Still holding their breath: Mortality on lung transplant wait list remains high for some Aug 24, 2009
Overall, mortality on the lung transplant waiting list has fallen as a result of the changes, especially among those with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and cystic fibrosis (CF); patients with idiopathic pulmonary arterial hypertension (IPAH), however, make up only a small minority of lung-transplant candidates, and therefore little is known about whether and how they have benefited from the changes to lung allocation protocols. "Most people... (EurekAlert!)
U-M researchers discover therapeutic target that could help patients with pulmonary fibrosis Aug 24, 2009
A diagnosis of Idiopathic Pulmonary Fibrosis is not much better than a death sentence: there is no treatment and the survival rate is less than three years ... " So those suffering from common cardiac or kidney diseases, which often involve fibrosis, also may benefit from treatments stemming from this research, Pennathur said. Pennathur said continued support from the National Institutes of Health will eventually allow researchers to take the treatment to human studies. The University of... (EurekAlert!)
Rare Pharmaceutical Fraud Trial Under Way in San Francisco Aug 20, 2009
But InterMune also sought to market it to patients suffering from idiopathic pulmonary fibrosis, a lung disease that occurs far more frequently. In 2002, InterMune issued a press release trumpeting a clinical study that supposedly showed benefits for some IPF patients. (Law.com)
A Man with Coma after Cardiac Arrest Aug 13, 2009
Although no structural abnormalities were identified on echocardiography or cardiac catheterization, primary ventricular fibrillation has many causes that are not readily diagnosed,2 and when idiopathic it has a high rate of recurrence. 3 Therefore, the suitability of the donor's heart for transplantation needs to be determined by means of a thorough anatomical and electrophysiological assessment, which may be difficult to perform under. (New England Journal of Medicine)
Schering-Plough Announces Resolution of Litigations on U.S. Marketing of Generic Forms of Solid Oral Dosage Forms of CLARINEX(R) Aug 12, 2009
CLARINEX brand 5 mg tablets and REDITABS, a nonsedating antihistamine, offers relief from seasonal allergic rhinitis and perennial allergic rhinitis, as well as chronic idiopathic urticaria, or hives of unknown cause. CLARINEX-D 24 Extended Release Tablets is the only once-daily prescription antihistamine and decongestant combination treatment on the market to provide 24-hour relief of nasal and non-nasal allergy symptoms. (PR Newswire)
Unlocking The Key To Human Fertility Aug 4, 2009
Says Dr Miller, Up until now, Doctors have struggled to understand idiopathic male infertility. Our latest research offers a plausible explanation for why some sperm malfunction or fail to function correctly. (Science Daily)
Summer heat increases risk of amniotic fluid level deficiency, Ben-Gurion University study reveals Jul 31, 2009
During the study period, there were 191,558 deliveries of which 4,335 were diagnosed with idiopathic oligohydramnios. Of these, a proportionally higher number, 1,553 deliveries (36 percent), occurred during these four summer months, while 2,782 deliveries occurred during the other eight months of the year (64 percent). (EurekAlert!)
Orangeburg woman receives RMC's 1st DAISY Award Jul 26, 2009
Patrick died at the age of 33 in late 1999 from complications of Idiopathic Thrombocytopenic Purpura, a little known but not uncommon auto-immune disease. The care Barnes and his family received from nurses while he was ill inspired this unique means of thanking nurses for making a profound difference in the lives of their patients and patient families. (Orangeburg Times and Democrat, SC)
Emphysema Severity Directly Linked To Coal Dust Exposure Jul 25, 2009
15, 2008) Smokers and ex-smokers with idiopathic pulmonary fibrosis, an untreatable progressive lung disease that usually leads to death within a few years of diagnosis, have a worse prognosis than nonsmokers. (May 30, 2006) A new imaging method has revealed early signs of emphysema in smokers with no external symptoms of the disease, according to a study published in the June issue of Radiology. (Science Daily)
Tips from the American Journal of Pathology Jul 23, 2009
Idiopathic portal hypertension (IPH) is a form of high blood pressure that often results from blockage of the peripheral veins in the liver ... Kitao A, Sato Y, Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y: Endothelial to mesenchymal transition via transforming growth factor-b1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. (EurekAlert!)
