Why Certain Drug Combinations Backfire Nov 17, 2009
For instance, drugs that block protein production work poorly with drugs that block DNA replication, but they work well with drugs that weaken the cell wall ... 12, 2008) Researchers are describing progress toward developing a new generation of chemotherapy agents that target and block uncontrolled DNA replication a hallmark of cancer, viral infections, and. (Science Daily)
Study reveals why certain drug combinations backfire Nov 14, 2009
For instance, drugs that block protein production work poorly with drugs that block DNA replication, but they work well with drugs that weaken the cell wall. According to first author and research fellow in systems biology Tobias Bollenbach, clinical researchers are primarily interested in drugs that together work better than either alone, and so studies tend to focus on explaining some of the mechanisms behind synergistic drug pairings. (EurekAlert!)
DNA Replication: Messenger RNA With FLASH A Key Player Oct 26, 2009
25, 2009) A study from the University of North Carolina at Chapel Hill has identified a key player in a molecular process essential for DNA replication within cells ... "We could then figure out exactly what portion of FLASH would restore the protein's function in generating histone mRNAs and remarkably, only the first 100 or so amino acids are required. The remaining 2,000 amino acids of this large protein likely control other processes in the cell, including apoptosis and DNA replication" he... (Science Daily)
Creating Less Toxic Anti-HIV Drugs: Discovery Of Enzyme Structure Points The Way Oct 16, 2009
"Many anti-HIV drugs are designed to stop the process of DNA replication," says Dr. Whitney Yin, assistant professor of chemistry and biochemistry ... " Yin and her graduate student, Young-sam Lee, have solved the atomic structure of an enzyme, known as Pol (pol gamma), that is responsible for DNA replication in human mitochondria. When mitochondria are working normally, they produce most of the energy that sustains human cells. When pol gamma comes into contact with certain anti-retroviral... (Science Daily)
Bioengineer Uses Nanoparticles To Target Drugs Oct 9, 2009
12, 2008) Researchers are describing progress toward developing a new generation of chemotherapy agents that target and block uncontrolled DNA replication a hallmark of cancer, viral infections, and. (July 11, 2008) Researchers have discovered a new way to make use of drugs' unwanted side effects. (Science Daily)
Nobel Prize in Medicine shared by three U.S. genetic researchers Oct 6, 2009
The work for which they received the award illuminated key aspects of the DNA replication process ... For the researchers, much of the early discoveries were driven by general curiosity about the workings of chromosomes and DNA replication. (Scientific American)
Trial Of New Treatment For Advanced Melanoma Shows Rapid Shrinking Of Tumors Sep 25, 2009
Dr Chapman said: "What makes this treatment different from standard chemotherapy is that standard chemotherapy attacks the machinery involved in cell division; so to stop the cancer cells dividing uncontrollably, most standard chemotherapy aims to block the mechanism of division by interfering directly with DNA replication or with microtubules in the dividing cells. PLX4302 is different because it attacks the genetic programme that is causing the cells to divide uncontrollably, and we think the... (Science Daily)
Mahlon Hoagland; biologist codiscovered transfer RNA Sep 25, 2009
He could take things as complicated as DNA replication and explain them in delightfully animating and engaging terms. After three years at Dartmouth, he moved back to Massachusetts to head the Worcester Foundation. (Boston Globe)
Six biologists win Nat'l Medal Sep 19, 2009
Biochemist JoAnne Stubbe from the Massachusetts Institute of Technology, whom is being honored for her work on enzymes involved in DNA replication and repair. Neuroscientist professor emeritus at the University of Oregon, is being recognized for his studies involving genetic mutations and attention in the brain. (The Scientist)
Scientific honor roll includes old genetic rivals Sep 18, 2009
JoAnne Stubbe of the Massachusetts Institute of Technology, a chemist studying the mechanisms behind DNA replication and repair. This year's recipients of the National Medal of Technology and Innovation include. (MSNBC -- Environment)
Disrupting A Destructive Duo: Researchers Inhibit Cancer Proteins Aug 25, 2009
12, 2008) Researchers are describing progress toward developing a new generation of chemotherapy agents that target and block uncontrolled DNA replication a hallmark of cancer, viral infections, and. (Nov. (Science Daily)
Math model accurately mimics cell division in carbon-cycling bacterium Aug 14, 2009
Scientists from the Department of Biological Sciences and the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a quantitative, mathematical model of DNA replication and cell division for the bacterium Caulobacter crescentus ... This regulatory core comprises three key proteins DnaA, GcrA, and CtrA that act as control points or master switches for DNA replication and cell division ... "However, prokaryotic cells like Caulobacter have been somewhat neglected as... (EurekAlert!)
