Lab employees get preview of super-powerful data center May 6, 2008
BAR HARBOR Once all of the computer equipment has been installed in the new data center at Jackson Laboratory, the place will be as secure as a NASA control room. So, before activating the electronic equivalent of a moat filled with alligators, lab officials invited employees to visit and learn all about the new facility last Wednesday. (Courier Publications, ME)
Interest spikes in Northeast Creek homes May 2, 2008
Mr. Kelley said quite a few of them work for the island s largest employers including Jackson Laboratory, and. A lot of them are single people, particularly middle-aged women, he said. (Courier Publications, ME)
Montville GMO ban may be illegal Apr 23, 2008
He said if Jackson Laboratory in Bar Harbor were located in Montville, it would have to shut down because it raises genetically altered mice with certain characteristics for laboratories conducting research in areas such as pharmaceuticals. Johnsons non-profit companies operate on contributions from pharmaceutical and agricultural companies including AstraZeneca International, Merck, Monsanto Co., DuPont, and Dow AgroSciences LLC.. (Courier Publications, ME)
Loss Of Egg Yolk Genes In Mammals And The Origin Of Lactation And Placentation Mar 20, 2008
4, 2006) A new paper by Jackson Laboratory researchers in the journal Genes & Development presents significant new information about what is happening within a fully grown, pre-ovulatory egg and some of. (May 2, 2005) In the May 1 issue of G&D, a new paper shows compelling evidence for the absence of predetermined polarity in the mouse egg. (Science Daily)
All The Wrong Numbers Mar 15, 2008
"I think we're too often fixated on numbers, and not enough on what outcomes they relate to," says Clifford Rosen, a top expert on bone disease at the Jackson Laboratory in Barr Harbor, Maine, who headed an FDA advisory panel on Avandia. That drug was linked in several analyses of published data to an increase in the risk of heart attacks, but big studies didn't provide a clear answer as to whether the risk was real. (Forbes -- Business)
'Female Sex Hormone' Protects Against Hearing Loss In Females And Males Mar 6, 2008
26, 1998) A team of scientists from the University of Cincinnati, the Jackson Laboratory in Bar Harbor, Maine and Northern Illinois University have mapped the first gene known to cause age-related hearing loss. . (Science Daily)
FDA Ponders Stricter Rules For Diabetes Drugs Mar 5, 2008
Clifford Rosen, a researcher at the Jackson Laboratory in Bar Harbor, Maine, who headed up an FDA advisory panel on Avandia's heart risk, says he is "encouraged" by the new guidance. He says that too often big studies to prove that drugs prevent hard outcomes like heart attacks or death are started too slowly. (Forbes -- Business)
Are Immune System Molecules Brain-Builders--And Destroyers? Mar 4, 2008
Upon further examination, Barres, in conjunction with Simon John a neuroscientist at Jackson Laboratory in Bar Harbor, Me. discovered that C1q appears to be involved in synapse loss linked to glaucoma. (Scientific American)
Gene Defect Causes Immune Deficiency And Balance Disorder Feb 26, 2008
25, 2008) A genetic defect that causes a severe immune deficiency in humans may also produce balance disorders, according to a new study by researchers at the University of Iowa, The Jackson Laboratory and East Carolina University ... The study, published online Feb. 21 in the Journal of Clinical Investigation, examined a specialized strain of Jackson Laboratory mice with a mutation that eliminates the production a protein called p22phox ... " In addition to Banfi, the research team included... (Science Daily)
Study: genetic defect may produce balance disorders Feb 26, 2008
A study by researchers at the University of Iowa, the Jackson Laboratory in Maine and East Carolina University was funded in part by grants from the National Institutes of Health, and published online Friday in the Journal of Clinical Investigation. The study examined a specialized strain of Jackson Lab mice that eliminates production a protein called p22phox. (Muscatine Journal, IO)
Breakdown Of Kidney's Ability To Clean Its Own Filters Likely Causes Disease Feb 4, 2008
D., professor at the Jackson Laboratory in Bar Harbor, Maine. Prior research there and in other laboratories had revealed that FcRn binds to both IgG and albumin and is present in human podocytes. (Science Daily)
