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    News and Articles on Idiopathic

    Archives: Idiopathic

    How The Brain Compensates For Vision Loss Shows Much More Versatility Than Previously Recognized  Aug 28, 2008
    10, 2008) Black people are more likely to lose vision as a result of idiopathic intracranial hypertension, or increased pressure in the brain, according to a new study. The cause of idiopathic intracranial. (Science Daily)

    Chief justice tumbles after seizure  Aug 28, 2008
    Doctors called the incident a "benign idiopathic seizure," similar to one suffered by the chief justice in 1993, the court statement said. An idiopathic seizure is one with no identifiable physiological cause. (Yahoo News -- Supreme Court)

    HEALTH BLOG: Digging into the latest cancer studies  Aug 28, 2008
    Known as (TNF) blockers, they're used to treat juvenile idiopathic arthritis (formerly called juvenile rheumatoid arthritis) and , a type of inflammatory bowel disease. Blocking the protein TNF reduces inflammation but also raises the risk of infection. (USA Today -- Money)

    A conversation with Kobe Marinko and his mother, Lee Marinko  Aug 22, 2008
    According to the Arthritis Foundation's Website, Idiopathic Polyarticular JRA affects five or more joints of a child, and more girls than boys. Kobe and his family found out that he had JRA in the spring of 2007. (Danvers Herald, MA)

    Obituaries for Thursday, Aug. 21, 2008  Aug 21, 2008
    Richard E. Wieman of La Crosse went to join his Mom, Dad, brother and sister in heaven after a long battle with idiopathic pulmonary fibrosis on Tuesday, Aug. 19, 2008, at the age of 68. He was proud to serve his country from 1958 to 1963 as a Navy crash crew firefighter. (La Crosse Tribune, WI)

    Idiopathic Sudden Sensorineural Hearing Loss  Aug 21, 2008
    Steven D. Rauch, M.D.. Since this article has no abstract, we have provided an extract of the first 100 words of the and any section headings. (New England Journal of Medicine)

    Laryngeal Paraysis in Dogs and Cats  Aug 14, 2008
    Most of the time laryngeal paralysis is idiopathic, meaning there is no known cause. Laryngeal paralysis may be congenital in Bouvier de Flandres, Siberian Huskies, Dalmatians, Rottweilers, and Bull Terriers. (Suite101.com)

    Causes of Chronic Fatigue  Aug 14, 2008
    Chronic Idiopathic Fatigue. Chronic idiopathic fatigue refers to persistent fatigue whose cause could not be found despite thorough examination. (Suite101.com)

    Danvers youth to lead 12th annual Boston Arthritis Walk  Aug 8, 2008
    Marinko was diagnosed with idiopathic polyarticular juvenile rheumatoid arthritis just over a year ago. Marinko is joining Honorary Chair Bob Lobel to raise funds and awareness of arthritis, which impacts 46 million Americans. (Danvers Herald, MA)

    HEALTH BLOG: Read the latest child wellness tips  Aug 5, 2008
    Parenting and kids' health - Better Life - USATODAY.com. Unhappy about Happy Meals and the like. (USA Today -- Money)

    Note to people with scarred and stiffened lungs: Monitor your sleep before severe fatigue sets in  Jul 30, 2008
    D., who treated Spaeth, found more than twice the amount of nighttime sleep disturbances and double the number of daytime episodes of drowsiness among 41 men and women with so-called idiopathic pulmonary fibrosis than in people with healthy lungs. "Physicians should strongly consider monitoring people with this scarring lung disease for sleep disorders as part of their standard care, because poor sleep has a profound effect on their quality of life," says Danoff, an assistant professor at the... (EurekAlert!)

