Neurochem announces eprodisate (KIACTA(TM)) receives acknowledgement of complete response and is granted Class 2 review Dec 7, 2007
About Amyloid A (AA) Amyloidosis A progressive and fatal condition, AA amyloidosis occurs in a proportion of patients with chronic inflammatory disorders, chronic infections and inherited diseases such as familial Mediterranean fever. The kidney is the organ most frequently affected and progression to dialysis/end-stage renal disease is the most common clinical manifestation in this disease. (PR Newswire)
Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease Nov 13, 2007
According to Dr. Alnemri, defects in pyrin, for example, have been linked to familial Mediterranean fever, a sometimes fatal disease found in the Mediterranean, Middle East and Europe ... For example, there is a synthetic analog of the IL-1 receptor antagonist called Anakinra that has been successfully used in clinical trials to treat autoinflammatory diseases, including PAPA syndrome and familial Mediterranean fever, in addition to other chronic inflammatory diseases such as rheumatoid... (EurekAlert!)
Eprodisate in AA Amyloidosis Sep 13, 2007
However, they do not mention the use of colchicine in patients with familial Mediterranean fever related AA amyloidosis (19% of their study population). In a related article, Lachmann et al.2 report that patients with AA amyloidosis associated with familial Mediterranean fever were treated with colchicine. (New England Journal of Medicine)
Landmark Study Published in the New England Journal of Medicine Shows Important Benefits of Eprodisate (KIACTA(TM)) Treatment for Patients with Amyloid A (AA) Amyloidosis Jun 7, 2007
About Amyloid A (AA) Amyloidosis A progressive and potentially fatal condition, AA amyloidosis occurs in a proportion of patients with chronic inflammatory disorders, chronic infections and inherited diseases such as Familial Mediterranean Fever. The kidney is the organ most frequently affected and progression to dialysis/end-stage renal disease is the most common clinical manifestation of this disease. (Canada Newswire)
