Single MicroRNA That Controls Blood Vessel Development Identified Aug 14, 2008
Third, they turned to the zebrafish system to investigate the in vivo function of miR-126 for three reasons. (1) It is a tractable system for perturbing microRNA levels and examining the consequences in a live organism. (Science Daily)
Widely Prescribed Anti-parasite Drug Targets Cancer-causing Protein Aug 13, 2008
Since submitting the article for publication, the authors have conducted additional pre-clinical studies of mebendazole in an in vivo model of chemotherapy-resistant melanoma and are now preparing a phase I clinical trial, expected to begin next year at NYU Cancer Institute. "While rational drug design remains a perfectly valid way to develop cancer therapies, we also need approaches that are less costly and more productive of new effective treatments," said lead author Seth J. Orlow, M.D. Ph. (Science Daily)
New gene technique 'stops HIV in its tracks' Aug 10, 2008
Priti Kumar, of Harvard Medical School, said: "No one has demonstrated before that HIV infection can be stopped in vivo, not just in cell lines, but in animals. It implies it might work in humans." Further animal studies, however, are needed before the approach can be used on humans in clinical trials. The discovery of RNA interference won a Nobel prize in 2006. (Independent)
MIR Preclinical Services Highlights Offerings At Fall 2008 Conferences Aug 8, 2008
As the in vivo imaging leader in the contract research industry, MIR continues to develop innovations to increase the efficiency of preclinical drug development ... The use of an array of preclinical in vivo imaging technologies in these models to measure response to therapy at anatomical, functional, and molecular levels will also be featured ... MIR's preclinical in vivo imaging technologies in these models will also be showcased. (Primezone Releases)
BELLUS Health moves forward on nutraceutical and pharmaceutical fronts - Reports Results for First Half of 2008 Aug 5, 2008
Leveraging the many years of accumulated knowledge and the experience it has gained in developing tramiprosate (ALZHEMED(TM)) for the treatment of AD, BELLUS Health is in the process of prioritizing and accelerating the development of a prodrug of tramiprosate (ALZHEMED(TM)), a new chemical entity (NCE), for the treatment of AD. A prodrug is a pharmaceutical substance which is administered in an inactive form and, once absorbed into the body, is metabolized in vivo into its active form (in this... (Canada Newswire)
Advanced Medical Isotope Corporation Delivers Initial Shipment of Short-Lived Radioisotopes to Kadlec Medical Center Aug 5, 2008
Advanced Medical Isotope Corporation is a medical isotope production company engaged in the production and distribution of medical isotopes and medical isotope in vivo delivery systems for advanced diagnostic and non-surgical therapeutic applications. AMIC's goal is to empower physicians, medical researchers, and ultimately patients by providing them with essential medical isotopes that, until now, have not been feasible or economical, in an effort to detect and cure human disease. (Primezone Releases)
Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods Aug 5, 2008
COLD SPRING HARBOR, N.Y. Combining the specificity of small interfering RNA (siRNA) silencing with the versatility of lentiviral vectors gives researchers a powerful tool for the investigation of gene function both in vivo and in vitro. This month's issue of Cold Spring Harbor Protocols () features a pair of protocols from Inder Verma () and colleagues at the Salk Institute describing this method for achieving long-term down-regulation of specific target genes in a wide range of cell types. (EurekAlert!)