Hybrid Human-Animal Embryo Research Approved In The UK Jan 19, 2008
27, 1998) A study conducted at The Jackson Laboratory and the University of Connecticut suggests that the maternal uterine environment in mice can have an enhancing effect on learning ability in offspring. (Jan. (Science Daily)
Genetics pioneer honored Jan 18, 2008
"Victor is a true pioneer who not only appreciated before many of his colleagues the extent to which our genetic inheritance determines sickness and health, but acted on that ... developing human genetics as a scientific discipline," said Kenneth Paigen, staff scientist and former director of the Jackson Laboratory in Maine. David Valle, director of the McKusick-Nathans Institute of Genetic Medicine at Hopkins, said McKusick "showed the power of understanding the genetic contribution to both... (SunSpot.net)
Body weight influenced by thousands of genes Jan 15, 2008
To obtain an estimate of how many genes contribute to body weight, the Monell researchers surveyed the Jackson Laboratory Mouse Genome Database for information on body weights of knockout mouse strains. Knockout mice have had a specific gene inactivated, or "knocked out. By studying how the knockout mice differ from normal mice, researchers obtain information about that genes function and how it might contribute to disease. Mice can provide valuable information on human disease because they... (EurekAlert!)
Federal grant to promote health care in northern New England Jan 8, 2008
Hospitals, the University of Maine, the University of New England and the Jackson Laboratory are among the facilities that will be connected, Baldacci said. The network is designed to provide health care providers with quick and convenient access to the latest research and medical advances, expert support and team consultations, said Collins, R-Maine. (Concord Monitor)
How Muscle Weakness Caused By Myasthenia Gravis Can Be Stopped, According To New Research Dec 24, 2007
(May 4, 2004) Researchers at The Jackson Laboratory have identified a novel therapeutic target for treating autoimmune. . (Science Daily)
Genes Influence Age-related Hearing Loss Nov 17, 2007
26, 1998) A team of scientists from the University of Cincinnati, the Jackson Laboratory in Bar Harbor, Maine and Northern Illinois University have mapped the first gene known to cause age-related hearing loss. (Oct. (Science Daily)
Leukemia Drug Proves Safe And Effective Over The Long Term, Study Suggests Nov 12, 2007
10, 2006) Researchers at the Jackson Laboratory, in collaboration with scientists at Bristol-Myers Squibb Oncology, discovered is that imatinib does not inactivate all BCR-ABL signaling pathways in the. (May 2, 2005) A new experimental drug may be effective against a certain form of leukemia resistant to current treatments, research at UT Southwestern Medical Center. (Science Daily)
New Insight Into The Link Between Genetics And Obesity Nov 9, 2007
9, 2007) Scientists have acquired new insight into how the 'obesity gene' triggers weight gain in some individuals. Their findings, reported online today in Science Express, could have implications for the future treatment of obesity as well as adult onset diabetes. (Science Daily)
Molecular Medical Research Points To Treatment Of Spinal Muscular Atrophy Nov 6, 2007
23, 1998) Scientists at The Jackson Laboratory have cloned the gene for the mouse mutation known as neuromuscular degeneration, or nmd, an advance that promises to boost research into such devastating. (Feb. (Science Daily)
Obesity Genes Found Hidden In Discarded Data Oct 26, 2007
In this month's issue of Genome Research, Edward Leiter and colleagues (The Jackson Laboratory) report that an. (Dec. (Science Daily)
Maine researcher says vibrations slim abdomen Oct 23, 2007
Clifford Rosen from The Jackson Laboratory and Maine Medical Center Research Institute says his study put mice on a vibrating platform for 15 minutes a day for 15 weeks. He says the mice developed 27 percent fewer abdominal fat cells and saw other benefits, including reduced triglycerides in the liver. (Seacoast New Hampshire)
Nobel goes to gene-knockouts. Oct 19, 2007