    Health Canada approves ORENCIA(R) (abatacept) for the treatment of moderate-to-severe juvenile idiopathic arthritis (JIA) in patients six years and older  Jul 29, 2008
    ORENCIA is a First-in-Class Biologic Treatment Option Now Available for Use in Pediatric Patients with JIA MONTREAL, July 29 /CNW Telbec/ - Bristol-Myers Squibb Canada today announced that Health Canada has approved ORENCIA(R) (abatacept) for reducing signs and symptoms of moderately to severely active juvenile idiopathic arthritis (JIA)/juvenile rheumatoid arthritis in pediatric patients 6 years of age and older who have had an inadequate response to one or more DMARDs, such as MTX ... The... (Canada Newswire)

    Custom-Made Insoles May Ease Certain Foot Pain  Jul 25, 2008
    Besides showing promise for painful high arches and bunions, the researchers found that custom orthoses may ease foot pain from juvenile idiopathic arthritis -- a form of arthritis that affects children. In these cases, though, it was not clear that custom orthotics were any more effective than "off-the-shelf" shoe inserts. (MEDLINEplus)

    Prescription for disaster  Jul 21, 2008
    He stayed at the hospital 10 days, sedated by a morphine pump, and was eventually diagnosed with idiopathic pancreatitis, a rare, painful stomach condition. At the end of the hospital stay, Havelka was prescribed two weeks bedrest and two types of opiate painkillers OxyContin, a time-release version (contin is short for continual release) of the narcotic oxycodone, which he was also given, mainly for immediate pain relief. (Helena Independent Record, MT)

    Prescription for Addiction: Painkillers for stomach condition spiraled out of control, almost ending man's life  Jul 21, 2008
    He stayed at the hospital for 10 days, sedated by a morphine pump, and was eventually diagnosed with idiopathic pancreatitis, a rare but painful stomach condition. At the end of the hospital stay, Havelka was prescribed two weeks' bedrest and two types of opiate painkillers OxyContin, a time-release version ( contin is short for continual release) of the narcotic oxycodone, which he was also given, mainly for immediate breakthrough pain relief. (Missoulian, MT)

    Overview of Bell's Palsy  Jul 20, 2008
    Diagnosis and Treatment of Idiopathic Facial Nerve Paralysis ... Rather, Bell's palsy is an idiopathic facial paralysis, one whose cause cannot be determined ... Assuming the facial paralysis is idiopathic and can be appropriately called Bell's palsy, the treatment includes the corticosteroid medication prednisone and a drug against herpes simplex virus (HSV), which can be acyclovir, valacyclovir, or famciclovir. (Suite101.com)

    Rebatis father lodges police complaint  Jul 20, 2008
    Kahanr has alleged that on Wednesday at around 9 in the morning, a staff nurse named Malati Swain had come and drew blood from both him and his daughter, who is undergoing a series of surgeries to get rid of the deformities caused by the rare idiopathic gingival enlargement disease at the SCB Medical College and Hospital. The nurse had said that she was doing so on instructions of treating surgeon Dr Suryakanta Narendra, he stated. (Newindpress)

    More on Motrin and Stevens-Johnson syndrome  Jul 19, 2008
    Here's the beginning of an account from the family who launched the : "Julie was 10 months old when she had a grand mal seizure. She was prescribed Phenobarbital to control idiopathic epilepsy. ... Julie awoke one morning with her right eye swollen shut. By that evening her left eye swelled also and the right one was now completely shut. My mother thought the baby had an allergy." The story continues from there -- and it's wrenching. Julie is now a teenager, blind in one eye, who has launched... (Los Angeles Times)

    Gene That Regulates And Blocks Ovulation Discovered  Jul 18, 2008
    1, 2006) For about one in 10 couples that cannot conceive a child, their reproductive problem falls under the broad category of "idiopathic infertility," meaning the cause remains to be determined. But these. (Science Daily)

    Finding a New Heart for a Toddler  Jul 18, 2008
    A team of pediatricians diagnosed Peyton with idiopathic cardio myopathy -- heart inflammation with no known cause. The pediatricians came to a bleak conclusion: Peyton needed a heart transplant, or he would die. (ABC News)

    Custom-Made Insoles Can Reduce Foot Pain  Jul 16, 2008
    Researchers found that custom foot orthoses can relieve pain within three months in adults with rheumatoid arthritis, as well as in children with juvenile idiopathic arthritis, an early onset form of the disease. Adults with painful highly arched feet or painfully prominent big toe joints also benefited from treatment with orthoses over three and six month periods respectively. (Newsmax)

    Clinicians Should Consider Economic Impact Of New Interventions, According To New Report  Jul 7, 2008
    1, 2007) A new study examined direct medical costs of children with juvenile idiopathic arthritis and found that the economic impact was. (May 12, 2008) Public investment in early childhood programs may be able to lower public costs for social services by improving children's long-term welfare. (Science Daily)

