With ARBs, a bigger dose is better for heart failure patients Nov 18, 2009
Until now, doctors have lacked the evidence they needed to determine the most effective dose. MORE FROM AHA MEETING. (USA Today -- News)
Jody Johnson: DLPA as a pain-reliever Sep 24, 2009
It is rather costly for an effective dose, and practitioners normally use it just for chronic pain that has been unresponsive to other products or measures. Examples would be arthritis and unrelenting lower back pain. (Belmont Citizen Herald, MA)
Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy Sep 12, 2009
F1-2000: 50% Effective Dose Determination of CXA-101 Alone or in Combination with Tazobactam for Treating Experimental Peritonitis in Mice Due to ESBL-Producing Escherichia coli strains: Comparison with Ceftazidime and Piperacillin/Tazobactam. F1-2001: Pharmacokinetics Study of CXA-101 (CXA) in Combination with Tazobactam in Dogs after Intravenous Administration. (PR Newswire)
H1N1 TRIALS: Pregnant women taking part Sep 11, 2009
Volunteers will receive 15 micrograms or 30 micrograms of a 2009 H1N1 influenza vaccine made by Sanofi Pasteur to determine the most effective dose. Women will receive two injections 21 days apart. (USA Today)
How Safe Or Unsafe Are Medical Imaging Procedures? Aug 29, 2009
28, 2009) In a new study of nearly one million adults between the ages of 18 and 64, nearly 70 percent of participants underwent at least one medical imaging procedure between July 2005 and December 2007, resulting in an average effective dose of radiation nearly double the amount they would otherwise be exposed to from natural sources ... Computed tomography (CT) scans and nuclear imaging accounted for three-fourths of radiation exposure, with nuclear stress tests to detect coronary heart... (Science Daily)
Exposure to Low-Dose Ionizing Radiation from Medical Imaging Procedures Aug 27, 2009
Utilization data were used to estimate cumulative effective doses of radiation from imaging procedures and to calculate population-based rates of exposure, with annual effective doses defined as low ... The mean ( SD) cumulative effective dose from imaging procedures was 2 ... 0 mSv per enrollee per year; however, a wide distribution was noted, with a median effective dose of 0. (New England Journal of Medicine)
Restless Leg Syndrome Treatments fo... Aug 26, 2009
The physician will typically start dosages low to determine the lowest effective dose to prevent unnecessary medications and side effects in seniors. The prescribing physician should carefully weigh pros and cons of treating RLS with medications. (Suite101.com)
Swine Flu Vaccine Seems Safe in Early Trials Aug 25, 2009
One trial, which started in early August, is designed to determine the most effective dose of the vaccine and whether one or two doses will be needed. "We expect first-dose data in mid-September and second-doses data in mid-October," he said. (MEDLINEplus)
Rosy outlook for sufferers of arthritis Aug 9, 2009
Efficacy varies from brand to brand and the most effective dose remains unknown. Kaj Winther, from the department of clinical biochemistry at the University of Copenhagen, has studied rosehip oil for 12 years and says Rosa canina acts as a natural anti-inflammatory and is rich in vitamin C, which has antioxidant properties. (Sydney Morning Herald -- Australia)
Study shows seed implants a suitable prostate cancer treatment option for men of all ages Aug 4, 2009
It is critical that the implant delivers an effective dose to the prostate while avoiding surrounding organs. The targeted use of radiation continues to be a common treatment option for men with clinically localized prostate cancer. (EurekAlert!)
Powerful Antacids Raise Chances of Fracture Jun 4, 2009
"People should only take the medications for a defined indication and should take them at the minimal effective dose," he added. "The next step is evaluating whether taking calcium or vitamin D actually changes the risk, because we don't know for sure what the mechanism is," he said. (MEDLINEplus)
Heartburn Drugs May Raise Hip Fracture Risk Jun 3, 2009
Patients taking acid blockers should continue treatment at the lowest effective dose, but people at risk of osteoporosis should talk to their doctors about other treatment options, he said. For the study, Corley and colleagues analyzed data on nearly 40,000 patients taking acid-reducing drugs, and compared them with more than 130,000 patients not taking the drugs. (Newsmax)
MediciNova Announces Plan to Modify Its Phase II Placebo-Controlled Clinical Trial Evaluating MN-221 in Patients With Severe, Acute Exacerbations of Asthma May 29, 2009
D., President and Chief Executive Officer of MediciNova, Inc. ``We believe that testing a lower potentially effective dose will maximize the benefit of MN-221's safety profile and offer a more convenient 15 minute dosing regimen. . (Primezone Releases)
Medication Challenges for Pediatric... Apr 6, 2009
Again, this can take months of readjusting the dosage before an effective dose is found. Even once a dose is found, it may not be effective for very long because children are growing and their body mass is constantly fluctuating. (Suite101.com)
New Device Treats Common Heart Rhythm Disorder Apr 1, 2009
Current treatment with warfarin is effective in preventing strokes caused by clots associated with atrial fibrillation, but its use needs to be monitored monthly to assure patients are receiving the safest and most effective dose because it can cause serious bleeding if given in doses that are too high, Holmes noted. In the Embolic Protection in Patients With Atrial Fibrillation (PROTECT AF) trial, researchers compared treatment with warfarin to a fabric-covered, expandable cage called the... (MEDLINEplus)
Folic Acid Supplements Raise Prostate Cancer Risk Mar 12, 2009
"Folic acid, the synthetic version, has more bioavailability, meaning that the effective dose in the cell is higher than what you get from natural sources.". Dietary sources of folic acid in the United States now include cereals and other grain products. (MEDLINEplus)
Kittitas County jailers crack down on inmate drug abuse Feb 27, 2009
According to Myers, inmates traditionally use the drugs for three things: stockpiling for a larger, more effective dose, selling them for cash or trading them for other commissary items. All inmates have accounts allowing them to purchase commissary items such as books and candy bars. (Ellensburg Daily Record, WA)
Genetics May Help Fine-Tune Warfarin Dosage Feb 20, 2009
WEDNESDAY, Feb. 18 (HealthDay News) -- A DNA test could make prescribing the widely used anticoagulant warfarin safer by predicting the lowest effective dose, a new study finds ... Because an effective dose of warfarin can vary as much as 10-fold from one person to the next, doctors start most people on a low dose and increase it until blood tests indicate the dose is correct. (MEDLINEplus)
NOVEL FOOD and PARNUTS approval granted for NKO(R) opens the 2nd largest nutraceutical market for Neptune Feb 19, 2009
"According to EFSA regulations, functional food and dietary supplements can only be commercialized at the daily dose established as safe, which is not always necessarily the effective dose. Fortunately, the daily dose accepted by EFSA as safe for NKO(R) is also the one proven to be effective in all clinical studies with NKO(R)," stated Dr. Tina Sampalis, Chief Scientific Officer of Neptune. "This opens the door for NKO(R) to gain a leadership position in both dietary supplements and functional... (Canada Newswire)
People Without Heart Disease Symptoms Urged To Use Caution In Obtaining Cardiac Imaging Exams Feb 11, 2009
The authors state that the most widely used measurement of radiation dose, called the effective dose, "isn't as precise as people would like to think." Because it doesn't take into account age, variations in human anatomy, or uncertainties as to the sensitivity of organs and tissues to radiation, "the effective dose applies generically to types of imaging studies but not to individual patients," Dr. Gerber says. For perspective, the committee notes, the risk of dying from cancer related to... (Science Daily)