In vivo analysis of Caenorhabditis elegans noncoding RNA promoter motifs Aug 5, 2008
Here we present an in vivo transcriptional analysis of three C. elegans ncRNA upstream motifs (UM1-3). Transcriptional activity of all three motifs has been demonstrated, and mutational analysis revealed differential contributions of different parts of each motif. (BioMed Central)
Advanced Medical Isotope Corporation Announces Intent to File Form 10 Aug 1, 2008
Advanced Medical Isotope Corporation (AMIC) is a medical isotope production company engaged in the production and distribution of medical isotopes and medical isotope in vivo delivery systems for advanced diagnostic and non-surgical therapeutic applications. AMIC's goal is to empower physicians, medical researchers, and ultimately patients by providing them with essential medial isotopes that, until now, have not been feasible or economical, in an effort to detect and cure human disease. (Primezone Releases)
Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's Jul 30, 2008
"Update on the relationship between in vivo amyloid imaging with 11C-PIB and CSF AB42." (Funders: : National Institute on Aging, Dana Foundation, Anonymous Foundation, Charles and Joanne Knight Alzheimer's Initiative) -- Harald Hampel. "Alteration of beta secretase (BACE1) functional candidate biomarkers in subjects with mild cognitive impairment and Alzheimer's disease." (Funders: Science Foundation Ireland, Federal Ministry of Education and Research (Germany), Alzheimer's Association) --... (PR Newswire)
Allon Therapeutics AL-108 Human Efficacy Data Presented to Two ICAD 2008 Scientific Workshops Jul 30, 2008
"These results suggest molecular and cellular specificity for NAP effects on microtubules. NAP interaction with microtubules is translated in vivo to decreased tau pathology, increased neuroprotection and enhanced cognitive function," said Prof. Gozes. (CCNMatthews Press Releases)
Plant-like substitutions in the large-subunit carboxy terminus of Chlamydomonas Rubisco increase CO2/O2 specificity Jul 30, 2008
The mutant substitutions do not influence protein stability in vivo or in vitro. Conclusions. (BioMed Central)
Target-seeking Antibodies For Cancer Therapy Jul 27, 2008
sli C., Borsi L. and Neri D. A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently target tumor neo-vasculature in vivo. Int J Cancer, Jun 1;122(11):2405-13 DOI. (Science Daily)
Parasitic Worm Infections Increase Susceptibility To AIDS Viruses Jul 25, 2008
The study represents a novel in vivo demonstration that parasitic worms increase a host's susceptibility to becoming infected with an AIDS-causing virus. The macaques co-infected with Schistosoma mansoni also demonstrated higher peak viral loads and higher memory cell concentrations of virus, both predictors of more rapid progression to AIDS. These findings are consistent with the hypothesis that persons living in areas highly endemic for parasitic worms may also have a higher risk of acquiring... (Science Daily)
Glia Guide Brain Development In Worms Jul 25, 2008
So now we can study glia and the contributions they make in the developing brain in this in vivo context. In the 1990s, glia took on a new level of importance as researchers found that most brain tumors and many neurodegenerative diseases, such as Alzheimer s Disease, may arise from these cells, suggesting the possibility that glia are more than mere support cells that cater to the needs of neurons, that in fact a more dynamic dialogue between glia and neurons takes place. (Science Daily)
UC Santa Barbara chemist goes nano with CoQ10 Jul 25, 2008
At some point in our evolution, the water-soluble antioxidant vitamin C was produced in vivo, or what would technically be "coenzyme C." Eventually, "a mutation took place that now prevents humans from making it," he said. "However, evolution chose not to mutate out CoQ10.". (EurekAlert!)
Cancer Drug Resistance: Enzyme Expression Levels Correlated With Chemotherapy Drug Response Jul 23, 2008
Along with the finding that Top1 knockdown hypersensitized cells for doxorubicin treatment, this result suggested to the CSHL researchers that "alterations in topoisomerase expression levels represent one of undoubtedly many therapy resistance mechanisms which can play a substantial role in chemotherapy response in vivo." ... Burgess et al. Topoisomerase levels determine chemotherapy response in vitro and in vivo. (Science Daily)
CSHL scientists correlate enzyme expression levels with chemotherapy drug response Jul 19, 2008
Along with the finding that Top1 knockdown hypersensitized cells for doxorubicin treatment, this result suggested to the CSHL researchers that "alterations in topoisomerase expression levels represent one of undoubtedly many therapy resistance mechanisms which can play a substantial role in chemotherapy response in vivo." ... "Topoisomerase levels determine chemotherapy response in vitro and in vivo" appeared in Proceedings of the National Academy of Sciences on July 1, 2008. (EurekAlert!)
From Foe To Friend: Researchers Use Salmonella As A Way To Administer Vaccines In The Body Jul 13, 2008
"Our goal is to design, engineer and evaluate a live bacterial (using salmonella) antigen delivery system that would display regulated delayed lysis in vivo after invasion into and colonizing internal lymphoid tissues in an immunized individual," said Roy Curtiss, director of the Center for Infectious Diseases and Vaccinology at the Biodesign Institute and a professor in ASU's School of Life Sciences ... "We wanted to do this in a way so that no disease symptoms due to salmonella would arise, a... (Science Daily)
News tips from the Journal of Neuroscience Jul 8, 2008
Preventing Programmed Cell Death In Vivo Christopher K. Thompson and Eliot A. Brenowitz. The size of song nuclei in some songbirds varies with seasonal changes in androgen levels, growing during the reproductive season and then shrinking via neurodegeneration. (EurekAlert!)