    Pain Beyond Words  Jul 7, 2008
    She was diagnosed with chronic idiopathic demyelinating polyradiculoneuropathya disease in which rogue antibodies present in one's blood plasma attack the myelin sheath, the protective and connective covering of one's nerves. For four years, Manguso suffered numerous episodes of escalating paralysis that could be reversed only through an arduous process called apherisis: Her veins were drained of the offending plasma and infused with new. (Slate)

    Pediatric researchers find possible 'master switch' gene in juvenile arthritis  Jul 2, 2008
    Researchers at The Children's Hospital of Philadelphia reported on the link between the gene region and juvenile idiopathic arthritis (JIA), formerly called juvenile rheumatoid arthritis. The genetic variant is on chromosome 9 in a region housing two genes, TRAF1 and C5. (EurekAlert!)

    FDA Panel OKs Enbrel for Psoriasis in Children  Jun 20, 2008
    It was first approved by the FDA in 1999 to treat in adults; the FDA later approved it to treat certain other arthritic conditions, including , which is now called juvenile idiopathic , in patients aged 2 and older. Enbrel's Clinical Trial. (WebMD)

    EpiPen(R) Partners with Lucy Waverman, Canadian Culinary Personality, to Offer Fresh, Natural Recipes for People Who Suffer from Life-Threatening Allergies  Jun 17, 2008
    Such emergencies may occur spontaneously or from insect stings, bites, foods, drugs, or other allergens, as well as idiopathic or exercise induced anaphylaxis. How Supplied: EpiPen and EpiPen Jr. auto-injectors are available in single cartons. (Canada Newswire)

    U.S. FDA Approves Requip(R) XL(TM), the First and Only Oral Once-Daily Non-Ergot Dopamine Agonist for Parkinson's Disease  Jun 14, 2008
    Requip XL Improved Symptoms in Patients Not Optimally Controlled with Levodopa and Reduced Patients' "Off" Time by Nearly Two Hours Per Day RESEARCH TRIANGLE PARK, N.C., June 13 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE: ) today announced the approval of Requip(R) XL(TM) (ropinirole extended-release tablets) in the U.S. for the treatment of the signs and symptoms of idiopathic Parkinson's disease ... Clinical Study FDA approval was based primarily on results from the EASE-PD (Efficacy And... (PR Newswire)

    Data Show that Abbott's HUMIRA(R) (adalimumab) Reduced the Signs and Symptoms of Ankylosing Spondylitis Up to Three Years  Jun 13, 2008
    In the United States, HUMIRA is also approved for the treatment of juvenile idiopathic arthritis (JIA). HUMIRA is indicated for the treatment of active and progressive psoriatic arthritis in adults when the response to previous disease-modifying anti-rheumatic drug therapy has been inadequate. (Canada Newswire)

    XOMA 052 Demonstrates Anti-Inflammatory Effects in Diabetes Animal Studies; Data Presented At ADA  Jun 8, 2008
    In 2008, XOMA plans to initiate clinical studies of XOMA 052 in rheumatoid arthritis, acute gout, and systemic juvenile idiopathic arthritis (sJIA) ... These disease indications include rheumatoid arthritis, systemic juvenile idiopathic arthritis, gout, Muckle-Wells syndrome and others. (Primezone Releases)

    Neuromyelitis Optica  Jun 5, 2008
    Devic's Syndrome: Multiple Sclerosis Variant Often Confused with MS. NMO antibodies are key to diagnosis. (Suite101.com)

    Abbott drugs in FDA risk reviews  Jun 5, 2008
    "The drugs Enbrel, Humira, and Remicade are being reviewed for a possible association between their use and the development of lymphoma and other cancers in children and young adults treated with TNF blockers for juvenile idiopathic arthritis and Crohn's disease," the FDA said. "Lymphoma is a cancer of the cells in the immune system.". (Chicago Tribune)

    FDA panel favors Glaxo, Ligand blood drug  May 31, 2008
    British drugmaker Glaxo and partner Ligand want Promacta approved to treat patients' with chronic idiopathic thrombocytopenic purpura, which causes excessive bruising and bleeding. About 60,000 people in the U.S. have the disease, according to Glaxo. (USA Today)

