Mapping gene expression with Gene Expression Atlas Jun 16, 2009
Misha Kapushesky, Atlas project leader at the EBI commented, "While the ArrayExpress Archive makes data from high throughput functional genomics assays available to experts, Gene Expression Atlas presents this information in a format accessible to any biologist. The Atlas takes data directly from the ArrayExpress Archive, which is then enriched by curation, re-annotation and statistical computations before the results are presented to the user in an easily accessible form.". . (EurekAlert! -- Business News)
Ovarian Cancer Breakthrough Heralds New Era of Treatment Jun 16, 2009
The discovery, made using state-of-the-art gene-sequencing technologies, may mark the beginning of a new era of cancer genomics, in which the complete genetic sequence of cancers and the mutations that cause them can be identified, researchers said. For women with granulosa cell tumors, the precise identification of the mutation may help in developing new, badly needed treatments. (MEDLINEplus)
TIME's Best Inventions of 2008 Jun 6, 2009
We are at the beginning of a personal-genomics revolution that will transform not only how we take care of ourselves but also what we mean by personal information ... And so for pioneering retail genomics, 23andMe's DNA-testing service is Time's 2008 Invention of the Year ... "The uncertainty is too great," says Dr. Muin Khoury, director of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention, who argues that it is wrong to charge people for access to... (Time.com)
JDRF launches innovative cure collaboration partnership with Sanford Health Jun 6, 2009
According to David Link, "The Sanford Project Cure Collaboration will provide Sanford Health patients greater access to the most advanced therapies and technologies via clinical trials and early adoption of evidence-based best practices. It will also leverage and enhance the data network utility provided by the health system's integrated electronic medical record system, DocZ which will help patients with type 1 diabetes and physicians better manage treatment protocols and follow-up... (EurekAlert! -- Business News)
Geography and history shape genetic differences in humans Jun 6, 2009
PLoS Genetics () reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology. About the Public Library of Science. (EurekAlert!)
Risks of sharing personal genetic information online need more study, Stanford bioethicists say Jun 5, 2009
Now, thanks to social networking sites set up by personal genomics companies, they can also share that information with family, friends and even strangers on the Internet. Bonding over a similar genetic background sounds relatively harmless. (EurekAlert!)
ESA and UAB MELiSSA Pilot Plant to prepare for human planetary exploration Jun 5, 2009
The scientists and engineers of MELiSSA are from various horizons (academic organizations, industries) and gather a comprehensive multidisciplinary expertise (microbiology, modelling, process engineering, biotechnology, system engineering, nutrition, automation, genomics, proteomics, etc. . (EurekAlert! -- Business News)
Estrogen Linked To Lowered Immunity In Fish Jun 5, 2009
The study, led by USGS genomics researcher Dr. Laura Robertson, revealed that largemouth bass injected with estrogen produced lowered levels of hepcidin, an important iron-regulating hormone in mammals that is also found in fish and amphibians. This is the first published study demonstrating control of hepcidin by estrogen in any animal. (Science Daily)
Advance in Bowel Cancer Test Research Jun 4, 2009
Being presented today at the Digestive Disease Week conference in Chicago, the preliminary findings are the result of a collaborative study - involving CSIRO, Flinders University and Australian healthcare company, Clinical Genomics Pty Ltd - designed to develop an improved screening/diagnostic test for detecting bowel cancer and significant pre-cancer lesions ... The CEO of Clinical Genomics Pty Ltd, Lawrence La Pointe, says if a more robust screening test for bowel cancer and especially... (PR Newswire)
Cloudera CEO: Hadoop Will Go Beyond Web Apps Jun 2, 2009
From the analysis of point-of-sale data to genomics data, the opportunities for Hadoop are plentiful, Olson said. Bioinformatics and pharmaceuticals are emerging as big opportunities for Hadoop, which first found favor with Web 2. (Salon)
A drop in the bucket, with very big impact Jun 1, 2009
With the incredible advancements in genomics, computational power, and miniaturization, we are arguably entering into a golden age of innovation in life sciences (which encompasses health IT, medical devices, diagnostics, and touches adjacent areas such as materials science and robotics. Having an NVCA chairman steeped in that world, at a time when the US government is looking to perform a top-down reengineering of the health are system, which is projected to make up 20 percent of GDP in a few... (Boston Globe)