Hana Biosciences Presents Alocrest and Menadione Data At the European Society for Medical Oncology Conference Jul 7, 2008
Researchers, led by Dr. Perez-Soler, conducted preclinical studies of menadione to better understand the potential interaction between topical menadione and systemically delivered erlotinib (Tarceva(r)), an approved EGFRI. Analysis from tests conducted in an in vivo model demonstrated that topical menadione did not affect the anti-tumor effect of erlotinib. In vitro studies were also conducted to investigate menadione's ability to restore kinase activity in the presence of specific kinase... (Primezone Releases)
Researchers Coat Titanium With Polymer To Improve Integration Of Joint Replacements Jul 6, 2008
To evaluate the in vivo performance of the coated titanium in bone healing, chemists Raynor and Collard coated the surfaces of tiny clinical-grade titanium cylinders with the polymer brushes. Then engineers Petrie and Garc;a modified them with peptide sequences. (Science Daily)
New model for tmRNA function Jul 5, 2008
An immunoblot assay for translation of the tmRNA tag revealed that certain mutations in U85, A86, and the -1 triplet sequence result in improper selection of the first codon and translation in the wrong frame (-1 or +1) in vivo. Conclusions. (BioMed Central)
Lorus Therapeutics Announces Publication of a Clinical Study Demonstrating Encouraging Results with LOR-2040 in Combination with Cytarabine in Patients with Acute Myeloid Leukemia (AML) Jul 2, 2008
Through downregulation of R2, LOR-2040 has demonstrated strong antitumor and antimetastatic activity in a variety of tumor types in both in vivo and in vitro models and is under study in a multiple Phase I/II clinical program. R2 has been described as a malignant determinant that is elevated in a wide range of tumors, which can cooperate with a variety of cellular cancer causing genes known as oncogenes to enhance tumor growth and metastatic potential. (Canada Newswire)
New paper offers insights into 'blinking' phenomena Jul 2, 2008
"Fluorescent molecules could be of fundamental importance in imaging biological systems and monitoring dynamic processes in vivo," Jank said. "One of the most attractive types of flourophores today are semiconductor nanocrystal quantum dots (NQD). Their small size, brightness, photostability and highly tunable fluorescent color make them vastly superior to organic dyes.". (EurekAlert!)
Adult Stem Cells Reprogrammed In Brain Jul 1, 2008
"When we grow stem cells in the lab, we add lots of growth factors resulting in artificial conditions, which might not tell us a lot about the in vivo situation," explains first author Sebastian Jessberger, M.D., formerly a post-doctoral researcher in Gage's lab and now an assistant professor at the Institute of Cell Biology at the Swiss Federal Institute of Technology in Zurich. "As a result we don't know much about the actual plasticity of neural stem cells within their adult brain niche.". (Science Daily)
Cells Have An Appetite For Micro-doughnuts Jun 25, 2008
The high cell specificity these doughnuts showed led the team to conduct extensive in vivo testing in rats ... Lois Alexander et al. Dunking doughnuts into cells selective cellular translocation and in vivo analysis of polymeric micro-doughnuts. (Science Daily)
Lyme Disease Spirochetes Tracked in 3D Jun 25, 2008
This use of high-resolution, 3D imaging to visualize the dissemination of a bacterial pathogen in vivo lays the groundwork for a better understanding of the mechanisms by which these and other bacteria disseminate throughout the body to cause disease. Journal reference. (Science Daily)
Idle computer time can help contribute to global cancer fight Jun 25, 2008
"We have launched a global effort to recreate the in vivo (live) environment of cancer cells in a computer model. This allows us to perform virtual experiments and study processes that are too costly or technically very difficult to study. By recreating this whole 'system of processes inside a cancer cell' we will be in a position to fully comprehend the problem and hopefully identify targets that will one day translate into anti-cancer drugs," said Zaman. According to him, only a background... (Sify)
Neuroscientists Show Insulin Receptor Signaling Regulates Structure Of Brain Circuits Jun 24, 2008
CHIU et al. Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo. Neuron, 2008; 58 (5): 708 DOI. (Science Daily)
MIR Preclinical Services Offers Preclinical Models of Collagen Antibody Induced Arthritis Jun 24, 2008
June 24, 2008 (PRIME NEWSWIRE) -- MIR Preclinical Services (MIR) has added a preclinical model of Collagen Antibody Induced Arthritis (CAIA) to its list of in vivo service offerings ... The company is unique in its ability to apply non-invasive in vivo imaging modalities including preclinical MRI, X-ray micro-CT, high resolution preclinical PET, and bioluminescence and fluorescence imaging to visualize biological processes such as signal transduction, apoptosis, angiogenesis, bone deformation,... (Primezone Releases)
Lorus Therapeutics announces that the European Medicines Agency (EMEA) has granted the orphan drug designation to LOR-2040 for the treatment of Acute Myeloid Leukemia (AML) Jun 23, 2008
Through downregulation of R2, LOR-2040 has demonstrated strong antitumor and antimetastatic activity in a variety of tumor types in both in vivo and in vitro models and is under study in a multiple Phase II clinical program. The present Phase II study was based on a completed Phase I and pharmacodynamic study in a similar AML population which demonstrated a correlation of favourable complete response frequency with R2 downregulation. (Canada Newswire)
New paradigm for cell-specific gene delivery Jun 23, 2008
It can be highly cell-specific, mimic or restore normal in vivo function, and can be permanent or transient depending on vector design. Currently, a number of gene delivery systems for use on the arterial wall are being studied, but as yet their low efficiency in gene transfer and lack of cell-specific targeting and expression are major limitations. (EurekAlert!)
