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    News and Articles on HLA

    Archives: HLA

    Study Helps Stop Drugs Slipping Through Safety Net  Sep 20, 2008
    There was particular interest in the role of the HLA (Human Leukocyte Antigen) system, which directs the production and operation of immunity proteins, and is the source of the individual variation in immune response that leads both to population-wide protection against disease, and rejection of incompatible blood, tissue, or donated organs. This variation in HLA genes can also cause adverse reactions to certain drugs in some individuals but not others, leading in some cases to liver damage for... (Science Daily)

    Mate selection more biologically determined in some human populations  Sep 12, 2008
    The testing employed genome-wide genotype data and HLA types in a sample of African and a sample of European American couples, enabling the researchers to distinguish MHC-specific effects from genome-wide effects. The group examined whether husband-wife couples were more MHC-similar or MHC-dissimilar in comparison to random pairs of individuals. (EurekAlert!)

    Local drive to save Donovan Sands  Sep 10, 2008
    The donor s HLA is identified by testing a sample from the inside of a cheek with a swab to come up with HLA type. Testing is done for potential donors between 18- and 60 years old. (Newton Tab, MA)

    BioMS Medical's lead drug, dirucotide (MBP8298) for the treatment of multiple sclerosis, receives fast track designation from FDA  Sep 4, 2008
    The primary clinical endpoint for the trial is defined as a statistically and clinically significant increase in the time to progression of the disease as measured by the Expanded Disability Status Scale (EDSS), in patients with HLA-DR2 and/or HLA-DR4 immune response genes (up to 75% of all MS patients are HLA-DR2 and/or HLA-DR4 positive) ... The sequence of dirucotide is associated with the autoimmune process in MS patients with certain immune response genes (HLA types DR2 and/or DR4); MS... (Canada Newswire)

    Kidney racket busted; five arrested  Sep 3, 2008
    Under the second category, applications would be accepted at hospital level but the donors were sent for the test of Human Leucocyte Antigen (HLA) to determine compatibility and linkage with the patient. If the HLA test report was negative, the accused used to scan the report copy, edit it suitably in the computer, take a fresh print-out and present it in the hospital. (Hindu)

    Inter-state kidney racket busted, 5 held  Sep 2, 2008
    In case the donor claims to be a blood relative of the recipient, the doctors concerned sends them for human leukocyte antigens (HLA) typing test to determine compatibility and linkage with patient ... "Srinivas used to digitally manipulate the HLA typing test report using a scanner, and submit the fake certificate to hospital authorities," task force inspector Ram Narasimha Reddy said. (Times of India)

    One Cause Of Higher Rates Of Transplanted Kidney Rejection In Blacks  Aug 31, 2008
    These cells, known as human leukocyte antigen-specific, or HLA-specific B cells, when "sensitized" produce antibodies linked to transplanted kidney rejection, says Andrea Zachary, professor of medicine at Johns Hopkins and lead researcher of the study. It's been long known that HLA-reactive antibodies produced by B cells are one of the ways that transplanted organs are rejected ... Zachary developed a novel method for counting HLA-specific B cells more accurately, leading to the hypothesis that... (Science Daily)

    Why Some Infected With HIV Remain Symptom Free Without Antiretroviral Drugs  Aug 14, 2008
    Genetic testing also confirmed that both husband and wife had an overactive strand of genetic material tied to gene HLA B57, found in previous studies to be more common in those whose HIV infection was suppressed or slowed. "The presence of this genetic spot is a discordant result that strongly contradicts theories that various genetic factors alone play a protective role in suppression," says Blankson. (Science Daily)

    Elite woman may hold key to AIDS vaccine  Aug 13, 2008
    Another clue: the woman may have unusual activity in her human leukocyte antigen system, or HLA, Blankson said. This important component of the immune system helps recognize antigens protein identifiers of enemies such as bacteria and viruses. (MSNBC -- Health)

    * Myanmar starker than portrayed  Aug 11, 2008
    By Hla Hla Htay AP, YANGON, MYANMAR Monday, Aug 11, 2008, Page 9. A rare bird's-eye look at Myanmar's Irrawaddy Delta shows the devastation still left from Cyclone Nargis X broken levies, flooded farm roads, the shattered remains of bamboo huts and trees strewn like matchsticks along the coast. (Taipei Times, Taiwan -- World)