Common Diabetic Therapy Reduces Risk Of Pancreatic Cancer Aug 3, 2009
18, 2009) Abnormalities in genes that repair mistakes in DNA replication may help identify people who are at high risk of developing pancreatic cancer, scientists report in Clinical Cancer. (Nov. (Science Daily)
Of Yeast And Men: Unraveling The Molecular Mechanisms Of Friedreich's Ataxia Jul 13, 2009
In a paper to be published in the July issue of Molecular Cell, a research team lead by Sergei Mirkin, White Family Professor of Biology at Tufts' School of Arts and Sciences, has created an experimental model that does indeed produce large-scale expansion of GAA repeats during DNA replication ... 28, 2004) Scientists have discovered a DNA sequence that is involved in controlling the timing of DNA replication ... Because alterations in DNA replication timing are associated with cancer, this... (Science Daily)
Two Ways to Tackle Tuberculosis Jun 5, 2009
"Some interrupt protein synthesis, some interfere with DNA replication, some interrupt cell wall construction.". The new drug cripples the activity of ATP synthase, an enzyme that plays a key role in biological energy metabolism. (MEDLINEplus)
Scientists Synthesize Gold To Shed Light On Cells' Inner Workings Apr 18, 2009
Tracking the cell nucleus can help scientists monitor the fundamental life processes of healthy DNA replication and any genomic changes. With improved bioimaging at the cell nucleus, scientists can also study the effectiveness of drug and gene therapies. (Science Daily)
The Cast of Merchants of Brooklyn Mar 13, 2009
He discovered his talent for DNA replication when he mixed a mosquito and a firefly so you could see the pesky insect at night. As Antonio grew older, he developed a deep hatred for his Uncle Frank, his heavy-handed methods and propensity for violence stirred up a rage inside the normally meek boy ; a rage that would follow Antonio throughout his life. (IGN PC Games)
First Step Towards A World Reclassification Of Viruses Feb 25, 2009
Rick Lewis, Professor of Structural Biology at the Institute for Cell and Molecular Biosciences at Newcastle University concludes: "It has been an exciting time for the team at Newcastle and our access to Diamond is integral to our goals to understand the molecular mechanisms behind DNA replication; the construction of the cell wall of bacteria, and how bacteria recognise and respond to harmful changes in their environments.". Adapted from materials provided by , via , a service of AAAS. Email... (Science Daily)
New models question old assumptions about how many molecules it takes to control cell division Feb 25, 2009
Virginia Tech biologists and engineers have created a mathematical model to explore the roles of noise in controlling the basic events of the cell cycle DNA replication and cell division ... Nonetheless, the ebb and flow of molecules in a cell must reliably convey instructions for such essential processes as DNA replication and cell division. (EurekAlert!)
Protein Domain Linked To Tumor Progression Isolated Feb 20, 2009
12, 2008) Researchers are describing progress toward developing a new generation of chemotherapy agents that target and block uncontrolled DNA replication a hallmark of cancer, viral infections, and. (May 3, 2006) A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug, according to. (Science Daily)
Empathy Partly Based On Genes: Mouse Study Feb 16, 2009
13, 2006) By discovering a mutant mouse that is highly susceptible to mammary tumors, Cornell researchers have found a novel potential link between genetic defects in DNA replication and breast. (Mar. (Science Daily)