Promising Chinese Herbal Targets Identified For Acute Pancreatitis Jun 22, 2008
This is pivotal research in exploring the pathogenesis of acute pancreatitis and the treatment mechanism of Chinese herbal compounds, using an excellent study design, including random grouping of rats, an acute pancreatitis model induced by intraperitoneal injection of caerulein, oral administration with Chaiqinchengqi decoction in vivo, pathological observation and scoring of pancreatic tissues by the agreement of pathologists, detection of SERCA1 and SERCA2 mRNA expression in pancreatic tissue... (Science Daily)
Researchers Witness Assembly Of Molecules Critical To Protein Function Jun 21, 2008
ScienceDaily (June 20, 2008) A Virginia Tech research group lead by two biochemistry graduate students has isolated proteins responsible for the iron-sulfur cluster assembly process and witnessed the necessary protein interactions in vivo -- within a cell ... Now Dean's students, Raulfs and O'Carroll, are the first to witness the assembly process in vivo -- within a cell ... "A vinelandii grows quickly and keeps the interior of the cell free of oxygen, which is important, since oxygen can... (Science Daily)
Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity Jun 21, 2008
Rapamycin has a direct anti-tumor effect on Wnt-1 breast cancer in vivo that involves inhibition of the mTOR pathway at doses that also suppress host immune responses. The complete article is available as a. (BioMed Central)
Gesture Computer Interface Device Developed For Surgeons Jun 20, 2008
The new article reports on what the authors believe is the first time a hand gesture recognition system was successfully implemented in an actual "in vivo" neurosurgical brain biopsy. It was tested at the Washington Hospital Center in Washington, D.C.. (Science Daily)
Ambrilia Validates its Targeted Delivery Technology for Cancer in Vivo Jun 19, 2008
MONTREAL, QUEBEC--(Marketwire - June 19, 2008) - Ambrilia Biopharma Inc. (TSX: - ) today reported that it demonstrated and validated the in vivo proof-of-concept with its NGR-delivery technology applied to a carrier containing a siRNA (small interfering RNA) ... "This validation represents another significant step forward in our strategy execution for our NGR-directed delivery technology. This latest in vivo proof-of-concept completes our investigation process ahead of schedule. It demonstrates... (CCNMatthews Press Releases)
Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins Jun 19, 2008
Using expression studies, two novel Jmjd6 splice variants were identified and validated in vivo. Analysis of the Jmjd6 neighbouring gene 1110005A03Rik revealed an incident deletion of this gene in two out of three earlier reported Jmjd6 knockout mice, which might affect previously described conflicting phenotypes. (BioMed Central)
Cytopia To Present Data on FMS Program With Anticancer Potential Jun 18, 2008
Preliminary data on the potential of Cytopia's potent FMS inhibitors to treat advanced cancer in in vivo models will also be presented at this conference. Cytopia CEO Mr Andrew Macdonald said, "We are very encouraged by the excellent preclinical profile of these compounds. This first public disclosure of our work raises the profile of this program to the broader scientific community and reflects the excellent science undertaken by the team." This presentation is in the same month that Cytopia... (PR Newswire)
Ability To Track Stem Cells In Tumors Could Advance Cancer Treatments Jun 18, 2008
and lead researcher of the study, Trafficking the Fate of Mesenchymal Stem Cells In Vivo ... "Trafficking the Fate of Mesenchymal Stem Cells In Vivo," SNM's 55th Annual Meeting, June 14-18, 2008. (Science Daily)
The APCs of nerve cell function Jun 17, 2008
In a new study published in the June 2008 issue of Molecular and Cellular Neuroscience, researchers at Tufts University School of Medicine (TUSM), uncover mechanisms that direct cholinergic synapse assembly between neurons in vivo ... "We study an in vivo model system to gain insights into mechanisms that likely direct synapse assembly and function in the human nervous system," Jacob explains ... "Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal... (EurekAlert!)
