Sierra Vista mayor: Veterans needing support Aug 3, 2008
CD4 in Virginia with, 15,850. Source: U.S. Rep. (Sierra Vista Herald, AZ)
Sensitive Testing Reveals Drug-resistant HIV With Possible Consequences For Treatment Jul 31, 2008
(May 1, 2007) New evidence shows that drug-resistant virus passed from mother-to-child can quickly establish itself in infants' CD4+ T cells where it can hide for years, likely limiting their options for future. (Sep. (Science Daily)
New Therapy For HIV Treatment Jul 31, 2008
The results were based on analyses of viral load reductions and CD4 cell count increases. A high CD4 cell count is crucial for a healthy immune system ... While this was feared to destroy, perhaps irreversibly, patient HIV-specific CD4+ T. (Science Daily)
AIDS widows honoured for fighting it out Jul 30, 2008
Another survivor related how her CD4 count (an indicator of a person's immunity) had gone up from 39 in 2004 to an encouraging 748 today. Explaining how tough the journey is for those like Koregaonkar , Dr Deshpande said women faced several hurdles while continuing their treatment. (Times of India)
Practice meditation, control AIDS: Study Jul 29, 2008
A team of researchers from the University of California, Los Angeles has found that meditation can decelerate the damaging of CD4 T cells. The CD4 T cells are considered to be the brains of the immune system and assist it in battling against the pernicious attacks ... But the researchers led by David Creswell did notice that practising meditation daily slow down the decaying of CD4 T cells also known as CD4+T lymphocytes. (Newstrack India)
Study Disproves Belief That Hepatitis C Blunts HIV Drugs Jul 29, 2008
Researchers at Wake Forest University Baptist Medical Center focused on levels of CD4 cells -- the immune cells that are attacked by HIV -- and whether CD4 cells can rebuild after HAART is used to suppress HIV infection ... "We've been observing that in some patients that are co-infected with hepatitis C, we were treating their HIV with HAART but didn't always get very good restoration of CD4," lead researcher Dr. Marina Nunez, an assistant professor of infectious diseases, said in a Wake Forest... (MEDLINEplus)
Meditation slows AIDS progression: study Jul 25, 2008
The more often the volunteers meditated, the higher their CD4 T-cell counts -- a standard measure of how well the immune system is fighting the AIDS virus. The CD4 counts were measured before and after the two-month program ... It may directly boost CD4 T-cell levels, or suppress the virus, he said. (Scientific American)
Mindfulness meditation slows progression of HIV, study shows Jul 25, 2008
CD4+ T lymphocytes, or simply CD4 T cells, are the "brains" of the immune system, coordinating its activity when the body comes under attack ... The virus slowly eats away at CD4 T cells, weakening the immune system ... But the immune systems of HIV/AIDS patients face another enemy as well stress, which can accelerate CD4 T cell declines. (EurekAlert!)
Researchers disprove long-standing belief about HIV treatment Jul 25, 2008
The research focused on levels of CD4 cells, the specific type of immune cell that is attacked by the HIV virus, and their ability to rebuild after HIV is suppressed. "We've been observing that in some patients that are co-infected with hepatitis C, we were treating their HIV with HAART but didn't always get very good restoration of CD4," said Marina Nunez, M.D., lead researcher and an assistant professor of infectious diseases ... "From a clinical standpoint, although these findings will not... (EurekAlert!)
Novel Computational Model Describes The Speed At Which HIV Escapes The Immune Response Jul 22, 2008
(July 14, 2008) Recent studies have shown that HIV causes a vigorous and prolonged immune response that eventually leads to the exhaustion of key immune system cells -- CD4+ and CD8+ T-cells -- that target HIV.. . (Science Daily)
HIV conquers immune system faster than previously realized Jul 19, 2008
Until now, scientists believed that the window of opportunity to intervene in the process of HIV-1 infection lay in the three to four weeks between transmission and the development of an established pool of infected CD4 T cells. HIV-1 cripples the immune system by invading and killing CD4 T cells, key infection-fighters in the body ... In measuring the levels of four products of CD4 T cell death during this period in these samples, they were able to track and establish a timetable of the virus's... (EurekAlert!)