    Hormone May Hold Key To Helping Elderly Men Live Longer  May 29, 2008
    7, 2005) A randomized UCLA study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short. (Apr. (Science Daily)

    Supreme Court Chief Taken to Hospital After Fall  May 29, 2008
    Roberts, 52, fell on a dock after having a "benign idiopathic seizure," said Kathleen Landin Arberg, the court's public information officer ... Arberg's description of a benign idiopathic seizure indicates an episode whose origins are unknown. (Yahoo News -- Supreme Court)

    AMITIZA 8 mcg now available to treat irritable bowel syndrome  May 28, 2008
    AMITIZA 24 mcg capsules have been available by prescription to treat Chronic Idiopathic Constipation in adults since 2006 ... AMITIZA has a mechanism of action that works locally in the intestine to increase fluid secretion, resulting in increased passage of stool and alleviating symptoms associated with Chronic Idiopathic Constipation ... About AMITIZA (lubiprostone) for Chronic Idiopathic Constipation and IBS-C. (EurekAlert! -- Business News)

    New Treatment Gives Hope For Pulmonary Fibrosis Patients  May 24, 2008
    ScienceDaily (May 23, 2008) Patients with idiopathic pulmonary fibrosis (IPF) may have a new treatment option, according to researchers in Japan ... 24, 2005) Every breath soon turns into a struggle for people living with idiopathic pulmonary fibrosis (IPF) ... 9, 2005) A lung disease known as idiopathic pulmonary fibrosis strikes without warning and often kills within only a few years. (Science Daily)

    Oxidative Stress May Predict Later Lung Trouble In Young Adults  May 23, 2008
    1, 2007) Reasearchers have announced a potential breakthrough in the treatment of idiopathic pulmonary hemosiderosis, a rare condition which can affect children and young. (Mar. (Science Daily)

    Drug for Deadly Lung Disease Shows Promise  May 23, 2008
    Idiopathic pulmonary fibrosis kills 40,000 Americans each year ... Japanese researchers say daily use of the drug pirfenidone improved the lung function and lengthened the survival of patients with the illness, called idiopathic pulmonary fibrosis (IPF). (Health-Finder)

    Drug Brings Relief For Many IBS Patients Who Experience Constipation  May 21, 2008
    The supplemental New Drug Application for AMITIZA -- which also is approved by the FDA for treatment of chronic idiopathic constipation -- was based on two phase III, multi-center trials involving 1,154 participants. These trials compared lubiprostone versus a placebo during the course of 12 weeks. (Science Daily)

    Drug Brings Relief for IBS Patients  May 20, 2008
    On a Handheld Device. SIGN UP FOR FREE NEWS ALERTS. (Newsmax)

    Walking again'My arthritis left me needing two new hips by the age of 22'  May 17, 2008
    Despite having had the condition, a rare form of the disease called juvenile idiopathic arthritis, since she was five, Natalie felt well enough to start her university course and her first year went as planned. Missed days. (BBC News -- UK)

    Trigeminal Neuritis in the Dog  May 10, 2008
    Any trauma or damage to the trigeminal nerve be it from an impact or injury or from a tumor can lead to TN, but in a significant portion of canine cases, this is an idiopathic condition where the precise cause is unknown, explained Dr. Michael Levine, DVM, a practicing veterinarian and professor of veterinary medicine. Due to its rarity, TN is most often diagnosed following an examination by a veterinary neurologist. (Suite101.com)

    New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients  May 9, 2008
    In April 2005, ACTEMRA was launched by Chugai in Japan as a therapy for Castleman's disease; in April 2008, ACTEMRA was approved for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis in Japan. The serious adverse events reported in ACTEMRA clinical trials were serious infections and hypersensitivity reactions including anaphylaxis. (PR Newswire)

    Augmentation of J Waves and Electrical Storms in Patients with Early Repolarization  May 8, 2008
    2 Sporadic case reports and basic electrophysiological research have suggested a critical role of the J wave in the pathogenesis of idiopathic ventricular fibrillation. 3,4 Clinical evidence in support of an. (New England Journal of Medicine)

    Sudden Cardiac Arrest and Early Repolarization  May 8, 2008
    Methods We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization ... Results Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P<0 ... Conclusions Among patients with a history of idiopathic ventricular fibrillation, there is an increased prevalence of early... (New England Journal of Medicine)

