GlaxoSmithKline, Exelixis to end 6-year collaboration Jun 28, 2008
GSK can pick an additional compound among six programs: XL184, which will start Phase III trials this summer for glioblastoma, medullary thyroid cancer and non-small cell lung cancer; XL820, in Phase II for gastrointestinal stromal tumor; XL281, in Phase I for patients with advanced solid tumors; XL228, in Phase I for chronic myelogenous leukemia, Philadelphia chromosome-positive acute lymphocytic leukemia and advanced malignancies; or XL844, in Phase I in combination with gemcitabine in... (San Francisco Business Journal)
SPECIAL REPORT: Drug markers questioned Apr 2, 2008
It is a wonderful drug which has revolutionised the way chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST) are managed. I do agree that the newer anticancer drugs are being tested using surrogate endpoints and not necessarily survival, which is the most robust efficacy assessment tool. (Nature News Service)
Another 'smart' cancer drug can have toxic effects on the heart Dec 14, 2007
However, a new retrospective analysis, focused on cardiovascular events, revealed a risk for heart failure, myocardial infarction and hypertension in 75 adult patients with imatinib-resistant, gastrointestinal stromal tumor (GIST) receiving multiple cycles of sunitinib in a phase I/II trial at Dana-Farber. Of the 75, six (8 percent) developed symptoms consistent with moderate-to-severe congestive heart failure, and two had heart attacks. (EurekAlert!)
Re-engineered Gleevec Reduces Heart Risks, Study Suggests Dec 6, 2007
The new study reports pre-clinical evidence that the newly re-engineered drug is just as effective as imatinib against gastrointestinal stromal tumor (GIST) and carries significantly less risk of heart failure. Developed by Novartis Pharmaceuticals, Gleevec is approved by the U.S. Food and Drug Administration for the treatment of chronic myeloid leukemia (CML), Philadelphia-chromosome positive acute lymphoblastic leukemia and GIST. The drug targets two proteins that have been linked with cancer. (Science Daily)
Rice, M.D. Anderson collaborate on anticancer drug Dec 5, 2007
The new study, which appears in the Dec. 3 issue of the Journal of Clinical Investigation, reports pre-clinical evidence that the newly re-engineered drug is as effective as imatinib against gastrointestinal stromal tumor and carries significantly less risk of heart failure. Developed by , Gleevec is approved by the for the treatment of certain types of leukemia -- cancer of the blood -- as well as the gastrointestinal cancer. (Houston Business Journal, TX)
Couple escapes burning truck without injury Oct 6, 2007
Last March, doctors found a malignant gastrointestinal stromal tumor in Ted s abdomen which could not be treated with chemotherapy. After surgery, doctors informed the Susans that the cancer had metastasized and spread; meaning Ted could live about a year unless cancer therapy drugs were effective. (Gaylord Herald Times, MI)
Study finds heart failure is rare among leukemia patients on imatinib Sep 7, 2007
Imatinib, known by its brand name Gleevec(tm) and developed by Novartis Pharmaceuticals, is approved by the U.S. Food and Drug Administration for the treatment of chronic myelogenous leukemia (CML), Philadelphia-chromosome positive acute lymphoblastic leukemia d(ALL) and gastrointestinal stromal tumor, a rare solid tumor cancer. Imatinib is a targeted therapy that inhibits two members of a class of enzymes called tyrosine kinases, which transmit growth and survival signals in cells. (EurekAlert!)
Dr. Amit Dhawan Promoted to Medical Director for The Mattson Jack Group Aug 21, 2007
Executive Vice President Jerry Fields commented, "Dr, Dhawan is a highly regarded individual who brings a unique combination of scientific and commercial perspectives together to help solve client problems. Our clients benefit from his exceptional knowledge and insight. About The Mattson Jack Group, Inc. () Formed in 1986, MattsonJack focuses its client support in three areas of Competency: Business Analytics, Brand Optimization, and Corporate Development services in the pharmaceutical and... (PR Newswire)
First Detailed View Of Molecular Structure May Usher In New Class Of Cancer Drugs Aug 8, 2007
It is also anticipated that the new family of drugs may be applied for the treatment of gastrointestinal stromal tumor (GIST) cancers that are resistant to Gleevec and Sutent. Although these drugs would target the same receptors as Gleevec and Sutent, they would do so by a different mechanism and may therefore be useful for patients who are resistant to these drugs. (Science Daily)
Paul Schaye is used to conquering physical challenges. So it's no surprise how he feels about his cancer. Aug 1, 2007
Last October, he was diagnosed with a rare form of stomach cancer called gastrointestinal stromal tumor. A tumor larger than a baseball was growing in his stomach. (Boston Globe)
ChemGenex reports successful personalized dosing of Quinamed at ASCO Jun 5, 2007
One patient with gastrointestinal stromal tumor (GIST) demonstrated stable disease which was sustained over 18 monthly cycles of amonafide. Greg Collier, Ph. (EurekAlert!)