University of Arizona medical school's growth may stall May 31, 2009
In addition to training students, Crist touts the medical research that will take place on a campus that is located next to the Translational Genomics Research Institute and International Genomics Consortium. He said the expanded campus will help make the area's bioscience community more competitive in securing grants. (AZCentral -- Business)
How Oxidative Stress May Help Prolong Life May 30, 2009
Ideker and first author Ryan Kelley used the rich functional genomics toolbox of yeast to identify pathways involved in the cell's adaption to hydrogen peroxide. Adaption (or hormesis) is an effect where a toxic substance acts like a stimulant in small doses, but is an inhibitor in large doses. (Science Daily)
Cytokine-dependent and -independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling May 30, 2009
BMC Genomics 2009, 10:252doi:10. 1186/1471-2164-10-252. (BioMed Central)
Sale of Avalon Pharmaceuticals completed May 30, 2009
It also sold another genomics services division for $17 million. Our company has consistently run tighter than most biotech companies, Fromkin said. (Washington Business Journal, DC)
New Malaria Agent Found In Chimpanzees Close To That Commonly Observed In Humans May 30, 2009
However, the lack of known related genomes has limited the development of comparative genomics according to the study's researchers from Centre International de Recherches M;dicales de Franceville, Centre National de la Recherche Scientifique, and l'Institut de Recherche pour le D;veloppement ... The development of comparative genomics to further understanding of P. falciparum has been hindered by a lack of knowledge of closely related species' genomes. (Science Daily)
Rapid approach to identify influenza A virus mutations and drug resistance developed May 29, 2009
The genomics infrastructure at the GIS is utilized to train new scientific talent, to function as a bridge for academic and industrial research, and to explore scientific questions of high impact. Agency for Science, Technology and Research (A*STAR). (EurekAlert! -- Business News)
TGen taps scientist to head new protein lab May 29, 2009
The Translational Genomics Research Institute has hired a scientist to oversee its newest lab that aims to help discover ways to diagnose and treat disease. Dr. Konstantinos Petritis will direct the newly created Center for Proteomics, which will be located at TGen's headquarters in downtown Phoenix. (AZCentral -- Business)
More Genetic Differences Between Mice And Humans Than Previously Thought May 28, 2009
"In retrospect, our previous picture of the mouse genome was incomplete. Only when all the missing pieces of the genomic puzzle had been filled in did we realize that we had been missing large numbers of genes found only in mice, and not in humans," says Dr. Leo Goodstadt from the MRC Functional Genomics Unit. "These new findings are extremely important in helping us to separate genes that underpin biology that is the same across all mammals, from genes that make humans and mice so different... (Science Daily)
Swiss Initiative in Systems Biology launches new projects May 28, 2009
In the second call for proposals, projects focus on either the development of new technologies or on the interface between biomedical research and genomics. The Swiss National Science Foundation (SNSF) approved six RTD-projects today. (EurekAlert! -- Business News)
TGen scientist lands $18M to fight cancer May 28, 2009
Dr. Daniel Von Hoff, physician in chief of the Translational Genomics Research Institute, will co-manage one of five research teams that will collectively receive $73. 6 million over three years to study cutting-edge approaches to fighting cancer. (AZCentral -- Business)
U picks team for biotech project May 28, 2009
Architectural Alliance s projects on the U of M campus include the Cargill Building for Microbial and Plant Genomics on the St. Paul campus and Jackson Hall, a science building. In addition, Architectural Alliance has been selected to design a new physics building for the Minneapolis campus. (Twin Cities Business Journal, MN)
Proteomics: Finding The Key Ingredients Of Disease May 27, 2009
The study was authored by Alexander Bell (McGill University), Eric Deutsch (Research Institute, MUHC), Catherine Au (McGill University), Robert Kearney (CODA Genomics), Ron Beavis (BioGrammatics), Salvatore Sechi (NIDDK (NIH)), Tommy Nilsson (Research Institute, MUHC0, John Bergeron (McGill University) and the HUPO Test Sample Working Group. Journal reference. (Science Daily)
Oldest Evidence Of Leprosy Found In India May 27, 2009
A report on genomics of Mycobacterium published in the magazine Science by Monot and colleagues in 2005, indicated the disease may have originated in Africa during the Late Pleistocene and that M. leprae spread out of Africa sometime after 40,000 years ago, when human population densities were small. A counter hypothesis was proposed in the same volume of Science by Pinhasi and colleagues suggesting that the same data could be interpreted as evidence for a Late Holocene migration of the disease... (Science Daily)