    Little steps, big change  May 7, 2008
    She was diagnosed with idiopathic gastroparesis, a rare disorder in which, basically, the stomach doesn't work. She was dehydrated and had been vomiting and enduring severe pain. (Albany Times Union)

    Scientists identify genomic 'fingerprint' for alcohol-induced heart failure  May 5, 2008
    While clinicians know that up to 36 percent of all cases of dilated cardiomyopathy may be due to excessive drinking, it has been difficult to differentiate between alcohol-induced heart failure and heart failure due to idiopathic dilated cardiomyopathy ... The etiology of alcohol-induced cardiomyopathy is unique and different from other forms of cardiomyopathy, especially the idiopathic dilated cardiomyopathy, said Gwathmey. (EurekAlert!)

    FDA approves irritable bowel drug  May 2, 2008
    Amitiza is already approved for the treatment of chronic idiopathic constipation at 24 micrograms twice a day, much higher than the 8 micrograms twice a day recommended for treatment of IBS-C.. The FDA, in its statement, described both Takeda and Sucampo as manufacturers of Amitiza but a spokesman for Sucampo said that while both companies market the drug, Sucampo was the developer. (MSNBC -- Health)

    Cause of Childhood-Onset Cardiac Hypertrophy  May 2, 2008
    Background The childhood onset of idiopathic cardiac hypertrophy that occurs without a family history of cardiomyopathy can portend a poor prognosis ... Methods We assessed the family and medical histories of 84 children (63 boys and 21 girls) with idiopathic cardiac hypertrophy diagnosed before 15 years of age (mean [ SD] age, 6. (New England Journal of Medicine)

    Growth Hormone Is Used To Treat Twice As Many Short Boys Than Girls In The US And Asia  Apr 21, 2008
    The greatest gender disparities occurred for diagnoses without an identifiable cause, such as idiopathic short stature and idiopathic GH deficiency because of the complexity of the diagnostic tests ... Prior to 1985, only children with the most severe growth hormone deficiency were treated because of the very limited supply of human pituitary GH. In 2003, the U.S. Food & Drug Administration (FDA) approved the use of rhGH for the treatment of idiopathic short stature, for children who are... (Science Daily)

    Chief justice tumbles after seizure  Apr 21, 2008
    Doctors called the incident a "benign idiopathic seizure," similar to one suffered by the chief justice in 1993, the court statement said. An idiopathic seizure is one with no identifiable physiological cause. (Yahoo News -- Supreme Court)

    Inflammation triggers cell fusions that could protect neurons, Stanford research shows  Apr 21, 2008
    "Clas noted significantly more heterokaryons than we ever had in the past," said Blau, "from fewer than 10 in an entire animal to several hundred." When the researchers looked more closely, they found that those animals with higher-than-expected numbers of fused cells also had an inflammatory skin condition common to aging laboratory mice called idiopathic ulcerative dermatitis. This type of chronic inflammation affects the entire immune system of the animal and causes a systemwide immune... (EurekAlert!)

    Genetic variant mimics effect of heart failure medications  Apr 21, 2008
    In some cases, called idiopathic cardiomyopathy, the cause is not identified. As heart failure progresses, adrenalin produces a fight or flight response to stimulate the heart into action by binding to receptors on heart cells called beta-adrenergic receptors. (EurekAlert!)

    Health Woes Not Always to Blame for Chronic Cough  Apr 20, 2008
    "Doctors should always work towards a clear diagnosis, considering common and rare illnesses. In some patients, no cause is identified, leading to the diagnosis of idiopathic cough," they noted. They said the many causes of chronic cough, plus the cough reflex itself, could cause inflammation or tissue remodeling. (Health-Finder)

    Different Mutations In Single Gene Suggest Parkinson's Is Primarily An Inherited Genetic Disorder  Apr 18, 2008
    22, 2007) Idiopathic hypogonadotropic hypogonadism (IHH) is an inherited genetic disorder that results in impaired sexual development due to a deficiency in a sex hormone known as GnRH. Although individuals. (Jun. (Science Daily)