Achilles Heel Of HIV Pinpointed? Jul 16, 2008
Additional data supporting the theory are to be presented at the XVII International AIDS Conference Aug. 3-8 in Mexico City in two studies titled Survivors of HIV infection produce potent, broadly neutralizing IgAs directed to the superantigenic region of the gp120 CD4 binding site and Prospective clinical utility and evolutionary implication of broadly neutralizing antibody fragments to HIV gp120 superantigenic epitope. First reported in the early 1980s, HIV has spread across the world,... (Science Daily)
Scientists Discover Key Patterns In The Packaging Of Genes Jul 15, 2008
D., of the National Heart, Blood, and Lung Institute of the National Institutes of Health, and his colleagues developed a method to map modifications in human white blood cells known as CD4+ T cells. First they used an enzyme to cut the DNA into short segments, which remained attached to histone "spools." For each of 39 distinct histone modifications, the scientists used an antibody to extract matching histone-DNA combinations. (Science Daily)
Woman uses struggle to help others Jul 14, 2008
- The number of CD4 cells has reached or fallen below 200 per cubic millimeter of blood (a measurement known as T-cell count). WOMEN AND HIV. (The Augusta Chronicle)
Facts of HIV/Aids Jul 8, 2008
HIV (Human Immunodeficiency Virus) targets the immune system, infecting the cells (CD4 or T-cells) that are supposed to protect the body from illness. HIV progresses into Aids (Acquired Immune Deficiency Syndrome), when your immune system loses too many CD4 cells ... You are officially classified as having Aids when your CD4 count drops below 200 (normal = 6001500) or when you develop one of the classified opportunistic infections (OI). (iAfrica.com)
South Africa:Refugees Denied Access to Health Care Jul 2, 2008
"Disruption of treatment can cause the viral load to go up and CD4 count (which measures the number of T-helper cells in a person's body) to go down over a reasonably short period of time," explains Geffen ... According to TAC, about half a million HIV-positive South Africans -- who with a CD4 count below 200 qualify for treatment -- are currently on the waiting list; South Africa's health department insists the number was much lower, at about 30,000 patients. (allAfrica.com)
Rwanda: When HIV Patients Have to Walk Days for Antiretrovirals Jul 2, 2008
She has a CD4 count or the immune system's strength at 180 - less than the 200 minimum. According to doctors, Daphroza's CD4 level is very worrying ... Treatment decisions are often based on Viral Load and CD4 count. (allAfrica.com)
Asthma risk increases in children treated for HIV Jul 2, 2008
"We think this occurs because important immune system components called CD4 cells increase in children treated with highly active antiretroviral therapy," said Dr. William T. Shearer, professor of pediatrics and immunology at BCM in Houston and chief of the allergy and immunology service at Texas Children's Hospital ... CD4 cells are thought to be associated with the inflammation in the lung tissue that accompanies asthma ... When CD4 cells decline in children with HIV, their asthma symptoms... (EurekAlert!)
Zinc Finger Proteins Put Personalized HIV Therapy Within Reach Jul 1, 2008
For the animal part of the study, the investigators used healthy human CD4 T cells and added DNA that expresses the zinc fingers, which modifies the CCR5 co-receptor. They grew the engineered cells in tissue culture flasks and transferred them into immune-deficient mice infected with HIV. "We followed them over time and showed that those mice that received the zinc-finger-treated cells showed less viral load than controls and improved CD4 counts," says Perez. (Science Daily)
Antiretroviral Therapy As HIV Prevention Strategy Jul 1, 2008
While this was feared to destroy, perhaps irreversibly, patient HIV-specific CD4+ T. . (Science Daily)
ATTACK OF THE CLONES Jun 29, 2008
Taking a simple blood sample from the patient, researchers isolated a single immune cell - the CD4+ T cell - cloned it in a laboratory and injected 5 billion copies of the infection-fighting cell back into the patient in a two-hour infusion. CD4+ T cells help other T cells to grow, particularly the CD8+ T cells - or "killer T cells" - that do the actual damage to the tumors ... (Yee had done experiments using infusions of just CD8+ T cells but found cloned CD8+ T can't survive in the body... (New York Post -- Opinions)
