Why Cannabis Stems Inflammation Jul 22, 2008
Whilst the CB1 receptor in the central nervous system influences perception, the CB2 receptor in the tissue plays a crucial role in inhibiting inflammation ... The scientists have now discovered that the substance beta-carophyllene, which composes between 12 and 35 percent of the cannabis plant s essential oil, activates the CB2 receptor selectively ... This is presumably why no one realized that the substance can also activate the CB2 receptor. (Science Daily)
Pharmos Corporation Announces Board and Management Changes Jan 4, 2008
The Company's core proprietary technology platform focuses on discovery and development of synthetic cannabinoid compounds, especially CB2 receptor- selective (CB2-selective) agonists. PRS-639,058, the leading CB2-selective agonist, has demonstrated promising preclinical data in neuropathic pain. (PR Newswire)
Medical Marijuana Growers Payback Dec 6, 2007
Another cannabinoid was found to attach to the CB2 receptor found on osteoclasts and osteoblasts, which are the cells reponsible for regulating bone density, and reduced bone loss in mice with induced mouse osteoporosis. It was also found that mice and humans with mutations to their CB2 receptors had three times more likelihood of contracting osteoporosis. (Washington Post)
Pharmos Corporation Reports 2007 Second Quarter Results Aug 8, 2007
The Company's core proprietary technology platform focuses on discovery and development of synthetic cannabinoid compounds with a focus on CB2 receptor selective agonists. Various CB2-selective compounds from Pharmos' pipeline are in preclinical studies targeting pain, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and other disorders. (PR Newswire)