    /R E P E A T -- Dr. Alain Moreau, world renowned scientist, wins Génome Québec's "Biotechnology Award of Tomorrow" at 2008 Genesis Awards Gala/  Apr 17, 2008
    His work focuses on molecular and genetic diagnostic testing for idiopathic scoliosis, the most common orthopedic deformity, osteoarthritis and the selection of compounds of pharmacological interest for preventing the development of scoliosis, osteoarthritis and osteoporosis or halting their progress. "Currently, there are no tests for the early detection of idiopathic scoliosis, which is why the work of Dr. Moreau and his team will help revolutionize the way clinicians treat this disorder,"... (Canada Newswire)

    HGH bill altered in order to help children  Apr 16, 2008
    She said her 9-year-old daughter, Madison, who was diagnosed with Idiopathic Short Stature (ISS), may not have been eligible to receive HGH if the bill would have passed in its original form. "Some disorders just aren't recognized, but there's still a need for the medication," Garrett said. (USA Today -- Sports)

    Barrier Therapeutics Announces Positive Results in Reducing Itch Symptoms With Novel Oral Antihistamine Agent Hivenyl  Apr 9, 2008
    In this study, the drug significantly reduced itch symptoms in patients with chronic idiopathic urticaria (CIU), or hives of unknown cause that last for a period of at least six weeks ... These results, demonstrating remarkable itch reduction in chronic idiopathic urticaria after only one week of treatment, considered together with previously reported positive clinical efficacy results in atopic dermatitis, demonstrate Hivenyl's potential as a versatile non-sedative, anti-itch agent,'' said Dr.... (Primezone Releases)

    Law & Disorder: Man charged with raping 11-year-old girl  Apr 8, 2008
    Christian Fitzgerald Allen's manner of death was idiopathic dilated cardiomyopathy, according to the report obtained Monday by the Times-Union. Allen collapsed in the back of a patrol car after police used a Taser on him three times. (Florida Times-Union)

    Medical fund raiser being raised by Gridley family  Apr 5, 2008
    Pure Autonomic Failure was previously referred to as idiopathic orthostatic hypotension or Bradbury-Eggleston syndrome. This disorder differs from multiple system atrophy, because it lacks central or preganglionic involvement. (Gridley Herald, CA)

    United Therapeutics inhaled treprostinil may have limited efficacy due to missed secondary endpoint, physicians say  Apr 4, 2008
    Out of the 235 patients enrolled, 55% had idiopathic or familial PAH, 35% had vascular disease, and 10% had PAH associated with anorexigens, HIV or other disease conditions. Still, Rubens speculated that inhaled treprostinil might not have caused a significant change on the NYHA scale because not enough patients were recruited. (FT.com -- Markets)

    IPO Profile: R-Tech Ueno Ltd.  Mar 28, 2008
    a venture firm specializing in development and production of pharmaceutical products, will make its debut on the Osaka Securities Exchange's Hercules market for startup companies on April 9 (JCN Network, Japan)

    Heart Pump as Effective as a Transplant?  Mar 27, 2008
    "We can say that all these patients with idiopathic heart failure, they have the potential for a normal active life without a transplant and without an assist device," Dr. Bud Frazier of the Texas Heart Institute said. "The challenge now is to learn how to use this technology most effectively," he said. (ABC News)

    Gene Linked to Form of Parkinson's Disease  Mar 25, 2008
    "The next step is to zero in on this gene to learn more about its involvement in triggering Parkinson's. It will also be important to evaluate additional and larger families with Parkinson's and these genetic mutations, as well as the frequency of GIGYF2 mutations in patients with the more common, idiopathic form of the disease," he said. The study appears online in the American Journal of Human Genetics and will be published in the April 11 print issue of the journal. (MEDLINEplus)

    Gene Linked To Development Of The Parkinson's Disease In Those With Family History Identified  Mar 24, 2008
    "The next step is to zero in on this gene to learn more about its involvement in triggering Parkinson's. It will also be important to evaluate additional and larger families with Parkinson's and these genetic mutations, as well as the frequency of GIGYF2 mutations in patients with the more common, idiopathic form of the disease.". The study -- which will also be published in the April 11th print issue of American Journal of Human Genetics -- was supported by grants from the National Institutes... (Science Daily)

    New Rheumatoid Arthritis Drug Works for Adults, Children  Mar 22, 2008
    These children all had systemic-onset juvenile idiopathic arthritis, which did not respond to the usual arthritis treatment ... "The results of this placebo-controlled and open-label extension study with tocilizumab in children with systemic-onset juvenile idiopathic arthritis show a sustained clinical improvement and a favorable risk-benefit profile," the Japanese team wrote. (MEDLINEplus)