    BioMS Medical completes patient recruitment in phase III U.S. multiple sclerosis trial  Aug 1, 2008
    The primary clinical endpoint for the trial is defined as a statistically and clinically significant increase in the time to progression of the disease as measured by the Expanded Disability Status Scale (EDSS), in patients with HLA-DR2 and/or HLA-DR4 immune response genes (up to 75% of all MS patients are HLA-DR2 and/or HLA-DR4 positive) ... The sequence of MBP8298 is associated with the autoimmune process in MS patients with certain immune response genes (HLA types DR2 and/or DR4); MS patients... (Canada Newswire)

    Bone marrow drive to help local man  Jul 23, 2008
    All that is necessary is for the donor to have the interior of their mouth swabbed to collect enough cells to be HLA tissue typed. For more information, please call 818-409-8198. (Los Angeles Daily News)

    New Protocol Streamlines Therapy That Makes More Kidney Transplants Possible  Jul 22, 2008
    The therapy may provide an option for many patients "sensitized" to transplant antigens (human leukocyte antigens, or HLA) who previously would not have been candidates for transplantation because of their intense immune response to these HLA targets. HLA exposure can come through blood transfusions, previous transplantation or pregnancy ... Antibodies to HLA were previously considered an absolute contraindication to transplantation -- the risk was too high for transplantation to be an option. (Science Daily)

    Viral recombination another way HIV fools the immune system  Jul 22, 2008
    Previous PARC/MGH research showed that the effectiveness of the CTL response varies depending on which version or allele of an immune system molecule called HLA Class I an individual has inherited. The current study was undertaken to investigate why an HIV-positive research participant known to have a powerfully protective Class I allele called HLA-B27 began to experience rapid increases in viral levels much sooner than would have been expected ... The effective CTL response was primarily... (EurekAlert!)

    Combo Therapy Makes More Kidney Transplants Possible  Jul 18, 2008
    This means they have previously been exposed to human leukocyte antigens (HLA). According to the National Marrow Donor Program, HLA refers to protein markers on most of the cells in the human body ... Patients who are sensitized to human leukocyte antigens (HLA) often aren't able to get organ transplants because their immune systems respond so voraciously to the HLA targets, effectively rejecting the new organ. (MEDLINEplus)

    Rituximab and Immune Globulin in Renal Transplantation  Jul 17, 2008
    Background Few options for transplantation currently exist for patients highly sensitized to HLA. This exploratory, open-label, phase 1 2, single-center study examined whether intravenous immune globulin plus rituximab could reduce anti-HLA antibody levels and improve transplantation rates ... From the Comprehensive Transplant Center, Transplant Immunology Laboratory, and HLA Laboratory, Cedars Sinai Medical Center, Los Angeles. (New England Journal of Medicine)

    Human Embryonic Stem Cells Developed From Four-cell Embryo; World First May Lessen Ethical Concerns  Jul 13, 2008
    "Currently, PGD is performed at the 8-cell stage, when one or two cells are removed; others have derived stable hESC lines at this stage but with low efficiency. If hESC derivation at the 4-cell stage turns out to be more efficient then at the 8-cell stage, we might consider to change our PGD policy in cases where we perform human leukocyte antigen (HLA) typing," said Dr. Van de Velde. HLA molecules play an important role in the immune system by ensuring that our bodies recognise their own cells... (Science Daily)

    Immune molecule that plays a powerful role in avoiding organ rejection identified  Jun 17, 2008
    "This is a molecule with huge potential to regulate immune response," Dr. Anatolij Horuzsko, reproductive immunologist at the Medical College of Georgia Center for Molecular Chaperone/Radiobiology and Cancer Virology, says of HLA-G dimer. Dimer appears to be the most powerful among several known forms of HLA-G at inhibiting the immune response, researchers have found ... Now that the scientists know which HLA-G is best at down-regulating the immune response and how it works, they believe the... (EurekAlert!)

