'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers Sep 15, 2008
The Fox Chase researchers studied patients with familial adenomatous polyposis (FAP), an inherited disorder that also serves as a classic model in support of the two-hit hypothesis. Patients with FAP, which predisposes people to colon cancer, carry mutations in one of their two copies of the adenomatous polyposis coli (APC) tumor-suppressor gene. (EurekAlert!)
Here comes the bride – no matter what Jun 14, 2008
Genetic testing would reveal that Ms. Heller had familial adenomatous polyposis (FAP), usually a hereditary illness, although neither of Ms. Heller's parents has the gene. Like 20 to 30 per cent of patients, Ms. Heller had a spontaneously occurring mutation. (Globe and Mail)
Fight corectal cancer, here's what you need to know May 20, 2008
Certain rare but high-risk genetic syndromes, including familial adenomatous polyposis and Lynch syndrome, caused by gene mutations that can now be detected with DNA testing, account for about 10 percent of the total cases, and as many as 30 percent are linked to family histories of colorectal cancer or inflammatory bowel diseases, says Dr. Keith Argenbright, medical director UT Southwestern Moncrief Cancer Resources. Q: Can colorectal cancer be prevented. (Atlanta Journal-Constitution -- Health)
Health Matters: Make colo-rectal screening a priority Feb 19, 2008
A family history or familial adenomatous polyposis, Gardner s syndrome, and hereditary nonpolyposis colon cancer are three conditions that carry a high risk of colorectal cancer. If polyposis or colorectal cancer seems to run in a family, members should talk to their doctors. (Needham Tab, MA)
Patient Zero for a Colon Cancer Gene Jan 22, 2008
The Fry family's mutation causes a relatively rare syndrome known as attenuated familial adenomatous polyposis (AFAP). Without proper clinical care, people with AFAP who account for less than 1% of the 153,000 colorectal cancer cases in the U.S. every year have a greater than two-in-three risk of developing cancer, compared with a one-in-24 chance in the general population. (Time.com)
US study shows English settlers to New World brought colon cancer Jan 7, 2008
The people in these two families have a slightly more than two out of three risk (69%) of getting colon cancer specifically, attenuated familial adenomatous polyposis (AFAP), a form of inherited colon cancer from the adenomatous polyposis coli (APC) gene that can lead to AFAP characterized by less than one hundred adenomatous polyps in the colon and rectum, by the age of 80 years. The general population in the United States has a slightly less than one in twenty-four chance (about 4%). (iTWire)
Colon Cancer Gene Traced to Arrival in United States Jan 4, 2008
The ACP gene mutation identified by Neklason and her colleagues causes attenuated familial adenomatous polyposis (AFAP), a condition which results in a 69 percent greater risk of developing colon cancer by the age of 80. This is compared to a roughly one in 24 chance for the general population. (MEDLINEplus)
Colon cancer risk traced to common ancestor Jan 3, 2008
In the study, the team identified the mutation that causes a condition called attenuated familial adenomatous polyposis (AFAP), which makes people more prone to developing polyps that can cause colon cancer. Without proper treatment, people with this mutation have a greater than 2 in 3 risk of developing colon cancer by age 80, compared to about 1 in 24 for the general population. (MSNBC -- Environment)
U.Va. hospital performs first intestinal transplant Oct 25, 2007
"She has a syndrome called FAP, or familial adenomatous polyposis, which made her predisposed to early colon cancer," he explained. Theoretically, doctors could have removed Wagner's small intestine and avoided the transplant, but Schmitt said this would have greatly reduced her quality of life. (The Cavalier Daily, VA)
Impaired DNA Repair Jul 20, 2007
These cancers differ from those due to mutations in the APC gene resulting in Familial Adenomatous Polyposis, in that they lack the gross chromosomal abnormalities associated with the latter. This is because they involve more discrete lesions resulting from mismatched bases. (Suite101.com)
Colorectal Cancer Summary Apr 7, 2007
Familial Adenomatous Polyposis (FAP) associated with several genetic abnormalities including mutations in the APC gene and later on, the p53 gene. Hereditary Non-Polyposis Colorectal Cancer (HNPCC) associated with various DNA mismatch repair gene mutations. (Suite101.com)
Web Extra: Colorectal cancer is serious disease in the United States Mar 29, 2007
Also, there are certain genetic factors that increase the likelihood of having colon cancer, including conditions called familial adenomatous polyposis (FAP), Gardner's syndrome, hereditary non-polyposis colorectal cancer, and being of Ashkenazi Jewish descent. Race: African-Americans have the highest colorectal cancer rates and the highest rate of death from the disease of any racial or ethnic group in the United States. (Sun Herald, MS -- Living)
People With Genetic Predictors Of Colorectal Cancer Are Not Getting Screened Feb 26, 2007
We studied families with a history of familial adenomatous polyposis, a condition that very often leads to colorectal cancer, says study author Dr. Anita Kinney. Unfortunately, only about half of those diagnosed with the condition had been tested for cancer recently, and even fewer of their at-risk relatives had been screened. (Science Daily)