Primary Tumors Can Drive The Growth Of Distant Cancers Jun 14, 2008
"Indeed, to our knowledge, methods to expedite the growth of human tumor surgical specimens in vivo have not been previously described. These results suggest that the presently described procedure can be used to study aspects of human tumor biology that would otherwise be difficult if not impossible to study. " In the longer term, identification of additional tumor-derived factors that perturb the host systemic environment in one way or another may allow one to predict the effects that a given... (Science Daily)
Primary Tumors Fuel Growth of Cancer Cells Jun 14, 2008
"Indeed, to our knowledge, methods to expedite the growth of human tumor surgical specimens in vivo have not been previously described. These results suggest that the presently described procedure can be used to study aspects of human tumor biology that would otherwise be difficult if not impossible to study.". HealthDay. (MEDLINEplus)
Wealth of genomic hotspots discovered in embryonic stem cells Jun 14, 2008
The researchers performed genome-wide mapping of the in vivo binding sites for 13 sequence-specific transcription factors in ES cells. These transcription factors play different roles in self-renewal, pluripotency, reprogramming and chromatin insulation. (EurekAlert!)
Pinning Down A Cause Of Disease In A Model Of Psoriasis Jun 10, 2008
This was also important for their inability to control disease in vivo, as transplantation of normal Tregs into Cd18hypo mice resulted in a substantial improvement in the psoriasis-like disease, whereas if these cells were transplanted in the presence of antibodies that neutralized TGF-beta there was no improvement in disease. The authors therefore conclude that psoriasis-like disease in Cd18hypo mice is caused mainly by a defect in Treg function and suggest that maintaining CD18 levels is... (Science Daily)
XOMA 052 Demonstrates Anti-Inflammatory Effect in Arthritis Animal Studies; Data Presented At FOCIS Jun 8, 2008
XOMA 052 neutralizes mouse and human IL-1 beta in vivo and in vitro; * XOMA 052 protects against the onset of collagen-induced arthritis; * XOMA 052 protects against the effects of collagen-induced arthritis after disease onset; * XOMA 052 reduces bone and cartilage destruction pathology. In 2008, XOMA plans to initiate clinical studies of XOMA 052 in rheumatoid arthritis, acute gout, and systemic juvenile idiopathic arthritis (sJIA). (Primezone Releases)
Another new wrinkle in treating skin aging Jun 6, 2008
From the article: "Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo.". Article link. (EurekAlert!)
Interface Biologics Inc. achieves reductions in platelet adhesion similar to heparin coated devices with use of non drug surface additive Jun 5, 2008
In Vivo sheep studies performed at MDEC tested for catheter patency between a control and an Endexo(TM) treated catheter ... "Both the in vitro and in vivo results show that Endexo(TM) additives perform to the standard set by Heparin coated devices, and will provide better patient outcomes in light of the recent adverse events and recalls. In addition, our pre-extrusion additive yields a simple and more cost effective manufacturing process. This provides a "win win" for medical device... (Canada Newswire)
CSHL scientists trace causal link between a tumor suppressor gene and liver cancer Jun 4, 2008
Short-hairpin RNAs (shRNAs) were designed to "knock down" DLC1 expression in vivo. When the DLC1 shRNAs are introduced into normal mouse liver cells, the production of DLC1 protein is blocked, or 'silenced. (EurekAlert!)
Over-expression of Adenine Nucleotide Translocase 1 (ANT1) induces apoptosis and tumor regression in vivo. Jun 4, 2008
Over-expression of Adenine Nucleotide Translocase 1 (ANT1) induces apoptosis and tumor regression in vivo ... Moreover, ANT1 transfection significantly suppressed tumor growth in vivo. (BioMed Central)
Computers: They're alive! Jun 3, 2008
The unique in vivo system takes advantage of the remarkable storage capacity of DNA and the efficiency of molecular self-assembly, Haynes said. DNA replication and bacterial cell division can quickly create millions or even billions of parallel processors. (MSNBC -- Technology)
Metformin increases pathologic complete response rates in breast cancer patients with diabetes Jun 3, 2008
"We need to study the mechanism of the drug - perhaps it's the decrease in insulin levels, or it may be that the drug has an anti-tumor effect that we to look at in vivo," said Gonzalez-Angulo. "Our next step is to conduct a number correlative studies to try and further understand its mechanism.". (EurekAlert!)
