Using RNAi-based Technique, Scientists Find New Tumor Suppressor Genes In Lymphoma Oct 15, 2009
Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model. Cancer Cell, 2009; 16 (4): 324 DOI. (Science Daily)
Bioluminescence Imaging Used For Eye Cancer Detection Oct 15, 2009
BLI has several advantages over biopsy analysis, including in vivo monitoring, higher sensitivity, easier use and an overall more accurate correlation between cell numbers detected and tumor growth ... "BLI allowed sensitive and quantitative localization and monitoring of intraocular and metastatic tumor growth in vivo and thus might be a useful tool to study cancer biology as well as anti-cancer therapies," said Huang. (Science Daily)
Novel Drug Screening Method: Informative Swellings Oct 12, 2009
11, 2009) A screening method for bioactive small molecules to treat vascular diseases and an in vivo functional test in a whole animal at the same time: ETH Zurich researchers at the Institute of Pharmaceutical Sciences achieved this feat with the aid of the frog Xenopus ... In this respect, the fact that there are substances that influence the lymph system specifically is particularly interesting because there had hitherto been no convenient in vivo test system for this vessel type ... ndli is... (Science Daily)
Hyper-SAGE boosts remote MRI sensitivity Oct 10, 2009
"It is absolutely amazing because we're looking at pure gas and can reconstruct the whole image of our target. With this degree of sensitivity, Hyper-SAGE becomes a highly promising tool for in vivo diagnostics and molecular imaging.". MRI is a painless and radiation-free means of obtaining high quality three-dimensional tomographical images of internal tissue and organs. (EurekAlert!)
New Approach For Growing Bone To Fight Osteoporosis And Other Diseases Oct 9, 2009
"With this in vivo study, we have reached the next level of specificity. With what we have learned, we may begin to create the keys to unlock targeted groups of receptors with this higher level of specificity.". With this refinement, the researchers also may achieve the control needed to avoid certain drug side effects, Lefkowitz said. (Science Daily)
Gene That Regulates Breast Cancer Metastasis Identified Oct 8, 2009
To examine the effect of Id1 upregulation in tumor metastasis in vivo, the team generated tagged mouse and human cell lines expressing mouse or human Id1, respectively. Following transplantation back into the mice, lung metastasis developed from Id1-upregulated cells but not in controls, demonstrating that Id1 expression promotes tumor metastasis in vivo. (Science Daily)
Body's Circadian Rhythm Tightly Entwined With Blood Sugar Control Oct 7, 2009
The new findings give the first in vivo evidence of a direct link between glucocorticoid hormones and genes that regulate our biological clock. The research may eventually help doctors reduce disabling side effects of glucocorticoid drugs such as prednisone, Feldman said. (Science Daily)
Breakthrough: Bone Graft Grown in Exact Shape of Complex Skull-Jaw Joint Oct 6, 2009
The pattern and rate of this perfusion guides how the bone structure grows, just as blood does in vivo, and the physical stimulation of the cells provided by this flow is critical for proper growth. 1. (Scientific American)
New Mathematical Model Suggests How The Brain Might Stay In Balance Oct 5, 2009
(May 29, 2007) For the first time ever, a researcher has succeeded in observing in vivo the generation of neurons in the brain of a mammal. The scientists used mouse models to study how neurons, or nerve cells. (Science Daily)
Cholesterol Necessary For Brain Development, Study Finds Oct 5, 2009
Liver X Receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell, 2 October 2009. (Science Daily)
Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy. Oct 3, 2009
Regarding genetic events involved in melanoma pathogenesis at somatic level, mutually-exclusive mutations of NRAS and BRAF genes were observed at quite same rate (about two thirds) in cultured and in vivo melanomas (either primary or metastatic lesions). Conversely, p16CDKN2A gene alterations were observed at increased rates moving from primary to metastatic melanomas and melanoma cell lines. (BioMed Central)
Malignant Tumor Cells Seen In Real Time Oct 2, 2009
fer et al. In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry. Angewandte Chemie International Edition, 2009; NA DOI. (Science Daily)
Molecular Imaging Holds Promise For Early Intervention In Common Uterine Cancer Oct 2, 2009
"The article in the JNM from Dr. Tsujikawa and colleagues provides an example of the unique capacity of molecular imaging to measure in vivo cancer biology," says David A. Mankoff, M.D., Ph. D., professor of radiology, medicine and bioengineering at the University of Washington and Seattle Cancer Care Alliance in Seattle. (Science Daily)
Better Brain Implants Using Polymer Nanotubes Sep 30, 2009
They also found that based on in vivo impedance data, PEDOT nanotubes might be used as a novel method for biosensing to indicate the transition between acute and chronic responses in brain tissue. The results are featured in the cover article of the Oct. 5 issue of the journal Advanced Materials. (Science Daily)