Jackson Laboratory is both a biomedical research institute and a storehouse that sells mice with interesting genetics to researchers, which puts Woychik in a good position to grasp the significance of gene targeting. "The ability to do very specific engineering -- to not just knock out ... but also introduce subtle changes in the gene -- helps you get a more complete picture of the function of the gene. The ability to conditionally modify, to knock down or knock out, to do this in specific cell... (Why Files)
A computer for your mouse! Oct 13, 2007
The consortium is joined in its discussions by the Wellcome Trust Sanger Institute, the Jackson Laboratory, USA, the Riken Genome Science Centre, Japan, and the United States National Institutes of Health, amongst many other major players, to establish a way forward to a global scientific information network. . (EurekAlert! -- Business News)
3 win Nobel in medicine for gene technology Oct 10, 2007
Knockout mice are so important in medical research that thousands of strains are kept available in institutions like the Jackson Laboratory in Bar Harbor, Maine. "The technique is revolutionary and has completely changed the way we use the mouse to study the function of genes," said Dr. Richard Woychik, the lab's director. (International Herald Tribune)
Immigrant to U.S. wins Nobel for gene studies Oct 9, 2007
The work has had "a revolutionary effect on the ability to understand how genes work," said Richard Woychik, director of the Jackson Laboratory in Bar Harbor, Maine, a center for mouse genetics. The prize is a particularly striking accomplishment for Capecchi. (AZCentral -- News)
Arphid Watch: Arphid Cancer II Sep 14, 2007
" (((Uh-oh.))) Dr. George Demetri, director of the Center for Sarcoma and Bone Oncology at the Dana-Farber Cancer Institute in Boston, agreed. Even though the tumor incidences were "reasonably small," in his view, the research underscored "certainly real risks" in RFID implants. In humans, sarcomas, which strike connective tissues, can range from the highly curable to "tumors that are incredibly aggressive and can kill people in three to six months," he said. (((Yeah but, uh... I really want to... (Wired Blogs)
Strains of laboratory mice more varied than previously thought Jul 30, 2007
CHAPEL HILL A collaborative study by scientists at the University of North Carolina at Chapel Hill and The Jackson Laboratory in Bar Harbor, Maine, has found that the genetic variation in the most widely used strains of laboratory mice is vastly greater than previously thought ... D., a Jackson Laboratory senior staff scientist ... The Jackson Laboratory is a world-wide source for more than 3,000 genetically defined mice. (EurekAlert!)
Mouse genome will help identify causes of environmental disease Jul 30, 2007
In addition to the NTP and Perlegen Sciences scientists, other key collaborators on the project include researchers from the Department of Computer Science and Department of Human Genetics, University of California, Los Angeles; the Department of Computer Science and Engineering, University of California, San Diego; The Jackson Laboratory, Bar Harbor, Maine; Broad Institute of Harvard and MIT; and the Center for Human Genetic Research, Massachusetts General Hospital. Reference: Kelly A. Frazer,... (EurekAlert!)
Increased Availability Of Genetically Altered Mice To Aid Studies Of Human Diseases Jun 28, 2007
NIH also supported the establishment of a data coordination center by the Jackson Laboratory in Bar Harbor, Maine, to track the scheduling and progress of knockout production. In addition, NIH issued smaller awards to the University of Pennsylvania and the Samuel Lunenfeld Research Institute of Mount Sinai Hospital in Toronto to improve the efficiency of methods for creating knockout lines. (Science Daily)
Shining Stars Jun 26, 2007
Seanna Pieper-Jordan of Kamehameha High School will participate in biomedical research with world-renowned geneticists for nine weeks this summer through the Summer Student program at the Jackson laboratory in Bar Harbor, Maine. She is one of 30 across the nation to be selected for the internship. (Honolulu Star-Bulletin)
NIH stops chimp breeding Jun 6, 2007
"There is great value in chimp research," Barbara Knowles, a staff scientist at the Jackson Laboratory in Bar Harbor, Maine, and a member of the NCRR's Chimpanzee Management Plan Working Group, told The Scientist. Given the high cost of their care, however, "the way they're supported has to be reconsidered.". (The Scientist)