Second-line drug free to combat AIDS Jun 28, 2008
Nearly 200 patients were evaluated by an expert panel and 110 were found to be eligible for second-line treatment with low CD4 count and high viral load. At present, 79 HIV patients are on second-line treatment in these two centres while the rest are being counselled. (India Times, India -- Health/Science)
Generex Biotechnology Expands Mayo Clinic Collaboration for Vaccine Studies Jun 26, 2008
Antigen Express has previously identified a novel peptide vaccine for melanoma and published its findings in an article titled, ``Enhanced CD4+ T-Cell Response in DR4-Transgenic Mice to a Hybrid Peptide Linking the Ii-Key Segment of the Invariant Chain to the Melanoma gp100(48-58) MHC Class II Epitope,'' in the Journal of Immunotherapy, volume 28, pages 352-358, 2005 ... The strategy is based on modifying fragments of a cancer-associated protein using proprietary methods to increase the... (Primezone Releases)
Free medical tool tackles disease Jun 25, 2008
"For example, their physical exam findings and their laboratory test results, like the CD4 count (a measure of the strength of the immune system) and the types of medications that they have been placed on. "By capturing that information the idea is that on subsequent visits that information can be used to further drive the process of care. The system also has a feature called "decision support", which provides tips to clinicians about prescriptions and tests which may be necessary. (BBC News -- Health)
Possible Cure For Fatal Skin Cancer? Jun 22, 2008
The research conducted in this instance, however, used (another type of lymphocyte; CD4, by the way, is the surface protein) instead. T helper cells don't have the ability to kill other cells like killer T cells do. (Inventorspot)
New medical research could lead to skin cancer vaccine Jun 20, 2008
But she says this time they concentrated on CD4 T cells to boost general immunity. NAOMI HUNDER: One thing we found that we showed in the paper was that their immunity to multiple tumour antigens was increased after the T cell infusion, not just the one we were targeting, but at least two others it was also increased. (ABC Online)
Man's Melanoma Thwarted by Immune Fix Jun 20, 2008
Yee and colleagues hunted for special immune system cells called CD4+ T cells in a blood sample provided by the melanoma patient. Specifically, the scientists looked for CD4+ T-cells that targeted the man's melanoma ... The researchers isolated those cells and cloned them in their lab over several months, and then infused 5 billion of the cloned CD4+ T-cells back into the patient. (WebMD)
Cancer beaten by dose of own cells Jun 20, 2008
American researchers led by Cassian Yee of the Fred Hutchinson Cancer Research Centre collected a type of white blood cell, known as CD4 T-cells, from the patient and separated those that targeted the melanoma cells ... "We were surprised by the anti-tumour effect of these CD4 T-cells and its duration of response," Dr Yee said. (Sydney Morning Herald -- Australia)
Small success with immunotherapy in skin cancer study Jun 20, 2008
Researchers used a single infection-fighting cell from the man's immune system, CD4 T cell, copies of which were grown in a laboratory. The disease had spread to the man's lungs and a lymph node before he received the two-hour infusion of lab-grown immune system cells. (Newsday)
Experimental Therapy Beats Back One Patient's Melanoma Jun 20, 2008
And that is essentially what the authors of the new study did, collecting CD4+ T-cells from nine melanoma patients, isolating single cells that they believed would target a certain protein on the tumor cells, cultivating and enriching these cells, and then re-infusing them into the patient. Patient Four, a 52-year-old man, received five billion cloned CD4+ T cells designed to go after the melanoma-associated NY-ESO-1 antigen ... "[Right now], we can only target a small fraction of patients. What... (MEDLINEplus)
Patient's Own Infection-Fighting T Cells Put Late-Stage Melanoma Into Long-Term Remission - Without Chemotherapy or Radiation Jun 19, 2008
Yee and colleagues removed CD4+ T cells, a type of white blood cell, from a 52-year-old man whose Stage 4 melanoma had spread to a groin lymph node and to a lung ... "We were surprised by the anti-tumor effect of these CD4 T cells and its duration of response," Yee said ... The patient in the journal report was one of nine patients with metastatic melanoma who were being treated in a recently completed clinical trial to test dose-escalation of autologous CD4+ T cells. (PR Newswire)