Sleep Loss Linked To Increase In Alzheimer's Plaques Sep 26, 2009
Holtzman's laboratory uses a technique called in vivo microdialysis to monitor levels of amyloid beta in the brains of mice genetically engineered as a model of Alzheimer's disease. Amyloid beta is a protein fragment that is the principal component of Alzheimer's plaques. (Science Daily)
New type of sirolimus-eluting stent demonstrates superior results Sep 22, 2009
In this clinical trial, detailed arterial responses to the new DES technology were also investigated in vivo using intravascular ultrasound (IVUS). With IVUS, a tiny catheter is inserted into a coronary vessel where high-frequency sound waves reflect off tissue or vessel walls. (EurekAlert!)
Binge Drinkers Let Down Guard Against Infection Sep 19, 2009
Stephen Pruett, currently at the College of Veterinary Medicine at Mississippi State University, and Ruping Fan of Louisiana State University Health Sciences Center, set out to compare the in vivo and in vitro effects of alcohol on cytokines and TLR4, using a mouse model ... The in vivo and in vitro results were similar, although using the mouse model the authors were able to pick up more detail on alcohol's inhibitory effect on NF- B, a protein complex that controls DNA transcription and which... (Science Daily)
NexBio(R) Presents DAS181 (Fludase(R)*) Potently Inhibits Novel Swine-Origin A(H1N1) and NAI-Resistant Influenza Viruses, at ICAAC 2009 Sep 14, 2009
Previously announced preclinical studies conducted in collaboration with the CDC and others have shown DAS181 to have significant therapeutic and prophylactic activity in in vivo animal models and in human ex vivo lung tissue for a highly virulent H5N1 (A/VN/1203/04) strain of influenza. A "Late Breaker" presentation, entitled "Novel Swine-Origin A (H1N1) Influenza Viruses are Potently Inhibited by DAS181, a Sialidase Fusion Protein" examined in vitro, ex vivo, and in vivo models to evaluate the... (PR Newswire)
Model Backs Green Tea And Lemon Claim, Lessens Need To Test Animals Sep 11, 2009
The results of the in vivo study compared well with those predicted by the in vitro model ... It will not be exact in terms of measurements, but when compared to the in vivo test in rats, the model's predictions matched directionally to the in vivo study and were relatively close proportionately ... The in vivo study backed up the model study that showed adding sugar and vitamin C to green tea enhanced the body's ability to absorb polyphenols. (Science Daily)
arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work Sep 10, 2009
arGEN-X's SIMPLE Antibodies(TM) are generated in vivo, starting from active immunization, and exhibit ultra high starting affinities and potencies without the need for further engineering ... The platform allows arGEN-X to create an unparalleled diversity of in vivo generated antibody leads against a broad range of human disease targets. (PR Newswire)
ZifBASE: a database of zinc finger proteins and associated resources Sep 9, 2009
There is a need to develop a computational resource of zinc finger proteins (ZFP) to identify the potential binding sites and its location, which reduce the time of in vivo task, and overcome the difficulties in selecting the specific type of zinc finger protein and the target site in the DNA sequence. Description: ZifBASE provides an extensive collection of various natural and engineered ZFP. It uses standard names and a genetic and structural classification scheme to present data retrieved... (BioMed Central)
Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma Sep 6, 2009
Moreover, in vivo, the proliferation of the tumor cells was evaluated in xenotransplant nude mice model with whole-body visualizing instrument ... In vivo, the average weight (p=0. (BioMed Central)
Prodrug Could Help Curb Skin Toxicity Related To EGFR-inhibiting Cancer Drugs Sep 4, 2009
"This work provides proof-of-principle evidence that the concept is feasible, and sets the stage for future studies using tumors grown in vivo," Dr. Rodeck said. This study was led by Dr. Rodeck and John C. Williams, Ph. (Science Daily)
A Breath Of Fresh Air Could Improve Drug Toxicity Screening Sep 3, 2009
Since one of the key stresses involved in moving cells from an in vivo environment into culture is a tenfold drop in oxygen levels, the researchers theorized that a high-oxygen, serum-free culture environment might be the answer. Their experiments first confirmed that serum interferes with the metabolism of cultured rat and human liver cells. (Science Daily)
Getting better visualization of joint cartilage through cationic CT contrast agents Sep 2, 2009
And while the data presented a compelling case for continued development of cationic CT contrast agents, the research team cautioned that the suitability for in vivo applications remains to be determined, adding that toxicity levels and radiation dosage will be the focus of future studies. "However, the ability to characterize ex vivo cartilage samples is clearly evident," the study concludes. (EurekAlert!)