    Genetic association study of synphilin-1 in idiopathic Parkinson's disease  Mar 22, 2008
    We screened the synphilin-1 gene for 11 single nucleotide polymorphisms (SNPs) in 300 affected subjects with idiopathic Parkinsons disease and 412 healthy controls ... Similarly, our indirect study of more heterozygous SNPs, including both single marker and haplotype analyses, showed no significant association to PD. However, marginal association of microsatellite alleles with idiopathic PD, within the chromosome 5q21, region indicates further studies are warranted. (BioMed Central)

    Former InterMune CEO indicted  Mar 20, 2008
    The Justice Department said Brisbane-based InterMune (NASDAQ:ITMN) put out a press release in 2002 under the direction of former CEO Scott Harkonen saying a clinical trial showed Actimmune effective in treating idiopathic pulmonary fibrosis. In fact, the indictment said, the trial showed just the opposite. (San Jose Business Journal)

    Former InterMune CEO W. Scott Harkonen Indicted for Wire Fraud and FDA Violations  Mar 19, 2008
    SAN FRANCISCO, March 18 /PRNewswire-USNewswire/ -- W. Scott Harkonen, M.D., the former CEO of InterMune Inc., was indicted on wire fraud and felony Food, Drug and Cosmetic Act charges for his role in the creation and dissemination of false and misleading information about the efficacy of InterMune's drug Actimmune (Interferon gamma-1b) as a treatment for idiopathic pulmonary fibrosis (IPF), the Justice Department announced today. The indictment alleges that Harkonen, a medical doctor, was the... (PR Newswire)

    Biotech leader charged with fraud  Mar 19, 2008
    The former Intermune CEO is accused of creating a market for Actimmune that reached $141 million in 2003 by falsely claiming through news releases and sales campaigns that the drug substantially reduced the death rate for patients with idiopathic pulmonary fibrosis, a progressive scarring of the lungs ... Actimmune is approved for two rare diseases afflicting children, but the Food and Drug Administration never approved it for idiopathic pulmonary fibrosis. (San Francisco Chronicle -- Business)

    Former CEO charged with improperly marketing drug  Mar 19, 2008
    During that time, he is accused of making false and misleading statements about how effective the drug was in combatting the fatal lung disease idiopathic pulmonary fibrosis, known as IPF.A press release Harkonen wrote touting the benefits of Actimmune to treat the lung disease in August 2002 is at the heart of the government's case. The press release stated that a large-scale scientific test of Actimmune showed it helped IPF patients live longer, prompting many doctors to start prescribing the... (Fresno Bee -- Business)

    Brain Disease Causes More Vision Loss in Blacks  Mar 15, 2008
    MONDAY, March 10 (HealthDay News) -- Black Americans are more likely than other racial groups to lose their vision due to idiopathic intracranial hypertension, or increased pressure in the brain, according to a new study. Researchers at Emory University School of Medicine in Atlanta reviewed the medical records of all 450 intracranial hypertension patients treated at Emory over a 17-year period. (MEDLINEplus)

    Former addict shares story to help others  Mar 2, 2008
    He was diagnosed in 2003 with idiopathic pulmonary fibrosis, which has left him with just a quarter of one lung functioning. Most people live five or six years after diagnosis. (The Augusta Chronicle)

    Gene Defect Causes Immune Deficiency And Balance Disorder  Feb 26, 2008
    25, 2008) A genetic defect that causes a severe immune deficiency in humans may also produce balance disorders, according to a new study by researchers at the University of Iowa, The Jackson Laboratory and East Carolina University. The study, published online Feb. 21 in the Journal of Clinical Investigation, examined a specialized strain of Jackson Laboratory mice with a mutation that eliminates the production a protein called p22phox. (Science Daily)

    Patient With Rare Disorder Responds To Cancer Drug  Feb 14, 2008
    10, 2007) Two new clinical reports shed light on why some people suffer from recurrent episodes of idiopathic anaphylaxis -- a potentially life-threatening condition of unknown cause characterized by a drop in. . (Science Daily)