Melanoma Stopped in Patient With 5 Billion Copies of Own Cell Jun 19, 2008
Copies of an infection-fighting CD4 T cell were grown in a laboratory, and then used to attack the 52-year-old patient's tumor, the report said ... We were surprised by the anti-tumor effect of these CD4 T cells and its duration of response,'' said Cassian Yee, the senior author of the paper and an associate member of the clinical research division, in a statement. (Bloomberg)
New Cellular Mechanism That Will Significantly Advance Vaccine Development Discovered Jun 19, 2008
" said LIAI scientist Shane Crotty, Ph.D., the lead researcher on the paper, "Selective CD4 T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. " Alessandro Sette, Ph.D., a renowned vaccine expert and director of the LIAI Center for Infectious Disease, also was a key contributor on the study. Dr. Crotty said the team studied the smallpox vaccine, considered the "gold standard" of vaccines, and found some startling answers. "We expected one thing... (Science Daily)
South Africa: Court Rules Aids Clinical Trials Unlawful Jun 14, 2008
"It was a case of sadness as the patient was doing extremely well with his CD4 count raised from 24 to 384 with his viral load suppressed," the doctor reported. "We win some and lose some, but we are facing a huge challenge of dealing with such cases and it is an unending, continuous battle that we are facing," he added. (allAfrica.com)
Babies and HIV/AIDS Jun 14, 2008
Once they are tested positive they are then referred to the Medical Research Centre where we assess the immunological status of the mothers (CD4 counts) and their viral loads. Depending on those levels, we then treat the mothers at a certain time in their gestation period and treatment continues during labour, after labour and onwards. (Suite101.com)
TB Treatment For Elderly Likely Requires Boost To Immune Response Jun 13, 2008
Simulations of TB infection in an old mouse showed that increasing the number of infection-fighting white blood cells, called CD4 T cells, could be particularly effective at bolstering the mouse s immune response, which naturally slows with aging ... These CD4 T cells secrete a substance called interferon gamma, which activates the macrophage to help it kill the bacteria ... The two most effective methods found to improve infection control in the old mouse model were increasing the number of CD4... (Science Daily)
Combo HIV Drug Therapy Safe, Effective In Children Jun 11, 2008
Significant reductions in average blood levels of the virus and increases in average blood levels of CD4 T cells, white blood cells that decrease as HIV infection advances, were seen within 4 weeks after the initiation of treatment with ritonavir, nelfinavir, or lopinavir/ritonavir, the authors report. These improvements persisted through week 96. (MEDLINEplus)
Circumcision Safe In Both HIV-infected And HIV-uninfected Men, Study Finds Jun 5, 2008
Men with symptoms of HIV infection or low CD4 T-cell counts were not included in the study. A separately reported analysis from one of these trials found that women partners are more likely to become HIV infected by HIV-positive men who resume sex prior to complete wound healing. (Science Daily)
Penn State Hershey Transplant Program Uses Assay to Monitor Cell-Mediated Immunity Jun 2, 2008
The ImmuKnow cell function test measures cell-mediated immunity (CMI) by assaying the concentration of adenosine triphosphate (ATP) from CD4 cells following stimulation. The assay is intended for use in the detection of CMI in an immunosuppressed population. (PR Newswire)
Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients Jun 2, 2008
The ImmuKnow assay of cell-mediated immunity is used to measure the degree of immune activation of CD4+ T-cell function. Circulating anti-HLA antibodies were determined by ELISA and expressed as percent ELISA-PRA for anti-HLA class I and II antibodies. (PR Newswire)
Getting better with a little help from our 'micro' friends May 29, 2008
In particular, Mazmanian and his colleagues found that PSA induced particular immune-system cells called CD4+ T cells to produce interleukin-10 (IL-10), a molecule that has previously been shown to suppress inflammation--and offer protection from inflammatory bowel disease. "Thus, bacteria help reprogram our own immune system to promote health," he says. (EurekAlert!)