Mouse Brain Rewires Its Neural Circuits To Recuperate From Damaged Neural Function After Stroke Sep 1, 2009
The research group, led by Professor Junichi Nabekura of the National Institute for Physiological Sciences, investigated how neural circuits rearrange themselves after cerebral strokes by using two-photon laser microscopy in vivo. In one to two weeks after strokes in the right side of the moue brain, the left side of the brain rearranged its neural circuits actively. (Science Daily)
Silk-based optical waveguides meet biomedical needs Sep 1, 2009
--There is a growing need for biocompatible photonic components for biomedical applications from in vivo glucose monitoring to detecting harmful viruses or the telltale markers of Alzheimer's. Optical waveguides are of particular interest because of their ability to manipulate and transport light in a controlled manner in a variety of configurations. (EurekAlert!)
Gene signal GS-101 data shows safe and effective inhibition of ophthalmic blood vessel growth Sep 1, 2009
"The publication of these positive phase II results for GS-101 is a major milestone for Gene Signal. As a novel approach to the management of ophthalmic angiogenesis, we are keen to provide rigorous scientific backup to support our ongoing clinical development program. We also recently published data in the Journal of Pharmacology and Experimental Therapeutics confirming that GS-101 prevents in vivo expression of IRS-1, a protein associated with new blood vessel formation (angiogenesis), and we... (EurekAlert!)
Cellular Crosstalk Linked To Lung Disease Sep 1, 2009
The team, led by Edward Morrisey and Ethan David Cohen, used numerous in vivo gain- and loss-of-function approaches to demonstrate that a Wnt7b/Tnc/Pdgfr crosstalk pathway was important for mouse smooth muscle development, with Wnt7b being exclusively expressed by lung epithelial cells and Pdgfr being expressed by the developing airway smooth muscle cells. Importantly, expression of the components of this crosstalk pathway was upregulated in a mouse model of asthma and humans with pulmonary... (Science Daily)
'Hedgehog' Pathway May Hold Key To Anti-cancer Therapy Aug 28, 2009
Using a new in vivo assay to test the participation of cancer stem cells in a growing tumour, the research team demonstrated the essential role of this pathway for the maintenance and survival of cancer stem cells. "This work firmly establishes the critical action of HH-GLI in human colon cancer cells, providing the platform for preclinical and future clinical work." concluded Ruiz i Altaba. (Science Daily)
Stemedica Selected by World Stem Cell Summit to Present Scientific Discoveries Aug 27, 2009
Stemedica's technology allows neural precursors to be distinguished at various stages of their maturation, providing timely and cost effective verification of neural stem cell potency in vivo. "The currently used process for assessing the in vivo potency of neural stem cells in newborn mice is extremely time consuming and expensive. This traditional process also involves the use and sacrifice of animals in facilities separate from manufacturing. Stemedica's discovery and patent pending... (PR Newswire)
Blood-flow Metabolism Mismatch Predicts Pancreatic Tumor Aggressiveness Aug 27, 2009
As researchers begin to use new methods, such as PET imaging to explore in vivo biology, they may uncover factors that point towards behavior that is more aggressive and suggests new avenues for treatment, therefore leading to better patient outcome. For example, Mankoff said that the findings identified by Komar and colleagues may lead researchers to study the role that tumor tissue oxygenation and hypoxia play in mediating tumor clinical behavior and responsiveness to systemic therapy. (Science Daily)
Cancer's Break-in Tools Possibly Identified: Nematode Worm Provides Model Of Invasive Cancer Aug 26, 2009
"In vivo, you're dealing with individual cancer cells moving around the body. It is very hard to watch that,." Sherwood said. "And then asking the cancer cell 'what genes are you using to do that?' is even more difficult.". (Science Daily)
Improvement of liver stem cell engraftment by protein delivery Aug 25, 2009
As the activating signal induced by TAT-Tpr-Met comes from inside the cells, it is independent of the extracellular environment, and continues even if cells are placed in vivo. This property was used to transplant cells with an advantage that allows cells pretreated with TAT-Tpr-Met to engraft twice more than untreated cells. (EurekAlert!)
