Genetics of Type 1A Diabetes Jul 9, 2009
Since this article has no abstract, we have provided an extract of the first 100 words of the and any section headings. Such data refer to siblings of persons with type 1A diabetes. (New England Journal of Medicine)
Narcolepsy is an Autoimmune Disorde... Jul 6, 2009
An association between certain HLA genes and narcolepsy was the first clue that the immune system played a key role in narcolepsy. Studies show that narcolepsy patients who also have cataplexy have low cerebrospinal levels of hypercetin-1. (Suite101.com)
New Test Can Detect Both Genetic And Chromosomal Abnormalities In Embryos Jul 2, 2009
The range of applications is broad and includes single gene defects, abnormal chromosome number, structural chromosome abnormalities and HLA [human leukocyte antigen] matching in 'saviour sibling' cases, said Mr Harton. Karyomapping was developed by Professor Alan Handyside of the London Bridge Fertility Gynaecology and Genetics Centre in London (UK), and Mr Harton has been providing samples and DNA information in order to test the method and validate it for use in the clinic. (Science Daily)
Dr. Jean Dausset, Nobel laureate, 92 Jun 27, 2009
Dr. Dausset s main achievement was demonstrating that molecules on the surface of cells, now called HLA antigens, determine an individual s immune response. These antigens, which are genetically coded by a particular location on one chromosome, determine the body s response to foreign tissue, for example. (Boston Globe)
DNA Sudoku: Logic Of 'Sudoku' Math Puzzle Used To Vastly Enhance Genome-sequencing Capability Jun 26, 2009
But as sequencing technologies improve and researchers gain the ability to generate sequences for longer segments of the genome, Hannon envisions wider clinical applications for their method such as HLA typing, already an important diagnostic tool for autoimmune diseases, cancer, and for predicting the risk of organ transplantation. Journal reference. (Science Daily)
Nobel Prize-winning Immunologist Jean Dausset Dies Jun 25, 2009
Dausset's discovery in 1958 of the human leucocyte antigen (HLA) tissue system allowed doctors to verify compatibility between donor and receiver for an organ transplant. "Thanks to this discovery, organ donations and transplants developed throughout the world, saving many lives," Sarkozy said. (CBS News -- World)
Placenta: New Source For Harvesting Stem Cells Jun 24, 2009
"The greater supply of stem cells in placentas will likely increase the chance that an HLA (human leukocyte antigen) matched unit of stem cells engrafts, making stem cell transplants available to more people. The more stem cells, the bigger the chance of success," said Dr. Kuypers. Drs. (Science Daily)
Genetic Links to Rare Liver Disease Found Jun 16, 2009
In addition, they confirmed that the human leukocyte antigen (HLA) area of the genome is associated with primary biliary cirrhosis, a link that had been identified before. Dr. Scott L. Friedman, chief of the division of liver diseases at Mount Sinai School of Medicine in New York City and president of the American Association for the Study of Liver Diseases, said the discoveries are an important step in understanding this disease, but the interaction between genes and environmental triggers is... (MEDLINEplus)
Primary Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants Jun 16, 2009
Results We found significant associations between primary biliary cirrhosis and 13 loci across the HLA class II region; the HLA-DQB1 locus (encoding the major histocompatibility complex class II, DQ chain 1) had the strongest association (P=1 ... Conclusions Our data show significant associations between primary biliary cirrhosis and common genetic variants at the HLA class II, IL12A, and IL12RB2 loci and suggest that the interleukin-12 immunoregulatory signaling axis is relevant to the... (New England Journal of Medicine)
QIAGEN Transfers Distribution Rights for Transplantation Testing Product Portfolio and Related Assets to LinkMed Jun 16, 2009
Transaction Allows QIAGEN to Increase Focus On Personalized Medicine Applications of HLA Testing Products ... The Olerup SSP(r) product line includes molecular transplantation testing products used for DNA HLA typing ... As part of the transaction, QIAGEN will transfer all assets related to its Olerup SSP(r) HLA sales infrastructure to LinkMed, including office infrastructure in Austria. (Primezone Releases)
Suu Kyi lawyers challenge barring of defence witnesses Jun 5, 2009
Fri, 5 Jun 07:21:54 GMT. Rejection of witnesses "grossly unfair", lawyer says. (AlertNet)
Vaccine Shows Therapeutic Promise Against Advanced Melanoma Jun 2, 2009