Pfizer Inc UK Regulatory Announcement: New Data Evaluating SUTENT, CP-751,871 and Axitinib in Patients with Non-Small Cell Lung Cancer Jun 4, 2007
SUTENT is a multi-kinase inhibitor approved for the treatment of advanced renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST) after disease progression on or intolerance to imatinib mesylate. Women of child bearing age who are (or become) pregnant during therapy should be informed of the potential for fetal harm while on SUTENT.. (BusinessWire)
Gleevec reduces recurrence in colon cancer Apr 17, 2007
The large national clinical trial, led by Dr. Ronald DeMatteo, of Memorial Sloan-Kettering Cancer Center, and conducted by a national network of researchers, treated patients with primary gastrointestinal stromal tumor (GIST), a type of tumor usually found in the stomach or small intestine. They released the early results because the study had met is primary objective of increasing recurrence-free survival. (Cancerfacts.com)
Gleevec keeps stomach tumor at bay: study Apr 13, 2007
The National Institutes of Health-funded team found that 97 per cent of patients with a stomach cancer called gastrointestinal stromal tumor of GIST who took Gleevec for one year remained cancer-free after surgery as compared to 83 percent of patients given a placebo ... The American Cancer Society says it is not known how many new gastrointestinal stromal tumors are diagnosed each year but estimated that around 1,500 malignant cases occur in the United States. (Scientific American)
Gleevec decreases cancer recurrence for patients with primary gastrointestinal stromal tumor Apr 13, 2007
Preliminary results from a large, randomized, placebo-controlled clinical trial for patients with primary gastrointestinal stromal tumor (GIST), a type of tumor usually found in the stomach or small intestine, showed that patients who received imatinib mesylate (Gleevec ) after complete removal of their tumor were significantly less likely to have a recurrence of their cancer compared to those who did not receive imatinib ... Z9001: A Phase III Randomized Double-blind Study of Adjuvant STI571... (EurekAlert!)
5-year Study Shows Gleevec's Potency Against Chronic Myeloid Leukemia Dec 9, 2006
The outcome of the five-year study also offers lessons for physicians who are using Gleevec to treat other cancers, such as gastrointestinal stromal tumor, said Druker ... "In CML, there is the advantage that most patients get diagnosed at an early, chronic stage; whereas gastrointestinal stromal tumors are often diagnosed at a more advanced stage. Our results demonstrating Gleevec's high efficacy in CML tell us that in applying the drug to other cancers, we need to diagnose and treat patients... (Science Daily)
Leukemia drug Gleevec: Questions and answers Jul 25, 2006
Gleevec, also known as STI571, is a new drug that was approved by the Food and Drug Administration in 2001 for the treatment of chronic myeloid leukemia (CML), a cancer of white blood cells, and for the treatment of a rare form of stomach cancer called gastrointestinal stromal tumor (GIST) in 2002 ... Currently, these tumors are: gastrointestinal stromal tumor (GIST), glioma, and soft tissue sarcoma. (Food Consumer)
Cancer Institute Study Points To Future Of Personalized Medicine Jun 5, 2006
Initially used to treat patients with chronic myelogenous leukemia, it has also proved successful in treating a rare stomach cancer called gastrointestinal stromal tumor (GIST). But imatinib doesn't work for every GIST patient, and even when it does work, many GIST patients develop resistance to it. (Science Daily)
Study: Drug curbs cancer Jun 5, 2006
Dr. Robert Mayer, a professor of medicine at Harvard Medical School said the new study "confirms as first-line therapy." He pointed to Gleevec's versatility because it is also first-line therapy for gastrointestinal stromal tumor, a rare cancer of the digestive system. Although the gastrointestinal cancer is unrelated to the leukemia, it possesses a similar enzymatic miscue that can be controlled by Gleevec. (Newsday)
A New Immune Cell and the Response to Imatinib Mesylate May 25, 2006
Tyrosine kinases are major targets of contemporary chemotherapy, and tyrosine kinase inhibitors such as imatinib mesylate (Gleevec, Novartis; formerly known as STI571) are approved for the treatment of some forms of chronic myelogenous leukemia and a rare form of stomach cancer called gastrointestinal stromal tumor. Surprisingly, some types of gastrointestinal stromal tumors refractory to the antiproliferative effects of imatinib mesylate in vitro were shown recently to respond to the drug in... (New England Journal of Medicine)