New Cancer Stem Cell Driving Metastatic Tumors Identified May 29, 2008
To understand the biology of CD133+ cells in a healthy state and during tumor formation the researchers generated a transgenic mouse in which the CD133 gene is replaced with a reporter gene called lacZ. "We relied on the expression of lacZ to detect the spatial and temporal location of CD133+ cells in vivo," explains co-researcher Andrea T. Hooper, a graduate student in Dr. Rafii's lab. Studying the expression of CD133 in this genetic model, the researchers, for the first time, were able to... (Science Daily)
Bone Repair Using Patient's Stem Cells Comes Closer May 29, 2008
Activating the PKA enzyme prior to implantation, however, produces a dramatic improvement in in vivo bone growth ... cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo ... (May 17, 2008) Researchers have successfully creating bone tissue "in vivo", using embryonic stem cells. (Science Daily)
Origin Of Cells For Connective Tissues Of Skull And Face Challenged May 28, 2008
(May 17, 2008) Researchers have successfully creating bone tissue "in vivo", using embryonic stem cells. They imitated bone formation in embryos and children, which uses cartilage as a template. (Science Daily)
Plant Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In The Brain May 24, 2008
To see if luteolin might have a similar effect in vivo, the researchers gave mice luteolin-laced drinking water for 21 days before injecting the mice with LPS.. Those mice that were fed luteolin had significantly lower levels of IL-6 in their blood plasma four hours after injection with the LPS. Luteolin also decreased LPS-induced transcription of IL-6 in the hippocampus, a brain region that is critical to spatial learning and memory. (Science Daily)
Blood-clotting Protein Modified For People With Hard-to-treat Hemophilia May 22, 2008
ScienceDaily (May 21, 2008) Pathologists at The University of Texas Health Science Center at Houston have developed a chemically modified protein that may help people with a hard-to-treat form of a genetic bleeding disorder known as Hemophilia A.. With a shortage of the blood-clotting protein Factor VIII (FVIII), people with Hemophilia A typically receive injections of FVIII derived from plasma or produced synthetically to control potentially life-threatening episodes of bleeding. (Science Daily)
Targeting A Pathological Area Using MRI May 22, 2008
Understanding the mechanism of these new molecules for medical imaging constitutes a major advance in visualizing molecular processes in vivo, as well as in detecting pathologies. Journal reference. (Science Daily)
Could Common Pain Killers Have A Role In Cancer Prevention? May 21, 2008
Urso modifies bile salt composition and possesses chemoprevention potential in vivo. Researchers are trying to find the explanation for the rapid rise in this type of esophageal cancer. (Science Daily)
World First Discovery: Genes From Extinct Tasmanian Tiger Function In A Mouse May 21, 2008
Pask AJ, Behringer RR, Renfree MB (2008) Resurrection of DNA Function In Vivo from an Extinct Genome. PLoS One 3(5): e2240. (Science Daily)
Pioneering Induction Of Bone Formation Using Embryonic Stem Cells May 18, 2008
ScienceDaily (May 17, 2008) Researchers at the University of Twente break new ground by successfully creating bone tissue in vivo , using embryonic stem cells. They imitated bone formation in embryos and children, which uses cartilage as a template. (Science Daily)
Arpida Announces FDA Acceptance of the Iclaprim New Drug Application May 16, 2008
An additional compound, AR-2474, has achieved in vivo proof of concept. AR-2474 has been shown to be effective in eradicating pathogens in preclinical models of skin infection and nasal carriage. (PR Newswire)
Spotlight On A Key Player In The Dance Of Chromosomes May 16, 2008
In vivo studies are hampered by the presence of lots of other proteins, making it hard to study how much a single protein moves, how fast it moves and how much force it produces, said Hasan Yardimci, a post doctoral researcher in Selvin's lab and lead author on the study ... Now we need to do it in vivo, on chromosomes. (Science Daily)
Chemistry Of Airborne Particulate: Lung Interactions Revealed May 16, 2008
He intends to continue the study in vivo. "Our tissues, except the stomach, were designed to function at about pH 7," Colussi notes. (Science Daily)