Earl Ubell, 80; journalist covered significant science and health breakthroughs May 31, 2007
He later worked for brief periods at the Weizmann Institute of Science in Israel and Jackson Laboratory in Bar Harbor, Maine. Ubell told Kluger his lab work "was an invaluable way of understanding what drives" scientists. (Los Angeles Times)
Gene tweak makes mice smarter May 28, 2007
A laboratory mouse climbs on the gloved hand of a technician at the Jackson Laboratory in this file photo taken on Jan. 24, 2006, in Bar Harbor, Maine. (Robert F. Bukaty/AP Photo). (Globe and Mail)
Gene therapy used to cure mice blindness May 25, 2007
BAR HARBOR, Maine (AP) Researchers at the University of Florida and The Jackson Laboratory in Maine say they used gene therapy to restore sight in mice with achromatopsia, a form of hereditary blindness that also strikes humans ... Chang said the mouse with achromatopsia was found about three years ago while screening many strains of mice for vision problems as part of The Jackson Laboratory's program to develop new mouse models for human eye conditions. (Herald Online, SC -- Health)
Health Highlights: May 23, 2007 May 24, 2007
In this study, researchers at the University of Florida and The Jackson Laboratory in Maine used a harmless virus to deliver corrective genes to the mice with achromatopsia. Within two months, 19 of the 21 treated eyes in the mice showed a positive response to the therapy, the AP reported. (Forbes)
Markets looking up Mar 21, 2007
BAR HARBOR, Maine (AP) "" The Jackson Laboratory, which expects to add 400 jobs to its work force within five years, announced Tuesday that it has obtained federal research grants totaling $24 ... 9 million in The Jackson Laboratory through the Maine Biomedical Research Fund. (Seacoast New Hampshire)
Recession risk 'low' Feb 28, 2007
BAR HARBOR, Maine (AP) -- The Jackson Laboratory expects to add 400 jobs to its existing 1,300-employee work force within five years as it expands the number of research groups. The lab, which specializes in mouse genetics, now has about 36 research groups; the long-term goal is to have 55 groups, said Joyce Peterson, the lab's spokeswoman. (Seacoast New Hampshire)
Breakthrough In Understanding Type-2 Diabetes As Key Genes Identified Feb 14, 2007
The most important genes associated with a risk of developing type-2 diabetes have been identified, scientists report in a new study. The researchers looked for mutations in the building blocks, called nucleotides, of DNA. They examined over 392,000 of these mutations to find the ones specific to type-2 diabetes. (Science Daily)
New Line Of Treatment Discovered For Acute Lymphoblastic Leukemia Feb 14, 2007
(November 10, 2006) -- Researchers at the Jackson Laboratory, in collaboration with scientists at Bristol-Myers Squibb Oncology, discovered is that imatinib does not inactivate all BCR-ABL signaling pathways in the. . (Science Daily)
Genetic Engineering Cures Mice Of Brain Disorder Feb 13, 2007
(October 4, 1997) -- Researchers at The Jackson Laboratory have identified the gene that is defective in a new mouse model known as "slow-wave epilepsy," or swe. This is the first genetic model to exhibit both petit mal. (Science Daily)
SRMC honors 168 employees for service Feb 9, 2007
The Robesonian Online. Weather Sponsored By. (Lumberton The Robesonian, NC)
NOTCHing Up Heart Development Feb 6, 2007
(July 23, 1998) -- Research conducted at The Jackson Laboratory has confirmed an important role in embryonic development for the Lunatic fringe gene, part of a cell communication mechanism known as the Notch signaling. . (Science Daily)
New Technique Assesses Effects Of Multiple Copies Of Genes On Disease Risk Feb 1, 2007
The project is headquartered at Jackson Laboratory in Bar Harbor, Maine. For their analysis, researchers compared the genome of each of the 20 mouse strains against that of the prototypical research mouse strain, C57BL/6J.. (Science Daily)
Gas On Your Mind: Snail's Brain Provides Insights Into Human Learning Dec 14, 2006
Scientists at the University of Leicester are to gain a greater insight into the workings of the human mind -- through the study of a snail's brain. Isolated snail nerve cells that have grown connections in cell culture. (Science Daily)
Nanoscale Microscope Sheds First Light On Gene Repair Nov 15, 2006