Scientists Break Into HIV 'Hideout' May 28, 2008
Previous research has shown that two other types of cells -- macrophages and latently infected CD4+ T-cells -- are reservoirs of HIV. It was suspected that FDCs also acted as HIV reservoirs, and this new study confirmed that suspicion. More information. (Health-Finder)
Undergoing HAART May 24, 2008
There is no textbook formula on the best time for an HIV+ individual to begin HAART. Generally, it is prescribed when the CD4 cell count is 200 350 per cubic millimetre of blood and administered prior to the advanced stages of the infection. Since ARV medications are most effective when used for the first time, it is critical to get the combination of drugs right upon commencement of HAART.. (Suite101.com)
Combination Therapy for HIV/AIDS May 22, 2008
The doctor has to regularly monitor the effectiveness of the drugs through testing for the patient s CD4 cell count and the viral load in his/her body. The patient must also provide feedback to the doctor on his/her reaction to the drugs, including side-effects and their severity. (Suite101.com)
How HIV Guts the Immune System May 22, 2008
Although in the absence of treatment, the acquired immunodeficiency syndrome (AIDS) generally develops 8 to 10 years after infection with human immunodeficiency virus (HIV) type 1 (HIV-1), the onslaught on the immune system by HIV-1 begins with the rapid depletion of memory CD4+ T cells, the majority of which reside in the gut. A recent report by Arthos et al.1 suggests that HIV-1 is able to mediate depletion of gut CD4+ T cells in part by co-opting the molecule that helps direct T cells to the... (New England Journal of Medicine)
Scientists Get Inside A Long-suspected HIV Hideout In Humans May 16, 2008
Two other types of cells, macrophages and the latently infected CD4+ T cell, have previously been shown to be reservoirs of HIV. With the BYU-Johns Hopkins study, FDCs conclusively join the list. FDCs act as bank vaults storing material necessary to maintain the immune system s armies of antibodies. (Science Daily)
Class-Sparing Regimens for Initial Treatment of HIV-1 Infection May 15, 2008
We randomly assigned 757 patients with a median CD4 count of 191 cells per cubic millimeter and a median HIV-1 RNA level of 4. 8 log10 copies per milliliter to the three groups. (New England Journal of Medicine)
New breed of traditional healers has sharp eye on marketing May 15, 2008
Most of the businesses specialise in manufacturing mixtures that improve the quality of the customer's sex life; as well as immune boosters, which, they claim, help improve the patient's CD4 blood count, which measures immunity. Ubhejane, a mixture owned by Zeblon Gwala, a former truck driver, is probably the most popular. (Business Report, South Africa)
Researchers Synthesize Compound To Flush HIV Out Of Hiding And Into Crosshairs May 5, 2008
While this was feared to destroy, perhaps irreversibly, patient HIV-specific CD4+ T. (Nov. (Science Daily)
New immune treatment may control AIDS virus May 3, 2008
It specifically goes after immune cells called CD4 T cells, the very cells that are supposed to attack and kill viruses. "Virus-specific CD4 T cells are typically very weak in HIV-infected humans or SIV-infected macaques; dramatic enhancement of these cells were induced by OPAL immunotherapy and this may underlie its efficacy," they wrote. (Scientific American)
NASA names minor planet after Indian May 2, 2008
Sainudeen Pattazhy, who teaches in a local college, was informed on Wednesday by Jet Propulsions Laboratory of the California Institute of Technology under NASA that minor planet '5178 No CD4' had been named after him. The planet was discovered by US-based scientist Rajmohan in 1989, Sainudeen said. (India Times, India -- Health/Science)
Second line of HIV drugs extended to patients at BMC hospitals Apr 12, 2008
Candidates are patients whose CD4 count falls below the base line after a high or persistently remains less than 100 ... Here, the SACEP will evaluate them and after a viral load test along with their CD4 count, they will be given the second line of drugs, said Dr B B Rewari, National Programme Officer (ART), NACO, who is in Mumbai with his team ... Among the rest, eight to nine patients who had a low CD4 count but showed no viral load, have been put on the first line of drugs. (Expressindia.com)
T-Cell Duplication Delayed Up to 3 Days After Infection Apr 11, 2008
In this study, the Scripps team used laboratory animals to trace the proliferation of CD4 and CD8 memory T-cells. CD4 cells help regulate the immune system's response to pathogens such as bacteria and viruses, while CD8 cells attack infected cells and may be play a role in transplant rejection ... "The principal conclusions from our study are that, in a virus-infected animal, both naive and memory CD4 T-cells shows a similar and extended delay of approximately 72 hours before they begin to... (Health-Finder)
The Challenge of HIV-1 Subtype Diversity Apr 10, 2008
Among the most prominent of these are the heavy glycosylation of the external glycoprotein, which protects neutralization epitopes; the virus' direct targeting of the CD4 molecule expressed by the key T lymphocyte in immune orchestration; integration into. . (New England Journal of Medicine)