    U.S. orders Navy vessels to leave Myanmar coast  Jun 5, 2008
    This will empower the survivors, said Hla Myint Hpu, who conducted the needs assessment for the project. People want to keep their dignity. (Globe and Mail -- International)

    Despite promises, Myanmar limits access for aid agencies  Jun 3, 2008
    (Aung Hla Tun/Reuters). Despite promises, Myanmar limits access for aid agencies. (International Herald Tribune)

    Myanmar reopens schools 1 month after cyclone  Jun 2, 2008
    In Hlaingthayar Township, fisherman Ko Niang has managed to patch together a rickety lean-to from scavenged bamboo bits and soggy palm fronds ... One resident, 45-year-old Hla Kyi, is luckier than most ... Hla Kyi's tiny dank hut houses his wife, four children and three other relatives. (Fresno Bee -- Local)

    Has Decreased Infection Load Of Infants Led To Increased Allergic And Autoimmune Diseases?  May 30, 2008
    The HLA gene variants that predispose people to autoimmune diseases are however approximately equally common in both populations. The studies have also revealed that Russian Karelian school children have helicobacter antibodies as signs of earlier infections 15 times more often, Toxoplasma antibodies five times more often, and hepatitis A antibodies 12 times more often than Finnish children. (Science Daily)

    Burma junta buries victims of cyclone  May 29, 2008
    Local Search Site Search. THIS STORY HAS BEEN FORMATTED FOR EASY PRINTING. (Boston Globe)

    AID AND ANGER  May 29, 2008
    Reuters AlertNet - West dismayed over Suu Kyi detention. Thu, 07:04 29 May 2008 GMT. (AlertNet)

    Aid workers head to Myanmar delta as more visas granted  May 29, 2008
    by Hla Hla Htay 19 minutes ago. YANGON (AFP) - Relief workers slowly moved into Myanmar's cyclone-ravaged delta on Thursday after the junta started to ease restrictions on access, as the United Nations said all its visa requests had been granted. (Yahoo News -- Politics)

    Systemic Lupus Erythematosus  May 29, 2008
    Volume 358:2412-2413. Since this article has no abstract, we have provided an extract of the first 100 words of the and any section headings. (New England Journal of Medicine)

    New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh  May 29, 2008
    His laboratory team at Childrens John G. Rangos Sr. Research Center has pioneered numerous important studies and also maintains a federally funded national bone marrow HLA typing center. For more information about type 1 diabetes or Dr. Truccos research, please visit. (EurekAlert!)

    West dismayed over Suu Kyi detention  May 28, 2008
    By Aung Hla Tun 1 hour, 22 minutes ago. YANGON (Reuters) - Myanmar's military has started to bury cyclone victims in communal graves, villagers said on Wednesday, as Western nations pledged to keep aid flowing despite anger at its detention of opposition leader Aung San Suu Kyi. (Yahoo News -- Top Stories)

    Aung San Suu Kyi detention 'will not affect cyclone aid'  May 28, 2008
    by Hla Hla Htay Wed May 28, 5:42 AM ET ... Florian Meyer, an aid expert with the German relief group Arbeiter-Samariter-Bund Deutschland, said he has tried and failed to win access for the past two weeks. (Yahoo News -- Politics)

    Aid workers ready for action after Myanmar vow  May 26, 2008
    Mon, 07:25 26 May 2008 GMT. (Adds dropped word "million" in paragraph 4). (AlertNet)

    Aid groups ready to test Myanmar on access  May 26, 2008
    by Hla Hla Htay 1 hour, 39 minutes ago. YANGON (AFP) - International aid groups said Monday they were planning to test Myanmar's commitment to open up to foreign aid workers, after the junta pledged to speed up relief for desperate cyclone survivors. (Yahoo News -- Top Stories)

    "No time to lose" after Myanmar deal for storm aid  May 24, 2008
    Reuters AlertNet - "No time to lose" after Myanmar deal for storm aid. Sat, 07:21 24 May 2008 GMT. (AlertNet)

    U.N. chief sees devastation on Myanmar aid mission  May 23, 2008
    (Additional reporting by Aung Hla Tun in Yangon, Nopporn Wong-Anan and Ed Cropley in Bangkok, Sue Pleming in California; writing by Grant McCool; editing by Bill Tarrant and Mohammad Zargham) (For more stories on Myanmar cyclone click on [nSP152717] or follow the link to Reuters AlertNet http://www. alertnet. (AlertNet)

    U.N.'s Ban heads for Asia on Myanmar aid mission  May 21, 2008
    Wed, 07:18 21 May 2008 GMT. U.N. chief Ban Ki-moon flies to region. (AlertNet)

    ASEAN to coordinate Myanmar aid effort  May 20, 2008
    Tue, 06:46 20 May 2008 GMT. ASEAN to coordinate international relief effort. (AlertNet)

    PHOTOS: Reconstruction begins  May 18, 2008
    REUTERS/Aung Hla Tun (MYANMAR) REF: RTX5QK1 ... REUTERS/Aung Hla Tun (MYANMAR) REF: RTX5QGO. (AlertNet)

