developed a fascinating scale that can predict 20-year risk for dementia sort of a brain aging speedometer. (Scientific American)
Lap Band Weight Loss Surgery Reduces Teens' Risk Factors For Heart Disease, Diabetes Jun 23, 2009
Six months after the operation, patients had a statistically significant decrease in their body mass index (BMI, a measure of body fat) as well as their waist circumference and blood levels of C-reactive protein, a measure of inflammation that is linked to increased risk of cardiovascular disease. These improvements continued to 1 year in the 12 patients whose follow-up was that long.. (Science Daily)
Most men deficient in key nutrients Jun 20, 2009
Plus, a study in the Journal of the American College of Nutrition found that low levels of magnesium may increase your blood levels of C-reactive protein, a key marker of heart disease. The shortfall: Nutrition surveys reveal that men consume only about 80 percent of the recommended 400 milligrams of magnesium a day. (MSNBC -- Health)
Genes That Regulate Human Circadian Rhythm Significantly Disturbed In Individuals With Arthritis Jun 17, 2009
These values were shown to correlate with several measures of arthritis disease activity, including levels of c-reactive protein, swollen joint count and DAS28. A further element of the study looked into the expression patterns of certain genes in mice with arthritis. (Science Daily)
Heart Dangers Seen in Very Young Obese Children Jun 16, 2009
The obese children had high levels of c-reactive protein, associated with inflammation, which is itself linked to heart disease. They also had abnormally high levels of the clotting factor fibrinogen compared to lean children of the same age and sex, Mauras told a meeting of the Endocrine Society. (MEDLINEplus)
Canakinumab in CAPS Jun 4, 2009
We evaluated therapeutic responses using disease-activity scores and analysis of levels of C-reactive protein (CRP) and serum amyloid A protein (SAA). Results In part 1 of the study, 34 of the 35 patients (97%) had a complete response to canakinumab. (New England Journal of Medicine)
Biological Markers That May Indicate Poor Breast Cancer Prognosis Identified May 31, 2009
D., and colleagues measured the levels of C-reactive protein (CRP) and serum amyloid A (SAA) in 734 breast cancer patients at 31 months after diagnosis. They found that elevated levels of CRP and SAA are associated with reduced overall survival, regardless of patient age, tumor stage, race and body mass index. (Science Daily)
Novel biomarkers in heart failure May 31, 2009
for inflammation C-reactive protein (CRP). for anemia hemoglobin. (EurekAlert!)
Drug May Extend Life When Breast Cancer Spreads May 28, 2009
A study from National Cancer Institute investigators that found that people with early-stage breast cancer who have high levels of C-reactive protein and serum amyloid A -- both markers of inflammation -- were two to three times more likely to die of their disease or see their cancer return than people with lower levels of the proteins. New guidelines from the American Society of Clinical Oncology stating that women at a heightened risk of developing breast cancer might benefit from the drug... (MEDLINEplus)
The Dangers of Statin Drug Use May 24, 2009
Other factors such as homocysteine and C-reactive protein levels are better predictors of a future heart attack. It's obvious that one of the many factors leading to the buildup of LDL, the bad cholesterol, is due in large part to a lifestyle that promotes ill health. (Suite101.com)
Depression gene 'discovered' May 19, 2009
According to the scientists, the study demonstrated that the risk of depression was greatest amongst people who carry a genetic polymorphism of the C-reactive protein (CRP) gene and is not linked to increased levels of CRP, as previous scientific studies had suggested. C-reactive protein (CRP) is a protein found in the blood in response to inflammation. (India Times, India)
Irregular Heartbeat Tied to Alzheimer's Disease May 19, 2009
It is also possible that inflammation is the underlying problem in both conditions, he said, since indicators of increased inflammation, such as the molecule C-reactive protein, have been found in both cases. Treatment with statins, which have anti-inflammatory properties, or medications aimed directly at inflammation, could thus be used. (MEDLINEplus)
29 Percent Of Cancer Studies Report Conflict Of Interest May 14, 2009
The C-reactive protein, also known as CRP, is a special type of protein produced by ... The C-reactive protein, also known as CRP, is a special type of protein. (Science Daily)
Recombinant C-Reactive Protein May 8, 2009
C-Reactive Protein is a protein found in the blood that operates as a marker for inflammation, meaning its presence indicates an increased state of inflammation in the body ... N-terminal amino acid sequence of r-hCRP is the same as that of the native human c-reactive protein ... attention to the clinical research community to stay ahead of their demands for acute phase proteins like C-Reactive Protein CRP. (PR Newswire)
Rosuvastatin to Prevent Venous Thromboembolism Apr 30, 2009
4 mmol per liter) and high-sensitivity C-reactive protein levels of 2. 0 mg per liter or higher to receive rosuvastatin, 20 mg per day, or placebo. (New England Journal of Medicine)
Laughter May Lower Heart Attack Risk in Diabetics Apr 28, 2009
After 12 months, the researchers evaluated both groups by such tests as measuring cholesterol levels and levels of C-reactive protein, a marker of inflammation thought to be associated with heart disease ... Harmful C-reactive proteins declined by 66 percent in the laughter group but just 26 percent for the control group. (MEDLINEplus)
Tests reveal risks of heart disease Apr 17, 2009
Another test that can be helpful in assessing your risk is a high-sensitivity c-reactive protein (CRP) test. CRP is an independent risk factor for heart disease a known inflammatory compound that could be damaging your blood vessel walls, setting you up for plaque formation and eventually a heart attack. (Honolulu Advertiser)
Radon Spa Therapy For Arthritis Apr 17, 2009
They were also monitored with blood tests that measure inflammation, including the erythrocyte sedimentation rate and the C-reactive protein test. Morning stiffness was also measured. (Suite101.com)
New Drug May Help Patients with Psoriatic Arthritis Apr 11, 2009
The improvements were in areas such as swollen and tender joints, pain, disease activity, physical function, and levels of C-reactive protein. In addition, more patients in the 50-mg or 100-mg golimumab groups achieved ACR50 and ACR70 responses than those in the placebo group. (MEDLINEplus)
New drug shows promising results for psoriatic arthritis Apr 8, 2009
This response included at least a 20 percent improvement in swollen and tender joint counts and other measures such as pain, disease activity, physical function, and C-reactive protein. ACR50 and ACR70 responses were defined by at least 50 percent and at least 70 percent improvement. (EurekAlert!)