In a paper published in the Proceedings of the National Academy of Sciences, Joerg Bewersdorf of the Institute for Molecular Biophysics at The Jackson Laboratory, with collaborators Brian Bennett of the UMass Medical School and Leica Microsystems and Kendall Knight of the UMass Medical School, used the 4Pi microscope to examine the cellular response to a type of severe damage to the genetic material, DNA double-strand breaks ... The Jackson Laboratory is an independent, nonprofit research... (Science Daily)
When Gleevec Is Not Enough: Researcher Demonstrates Value Of 'Helper' Compound In Treating Some Leukemias Nov 11, 2006
D., researchers at The Jackson Laboratory, in collaboration with scientists at Bristol-Myers Squibb Oncology, are discovering startling new information about the mechanisms of Philadelphia-positive (Ph+) leukemias that will affect how they are treated clinically. The Philadelphia Chromosome is actually a faulty mixture of two chromosomes, 9 and 22, which typically work perfectly well independent of each other. (Science Daily)
When Gleevec is not enough Nov 8, 2006
Jackson Laboratory researcher demonstrates value of 'helper' compound in treating some leukemias ... D., researchers at The Jackson Laboratory, in collaboration with scientists at Bristol-Myers Squibb Oncology, are discovering startling new information about the mechanisms of Philadelphia-positive (Ph+) leukemias that will affect how they are treated clinically. (EurekAlert!)
Red Wine Molecule Extends Lifespan Of Fat Mice Lives By Reversing Obesity-Related Gene Pathways Nov 3, 2006
Researchers have used a single compound to increase the lifespan of obese mice, and found that the drug reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets--some of which are associated with diabetes, heart disease, and other significant diseases related to obesity. The research, led by investigators at Harvard Medical School and the National Institute on Aging, is the first time that the small molecule resveratrol has been shown to offer survival... (Science Daily)
Mouse DNA To Aid Biomedical Research Oct 27, 2006
(July 22, 2006) -- A study in mice by scientists at The Jackson Laboratory suggests that the body mass index or BMI is not always a good indicator of how much body fat an individual. . (Science Daily)
Diabetes Gene Carries Similar Risk To Obesity Oct 24, 2006
Carrying two copies of a common variant of a particular gene doubles your chances of developing diabetes and puts you in a similar risk category to being clinically obese, according to a collaborative study led by UCL (University College London) researchers. The collaborative team led by UCL Professor Steve Humphries studied the TCF7L2 gene, which was discovered to be implicated in diabetes earlier this year by a group working in Iceland. (Science Daily)
Cracking The Egg: Unraveling Our First Transitions Oct 5, 2006
Scientists led by Drs Barbara Knowles and Alexei Evsikov at The Jackson Laboratory have certainly been thinking about this topic for years ... (June 26, 2006) -- Jackson Laboratory researchers showed that Snail family genes operate consistently in mice and birds in controlling the acquisition of differences between the two sides of the body ... (July 23, 1998) -- Research conducted at The Jackson Laboratory has confirmed an important role in embryonic development for the Lunatic fringe gene,... (Science Daily)
Brown Seaweed Contains Promising Fat Fighter, Weight Reducer Sep 20, 2006
(April 30, 1997) -- Unexpected results from an experiment at The Jackson Laboratory designed to probe the role of a protein implicated in human obesity will help researchers identify the complex thermogenic mechanisms. . (Science Daily)
Odd mice in apnea study Sep 19, 2006
Here at the Jackson Laboratory, where the search for mutant mice mimicking human diseases is constant, the recent discovery of a mouse that sleeps while vertical may lead to powerful new insights into a common and distressing human disorder, sleep apnea ... "For the first time, this gives us genetically defined mice in which we can start to look for the genes that cause this disorder," said Luanne Peters, a senior staff scientist also at the Jackson Laboratory. (Newsday -- Health)
New misfolding mechanism spotted Aug 15, 2006