Juvenile Arthritis: More than growing pains Jul 21, 2009
Eventually the Vicksburg youth was diagnosed with polyarticular juvenile arthritis and became one of the nearly 300,000 children diagnosed yearly with one of the multiple forms of juvenile idiopathic arthritis ... Juvenile idiopathic arthritis is classified by the number of joints involved ... Impairment from juvenile idiopathic arthritis ranges from mild to severe. (The Clarion-Ledger)
Shriners stage motorcyle rally to help hospital Jul 17, 2009
The hospital treats children with limb deficiencies/deformities, arthrogryposis, cerebral palsy, hip problems, juvenile idiopathic arthritis, spina bifida, neurological disorders, osteogenesis imperfecta, specialized plastic surgery/scar revision, rickets, burn injuries, spine deformities and sports injuries. Children are eligible to receive care if they are younger than 18 with a treatable orthopedic condition. (Brainerd Daily Dispatch)
Dogs and Seizures Jul 15, 2009
These are called idiopathic. Others are acquired and brought on by underlying health issues such as the following. (Suite101.com)
Medical Researchers Profile Genes In Acutely Ill Idiopathic Pulmonary Fibrosis Patients Jul 15, 2009
ScienceDaily (July 15, 2009) The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain them until life-saving transplants can be performed ... 16, 2006) For idiopathic pulmonary fibrosis patients awaiting lung transplantation, a simple walk test can predict mortality rates ... 9,... (Science Daily)
Genetic Breakthrough Spells Hope For Lung Fibrosis Patients Jul 10, 2009
WEDNESDAY, July 8 (HealthDay News) -- Genes that can help doctors predict when patients with idiopathic pulmonary fibrosis are becoming seriously ill have been identified by U.S. researchers, who said the findings might help keep patients alive until they can get a lung transplant. Idiopathic pulmonary fibrosis (IPF) is a lung-scarring disease that progresses slowly and causes a gradual decline in lung function. (MEDLINEplus)
New Discovery To Aid In Diagnosis And Treatment Of Kidney Disease Jul 10, 2009
ScienceDaily (July 10, 2009) Researchers from Boston University School of Medicine (BUSM) in collaboration with scientists at the University of Louisville and the University of Nice Sophia Antipolis in France, have identified the target antigen PLA2R in patients with idiopathic membranous nephropathy (kidney disease), which has implications for the diagnosis and treatment of this disease ... Idiopathic membranous nephropathy involves the thickening and dysfunction of the filtering parts of the... (Science Daily)
Gene Expression Findings A Step Toward Better Classification And Treatment Of Juvenile Arthritis Jul 9, 2009
ScienceDaily (July 8, 2009) Scientists have discovered gene expression differences that could lead to better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA) ... Barnes M, Grom A, Thompson S, et al. Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis ... Griffin T, Barnes M, Ilowite N, et al. Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a... (Science Daily)
Inhaled Growth Hormone Safe For Children Deficient In This Key Protein, Study Suggests Jul 8, 2009
(June 7, 2005) A randomized UCLA study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short. (Nov. (Science Daily)
Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients Jul 7, 2009
PITTSBURGH, July 7 The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain them until life-saving transplants can be performed. According to senior author Naftali Kaminski, M.D., associate professor of medicine, computational biology and pathology, and director of the Dorothy P.... (EurekAlert!)
News briefs from the July issue of CHEST Jul 7, 2009
New research shows that mortality from idiopathic pulmonary fibrosis (IPF) and/or pulmonary fibrosis (PF) may be highest during the winter months. Using death records from the National Center for Health Statistics, a research team from the University of Colorado Health Sciences Center in Denver, CO, calculated the monthly mortality rates for persons with PF. Results showed that mortality rates from PF significantly varied by season. (EurekAlert!)