    Myanmar death toll soars, diplomats tour delta  May 17, 2008
    Sat, 07:13 17 May 2008 GMT. Toll of dead and missing soars to above 133,000. (AlertNet)

    More rain deepens Myanmar misery  May 17, 2008
    May 16, 2008 at 12:01 PM EDT. Torrential tropical downpours lashed Myanmar's cyclone-hit Irrawaddy delta on Friday as thousands of destitute victims took to roadsides to beg for help to supplement the meagre trickle of aid flowing in. (Globe and Mail -- International)

    Junta uses survivors in labour camps  May 17, 2008
    Ko Hla Min, a 35-year-old farmer who lost nine relatives in the storm, said those rounded up by soldiers around the devastated town of Bogalay were being used as work gangs. "They have to break stones at the construction sites," he said. (Sydney Morning Herald -- World)

    Myanmar's cyclone survivors beg for help  May 14, 2008
    Wed, 07:01 14 May 2008 GMT. (Repeats adding retrieval codes). (AlertNet)

    Myanmar aid trickles in, new cyclone fear discounted  May 14, 2008
    By Aung Hla Tun 35 minutes ago. YANGON (Reuters) - The 1. (Yahoo News -- Top Stories)

    Alumni Myanmar Institutes of Medicine Association (AMIMA) Races Time to Help Cyclone Victims  May 12, 2008
    AMIMA has funded the traveling medical team led by Dr. U Hla Myint, a revered Professor of Medicine and the Chairman of the Myanmar Medical Council (MMC), a local well-respected non-governmental organization ... Dr. Kyi Minn, a regional advisor for World Vision, a global humanitarian organization dedicated to working with children, families, and their communities assists Professor U Hla Myint's team. (PR Newswire)

    U.S. flys cyclone aid to "outpost of tyranny"  May 12, 2008
    Reuters AlertNet - U.S. flys cyclone aid to "outpost of tyranny". Mon, 07:12 12 May 2008 GMT. (AlertNet)

    First U.S. Relief Flight Lands In Myanmar  May 12, 2008
    HLA HLA HTAY/AFP/Getty ImagesPeople cross a destroyed bridge in Yangon, Myanmar, on May 9. CYCLONE. (TheSanDiegoChannel.com, CA)

    "Unimaginable tragedy" if Myanmar delays aid  May 12, 2008
    "I voted yes. It was what I was asked to do," 57-year-old U Hlaing told Reuters in the town of Hlegu, northwest of Yangon ... Story by Aung Hla Tun. (Planet Ark, United States)

    "Unimaginable tragedy" if Myanmar delays aid  May 11, 2008
    It was what I was asked to do," 57-year-old U Hlaing told Reuters in the town of Hlegu, northwest of Yangon. PROTESTS AGAINST REFERENDUM Even before Cyclone Nargis hit on the night of May 2, groups opposed to military rule, and foreign governments led by the United States, had denounced the vote as an attempt by the military to legitimise its 46-year grip on power. Washington regards Myanmar as an "outpost of tyranny" but sidestepped direct criticism of the constitutional vote, saying only that... (AlertNet)

    Myanmar holds referendum despite cyclone chaos  May 10, 2008
    By Aung Hla Tun Sat May 10, 4:34 AM ET. YANGON (Reuters) - Myanmar held a rare election on Saturday to approve a new army-drafted constitution, ignoring calls from the outside world to postpone the vote amid the devastation wreaked by Cyclone Nargis. (Yahoo News -- Top Stories)

    Myanmar aid crisis deepens  May 10, 2008
    Article By: Hla Hla Htay Fri, 09 May 2008 17:24 The UN food agency on Friday suspended all aid flights into Myanmar over "unacceptable" restrictions by the junta, which has refused to allow foreign relief workers to help desperate cyclone survivors. The World Food Programme's decision cast new doubt on the regime's claim to be doing all it can to save the 1. (iAfrica.com)

    Myanmar Cyclone Relief Fund  May 9, 2008
    Alumni Myanmar Institutes of Medicine (AMIMA) intends to donate to Yangon General Hospital and to the Emergency Medical Relief Team headed by Professor U Hla Myint, President, Myanmar Medical Council ... Dr. Kyi Minn, adviser, World Vision will assist Professor U Hla Myint's team. (PR Newswire)

