Anti-tumor Effects Are Enhanced By Inhibiting Two Pathways Rather Than One Aug 26, 2008
Nearly a decade ago, while it was being tested as an immunosuppressive agent to. (June 26, 2008) New data, generated by David Ornitz and colleagues, at Washington University School of Medicine, St. Louis, have indicated a crucial role for signaling pathways that involve the protein sonic. (Science Daily)
Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity Jun 21, 2008
Rapamycin, an inhibitor of mammalian target of Rapamycin (mTOR), is an immunosuppressive agent that has anti-proliferative effects on some tumors. However, the role of Rapamycin-induced immune suppression on tumor progression has not been examined. (BioMed Central)
Pixantrone to be Studied in Phase I/II Trial for Aggressive Multiple Sclerosis Mar 6, 2008
The objectives of the study are to determine the efficacy of pixantrone as an immunosuppressive agent based on its ability to decrease the lymphocyte count and to evaluate efficacy in MS based on gadolinium enhanced magnetic resonance imaging. This trial is an open-label, multi-center, non-comparative study of pixantrone administered at a dose of 120 mg/m2 once every 21 days (3 weeks). (PR Newswire)
Weight-based Dosing Of Ribavirin Improves Outcomes For Patients With Hepatitis C Oct 26, 2007
6, 2006) Liver transplant patients with hepatitis C virus achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin. . (Science Daily)
Drug Effective In Treatment Of Heavy Psoriasis Patients Aug 5, 2007
Because RAPTIVA is an immunosuppressive agent, it has the potential to increase the risk of infection and cancer. The most common side effects of RAPTIVA include headache, chills, fever, nausea, and muscle aches. (Science Daily)
A newly identified immunosuppressive protein in rheumatoid arthritis Mar 28, 2007
This study affirms DcR3 as an immunosuppressive agent that actually protects destructive rheumatoid synovial cells against death. "We suggest that DcR3 expressed in RA FLS is increased by TNF, making it one of the pathologic factors that induces hyperplasia of rheumatoid synovium," states researcher and author, Dr. Yasushi Miura. (EurekAlert!)
Cancer Drug May Fight Scleroderma Lung Disease Jun 22, 2006
Fernando Martinez and W. Joseph McCune, from the University of Michigan Health System, wrote that cyclophosphamide is "arguably the most toxic immunosuppressive agent currently used to treat autoimmune diseases.". Still, Martinez said, there may be patients for which the benefits of the drug outweigh the risks. (Forbes)
Landmark Study Of Hepatitis C Virus Solves Mystery That Has Stymied Quest For Cure Feb 15, 2006
(January 6, 2006) -- Liver transplant patients with hepatitis C virus achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin. . (Science Daily)
Cyclosporine inhibits hepatitis C virus in vitro Jan 8, 2006
Liver transplant patients with hepatitis C virus (HCV) achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin combination therapy ... At the same time, of course, the patients must take immunosuppressive agents to guard against transplant rejection. (EurekAlert!)