Mouse genome laid bare to science May 27, 2009
Professor Ponting, from the Medical Research Council's (MRC) Functional Genomics Unit at Oxford, said the complete genome could provide insights into the evolution of mammals. Humans and mice share a remarkable level of similarity, despite having evolved independently for the last 90 million years. (BBC News -- Science)
Integrated Microbial Genomes Expert Review Goes Primetime May 26, 2009
Armed with the powerful tools of comparative genomics and mathematics, TIGR scientists have concluded. . (Science Daily)
Knowledge Of Epigenetics Helps Scientists Develop Tool To Study Deadly Parasite’s Histone Code May 25, 2009
8, 2008) Scientists from the Structural Genomics Consortium have determined the 3-D structure of a key protein component involved in enabling "epigenetic code" to be copied accurately from cell to cell. The. (Science Daily)
On MPs' expenses, Iranian dissidents, Chrysler, Nordic countries, genetic information, the Supreme Court May 25, 2009
SIR It is not surprising that Google and 23andMe, a genomics firm, want the power of information that comes from new technologies in health care to be wrested from the medical profession (, April 18th). Data mining leads to personalised marketing, yet half the genetic information up for sale from companies that interpret your genome to tell you your supposed genetic risk has been shown to be false. (The Economist)
Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data May 23, 2009
Free News and Study information on Genomics, Health iosciences. Informative non-lethal self-defense training lessons. (Yahoo News -- Press Releases)
DNA Deletion Makes Swedish Chlamydia 'Invisible' May 23, 2009
"We have confidently placed great reliance on nucleic acid based diagnostic tests for many years," explains Professor Ian Clarke, University of Southampton, senior author on the study, "but we must always be alert to changes in the biology of this organism. Chlamydia are notoriously difficult to study in the laboratory and genomics can make a vital contribution to adding to our understanding of this insidious parasite.". After careful analysis of the newly sequenced plasmids of these strains,... (Science Daily)
Fast, Affordable Tool For Finding Gene 'On-off' Switches May 22, 2009
Since their discovery in the past decade, biologically active small RNAs have become the holy grail of much pharmaceutical and genomics research, offering the hope of creating targeted therapeutics to turn off or turn down the volume of various genes involved in disease, according to Michael McManus, PhD, a UCSF microbiology professor and senior author on the paper ... Emily M. LeProust, in the Genomics Solutions Unit at Agilent Technologies, Inc., Santa Clara, CA, was also a co-author. (Science Daily)
NIH Launches Drug Program for Rare Diseases May 21, 2009
"We will be de-risking these projects sufficiently to make them adoptable by private industry," said Christopher Austin, the director of NIH's Chemical Genomics Center, which will be involved in research. He and other NIH officials said the goal is to work with private industry, not compete against it. (SmartMoney)
NIH announces new program to develop therapeutics for rare and neglected diseases May 21, 2009
The NIH Office of Rare Diseases Research will oversee the program, and TRND's laboratory operations will be administered by the National Human Genome Research Institute (NHGRI), which also operates the NIH Chemical Genomics Center, a principal collaborator in TRND. Other NIH components will also participate in the initiative ... TRND will begin its work in collaboration with the NIH Chemical Genomics Center (NCGC), initially developed as part of the NIH Roadmap for Medical Research. (EurekAlert! -- Business News)
High Tech, High Touch, High Growth - The Future of Work - TIME May 20, 2009
High Tech, High Touch, High Growth. Ryan Mcvay / Getty Article Tools. (Time.com)
St. Joseph's, UA in talks for Phoenix cancer clinic May 20, 2009
Phoenix officials favor a critical mass of research at the downtown biomedical campus, which is anchored by the medical school as well as research groups such as the Translational Genomics Research Institute and the International Genomics Consortium. Rick Naimark, deputy city manager for Phoenix, said it is not realistic to expect one location to meet all the downtown medical school's needs. (AZCentral -- News)
Mutant genes in high-risk childhood leukemias identified May 20, 2009
This research was done as part of the NCI Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative, which seeks to utilize the study of genomics to identify therapeutic targets in order to develop more effective treatments for childhood cancers. The article appears online May 18 in the early edition of the Proceedings of the National Academy of Sciences. (EurekAlert!)