New Evidence Of Periodontal Disease Leading To Gestational Diabetes Apr 7, 2009
(May 5, 2006) Researchers found that pregnant women with periodontitis had 65 percent higher C-reactive protein (CRP) levels compared to periodontally healthy women. This study appears in the May issue of the. (Science Daily)
The More Oral Bacteria, The Higher The Risk Of Heart Attack, Study Shows Apr 3, 2009
2, 2009) Several studies have suggested there is a connection between organisms that cause gum disease, known scientifically as periodontal disease, and the development of heart disease, but few studies have tested this theory. A study conducted at the University at Buffalo, where the gum disease/heart disease connection was uncovered, now has shown that two oral pathogens in the mouth were associated with an increased risk of having a heart attack, but that the total number of germs, regardless... (Science Daily)
Statin Might Help Fight Blood Clots in Veins Apr 1, 2009
did not have elevated levels of LDL, or "bad," cholesterol, but they did have increased levels of the inflammatory marker called C-reactive protein (CRP) ... The findings also suggest that statins may derive some of their benefit from their effect on C-reactive protein ... All the participants were "apparently healthy," with LDL cholesterol levels under 130 milligrams per deciliter of blood, and high-sensitivity C-reactive protein levels of 2 mg/liter or higher (slightly elevated). (MEDLINEplus)
Statins May Help Before Artery-Opening Surgery Apr 1, 2009
Blood levels of C-reactive protein, a molecule associated with inflammation, were significantly lower in those who got the statin, he noted, and the drug also acts on clot-forming blood platelet cells and improves the function of the endothelium, the sensitive layer of cells that lines the arteries. "These findings have the potential to change current clinical practice," Di Sciascio said. (MEDLINEplus)
Low Inflammation, Cholesterol Cuts Heart Risk Apr 1, 2009
The results come from the Jupiter study, which originally found that Crestor significantly cut such cardiovascular events in patients with healthy cholesterol levels, but who had high amounts of the protein, known as C-reactive protein (CRP) ... The initial Jupiter results shined a bright light on C-reactive protein and its connection to serious heart risks. (MEDLINEplus)
Cholesterol drug reduces blood clots by over 40% Mar 30, 2009
The study was a long-term, large-scale study of 17,802 patients designed to determine if treatment with Crestor lowered the risk of heart attack, stroke and other major cardiovascular events in patients with low levels of "bad" cholesterol (or LDL-C), and raised levels of the inflammatory marker C-reactive protein (CRP). The results showed that patients taking rosuvastatin cut their risk of heart attack by more than half (54 percent), lowered their risk of stroke by 48 percent, and reduced their... (Xinhuanet, China)
CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis Mar 30, 2009
March 29 /PRNewswire-FirstCall/ -- Results from a new sub- analysis of the JUPITER study show that patients with low to normal cholesterol levels and elevated high sensitivity C-reactive protein (hsCRP) who attained a dual treatment target of LDL-C <70mg/dL and hsCRP <2mg/L with CRESTOR(R) (rosuvastatin calcium) 20mg achieved a greater reduction in cardiovascular events compared to placebo than those who did not (65% vs 36%; p=0 ... JUPITER was a long-term, randomized, double-blind,... (PR Newswire)
Video: CRESTOR(R) Reduced Risk of Blood Clots in the Veins Mar 30, 2009
007) compared to placebo among men and women with low to normal cholesterol levels and elevated high-sensitivity C-reactive protein (hsCRP) ... JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin) was a long-term, randomized, double-blind, placebo-controlled, large-scale study of 17,802 patients designed to determine if rosuvastatin 20 mg decreases the risk of heart attack, stroke and other major cardiovascular events in patients... (PR Newswire)
Study of statin drug finds it may lower risk of blood clots Mar 30, 2009
Ridker is a co-inventor on a patent of the test for high-sensitivity C-reactive protein, or CRP. It is a measure of inflammation, which can mean clogged arteries or less serious problems, such as an infection or injury. It costs about $80 to have the blood test done. (Boston Globe)
Conference to battle heart diseases Mar 28, 2009
The key question in the cardio community is whether the results could be applied to millions of people without a high risk of cardiovascular disease but with elevated levels of C-reactive protein -- a sign of artery inflammation. At the conference three cardiologists who examined the reams of Jupiter data will present their analysis. (India Times, India)
Cross sectional study of childhood obesity and prevalence of risk factors for cardiovascular disease and diabetes in children aged 11-13 Mar 25, 2009
Data will include: anthropometrical variables (height, weight, waist, hip and neck circumferences, skinfold thickness at 4 sites), physiological variables (blood pressure and aerobic fitness (20 metre multi stage fitness test (20MSFT)), diet (self-reported seven-day food diary), physical activity (Physical Activity Questionnire for Adolescents (PAQ-A), accelerometery) and blood tests (fasting glucose, insulin, lipids, fibrinogen (Fg), adiponectin (high molecular weight), C-reactive protein (CRP)... (BioMed Central)