Friendly Gut Bacteria Lend A Hand To Fight Infection, Study Suggests Aug 24, 2009
"This seems to be the first example of indirect pathogen recognition in vivo where activation of the immune system depends on indirect rather than direct sensing of a pathogen," Dr. Yarovinsky said. The problem, Dr. Yarovinsky said, is that TLR-11 appears to cause more harm than good. (Science Daily)
Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis Aug 18, 2009
The results obtained from these studies identify amino acid residues and regions within the Cdc1 protein that are essential for interaction with Pol3 and Cdc27 and for in vivo function ... In the absence of a three-dimensional structure of the entire Pol delta complex, the results of this study highlight regions in Cdc1 that are vital for protein function in vivo and provide valuable clues to possible protein-protein interaction surfaces on the Cdc1 protein that will be important targets for... (BioMed Central)
Phospholipid and connexin association Aug 17, 2009
Additionally, the data suggest that the likely in vivo phospholipid modulators of connexin channel structure-function that are connexin isoform-specific are found in the cytoplasmic leaflet. A modulatory role for phospholipids that promote negative curvature is also inferred. (BioMed Central)
Bone From Blood: Circulating Cells Form Bone Outside The Normal Skeleton Aug 13, 2009
Circulating osteogenic precursor (COP) cells form bone in vivo. COP cells were transplanted into nude mice with histological sections revealing hard tissue containing osteoctyes and bone-lining cells (boxed area) eight weeks later. (Science Daily)
Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation Aug 8, 2009
This was further explored by blocking complement activation by in vivo administration of CD55 (decay accelerating factor for complement). Results. (BioMed Central)
Transcription control in oocytes Aug 5, 2009
Using an altered binding specificity mutant reporter system we show that TBP2 promotes RNA polymerase II transcription in vivo. Intriguingly, TBP, which in oocytes is undetectable at the protein level, can functionally replace TBP2 when ectopically expressed in oocytes, showing that switching of initiation factors can be driven by changes in their expression. (BioMed Central)
Brain Difference In Psychopaths Identified Aug 5, 2009
The team from King's used an imaging method called in vivo diffusion tensor magnetic resonance imaging (DT-MRI) tractography to analyse the UF in psychopaths. They found a significant reduction in the integrity of the small particles that make up the structure of the UF of psychopaths, compared to control groups of people with the same age and IQ. Also, the degree of abnormality was significantly related to the degree of psychopathy. (Science Daily)
Scientists Track Impact Of DNA Damage In The Developing Brain Jul 30, 2009
"The cells appear to undergo permanent arrest," said McKinnon, noting it is one of the few in vivo examples of the p53 pathway leading to cell cycle arrest rather than apoptosis. In the hippocampus, which plays a role in memory and emotion, investigators reported abnormal gene expression and neuronal function. (Science Daily)
Male germ cells can be directly converted into other cell types Jul 29, 2009
When combined with skin mesenchyme and grown in vivo, the SSCs became skin epithelum. The researchers were even able to convert SSCs into uterine epithelium by using uterine mesenchyme. (EurekAlert!)