MMRF and the Broad Institute to perform whole genome sequencing of multiple myeloma samples May 19, 2009
"Three years ago, the MMRF launched a partnership with the Broad Institute and the Translational Genomics Research Institute the Multiple Myeloma Genomics Initiative a comprehensive genome mapping program to identity new targets and eventually new therapies for this incurable disease," said Kathy Giusti, Founder and CEO of the MMRF, and a multiple myeloma patient ... About the Multiple Myeloma Genomics Initiative ... The Multiple Myeloma Genomics Initiative is a genome-mapping program... (EurekAlert! -- Business News)
Molecular characterisation and genetic mapping of candidate genes for qualitative disease resistance in perennial ryegrass (Lolium perenne L.) May 19, 2009
A comparative genomics analysis revealed the co-location of several candidate R genes with disease resistance quantitative trait loci (QTLs). Conclusion. (BioMed Central)
NC State and UNC Lineberger collaborate to combat cancer May 19, 2009
Steven Suter, professor of clinical sciences, and Matthew Breen, professor of genomics, along with statistics professor Dr. Alison Motsinger-Reif and Dr. Dahlia Nielsen, research assistant professor of genetics, lead the NC State component. Researchers at UNC Lineberger are led by Dr. Kristy Richards, geneticist and clinical oncologist. (EurekAlert! -- Business News)
"For CARTaGENE to be a success, it must recruit 20,000 people between 40 and 69 years of age." - Dr. Claude Laberge May 18, 2009
MONTREAL, May 18 /CNW Telbec/ - The CARTaGENE Project, one of the largest health and genomics projects ever carried out in Quebec, seeks to recruit 20,000 people to participate in Phase A of its wide-ranging study on the determinants of health (lifestyles, genetics, environment and nutrition) of Quebecers ... CARTaGENE also has an international scope as a member of the Public Population Project in Genomics (P3G), which coordinates collaboration between 25 similar projects around the world ...... (Canada Newswire)
* Research team develops cancer immunotherapy May 17, 2009
The new immunotherapy treatment pioneered by the research team, headed by Alice Yu (az), deputy director of Academia Sinicas Genomics Research Center, is the first study that confirms that immunotherapy is effective in improving cure rates for this childhood cancer, the statement said. Yu, a pediatrician, has been working on the therapy for more than 20 years. (Taipei Times, Taiwan -- Taiwan)
Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi May 17, 2009
g., genomics, primary biochemical literature, proteomics) to generate testable hypotheses. This model represents an approach for the systematic study of T. cruzi metabolism under a wide range of conditions and perturbations, and should eventually aid in the identification of urgently needed novel chemotherapeutic targets. (BioMed Central)
Whos who in the project May 16, 2009
The Malaysian Palm Oil Board has reportedly tied up with South Koreas Macrogen Inc, US-based Orion Genomics LLC and Britains Oxford Gene Technology IP Ltd. Asiatic Centre for Genome Technology Sdn Bhds collaborator is Synthetic Genomics Inc.. Sime Darby Bhd has not ventured into genomics as a lone ranger either ... In his speech during the launch of Sime Darby Genomics Sdn Bhd on Tuesday, Sime Darby chairman Tun Musa Hitam introduced Pavel Pevzner as an authority on the use of computers in... (The Star Online, Malaysia -- Business)
Unravelling the process May 16, 2009
SIME Darby Bhds announcement that it had completed the sequencing of the oil palm genome took many people by surprise because before that, there had been no indication of the conglomerates interest in genomics ... We came up with this idea (of using genomics) in 2003. (The Star Online, Malaysia -- Business)
Ore Pharmaceutials cuts losses May 16, 2009
Ore, known as before selling off its genomics services division, is working against a brutal economy to get at least $10 million in financing or a larger partner to help fund further clinical trials of its lead compound to treat inflammatory bowel disease ... It is still owed $3 million, due that month, by the company that bought its genomics division. (Washington Business Journal, DC)
Sime Darby in the spotlight with oil palm breakthrough May 16, 2009