    Myanmar says no need for foreign aid distribution  May 9, 2008
    Fri, 9 May 07:08:30 GMT. Myanmar turns back Qatari rescue team. (AlertNet)

    Myanmar says 'not ready' for foreign aid workers  May 9, 2008
    by Hla Hla Htay 2 hours, 35 minutes ago. YANGON (AFP) - Myanmar said Friday it was not ready to let in foreign aid workers, rejecting international pressure to allow experts into the isolated nation where disease and starvation are stalking cyclone survivors. (Yahoo News -- Top Stories)

    Myanmar junta allows US military relief flights  May 8, 2008
    Thu, 8 May 07:09:45 GMT. (Repeats with updated headline). (AlertNet)

    Food dropped to Myanmar towns; 22,500 killed in storm  May 7, 2008
    Wed, 7 May 07:16:47 GMT. Nearly 22,500 killed, 41,000 missing. (AlertNet)

    Death toll could reach 10,000 in Myanmar cyclone  May 6, 2008
    "Without my daily earning, just survival has become a big problem for us," said Tin Hla, who normally repairs umbrellas at a roadside stand. With his home destroyed by the storm, Tin Hla said he has had to place his family of five into one of the monasteries that have offered temporary shelter to those left homeless. (FOX 11, AZ)

    Myanmar believes 13,000 dead, missing from cyclone  May 6, 2008
    Tue, 6 May 06:57:33 GMT. (Adds State Dept spokesman). (AlertNet)

    Cyclone slams into main Myanmar city and shuts airport  May 3, 2008
    (Reporting by Aung Hla Tun; Writing by Ed Cropley; Editing by Bill Tarrant). . (International Herald Tribune)

    Some People May Transmit Weaker AIDS Virus  Mar 25, 2008
    HIV must evade several genes to do this, including an immunity gene called HLA.. "Some people have versions of the HLA gene that are known to force HIV to tolerate mutations that damage its ability to reproduce," Carolyn Williamson and Salim Abdool Karim at the Centre for the AIDS Program of Research in South Africa wrote in the Public Library of Science journal PLoS Pathogens ... Now it seems this weakened virus may get passed on and act the same way in others -- even if they do not have the... (MEDLINEplus)

    Protester burns himself at Myanmar pagoda-witnesses  Mar 23, 2008
    (Reporting by Aung Hla Tun; Editing by Nopporn Wong-Anan). . (International Herald Tribune)

    Infection With A Mutated HIV Strain Results In Better Survival  Mar 22, 2008
    HLA genes affect the rate of disease progression in HIV-infected individuals, alerting the immune system to HIV's presence. HIV can evade the immune system by mutating into forms unrecognizable by the HLA. However, it is known that some people have versions of the HLA gene (for example HLA-B*57 and HLA-B*5801) that can only be evaded by the virus if it mutates to a form that has a reduced replication rate ... In this study the researchers identified two mutations, A146X and T242N, in the Gag... (Science Daily)

    Improving The Quality Of Laboratory Data With Computer Modeling  Mar 3, 2008
    However, for sensitization and killing to occur, the pathogen must be "paired up" with one of the infected person's specialized immune proteins--an HLA (human leukocyte antigen). The way in which pathogen peptides interact with these HLA proteins defines if and how an immune response will be generated ... Therefore, knowing which HLA proteins a person has is vital in transplant medicine, finding immunogenetic risk factors for disease, and understanding the way viruses like HIV mutate inside... (Science Daily)

    Potential New Drug Targets Against Hormone-dependent Breast Cancer Identified  Mar 1, 2008
    Co-researchers include Dr. Clifford Hudis of Memorial Sloan-Kettering Cancer Center, New York City; as well as Dr. Sung-Hee Chang and Dr. Timothy Hla of the University of Connecticut Health Center, Farmington. This work was supported by the Breast Cancer Research Foundation, the U.S. National Institutes of Health, the Botwinick-Wolfensohn Foundation, and the Center for Cancer Prevention Research. (Science Daily)

    Functional Immune System Can Be Derived From Embryonic Stem Cells, Preliminary Study Finds  Feb 14, 2008
    The antigens on the surface of donated cells must be compatible (determined by a method called HLA matching) with those of the patient to prevent rejection. The use of embryonic stem cells, which have low levels of these antigens and may therefore be less likely to provoke a defensive reaction by the patient's body, may allow patients who can't find suitable HLA-matched donors to receive transplants. (Science Daily)