Human Idiopathic Membranous Nephropathy — A Mystery Solved? Jul 2, 2009
NEJM -- Human Idiopathic Membranous Nephropathy -- A Mystery Solved ... Human Idiopathic Membranous Nephropathy A Mystery Solved. (New England Journal of Medicine)
Isolated Familial Hypogonadotropic Hypogonadism and a GNRH1 Mutation Jun 25, 2009
We investigated whether mutations in the gene encoding gonadotropin-releasing hormone 1 (GNRH1) might be responsible for idiopathic hypogonadotropic hypogonadism (IHH) in humans. We identified a homozygous GNRH1 frameshift mutation, an insertion of an adenine at nucleotide position 18 (c. (New England Journal of Medicine)
The Causes of Male Breast Enlargmen... Jun 22, 2009
In up to one in four cases, a cause of male breast enlargement won t be found and the condition becomes known as idiopathic gynecomastia. Gynecomastia can sometimes be treated with testosterone supplements or medications that block the effects of estrogen. (Suite101.com)
Novartis drug Ilaris wins FDA approval Jun 20, 2009
Novartis (NYSE: NVS), is also studying Illaris in clinical trials for the treatment of systemic juvenile idiopathic arthritis (SJIA), as well as for gout, chronic obstructive pulmonary disorder and type 2 diabetes. Novartis has been granted orphan drug designation for SJIA in the United States, European Union and Switzerland. (Raleigh Triangle Business Journal, NC)
Vet clinic tests dog epilepsy drug Jun 16, 2009
The gives qualifying dogs free test medication for idiopathic epilepsy essentially seizures with unknown causes which affect almost 6 percent of all canines. It s a FDA study just like human drugs go through, says Dr. Carol Price, one of two vets on staff at Bear Creek. (Houston Business Journal, TX)
Sanko Junyaku Launches Diagnostic Reagent Kit For Automated Clinical Chemistry Analyser To Determine KL-6, Detecting Marker of Interstitial Pneumonia Jun 2, 2009
Idiopathic interstitial pneumonia and drug-induced pneumonia are the most common types of interstitial pneumonia. Recent increase in number of patients with drug-induced pneumonia has raised social concern about and awareness of the importance of the disease. (JCN Network, Japan)
Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients May 25, 2009
ACTEMRA is part of a co-development agreement between Roche and Chugai Pharmaceutical Co. In June 2005, ACTEMRA was launched by Chugai in Japan as a therapy for Castleman's disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. ACTEMRA (known as RoACTEMRA in Europe), was also recently approved in the European Union, Switzerland and India. (PR Newswire)
The dangers of deep vein thrombosis May 20, 2009
" Neither Mr. Gathagan, Ms. Mazzoni, nor Mr. Bloom had been hospitalized at the time they developed their clots. Mr. Gathagan's case, Dr. Kennedy said, "is grouped as an idiopathic, a we-do-not-know-why. I suspect the fact he was somewhat overweight played a role. (Pittsburgh Post-Gazette, PA)
Key Proteins Needed For Ovulation Identified May 19, 2009
1, 2006) For about one in 10 couples that cannot conceive a child, their reproductive problem falls under the broad category of "idiopathic infertility," meaning the cause remains to be determined. But these. (Science Daily)
Weinberg serving up winners May 14, 2009
At age 6 she was diagnosed with juvenile idiopathic arthritis --- a chronic disease that causes pain and swelling in the joints. "Anything from shaking hands to picking up a ball would hurt my joints so bad that I wasn't allowed the opportunities I would have loved to have as a kid," Weinberg said. (Waterloo Courier, IO)
First-Time National Poll Confirms Neuropathy Hits Millions in Their Prime May 14, 2009
While there are over 100 known types of peripheral neuropathy, 52% of the patients responded their neuropathy was "idiopathic," meaning of no known cause. Other types noted were. (PR Newswire)
Overview of Seizures May 10, 2009
Seizures in children are often due to congenital conditions or fever but may also have an unknown cause (idiopathic). For adults, common causes of seizures include tumors, strokes, alcohol withdrawal, and traumatic brain injury. (Suite101.com)
Ipsogen Expands its US Market Presence Through Licensing Agreement With ARUP Laboratories for the Commercialization of JAK2 Molecular Diagnostic Assays May 4, 2009