AMONG the worlds heads of government, Prime Minister Datuk Seri Najib Razak must surely be the one most familiar with genomics research on oil palm ... Sime Darby also launched Sime Darby Genomics Sdn Bhd that day ... Indeed, the industry needs a leap in productivity and efficiency, and genomics is the big scientific hope. (The Star Online, Malaysia -- Business)
Honorees for the 41st Wellesley Veterans Parade May 16, 2009
The Chatham Circle resident worked for the New England Healthcare Institute, Harvard/Partners Center for Human Genetics and Genomics and Coral Therapeutics Inc. She was campaign manager for the Committee to Elect Alice Peisch for State Representative from May to November 2002. Wellesley Chamber of Commerce Special Recognition Award. (Wellesley Townsman, MA)
Ginseng: Nature's Anti-inflammatory? May 15, 2009
Uniquely, the researchers were able to holistically test the ginseng extract's immune effects by using sophisticated purification technologies to identify individual constituents and define their bioactivity using genomics and bioactivity assays. After that, they reconstituted them back into a whole extract with definable individual ginsenosides for re-confirmation of effects. (Science Daily)
Analysis Of Flu Virus Could Lead To Better Vaccines May 14, 2009
"We have proposed that antibody interference plays a major role in determining the effectiveness of the antibody response to a viral infection," said Ned Wingreen, a professor of molecular biology and a member of the Lewis-Sigler Institute for Integrative Genomics. "And we believe that in order to get a more powerful vaccine, people are going to want one that minimizes this interference.". (Science Daily)
Association for Molecular Pathology joins ACLU to challenge gene patents May 14, 2009
The Association for Molecular Pathology is an international medical professional association dedicated to the advancement, practice, and science of clinical molecular laboratory medicine and translational research based on the applications of molecular biology, genetics and genomics. Through the efforts of an enthusiastic membership from across the United States and around the world, AMP continues to grow in numbers and influence. (EurekAlert! -- Business News)
160 million years of milk May 13, 2009
Funding for researchers participating in the bovine lactation genome study was provided by the International Milk Genomics Consortium, National Institute of Environmental Health Sciences, U.S. Department of Agriculture Agricultural Research Service, New Zealand s Foundation for Research Science and Technology, California Dairy Research Foundation, National Human Genome Research Institute, Genome Canada and Genome BC, Swiss National Science Foundation, Australia s Cooperative Research Centre for... (Harper's Magazine)
Landmark Study Reveals Significant Genetic Variation Between Mexico's Population And World's Other Known Genetic Subgroups May 13, 2009
"It will also help develop pharmacogenomics to help produce medicines tailored to people of a specific genetic group, to the creation of drugs that are both safer and more effective." ... "Studies such as this are helping us define the future of the genome era," says Dr. Jeffrey Trent, President of the Translational Genomics Research Institute, Phoenix, Arizona ... "We have studied a number of genomics initiatives in the developing world and emerging economies, recently published in Nature... (Science Daily)
How Cells Move: Cooperative Forces Boost Collective Mobility Of Cells May 12, 2009
7, 2008) A study describing how cells within blood vessel walls move en masse overturns an assumption common in the age of genomics -- that the proteins driving cell behavior are doing so much multitasking. (May 15, 2007) Who must go. (Science Daily)
Gene Responsible For Acetaminophen-induced Liver Injury Identified May 12, 2009
Scientists from the University of North Carolina (Chapel Hill, NC), the Genomics Institute of the Novartis Research Foundation (San Diego, CA), the Jackson Laboratory (Bar Harbor, ME), the National Institute of Environmental Health Sciences (Research Triangle Park, NC), Verto Institute Research Laboratories (New Brunswick, NJ), the Cancer Institute of New Jersey (New Brunswick, NJ), Purdue Pharma (Stamford, CT), and North Carolina State University (Raleigh, NC) contributed to this study. This... (Science Daily)
Producing Pigs That Provide Us With Healthy And Yet Good Tasting Meat May 12, 2009