    Houston Group Calls for DA's Resignation in Wake of Controversial E-Mails  Jan 26, 2008
    Linda Dunson, president of the Houston Lawyers Association (HLA) -- a minority bar organization representing African-American attorneys in Harris and contiguous counties -- notes that the overwhelming majority of Harris County prosecutors are fair and unbiased ... And on Jan. 22, the HLA issued a press release calling for Rosenthal's resignation, noting his "misuse of the [c]ounty assets to further his own political agenda and his distribution of racist and pornographic e-mails." ... In its... (Law.com)

    Experimental Procedure Induces Tolerance To Mismatched Kidney Transplants  Jan 25, 2008
    24, 2008) Four of five patients participating in a trial of an experimental protocol designed to induce immune tolerance to HLA-mismatched kidney transplants have been able to discontinue immunosuppressive drugs. A mismatch of HLA (human leukocyte antigen) proteins is the most difficult immunological barrier to transplantation ... "We are very encouraged by our initial success in inducing tolerance across the HLA barrier, something that has been a major goal of transplant immunology for years,"... (Science Daily)

    Stem Cells May Gradually Replace Antirejection Drugs For Kidney Transplant Patients  Jan 25, 2008
    5 million grant from the National Institutes of Health to enroll 20 patients in the study, which is called "Donor Stem Cells, Campath, T/B Cell Regulation In HLA-Identical Renal Transplants." ... This study is open to HLA-identical sibling kidney donor and recipient pairs ... HLA, or human leukocyte antigen, is one of a group of proteins found on the surface of white blood cells and other cells that play an important part in the body's immune response to foreign substances. (Science Daily)

    New Therapies Could Change Organ Transplants  Jan 24, 2008
    In the Sachs study, four of five patients who had HLA-mismatched kidney transplants were able to stop taking immunosuppressive drugs nine to 14 months after the transplant ... HLA refers to human leukocyte antigens, which is one of the primary ways donors and recipients are matched ... HLAs, found on the surface of virtually all cells, help tell the difference between normal body tissue and foreign substances. (Health-Finder)

    HLA-Matched Renal Transplantation without Maintenance Immunosuppression  Jan 24, 2008
    NEJM -- HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression ... HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression ... Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. (New England Journal of Medicine)

    Aung Suu Kyi taken to state guesthouse  Jan 11, 2008
    (Reporting by Aung Hla Tun; Editing by Darren Schuettler and Alex Richardson). . (International Herald Tribune)

    Kidney Rejection and Anti-MICA Antibodies  Jan 10, 2008
    27 issue)1 on kidney-transplant rejection and major-histocompatibility-complex (MHC) class I related chain A (MICA) antibodies, caution is needed in asserting that presensitization against MICA antigens might contribute to allograft loss among recipients who are well matched for HLA. Not stated are possible variations in the methodologies, testing criteria, and cutoff values used for anti-HLA antibody testing and panel-reactive antibody determination among the 20 centers in 13 countries that... (New England Journal of Medicine)

    Stem cell bank by March-end  Jan 7, 2008
    While units stored in a private bank could be used restrictively, cord blood in the public bank would be available for those in need of stem cell transplantation after HLA typing was done. When a match was detected, the required unit of frozen stem cells would be transported to the hospital where the transplantation was scheduled. (Hindu)

    Jindal names Leggett as head of environmental quality  Jan 5, 2008
    He was a senior manager of HLA, an environmental consulting company in Zachary, and worked for Georgia-Pacific Corp. for nine years. Leggett was also an environmental program specialist at DEQ and a biologist for the state Department of Wildlife and Fisheries. (KSLA.com, LA)

    Human Embryonic Stem Cell Lines Created That Avoid Immune Rejection  Dec 22, 2007
    The stem cell lines are HLA-homozygous, meaning that they have a simple genetic profile in the critical areas of the DNA that code for immune rejection ... First, the four human parthenogenetic stem cell lines, designated as HpSC-Hhom, are HLA (human leukocyte antigen) homozygous ... This makes it possible to match the HLA types of a donor and recipient, reducing the chances of provoking an immune reaction against the transplanted donor cells. (Science Daily)

    Mike Heneghan of Sandy Hook Bone Marrow Drive Monday Slated for Local Man With MDS  Dec 12, 2007
    Doctors look for a donor who matches the patient's human leukocyte antigen tissue type, or HLA protein marker. The closer the match between the patient's HLA markers and the donor's, the better for the patient. (Voices, CT)