This team identified the key role played by this mutation of the JAK2 gene in the development of MPN such as Vaquez disease (Polycythemia Vera), Idiopathic Myelofibrose or Essential Thrombocythemia. Following this agreement, the company developed and marketed a complete portfolio of tests for the identification and quantification of this mutation (JAK2 MutaScreen(TM) et JAK2 MutaQuant(TM), respectively). (PR Newswire)
Dr. Jeff Hersh: Cause of painful bladder syndrome unknown Apr 29, 2009
IC, also called painful bladder syndrome, is an idiopathic condition (we don't know what causes it) which manifests as bladder and/or pelvic pain, as well as urinary urgency and frequency, and can have significant negative impact on the patient's quality of life. Symptoms from IC can fluctuate from person to person, and from time to time for a given patient, making it a tricky condition to diagnose. (Belmont Citizen Herald, MA)
Targeting Oxidized Cysteine Through Diet Could Reduce Inflammation And Lower Disease Risk Apr 1, 2009
(June 1, 2007) Reasearchers have announced a potential breakthrough in the treatment of idiopathic pulmonary hemosiderosis, a rare condition which can affect children and young. (Dec. (Science Daily)
New, Highly Effective Treatment For Blood Disorder Mar 27, 2009
Promacta (eltrombopag) was granted accelerated approval by the U.S. Food and Drug Administration in November 2008 for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglobulins or splenectomy. Promising results of an international, multicenter Phase III clinical trial, led by NewYork-Presbyterian/Weill Cornell researchers, were the basis of this approval and are published in a... (Science Daily)
Ten Genes Associated With A Risk Factor For Sudden Cardiac Death Identified Mar 24, 2009
11, 2009) Researchers conducting a large, ongoing study to improve detection and prevention of sudden cardiac death were surprised to discover that a specific heart rhythm abnormality -- idiopathic QT interval. (Nov. (Science Daily)
How to Help a Dog with Seizures Mar 18, 2009
Most often than not, the condition is idiopathic, meaning that there is not a known cause. Most dogs are therefore, put on common prescription medications such as "Phenobarbital" or "Potassium Bromide" or a combination of both. (Suite101.com)
Diabetes, Parkinson's can lead to gastroparesis Mar 16, 2009
There is also a form called idiopathic gastroparesis, which simply means that no cause can be found despite extensive medical testing. Symptoms can include nausea, heartburn, gastroesophageal reflux, abdominal bloating, little to no appetite, feelings of fullness after a minimal amount of food, abdominal spasms and/or pain, vomiting undigested food and more. (Erie Times-News, PA)
Wakefields Shawna Kohout is DAISY award winner Mar 14, 2009
the non-profit DAISY Foundation was established in memory of J. Patrick Barnes, who died in 1999 at age 33 from complications of the autoimmune disease Idiopathic Thrombocytopenic Purpura (ITP). The DAISY Award, which stands for Diseases Attacking the Immune System, was established by Barnes wife and parents as a gesture of thanks to nurses nationwide for the profound difference they make in the lives of patients and their families. (Wakefield Daily Item, MA)
3SBio Inc. Announces Unaudited Fourth Quarter and Fiscal Year 2008 Results Mar 12, 2009
-- In December 2008, the Company filed for approval of a TPIAO label extension for the treatment of idiopathic thrombocytopenic purpura (ITP) in China, representing the first of a series of indications that the Company plans to pursue to build and grow TPIAO brand. -- 3SBio demonstrated its business development capabilities through a strategic partnership with AMAG Pharmaceutical, to develop and commercialize Ferumoxytol, a new generation of IV Iron therapy, in China. (PR Newswire)
Questcor to Present At Cowen and Company 29th Annual Health Care Conference Mar 12, 2009
Acthar (repository corticotropin injection) is an injectable drug that is approved for the treatment of certain disorders with an inflammatory component, including the treatment of exacerbations associated with multiple sclerosis (``MS'') and to induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that due to lupus erythamatosus. In addition, Acthar is not indicated for, but is used in treating patients with infantile spasms (``IS''),... (Primezone Releases)
