TRACON Pharmaceuticals Doses the First Patient in a Phase 1 Clinical Trial With Oral TRC102, An Inhibitor of Chemotherapy Resistance, in Combination With Alimta Jun 18, 2008
SAN DIEGO, June 18, 2008 (PRIME NEWSWIRE) -- TRACON Pharmaceuticals, Inc., announced that the first cancer patient has been treated in a Phase 1 clinical trial with oral TRC102, a novel anti-cancer drug intended to reverse resistance to Alimta(r) chemotherapy by targeting a specific DNA repair pathway. ADVERTISEMENT. (Primezone Releases)
Ireland Cancer Center and TRACON Pharmaceuticals Announce Treating the First Cancer Patient With TRC102, An Inhibitor of Chemotherapy Resistance Feb 25, 2008
CLEVELAND and SAN DIEGO, Feb. 25, 2008 (PRIME NEWSWIRE) -- The Ireland Cancer Center of University Hospitals Case Medical Center and TRACON Pharmaceuticals, Inc. announced that the first cancer patient has been treated in a Phase 1 clinical trial with TRC102, a novel anti-cancer drug intended to reverse resistance to Temodar(r) chemotherapy by targeting a specific DNA repair pathway. ADVERTISEMENT. (Primezone Releases)
Research Yields Clues to Radiation Resistant Brain Cancer Oct 20, 2006
Glioblastoma stem cells that carry a protein called CD133 are able to activate a DNA repair pathway. This makes them better able to survive DNA damage, and more resistant to radiation therapy, the researchers found. (MEDLINEplus)
Case Western Reserve University licenses methoxyamine to Tracon Oct 14, 2006
Methoxyamine is a "first in class" drug that targets a specific DNA repair pathway. TRACON Pharmaceuticals is an emerging biotechnology company focused on identifying, developing and commercializing targeted therapies for cancer and angiogenesis. (EurekAlert! -- Business News)
DNA repair in mammal embryos is a matter of timing Jun 20, 2006
Specifically, the St. Jude researchers showed that the DNA repair pathway called homologous recombination (HR) works primarily during the first half of embryo development, when many cells are dividing inside the growing body ... This new work points to the specific DNA repair pathway that ATM is required to monitor in order to prevent neurodegeneration. (EurekAlert!)
Study Shows That Cells Have A Natural Defense Against HIV Mar 28, 2006
When we weakened a DNA repair pathway, we got more integration of the provirus, Yoder says. This was a total surprise. (Science Daily)
