Key Step In Programmed Cell Death Discovered Mar 3, 2008
For example, they demonstrated earlier that most cytokines controlling hematopoietic cells require an enzyme called Jak2, or Jak3 in lymphocytes, at the receptors where cytokines attached to the cell. In screening for components that are regulated by the Jak enzymes, the St. Jude team found the Hax1 protein. (Science Daily)
STAT3 Signaling and the Hyper-IgE Syndrome Oct 18, 2007
The human genome encodes four JAK family members JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2) and seven STAT proteins. 1 JAKs are protein tyrosine kinases that interact with the intracellular domains of cytokine receptors (Figure 1) and that have enhanced catalytic activity toward substrate proteins after receptor activation. (New England Journal of Medicine)
New strategy rapidly identifies cancer targets Jul 17, 2006
"That left one gene to sequence. We found that the gene, called JAK3, had a mutation that drives the growth of leukemia cells in mice," said Druker. Analysis of additional patient samples later identified two more mutations in the JAK3 gene ... "It was important to show that the JAK3 mutation, when introduced in mice, would lead to a leukemia-like illness. It did, confirming that the JAK3 mutations play a central role in leukemia," said Gilliland. (EurekAlert!)
Cytopia Announces Major License and R&D Collaboration Jun 5, 2006
MELBOURNE, Australia, June 4 /PRNewswire-FirstCall/ -- Cytopia Ltd (ASX: CYT) today announced the signing of a global license and research and development collaboration with Novartis to develop orally active, small molecule therapeutics targeting JAK3 kinase for the prevention of transplant rejection and the treatment of multiple indications in autoimmune diseases such as rheumatoid arthritis. Both companies will contribute expertise and intellectual property relating to JAK3 inhibitors for the... (PR Newswire)