Why Neural Stem Cells Divide And Differentiate Jul 18, 2009
In order to verify their findings in vivo, the researchers analyzed mouse brains and identified mature neurons as a source of EGFL7 in the adult brain. The distribution of these cells in the brain was biologically significant, as EGFL7 was absent from regions with high amounts of neural stem cells, e.g. the subventricular zone. (Science Daily)
Innovative Technology Shatters The Barriers Of Modern Light Microscopy Jul 6, 2009
ScienceDaily (July 5, 2009) Researchers at the Helmholtz Zentrum M. nchen and the Technische Universit. (Science Daily)
New Insight On Therapy For Devastating Parasitic Disease Jul 3, 2009
"Our discovery of this new biological activity of praziquantel provides a foundation for defining the relevant in vivo targets of a very important clinical drug," said Jonathan Marchant, M.A. Ph. D., principal investigator of the study. (Science Daily)
Dual Role In Breast Tissue For Protein Involved In Leukemia Jun 30, 2009
"Our studies in in vivo mouse models illustrate a dual role for the Stat5a protein in breast tissue. While it can contribute to the growth of one type of precancerous lesion in the breast, this protein also appears to protects mammary cells from carcinogenic exposure," says Miermont. These findings need to be validated and expanded, Furth says, but she adds that "while Stat5a is obviously a complicated protein that has many functions, the results underscore the need to specifically understand... (Science Daily)
Anti-inflammatory Drugs May Defeat Treatment-resistant Type Of Cancer Jun 26, 2009
Researchers are offering this in vivo model for sale to spearhead discovery. (Jan. (Science Daily)
Brain plasticity: Changes and resets in homeostasis Jun 26, 2009
These observations provide the first set of synaptic rules that help us understand how homeostatic setpoints are re-set in vivo. Based on their findings, Bains and colleagues, demonstrate that synaptic plasticity is essential for maintaining stability in a nervous system constantly bombarded by inputs from the outside world. (EurekAlert!)
Vaccines From The Bioreactor: Bioprocess Increases Vaccine Yield Jun 24, 2009
For this purpose GlycoVaxyn has developed an enzyme-based in vivo method. The Escherichia coli bacteria were genetically modified, so that they glycosylate certain proteins in order words, they generate vaccine material. (Science Daily)
Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues Jun 23, 2009
In vivo studies using VCaP cell xenografts showed reduced tumour growth in response to disulfiram exposure; disulfiram was not able to block tumour growth indicating the need for combined approaches. Disulfiram induced metallothionein expression, knockdown of MTI increased efficiency by five-fold. (EurekAlert!)
Newly Discovered Interferon Response May Offer Early Control Of H5N1 Influenza Virus Jun 22, 2009
"These results suggest a role for the IFN-a/ response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection," say the researchers. Journal reference. (Science Daily)
Tips from the journals of the American Society for Microbiology Jun 20, 2009
"These results suggest a role for the IFN-a/ response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection," say the researchers. (K.J. Szretter, S. Gangappa, J.A. Belser, H. Zeng, H. Chen, Y. Matsuoka, S. Sambhara, D.E. Swayne, T.M. Tumpey, J.M. Katz. (EurekAlert!)
Type-1 collagen differentially alters beta-catenin accumulation in primary Dupuytren's Disease cord and adjacent palmar fascia cells Jun 20, 2009
The aim of this study was to determine if a collagen-enriched environment, similar to in vivo conditions, altered beta-catenin accumulation by primary DD cells in the presence or absence of Transforming Growth Factor-beta. Methods. (BioMed Central)
TRAPping Proteins That Work Together Inside Living Cells Jun 18, 2009
A Targeted Releasable Affinity Probe (TRAP) for In Vivo Photocrosslinking. ChemBioChem, 2009; 10: 1507-1518 DOI. (Science Daily)
Researchers test nanoparticle to treat cardiovascular disease in mice Jun 5, 2009
Tirrell added:"We think that self-assembled micelles (of peptide amphiphiles) of the sort we have used in this work are the most versatile, flexible nanoparticles for delivering diagnostic and therapeutic biofunctionality in vivo. The ease with which small particles, with sufficiently long circulation times and carrying peptides that target and treat pathological tissue, can be constructed by self-assembly is an important advantage.". Ruoslahti said that UCSB's strength in the areas of... (EurekAlert!)