The Genesis Faraday Partnership supports industry-relevant research in the area of genetics and genomics of farm animals and this is the first Genesis Faraday BBSRC CASE Studentship awarded to UWE. The project is undertaken by PhD student Duncan Marriott under supervision of Dr Olena Doran, Coordinator of Institute of Biosensing Technology. Duncan is a Biology graduate with an MSc in Meat Science and five years experience as a research technician at the University of Bristol s School of Clinical... (Science Daily)
Random Picks Better Than Complicated Process In Gene Identification May 12, 2009
BMC Genomics, 2009; 10 (1): 203 DOI. Adapted from materials provided by. (Science Daily)
Scientist to Watch: Dennis Wall May 12, 2009
D.P. Wall et al., "Comparative analysis of neurological disorders focuses genome-wide search for autism genes," Genomics, 93:120 29, 2009. (Cited in 0 papers). (The Scientist)
In this market, cancer has competition May 10, 2009
Scottsdale Healthcare, too, offers experimental Phase 1 cancer drugs through its partnership with the Translational Genomics Research Institute. Some physician offices such as Premiere Oncology in Scottsdale also offer this option. (AZCentral -- Business)
Researchers identify the gene responsible for a rare form of congenital anemia May 9, 2009
This Genome Canada project, co-directed by Dr. Mark Samuels, an investigator with the Sainte-Justine University Hospital Research Center and a professor at the Universit de Montral Department of Medicine, is being conducted under the Atlantic Medical Genetics and Genomics Initiative (AMGGI). The clinical research team identified three families from Canada's Maritime provinces, each with a child suffering from this disease. (EurekAlert!)
Investing dropoff hurting biotechs May 9, 2009
"In 1999 and 2000, you had the genomics bubble, when huge amounts of money were going into biotech," said Gilman. "The fundamentals of the business were no different then, but today, no one wants to put in a nickel. People were just jazzed about it then, and they're pessimistic about it now.". (Boston Globe)
She'll race back to lab to look for cure May 9, 2009
"A lot of our focus lately is individualized care -- we sort out what people respond to, what drugs work best, and the term behind that is 'genomics.' "And the other thing we're looking at a lot is treatments without chemotherapy, more biologically based treatments. " Those are called "anti-angiogenic" drugs, and they affect the blood supply to cancerous tumors. "Chemotherapy is still an important backbone that we use frequently," Dr. Puhalla said, "but we're trying to use drugs that... (Pittsburgh Post-Gazette, PA)
Treating Wrinkles with Cutting-Edge Technology--Without Going Under the Knife May 9, 2009
"We are trying to gain a deeper, molecular understanding of the skin aging process," says , a biologist and genomics research group leader at Proctor & Gamble (P&G) in Cincinnati, which makes beauty products under the Olay brand. Researchers are exploring the use of such biological tools as stem cells and to prevent and even reverse the ravages of time. (Scientific American)
Screening your genes May 9, 2009
Consumer genomics market in early stages, but has potential, analysts say ... Welcome to the world of personal genomics ... While there's plenty of potential for retail genomics, they say the budding market is still in its early stages. (CNN -- International)
Driving On Mushroom Fumes May 8, 2009
Genomics pioneer Craig Venter and the venture capitalists at Kleiner Perkins Caufield offered to license the discovery. Montana State turned them down, choosing instead to develop mycodiesel through a joint venture with Yale University, where Strobel's son Scott is chairman of the biophysics department. (Forbes -- Technology)
Genes Found To Play Role In Breast Cancer's Spread To Brain May 8, 2009
Researchers from the University of Chicago and the following institutions in The Netherlands contributed to this research: Academic Medical Center, Amsterdam; Erasmus Medical College, Rotterdam; Josephine Nefkens Institute, Rotterdam; and Cancer Genomics Centre, Rotterdam. The work was supported by grants from the National Institutes of Health, the Kleberg Foundation, the Hearst Foundation, and the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research. (Science Daily)
