Link Between Genetic Defect And Brain Changes In Schizophrenia DemonstratedOct 18, 2009 Now, researchers at the University of North Carolina at Chapel Hill School of Medicine have found that the 22q11 gene deletion a mutation that confers the highest known genetic risk for schizophrenia is associated with changes in the development of the brain that ultimately affect how its circuit elements are assembled. In studies conducted in mice, the researchers discovered that the genetic lesion alters the number of a critical subset of neurons that end up in the brain s cerebral cortex the... (Science Daily)
Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditionsJul 18, 2009 In this study, we combine quantitative fitness data for single gene knock-outs in yeast with large-scale interaction discovery experiments to understand the effect of gene deletion on the modular architecture of protein complexes, under different growth conditions ... This study presents a powerful approach to unveil the molecular basis for various complex phenotypic profiles observed in gene deletion experiments. (BioMed Central)