Jessica tugs heart strings Jan 29, 2007
Sharing Jessica's wish was her 11-year-old sister, Emma, who also suffers from familial adenomatous polyposis, an inherited bowel cancer syndrome. Jessica said breakfasts with Chambers, Cole and Sarah Storer were amazing, but nothing compared with meeting Kernaghan as he added another four Golden Guitars to his collection. (Melbourne Herald Sun)
A 19-Year-Old Woman with Thyroid Cancer and Lower Gastrointestinal Bleeding Nov 30, 2006
Please for full text and personal services. Volume 355:2349-2357. (New England Journal of Medicine)
Gene Study Reveals New Cancer-Related Mutations Sep 8, 2006
Changes in a gene called APC are responsible for familial adenomatous polyposis, a condition that causes people to develop hundreds of colon polyps and puts them at high risk of developing colon cancer. Until now, however, no one had sequenced the entire genome of these cancers in hopes of finding all -- or at least many -- of the gene changes that might cause these diseases. (ACS News Center)
Study Finds That Vioxx Reduces The Risk Of Colorectal Polyps Sep 1, 2006
Previous randomized studies have also shown that COX-2 inhibitors can lower the risk of polyps in patients with a rare genetic syndrome called familial adenomatous polyposis (FAP), but this is the first to illustrate the effect in the broad population of people at risk for colorectal cancer. Patients taking rofecoxib had a lower recurrence rate of adenomas than those taking placebo (41 percent vs 55 percent; p<0. (Science Daily)
Celebrex: Colon Benefit, Heart Risk Aug 31, 2006
It's known that Celebrex helps prevent precancerous polyps in people with a rare condition called familial adenomatous polyposis that greatly increases the chance of getting colon cancer. In this condition, polyps are much more likely to become cancerous. (CBS News)
Celecoxib for the Prevention of Sporadic Colorectal Adenomas Aug 31, 2006
Background Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the number of colorectal adenomas in animals and patients with familial adenomatous polyposis suggest that COX-2 inhibitors may also prevent sporadic colorectal neoplasia. Methods We randomly assigned patients who had adenomas removed before study entry to receive placebo (679 patients) or 200 mg (685 patients) or 400 mg (671 patients) of celecoxib twice daily. (New England Journal of Medicine)
Curry, onions might prevent colon cancer Aug 15, 2006
Five people with an inherited disease called familial adenomatous polyposis, which often leads to colon cancer, took the pill for six months ... People with familial adenomatous polyposis typically take nonsteroidal anti-inflammatory drugs to help reduce their cancer risk. (The Miami Herald)
Curry May Cut Down Colon Cancer Aug 3, 2006
The condition, Familial Adenomatous Polyposis (FAP), is usually inherited. If the colon is not surgically removed, there is a 100% chance some of the polyps will develop into cancer, usually by age 40. (CBS News)
Curry and onion extracts could protect against colon cancer Aug 3, 2006
Familial adenomatous polyposis (FAP) is a hereditary disorder characterised by the development of hundreds of colorectal adenomas (polyps) and eventually. Nonsteroidal anti-inflammatory drugs (NSAIDs) have recently been given to some patients with this condition, but these compounds, said Giardiello, frequently produce significant side effects, such as gastrointestinal ulcerations and bleeding. (NutraIngredients.com)
Chemicals In Curry And Onions May Help Prevent Colon Cancer Aug 2, 2006
In the study, published in the August issue of Clinical Gastroenterology and Hepatology, five patients with an inherited form of precancerous polyps in the lower bowel known as familial adenomatous polyposis (FAP) were treated with regular doses of curcumin (the chemical found in turmeric) and quercetin, an antioxidant in onions, over an average of six months ... Familial adenomatous polyposis is a disorder that runs in families and is characterized by the development of hundreds of colorectal... (Science Daily)
Study: Exercise, diet may protect against colorectal cancer May 16, 2006
Mutations in the APC gene in humans are responsible for an inherited condition called familial adenomatous polyposis (FAP). This condition affects about one in 10,000-15,000 people worldwide, and 95 percent of those affected develop polyps in the colon that eventually progress into cancer, usually before age 40. (EurekAlert!)
Studies shed new light on why exercise can protect against skin and bowel cancers May 13, 2006
Mutations in the APC gene in humans are responsible for an inherited condition called familial adenomatous polyposis (FAP). FAP affects about one in 10,000-15,000 people worldwide, 95% of whom will develop numerous polyps in the bowel which eventually develop into colon cancer, usually before the age of 40. (EurekAlert!)
Q&A: Preimplantation genetic diagnosis May 11, 2006
The HFEA has also allowed PGD can be used to check for an inherited form of bowel cancer called familial adenomatous polyposis and retinoblastoma - a very rare form of eye cancer. It also gave the go-ahead for the technique to be used so that embryos could be selected purely because they are a tissue match for a sick sibling. (BBC News)