When it comes to diseases involving misfolded proteins, scientists typically link a particular disorder with a specific misfolded protein, such as a or , said coauthor at the Jackson Laboratory in Bar Harbor, Maine. This study, in contrast, found a more generalized mechanism that upsets the accuracy of RNA translation, creating misfolded proteins. (The Scientist)
Deep-freeze mice become dads Aug 15, 2006
Robert Taft, associate director of reproductive sciences at the Jackson Laboratory in Bar Harbor, Maine, calls Ogura's findings "quite a feat". Taft says that the Jackson Laboratory will stick to its current methods for preserving sperm, however ... While he realizes that individual labs may find it convenient to simply toss their mice into a freezer, he urges every lab to deposit important strains into curated collections like the Jackson Laboratory's. (Nature News Service)
'Sticky' mice lead to discovery of new cause of neurodegenerative disease Aug 14, 2006
The new studies by Howard Hughes Medical Institute (HHMI) investigator Susan L. Ackerman and colleagues at The Jackson Laboratory point to a novel mechanism behind the buildup of the toxic sludge that accumulates in neurons. Researchers have long known that neurodegenerative disorders can be caused by the gradual yet persistent accumulation of misfolded proteins in neurons that eventually triggers cell death. (EurekAlert!)
Ultrasound Affects Embryonic Mouse Brain Development Aug 10, 2006
(April 24, 1997) -- Genetic research conducted at The Jackson Laboratory has identified a protein in mice that may play a fundamental role in the critical process of "wiring" the central nervous system during vertebrate. . (Science Daily)
High BMI doesn't always spell obesity, Jackson Laboratory researchers show Jul 21, 2006
Now a study in mice by scientists at The Jackson Laboratory indicates that the usefulness of the BMI is suspect even at the genetic level ... The Jackson Laboratory is an independent, nonprofit research institution based in Bar Harbor, Maine, with facilities in West Sacramento, Calif. (EurekAlert!)
UCD hopes to help build better mouse-gene model Jul 13, 2006
"About 95 percent of the gene- coding portion of the mouse and human genome is identical," said Muriel Davisson, director of genetic resources at the Jackson Laboratory in Maine, a major creator and distributor of lab mice. "It's really quite incredible considering we look so different.". (Sacramento Bee)
Making A Face: A New And Earlier Marker Of Neural Crest Development Jul 12, 2006
(June 26, 2006) -- Jackson Laboratory researchers showed that Snail family genes operate consistently in mice and birds in controlling the acquisition of differences between the two sides of the body. The researchers. (Science Daily)
Scientists using sperm-like cells make mice Jul 12, 2006
That result is a significant advance, said Mary Ann Handel, who studies sperm formation and male infertility at the Jackson Laboratory in Bar Harbor, Maine. Previously, other researchers had gotten as far as injecting such cells into eggs and producing early embryos, she said. (Seattle Post Intelligencer)
It was a bang-up Fourth Jul 7, 2006
Judges Award: first place, Bar Harbor Bank ; second place, Island Connections; third place, Jackson Laboratory; fourth place, John B. Dean Family. Most Humorous: first place, MDI Biological Lab; second place, U.S. Post Office. (Bar Harbor Times, ME)
Mouse, frog and bird put Snail and Slug to different uses Jun 27, 2006
In a paper just released in the Proceedings of the National Academy of Sciences, two Jackson Laboratory scientists have demonstrated both a confirmation of the consistent role of Snail genes in vertebrates, and a surprising exception ... The Jackson Laboratory is an independent, nonprofit research institution based in Bar Harbor, Maine, with facilities in West Sacramento, Calif. (EurekAlert!)
Theory that fertility can be regained is dealt blow Jun 15, 2006
I think this argues very strongly against the Tilly hypothesis," said John J. Eppig , a Jackson Laboratory senior staff scientist who was not involved in the research.The team is not accusing Tilly of misconduct -- his original data may all be correct -- but says that he overstated the significance of what he found. Biology has been roiled by the idea that the body can regenerate itself in entirely unexpected ways, including a wave of recent findings about adult stem cells. In some cases, these... (Boston Globe)