    Genomewide Study of Multiple Sclerosis  Nov 22, 2007
    3 In addition, the large effect of the HLA class II region. . (New England Journal of Medicine)

    * Most Hoklo, Hakka have Aboriginal genes, study finds  Nov 21, 2007
    An additional 18 percent were found to have Aboriginal ancestry through HLA chromosome typing, bringing the total to 85 percent. An analysis of the DNA of "pure" Aborigines as a group compared with the DNA of non-Aboriginal ethnic Taiwanese as a group showed that the Aborigines had a highly homogeneous genetic range because of thousands of years of isolation from other ethnic groups, Lin said. (Taipei Times, Taiwan)

    FDA Grants Kiadis Pharma Lead Product ATIR Orphan Drug Designation  Nov 7, 2007
    Allogeneic bone marrow transplantations today require that the patient and donor immune systems (HLA type) are highly similar in order to reduce the risk of GvHD and therefore rely on matching donors. By preventing the occurrence of GvHD, ATIR enables the use of a mismatched donor and consequently addresses a significant limitation in bone marrow transplantation, the timely availability of a donor. (PR Newswire)

    Family trio gets into the saddle to battle MS  Nov 3, 2007
    The first gene responsible for causing MS, called HLA, was discovered in the 1970s. A second, called IL-7R, was only found in 2003 by researchers at the Westmead Millennium Institute at Westmead Hospital. (Sydney Morning Herald -- Australia)

    Genomics Yields Ankylosing Spondylitis Genes Variants  Oct 23, 2007
    "We've long known that the HLA-B27 gene accounts for 40% of the overall cause of ankylosing spondylitis," said co-author John D. Reveille, M.D., of the University of Texas Medical School at Houston. "Now we have found two new genes. Together with HLA-B27, these genes account for roughly 70% of the overall cause. That means we've almost nailed this disease." ... "For each of the autoimmune diseases, the maximum signal was centered around the known HLA-associated genes (for example, those encoding... (MedPage Today)

    Gene factor key in AIDS progression  Oct 22, 2007
    Similar research in the field of genetic variation and HIV has looked at differences among three genes that control signalling molecules called human leucocyte antigens (HLA), which tag an intruder for destruction by the immune system. A total of 39. (India Times, India -- Health/Science)

    Myanmar restores Internet, but arrests continue  Oct 14, 2007
    Select an Edition: Sun Oct 14 07:03:03 2007. YANGON, Oct 14 (Reuters) - Myanmar's ruling generals have restored public Internet access, more than two weeks after cutting Web connections to stem the flow of images of mass protests and a ruthless crackdown that outraged the world. (AlertNet)

    Myanmar junta rallies forces, arrests top dissident  Oct 14, 2007
    Select an Edition: Sun Oct 14 07:05:11 2007. (Refiles to remove extraneous material at foot of story). (AlertNet)

    Myanmar crackdown continues  Oct 11, 2007
    Khin Ohmar, APPPB's co-ordinator, said Hla Myo Naung, 39, was arrested together with Tharaphee who was accompanying him to a clinic to seek treatment for an eye infection. "Not only family members and relatives, but also neighbours have been threatened to turn in those who are on the run," she said. (Aljazeera.Net)

    Concern mounts for Myanmar prisoners as UN mulls action  Oct 11, 2007
    The rights watchdog said Hla Myo Naung, one of the people who led a student uprising in 1988 and took part in recent anti-government protests, was arrested Wednesday at a Yangon clinic while seeking treatment for a ruptured cornea. "Unless operated on soon, Hla Myo Naung may go blind in this eye," Amnesty said in a statement. (Yahoo! Asia News)

    Kiadis Pharma Announces ATIR Interim Clinical Results  Oct 10, 2007
    Therefore it is currently essential that the patient and donor blood systems (the human leukocyte antigens, HLA) are highly similar in order to reduce the chance of acute GvHD. As a consequence, bone marrow transplantations strongly rely on the availability of a matching donor. However, the timely availability of a matching donor is a limiting factor for many patients to receive a bone marrow transplantation. (PR Newswire)

    Widow launches bone marrow drive  Oct 2, 2007
    Although some health insurances cover the cost of Human Leukocyte Antigen (HLA) typing, donors may be asked to contribute $52 to help cover the cost to join the registry. Diane said she will hold a raffle and auction at the event to help cover the typing fees. (Easton Journal, MA)

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