Roswell Park Cancer Institute awarded three-years funding for ... Apr 8, 2008
But our bodies are full of proteins, so to prevent our own proteins from coming under immune attack, the second type of white blood cells (CD4 T regulatory lymphocytes) remember which proteins are our own and prevent the CD8 lymphocytes from attacking and destroying healthy cells ... The CD4 lymphocytes can get confused and shield the tumor cells from being attacked ... Dr. Shrikant is looking for ways to keep the CD4 lymphocytes from being fooled and restrict their ability to chain and render... (News-Medical.net)
Gene Mutations Tied To Immune Comeback During Therapy For HIV-1 Apr 3, 2008
The two genes are CCR5, an HIV-1 co-receptor or portal of entry for the virus into CD4+ T cells, and CCL3L1, an HIV-suppressing molecule that binds to CCR5. Tailored therapy. (Science Daily)
Galea Life Sciences' Subsidiary Awarded Presentation Slot for Clinical Policy Abstract At 15th International Symposium on HIV and Emerging Infectious Diseases Apr 1, 2008
Presenting author, Dr. Peggy Achenbach, discusses the evidence-based utilization of micronutrient supplementation during HAART to enhance CD4 count, decrease viral load and decrease HIV/AIDS associated involuntary muscle loss. Catabolic Cachexia is a term used to describe the gradual breakdown of muscle and skeletal components associated with disease. (Primezone Releases)
Expansion of monocyte subset could serve as a biomarker for HIV progressions Mar 28, 2008
We were surprised to find that patients with CD4+ T cell counts of less than 450 cells per microliter [200 or less per microliter is defined as AIDS], the increase of this monocyte subset correlates inversely with the number of T cells ... Fischer-Smith said this finding suggests that as the monocyte cells are increasing, these patients are losing CD4+ T cells, which are critical for the maintenance of immunological competence ... This may actually provide an earlier window into what is... (EurekAlert!)
Laureate Announces Second Manufacturing Agreement with Cytheris Mar 27, 2008
This is a testimonial to our successful partnership with our clients and our effort to achieve their total satisfaction in our ability to meet their manufacturing needs," said Robert J. Broeze, Ph.D., President f Laureate. "We will work with the Cytheris team very closely and help them realize the greatest potential of their IL-7 development and production program. " "As we move towards large scale production of our IL-7 biotherapeutic, we are pleased to continue our strong working relationship... (Canada Newswire)
How HIV Turns Food-poisoning Into Lethal Infection Mar 25, 2008
In HIV-infected patients, there is a gradual loss of CD4+ T cells over time ... Unlike the steady decline of T cells in peripheral blood, there is a very rapid loss of CD4+ T cells in the gut mucosa, Dandekar said ... "We wanted to know whether the loss of the CD4+ T-cells in the gut contributed to the inactivation of the immune system one sees in HIV-infected patients," she said. (Science Daily)
Some People May Transmit Weaker AIDS Virus Mar 25, 2008
The researchers followed the women from between one to three years and found that while the levels of HIV in their bodies fell, their number of crucial CD4 T cells that coordinate the immune system rose. The goal of treatment is to lower HIV levels to help the immune system renew itself and keep people healthier longer, in part to stem the spread of the virus. (MEDLINEplus)
Infection With A Mutated HIV Strain Results In Better Survival Mar 22, 2008
In this study the researchers identified two mutations, A146X and T242N, in the Gag sequences of acutely infected HLA-B*57/5801 negative women, that were associated with lower viral loads and higher CD4+ counts in these women up to a year post-infection. Both mutations have been previously identified as HLA-B*57/5801 immune evasion mutations and T242N has been shown to compromise viral replication capacity. (Science Daily)
Islet Transplantation and Immunosuppression Mar 15, 2008
Insulin-dependent (type 1) diabetes mellitus is an autoimmune disease caused by the selective destruction of pancreatic beta cells by CD4+ and CD8+ autoreactive T lymphocytes. The induction of effective and sustained beta-cell regeneration represents the holy grail of therapy for this disease. (New England Journal of Medicine)
FOXSexpert: Matching Up Mismatched Libidos Mar 7, 2008
According to the Globe and Mail, a protein found in the nucleus of CD4+ T cells, known as FOX03a, may be the key to an HIV vaccine and new treatments. Researchers at the University of Montreal, McGill University and BD BioSciences believe their findings also may help in developing therapies for other diseases, such as hepatitis C and some cancers. (Fox News)
New More Effective Tuberculosis Screening Test For HIV Victims Mar 7, 2008
Nevertheless the ability to respond to the ELISPOT test decreases with the decrease in CD4 lymphocyte count, which appears to indicate the limits of this type of test in severely immunosuppressed individuals, as advanced-stage HIV infected patients can be. In parallel, a cohort of 243 TB patients was followed up for 2 years. (Science Daily)
