New DNA Method Makes It Easier To Trace Criminals Nov 1, 2009
"The DNA analysis, on the other hand, has been something of a black box, since it is purchased as a finished product. No one has tried to improve it to be able to deal with dirty samples. But this is absolutely crucial, since the samples often have extremely small amounts of DNA. In this phase you copy certain parts of the DNA strands and then obtain a DNA profile that is unique to each person. In the copying step, I have optimized the chemical environment and replaced a key enzyme, a so-called... (Science Daily)
Scientists Are First To Observe The Global Motions Of An Enzyme Copying DNA Oct 30, 2009
The research group used an enzyme called Dpo4, or DNA polymerase IV, for the experiments ... Those who study DNA polymerases seek to define what is called a rate-limiting event, which could be thought of as a moment when all parts of the process pause and check themselves over. (Science Daily)
Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis Aug 18, 2009
DNA polymerase delta plays an essential role in chromosomal DNA replication in eukaryotic cells, being responsible for synthesising the bulk of the lagging strand. In fission yeast, Pol delta is a heterotetrameric enzyme comprising four evolutionarily well-conserved proteins: the catalytic subunit Pol3 and three smaller subunits Cdc1, Cdc27 and Cdm1. (BioMed Central)
DNA template could explain evolutionary shifts Jun 22, 2009
On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand of complementary DNA to pair to it. Again, the code is A to T and C to G. This process is continuous. (EurekAlert!)
Cells Get Two Chances, Not Just One, To Fix Their Mistakes Mar 20, 2009
The protein, called DNA polymerase. (Jan. (Science Daily)
Eisai Announces Approval of Clevudine for the Treatment of Chronic Hepatitis B in the Philippines Mar 18, 2009
Clevudine is an antiviral drug with an inhibitory effect on DNA polymerase for the treatment of chronic hepatitis B. In the Philippines, about 8 million people are believed to be infected with hepatitis B. With its potent and sustained anti-viral effect, Clevudine is expected to be a new treatment option for patients with deterioration in liver function caused by hepatitis B. ... Clevudine is an antiviral drug developed for the treatment of hepatitis B. It exerts its anti-HBV effect by... (JCN Network, Japan)
