Method To Deliver Molecules Within Embryonic Stem Cells Improves Differentiation Apr 15, 2008
The results revealed enhanced expression of fibroblast growth factor 5 (FGF-5) -- a marker for primitive ectoderm -- in the embryoid bodies mixed with retinoic acid-loaded microspheres compared to the other treatment groups after 10 days. The researchers also confirmed increased or inhibited expression of many additional markers. (Science Daily)
Role Of Tiny RNAs In Controlling Stem Cell Fate Identified Mar 10, 2008
Equally important, they caused other genes that would have told the cell to become ectoderm or endoderm to turn off. For example, expression of a specific factor called Delta-like 1 was repressed by miR-1. (Science Daily)
Catching birth defects early Jan 13, 2008
This embryoid body (EB) consists of different types of cells, representing the three germ layers (the ectoderm, endoderm and mesoderm) ... For example, the skin and the nervous system are formed from the ectoderm, tissues such as cardiomyocytes, bone and blood from the mesoderm and lungs and intestines from the endoderm. (Times of India)
Difference Between Fish And Humans: Century-old Developmental Question Answered Oct 13, 2007
During this stage, the cells group into three layers, the first is the 'ectoderm' which then in turn generates the 'mesoderm' and 'endoderm' layers. In higher vertebrates, such as mammals and birds, the mesoderm and endoderm are generated from an axis running through the centre of the embryo. (Science Daily)
Rare disease doesn't affect boy's spirit Feb 9, 2007
Most people associate the month of February with Valentine's Day and as National Black History Month, but it is also a national awareness month for the medical disorder known as Ectodermal Dysplasia (ED). ED is a disorder which affects the "ectoderm," or outer layer of tissue in a developing baby, which contributes to the formation of the skin, sweat glands, hair, teeth and nails ... Oxford's three year-old Aiden Galdes is affected by a special form of ED called Hypohidrotic Ectodermal Dysplasia... (Oxford Tribune, PA)
Lipid Plays Big Role In Embryonic Development Feb 6, 2007
Medical College of Georgia researchers found that in the first few days of life, ceramide helps stem cells line up to form the primitive ectoderm from which embryonic tissues develop ... They found that in the first few days of life, ceramide helps stem cells line up to form the primitive ectoderm from which embryonic tissues develop, says Dr. Erhard Bieberich, biochemist at the Medical College of Georgia ... In fact, we start out as a wad of cells, but within 24 hours, some cells die and others... (Science Daily)
New Source of Stem Cells: Amniotic Fluid Jan 8, 2007
This range comprises all three embryonic germ layers: the mesoderm, the progenitor of bone, muscle and connective tissue; the endoderm, which develops into digestive organs as well as the lungs; and ectoderm, which becomes nerves, skin and the brain. In addition to laboratory experiments, the team studied AFS cells in mouse models, grafting neural stem cells into the brains of mutant mice with disrupted neural development and growing bone tissue in another set of immunodeficient mice. (Scientific American)
Scientists discover new, readily available source of stem cells Jan 8, 2007
The scientists noted that specialized cells generated from the AFS cells included all three classes of cells found in the developing embryo - termed ectoderm, mesoderm, and endoderm. In their high degree of flexibility and growth potential, the AFS cells resemble human embryonic stem cells, which are believed capable of generating every type of adult cell. (EurekAlert!)
New Therapeutic Hope For Degenerative Disc Disease Dec 1, 2006
-- In animal development, organogenesis is the process by which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. The germ layers in organogenesis differ by three. (Science Daily)
Researchers Turn Cord Blood Into Lung Cells Nov 14, 2006
This stem cell, which was first isolated and characterized by BioE, Inc., St. Paul, is a precursor cell that can be expanded in culture, then differentiated into different types of tissue representative of all three embryonic lineages, endoderm, mesoderm and ectoderm. In this series of experiments, McKenna and his group cultured the MLPC and differentiated it into the lung cells, an endoderm-type cell. (Science Daily)
Key gene controlling eye lens development identified Oct 27, 2006
This permitted the investigators to remove Six3 activity from the presumptive lens ectoderm (PLE)--the area of the developing head where the lens will ultimately form in response to a series of biochemical signals. Following this systematic approach, the St. Jude team demonstrated that Six3 plays its important role in the PLE. The investigators also showed that a key consequence of removing Six3 during early development is that the PLE fails to undergo its normal thickening, an initial critical... (EurekAlert!)
HORACE COOPER: Progress in stem-cell R&D Sep 22, 2006
But the true breakthrough is that the primecells are pluripotent -- meaning they can develop into any of the three major tissue types: endoderm (interior gut lining), mesoderm (muscle, bone, blood) and ectoderm (epidermal tissues and nervous system). Thus these cells could be the basis for cellular replacement therapies to potentially treat Alzheimer's, heart disease, Parkinson's, diabetes, various autoimmune diseases and some forms of cancer, among other diseases. (Washington Times)
Flies, Moths And Cuttlefish: Spineless Tales Provide Strong Backbone To Human Brain Research Aug 17, 2006
Scientists for years, he said, have held "one hard rule" about what constitutes a neuron -- that a neuron cell always arises from the ectoderm of a developing embryo. However, a discovery in Drosophila -- fruit flies -- has softened that assumption. (Science Daily)
A way around dilemmas of stem cells Jun 16, 2006
Thursday, June 15, 2006. Stem cell scientists in the United Kingdom are reporting today a gene discovery that suggests a way to take adult cells back to an embryonic state -- a discovery that could help treat diseases without relying on controversial human embryonic stem cells or cloning. (San Francisco Chronicle)
Stem Cells in Mice Hold Hope Mar 26, 2006
These are endoderm (which becomes the interior lining of the gut), mesoderm (which becomes muscle, blood, and bone), and ectoderm (which becomes skin and nerve cells). It follows that the analogous cells taken from a human male could be extracted and carefully nurtured to develop into new tissues that would replace diseased or injured tissues in the same man. (Red Herring)