Functions of the Clostridium acetobutylicium FabF and FabZ Proteins in Unsaturated Fatty Acid Biosynthesis Jun 4, 2009
The original anaerobic unsaturated fatty acid biosynthesis pathway proposed by Goldfine and Bloch was based on in vivo labeling studies in Clostridium butyricum ATCC 6015 (now C. beijerinckii) but to date no dedicated unsaturated fatty acid biosynthetic enzyme has been identified in Clostridia ... Expression of this protein in E. coli functionally replaced both the FabB and FabF proteins of the host in vivo and replaced E. coli FabB in a defined in vitro fatty acid synthesis system ... In... (BioMed Central)
Scientists Devise Accelerated Method To Determine Infectious Prion Strains Jun 2, 2009
Karapetyan et al. Prion Strain Discrimination Based on Rapid In Vivo Amplification and Analysis by the Cell Panel Assay. PLoS ONE, 2009; 4 (5): e5730 DOI. (Science Daily)
Scripps Florida scientists devise accelerated method to determine infectious prion strains May 29, 2009
The first authors of the study, "Prion Strain Discrimination Based on Rapid in Vivo Amplification and Analysis by the Cell Panel Assay," are Yervand E. Karapetyan and Paula Sa of The Scripps Research Institute. Other authors include Sukhvir P. Mahal, Gian Franco Sferrazza, Alexandra Sherman and Nicole Sals, also of Scripps Research. (EurekAlert!)
A potential drug for liver carcinoma May 23, 2009
However, Chrysin is limited in its clinical application because of its modest absorption in the intestine and rapid in vivo glycosylation. To improve the biological activity of chrysin, a number of its derivatives have been prepared for biological testing. (EurekAlert!)
Swine Flu Risk Linked To Arsenic Exposure May 21, 2009
Kozul et al. Low Dose Arsenic Compromises the Immune Response to Influenza A Infection in vivo. Environmental Health Perspectives, Online May 20, 2009; DOI. (Science Daily)
Scientists link influenza A (H1N1) susceptibility to common levels of arsenic exposure May 21, 2009
Kozul, C.D., Ely, K.H., Enelow, R.I., and Hamilton, J.W. (2009) Low dose arsenic compromises the immune response to influenza infection in vivo. Environ Health Perspec. (EurekAlert!)
OXiGENE Announces Clinical Data to be Presented At the 2009 Annual Meeting of the American Society of Clinical Oncology May 21, 2009
Abstract # e14510: A PET imaging study of the vascular disruptive agent OXi4503 to confirm in vivo mechanism of action in a phase I trial. P. M. Price, M. Asselin, B. Koetz, C. Dickinson, N. Charnley, P. Lorigan, J. Valle, M. Stratford, G. Rustin, A. Saleem; Academic Radiation Oncology, University of Manchester, Manchester, United Kingdom; Wolfson Molecular Imaging Centre, University of Manchester, United Kingdom; Medical Oncology, The Christie NHS Foundation Trust, United Kingdom; Gray... (Primezone Releases)
Disruption Of Immune-system Pathway Key Step In Cancer Progression, Study Shows May 20, 2009
"If these forces are still at play in vivo, the patient's immune response to these types of treatments will be blunted.". Other Stanford researchers who contributed to the work include postdoctoral scholars Rebecca Critchley-Thorne, PhD; Ning Yan, PhD; Andrea Miyahira, PhD; research assistant Diana Simons; associate professor of surgery Frederick Dirbas, MD; associate professor of surgery Denise Johnson, MD; associate professor of dermatology Susan Swetter, MD; professor of medicine Robert... (Science Daily)
How Glucocorticoid Drugs Protect The Heart May 20, 2009
Specifically, glucocorticoids, acting via the glucocorticoid receptor (GR), induced mouse and rat heart muscle cells to produce PGD2, and this was responsible for the ability of glucocorticoids to reduce damage to mouse hearts in both an ex vivo and an in vivo model of heart attack. The authors therefore suggest that GR-selective glucocorticoids might be more beneficial to humans following heart attack than glucocorticoids that activate both GR and the MR protein, activation of which occurs in... (Science Daily)