    A GPR54-Activating Mutation in a Patient with Central Precocious Puberty  Feb 14, 2008
    In girls, this condition is most often idiopathic ... In this study, we have identified an autosomal dominant GPR54 mutation the substitution of proline for arginine at codon 386 (Arg386Pro) in an adopted girl with idiopathic central precocious puberty (whose biologic family was not available for genetic studies). (New England Journal of Medicine)

    Female Incontinence: What Works?  Feb 12, 2008
    We use an anticholinergic agent, a trycyclic drug and/or an alpha blocking agent in combination for all and in resistant idiopathic incontinence. Stress incontinence can be treated with pelvic floor exercise, with bulking agents and with surgery. (Science Daily)

    Lungs' Mast Cells Could Provide New Treatment Target For Asthma, Other Respiratory Disease  Jan 31, 2008
    In fact, Dr. Silver's lab is now looking at the role locally produced renin might play in a rare, deadly illness called idiopathic pulmonary fibrosis (IPF), where lung tissue becomes increasingly inflexible over time. "We're interested in any disease in which we can also detect local renin/angiotensin production because it appears to be linked to fibrosis, vasoconstriction, and now bronchoconstriction," Dr. Silver explains. (Science Daily)

    Smoking Worsens Prognosis for Idiopathic Pulmonary Fibrosis Patients  Jan 23, 2008
    MONDAY, Jan. 21 (HealthDay News) -- Current and former smokers with the lung disease idiopathic pulmonary fibrosis (IPF) have a worse prognosis than nonsmokers, says a British study. IPF is untreatable, and patients usually die within five years of diagnosis. (MEDLINEplus)

    Rare Lung Disease Cells Indicate Higher Death Risk  Jan 20, 2008
    19, 2008) Large numbers of certain cells in the lungs of patients diagnosed with idiopathic pulmonary fibrosis may increase their chance of death, UC researchers have discovered ... According to a new study, increased numbers of neutrophil (pronounced new-tro-fil) cells a type of white blood cell in patients lungs were associated with a 30 percent increased risk of mortality in the first year following diagnosis with idiopathic pulmonary fibrosis (IPF) ... 13, 2007) Researchers have found that... (Science Daily)

    Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis  Jan 19, 2008
    In May 2007, Abbott announced it had also submitted an FDA regulatory application for HUMIRA to treat juvenile rheumatoid arthritis and an EMEA regulatory application for HUMIRA to treat juvenile idiopathic arthritis. Clinical trials are currently underway evaluating the potential of HUMIRA in ulcerative colitis. (PR Newswire)

    Supreme Court Chief Taken to Hospital After Fall  Jan 19, 2008
    Roberts, 52, fell on a dock after having a "benign idiopathic seizure," said Kathleen Landin Arberg, the court's public information officer ... Arberg's description of a benign idiopathic seizure indicates an episode whose origins are unknown. (Yahoo News -- Supreme Court)

    Prednisolone or Acyclovir in Bell’s Palsy  Jan 17, 2008
    Idiopathic peripheral-facial-nerve paralysis of sudden onset is difficult to diagnose because other causes that are associated with a significantly higher risk of defective healing2 must be ruled out. Since zoster sine herpete which can mimic the signs and symptoms of Bell's palsy caused by varicella zoster virus has an incidence rate of up to 34% among patients with "Bell's palsy,"3 information. (New England Journal of Medicine)

    Smoking Belies Milder Disease But Worse Prognosis For Idiopathic Pulmonary Fibrosis Patients  Jan 16, 2008
    15, 2008) Smokers and ex-smokers with idiopathic pulmonary fibrosis (IPF), an untreatable progressive lung disease that usually leads to death within a few years of diagnosis, have a worse prognosis than non-smokers, according to research from London ... 13, 2007) Researchers have found that Viagra may help patients with idiopathic pulmonary fibrosis, an incurable disease characterized by progressive scarring in the lungs, which often leads to a lung ... 2, 2005) In a study of 111 families that... (Science Daily)

    Doctor 'Pay-for-performance' Improves Patient Care, Study Shows  Jan 12, 2008
    20, 2007) Physicians who treat a blood disorder called idiopathic thrombocytopenic purpura, characterized by easy bruising and excessive bleeding, now have a new tool to help them provide the best care for. (Nov. (Science Daily)

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