Epilepsy - Stopping Anti-Seizure Me... Mar 9, 2009
Idiopathic seizures Abnormal EEG. A doctor might also consider withdrawing anti-seizure medication in six months to a year for someone who has had only a single seizure (Schacter). (Suite101.com)
Causes of Itchy Palms and Soles Mar 7, 2009
Idiopathic causes for itchy palms and soles ... These are called idiopathic itchy palms and soles. (Suite101.com)
Talk Therapy for Kids' Pain: Better than Pills? Mar 4, 2009
Doctors call this pain idiopathic, a medical term for "we have no clue." Idiopathic pain arises spontaneously and without a known cause ... How best to treat idiopathic pain is one of medicine's great mysteries. (Time.com)
Risk worth taking Mar 3, 2009
Londyn was diagnosed with infantile idiopathic scoliosis at 4 months old. The condition is rare and found mostly in males, according to the National Scoliosis Foundation. (Waterloo-Cedar Falls Courier)
How to Get Rid of Hand Eczema Mar 2, 2009
Managing Contact Dermatitis of the Hands. Contact dermatitis of the hands is a very disturbing problem for housewives and industrial workers. (Suite101.com)
PlayStation Skin Disease Feb 25, 2009
The doctors that examined her came to the conclusion that the girl has idiopathic eccrine hidradenitis, a skin disorder that causes sore lumps on the palms of the hands and feet, a condition thought linked to intense sweating. Doctors believe that tight and continuous grasping of the controller and repeated pushing of the buttons, combined with sweating brought on by tension is what caused the sores on the girl to manifest. (IGN Gear)
Game consoles 'cause skin sores' Feb 25, 2009
Doctors who examined her at the Geneva University Hospital concluded she had a condition known as 'idiopathic eccrine hidradenitis', a skin disorder that generally causes red, sore lumps on the palms of the hands and soles of the feet. The condition has been previously found on the soles of the feet in children taking part in heavy physical activity, such as jogging. (BBC News -- Technology)
Rhythm Abnormality Of Unknown Origin Strongly Predicts Sudden Death Risk In Heart Disease Patients Feb 12, 2009
11, 2009) Researchers conducting a large, ongoing study to improve detection and prevention of sudden cardiac death were surprised to discover that a specific heart rhythm abnormality idiopathic QT interval prolongation increased risk five-fold among patients with coronary artery disease. See also. (Science Daily)
Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Feb 7, 2009
ZUG, Switzerland, Feb. 6 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: ) today announced that the European Commission (EC) has granted marketing authorisation for Nplate(R) (romiplostim) for the treatment of splenectomised adult chronic immune (idiopathic) thrombocytopenic purpura (ITP) patients who are refractory to other treatments (e. g. corticosteroids, immunoglobulins). (PR Newswire)
Kids with Arthritis Benefit from Early Treatment Feb 7, 2009
So-called juvenile idiopathic arthritis, or JIA, strikes before the age of 16, causing pain, inflammation and cell damage in the lining of the joints. The disease may have a variety of symptoms and degree of severity. (MEDLINEplus)
Causes of Autoimmune Hemolytic Anem... Feb 7, 2009
I.G. Lentzas, P. Papagiannopoulos, I. Nikilaidis, and V. Garmiri, Idiopathic Autoimmune hemolytic anemia due to a lecithin overdose: a case report, Cases J. 2009, Jan; 21;2(1). C.D. Packer, T Hornick, S Augustine, Fatal hemolytic anemia associated with metformin: A case report, J Medicine Case Reports, Sept 2008;2:300. (Suite101.com)
'Nonsense' In Our Genes: One In 200 Human Genes Superfluous? Feb 7, 2009
Nonsense' In Our Genes: One In 200 Human Genes Superfluous. Nonsense' In Our Genes: One In 200 Human Genes Superfluous. (Science Daily)
Kids with Arthritis Often Disabled Feb 7, 2009
NEW YORK (Reuters Health) - Although many children with so-called juvenile idiopathic arthritis have a low level of disease, about one in five have moderate to severe disability, Italian researchers report. "These findings," Dr. Angelo Ravelli told Reuters Health, "underscore the critical need for treatments and treatment strategies that have the ability to better control disease activity.". (MEDLINEplus)