"Right now, the vaccine only can be given to half of those with melanoma because it has to match a patient's tissue type, or HLA. A major priority for us is to figure out ways to broaden our approach and use mixtures of peptides so that more patients are eligible," Hwu said. "We also would like to improve upon it by including other immune-stimulatory agents, such as anti-CTLA4, an antibody that can take the breaks off the immune cells.". (Science Daily)
DNA 'creates that initial spark between two people' May 25, 2009
The women, it turned out, preferred the smell of men with genes that were different from their own in this HLA section. All the women, except for those on the contraceptive pill, seems to affect their sense of smell. (India Times, India -- Health/Science)
Burma's Suu Kyi wishes for 'better days' May 21, 2009
Burma's Suu Kyi wishes for 'better days. Search brisbanetimes. (Sydney Morning Herald -- World)
Myanmar's Suu Kyi defiant ahead of trial: lawyer May 17, 2009
By Aung Hla Tun Aung Hla Tun. 2 hrs 45 mins ago. (Yahoo News -- Top Stories)
Suu Kyi's legal plight sparks global outrage May 16, 2009
She was scheduled to be freed May 27 after six consecutive years of incarceration but now faces up to five years in prison if convicted, according to one of her lawyers, Hla Myo Myint. She is now is being held in a "guest house" within the prison compound during her trial proceedings, said another of her lawyers, Kyi Win. (MSNBC -- International)
Junta charges Suu Kyi May 15, 2009
"The authorities have charged Aung San Suu Kyi and her two maids" under the Law Safeguarding the State from the Dangers of Subversive Elements, one of her lawyers, Hla Myo Myint, told reporters outside the prison ... All those charged face jail terms of between three and five years under the security law, Hla Myo Myint said. (iAfrica.com)
Democracy Icon Trial May 15, 2009
Suu Kyi, whose detention was set to end May 27, could face a prison term of up to five years if convicted, said lawyer Hla Myo Myint ... Yettaw, who was arrested last week, was charged at Thursday's hearing with illegally entering a restricted zone, which carries a maximum penalty of five years in prison, and breaking immigration laws, which is punishable by up to one year in jail, said Hla Myo Myint. (Fox News)
Critics hit Myanmar on "trumped-up" Suu Kyi charges May 15, 2009
By Aung Hla Tun Aung Hla Tun. Fri May 15, 12:46 am ET. (Yahoo News -- Top Stories)
Suu Kyi charged with violating house arrest May 14, 2009
Suu Kyi, whose latest detention period officially ends May 27, could face a prison term of up to five years if convicted, said lawyer Hla Myo Myint ... "This is a non-bailable case but we will fight for bail," Hla Myo Myint told reporters outside the prison after Suu Kyi and Yettaw were charged. (The Star Online, Malaysia)
Junta charges Suu Kyi over US 'fool' May 14, 2009
"The authorities have charged Aung San Suu Kyi and her two maids [under the Law Safeguarding the State from the Dangers of Subversive Elements]," lawyer Hla Myo Myint said. Suu Kyi and the others face a prison term of between three and five years, the lawyer said, which would leave her behind bars next year when the junta has said it will make good on a long-standing vow to hold fresh elections. (Sydney Morning Herald -- World)
HLA remains optimistic on outlook for insurance sector May 14, 2009
KUALA LUMPUR: Total premiums collected by Hong Leong Assurance (HLA) grew 45% as at end-April ... On sales of The Perfect Series, Loh said HLA was targeting a total premium of RM50mil before the year-end. (The Star Online, Malaysia -- Business)
Narcolepsy is an autoimmune disorder, Stanford researcher says May 4, 2009
Mignot and others believe that the body's immune system plays a role in killing hypocretin-making cells, primarily because of scientific literature showing a link between narcolepsy and a variant for the human leukocyte antigen, or HLA, gene. The immune system uses HLAs to differentiate between "self" cells and foreign cells (and attacks those presented as foreign), and most autoimmune diseases are associated with variants of HLA. In recent studies, more than 90 percent of narcolepsy patients... (EurekAlert!)
Genetic study confirms the immune system's role in narcolepsy May 4, 2009
Until now, the best evidence for autoimmunity as a cause of the disorder was the discovery that nearly everyone with the disorder has unique variants of a gene called HLA-DQB1*0602. This is one of the genes that encodes HLA proteins, which dot the surface of the body's cells and help the immune system identify foreign proteins ... Some researchers theorize that the HLA variants found in people with narcolepsy-cataplexy predispose them to an autoimmune reaction that destroys their... (EurekAlert!)
Myanmar marks cyclone anniversary May 3, 2009
"My sister and brother died saving my parents, and my life without them is never the same," said Hlaing Bwa, a 34-year-old fisherman, who lives in Thaunglay village in Haing Gyi island where the cyclone first made landfall before pummeling the mainland ... "My parents have not recovered from the loss, but life has to go on and there is no use in crying," Hlaing said ... Hla Phin, a 38-year-old farmer, lives with her husband in a flimsy palm-and-thatch hut built from debris collected after the... (MSNBC -- International)
Double-lung Transplants Work Better Than Single For Long-term Survival Apr 29, 2009
28, 2009) Having both lungs replaced instead of just one is the single most important feature determining who lives longest after having a lung transplant, more than doubling an organ recipient's chances of extending their life by over a decade, a study by a team of transplant surgeons at Johns Hopkins shows. The finding is potentially controversial, researchers say, because there is already a shortage of organ donors, and more widespread use of bilateral lung transplants could nearly halve the... (Science Daily)
HIV pays a price for invisibility Apr 13, 2009
When HIV infects a cell, a complex of human immune proteins called HLA (short for human leukocyte antigen) alert killer T cells by displaying bits of the virus on the surface of the cell ... Individuals who have certain types of HLA proteins control infection better than others ... In people with HLA-B*5703, for example, the virus multiplies less than in people with some other HLA variantslikely because killer T cells in these individuals are quick to attack infected cells. (EurekAlert!)
Genetic risk factors play role in autoantibody-negative rheumatoid arthritis Apr 8, 2009
A new study led by Diane van der Woude of Leiden University Medical Center in The Netherlands examined 148 twin pairs in which one twin had RA. Participants were tested for antibodies known as anti-citrullinated protein antibodies (ACPAs), which are used because of their specificity and predictive value and for HLA SE (human leukocyte antigen shared epitope) alleles, the most important genetic risk factor for RA. The study was published in the April issue of Arthritis atism () ... The HLA SE... (EurekAlert!)
Workhorse Immune Molecules Lead Secret Lives In The Brain Apr 8, 2009
Carla Shatz, PhD, professor of neurobiology and of biology, and her colleagues at the Stanford University School of Medicine have shown that members of a large family of proteins critical to immune function (collectively known as HLA molecules in humans and MHC molecules in mice) also play a role in the brain. "We think that this family of molecules has an important role in learning and memory," Shatz said. (Science Daily)
Women have a keener nose for body odours Apr 7, 2009
She highlighted HLA genes involved in the immune response. She said in evolutionary terms it was desirable for a women to mate with a man whose genes were different to hers, as this was likely to produce more robust offspring. (BBC News -- Health)
From bamboo hut to Logan apartment Mar 8, 2009
Her mother, Ma Htwe Hla, stood nearby rubbing Bi s arm protectively ... Just before Mortensen showed up at the home of the nine members of the Ma Htwe Hla and Ba Hlaing family, to take three to get shots, Melissa Spencer, community coordinator with the Cache Valley Refugee Organization, was already there letting Hla know she had found a washer the family could purchase for 50, if they wanted ... With a daughter translating, the mother, Hla, said, OK and so Spencer said she d purchase the washer... (Logan Herald Journal, UT)
HIV Evolving To Evade Immune Response Feb 28, 2009
Genes encoding a key set of molecules in the human immune system called the human leucocyte antigens (HLA) are critically important. HLA determine the progress of many infectious diseases including HIV, and enable the recognition and killing of HIV-infected cells ... Humans differ from each other in the exact HLA genes they have, and small differences can make the difference in how long it takes to progress to AIDS.. (Science Daily)
HIV Quickly Evolving Among Large Groups Feb 27, 2009
HIV must evade several genes to do this, including an immunity gene called HLA.. The team, which included researchers from Australia and Japan, analyzed the genetic sequences of HIV and versions of HLA genes known to control the virus in 2,800 people ... In the study, the researchers found that mutations that allow HIV to evade immune responses directed by HLA were more common in people with the protective variant of the gene. (MEDLINEplus)
Rapid HIV evolution avoids attack Feb 26, 2009
The rate of progress is tied to genes which control production of key immune system molecules called human leucocyte antigens (HLAs). Humans differ in the exact HLA genes they have, and even small differences can have a big impact on how quickly Aids develops ... The researchers examined HIV genetic sequences and HLA genes in over 2,800 people in countries, including the UK, Australia, South Africa, Canada and Japan. (BBC News)
HIV mutates at high speed to avoid immune system: study Feb 26, 2009
Their big focus was on so-called human leukocyte antigen (HLA) genes ... The span depends largely on inherited luck, for there are variants of HLA genes that are far better at combatting HIV than others ... "Where a favourable HLA gene is present at high levels in a given population, we see high levels of the mutation that enable HIV to resist this particular gene effect," said co-author Rodney Phillips in a press release issued by Oxford University. (Yahoo News -- Top Stories)
Even Mismatched Cord Blood Can Help Kids Feb 15, 2009
"In order to match a donor to a recipient, doctors compare HLA typing, a test usually performed on a blood sample," Prasad explained. "In every individual, HLA typing includes the specific genetic make-up at three locations -- within those locations, you are looking at one set from the mother and one from the father, so it ends up to be a six-point comparison.". (U.S. News & World Report)
Not an HIV Cure, but Encouraging New Directions Feb 12, 2009
g., the HLA subtype) or innate (natural) immunity resulting from the genetic makeup of the host. 2. (New England Journal of Medicine)
