Protein May Be Key To New Therapies For Elevated Triglycerides May 28, 2008
Results of their study are published in the June issue of the Journal of Clinical Investigation. Heart disease is the leading cause of death in the United States and is a major cause of disability, according to the Centers for Disease Control and Prevention. (Science Daily)
Immune system protein could help develop cancer vaccine: study May 27, 2008
The research was published Friday in The Journal of Clinical Investigation. Story Tools: | | Text Size. (CBC.ca)
Cancer vaccine target pinpointed May 24, 2008
The research is published in the Journal of Clinical Investigation. The protein is unique to a type of immune cell called a dendritic cell, which is responsible for triggering the body's defence system. (BBC News -- Health)
Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides May 24, 2008
Results of their study are published in the June issue of the Journal of Clinical Investigation. Scientists in the Division of Immunogenetics at Childrens Hospital studied the role of a protein known as Forkhead Box O1 (FoxO1) that mediates the metabolism of glucose and cholesterol. (EurekAlert!)
New Drug Reduces One Cause Of Vision Loss May 20, 2008
Journal of Clinical Investigation, May 15, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)
Novel Insight Into Cardiac Arrhythmias, Sudden Cardiac Death May 12, 2008
Their findings, published online in the Journal of Clinical Investigation, could pave the way for the development of new, genetically-targeted therapies to treat and prevent fatal arrythmias. See also. (Science Daily)
Study Offers Clues to Link Between Arrhythmia, Sudden Death May 10, 2008
The study was published online Thursday in The Journal of Clinical Investigation. "We are still struggling to understand why arrhythmia causes sudden cardiac death in some patients, but not others, and what underlying molecular mechanisms or abnormalities may be at play," study senior author Dr. Gideon Koren, director of the cardiovascular research center at Rhode Island Hospital and a professor of medicine at Brown University's medical school, said in a prepared statement. (MEDLINEplus)
Scientists Discover How Stomach Tumors Form May 2, 2008
The findings were published online April 22 in The Journal of Clinical Investigation. The study shows that IL-11 promotes chronic inflammation and the formation of tumors in the stomach by increasing activation of the Stat3 protein, a known player in inflammation-associated carcinogenesis. (MEDLINEplus)
Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia May 2, 2008
The surprising findings, published in the April 22 online issue of The Journal of Clinical Investigation, are significant, because individuals with frontotemporal dementia with parkinsonism-17 -- a relatively rare hereditary form of dementia -- are often used as models for studying Alzheimer's disease. Alzheimer's disease and frontotemporal dementia each develop as a result of too many tau proteins accumulating and causing tangled lesions in the brain's neurons. (MEDLINEplus)
Regenerative Medicine To Repair Wounded Warriors Apr 23, 2008
5, 2004) In the February 2 issue of the Journal of Clinical Investigation, Pritinder Kaur and colleagues at the Peter MacCallum Cancer Centre, Australia, demonstrate that both epidermal stems cells and their. (Nov. (Science Daily)
Scan Detects Oxygen Levels in Tumors Apr 23, 2008
April 22, 2008, Journal of Clinical Investigation) ... "If successful, [the trend] will revolutionize the way that we treat cancer," said Dewhirst, who co-wrote a commentary accompanying the new study, published April 22 in the Journal of Clinical Investigation. (Health-Finder)
World-first Discovery Could Help Treat Life-threatening Tumors Apr 20, 2008
19, 2008) WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumours. Western Australian Institute for Medical Research (WAIMR) Associate Professor Ruth Ganss and her team have found that a gene called RGS5 can reverse angiogenesis -- the growth of blood vessels inside the tumour. (Science Daily)
Hepatitis B Virus Triggers Cell 'Suicide' In Patients With Chronic Infection Apr 10, 2008
Their findings are published today in the Journal of Clinical Investigation ... Journal reference: 'Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control hepatitis B virus' is published online ahead of print in the Journal of Clinical Investigation and is embargoed to Tuesday 8th April 2008 at 9pm GMT (5pm Eastern). (Science Daily)
A Random Analysis Apr 3, 2008
Journal of Clinical Investigation 107: 657-662. For genome defense in Neurospora, see Galagan, J. E. and Selker, E. U. 2004. (New York Times)
Korean scientists find gene promoting liver cancer growth Mar 24, 2008
The paper about the research was published in Journal of Clinical Investigation on Friday. "We are now searching for a business partner to conduct clinical research into liver cancer drugs," the daily quoted the team as saying. (Xinhuanet, China)
Clues To Prevent Spread Of Ovarian Cancer Mar 19, 2008
In the April issue of the Journal of Clinical Investigation, the researchers show that an enzyme known as MMP-2 is necessary for ovarian cancer to attach itself to the sites where it tends to spread. Several drugs known as MMP inhibitors (for example, marimastat or prinomastat) inhibit the enzyme, dramatically reducing the tumor's ability to establish itself at sites beyond the ovary. (Science Daily)
Parkinson's Disease Drug Might Work In Cancer Patients Mar 19, 2008
This research was published in the March 13 online issue of The Journal of Clinical Investigation. Other authors include: Chandrani Sarkar, Ph. (Science Daily)
Pinpointing When A Fetus Develops Male Genitalia, And Birth Defects Related To Male Sex Organs Mar 18, 2008
Journal of Clinical Investigation ... 2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (Science Daily)
New Drug Protects Nerve Cells From Damage In Mice Mar 18, 2008
Journal of Clinical Investigation. March 12, 2008. (Science Daily)
Male fertility decided in womb by hormones Mar 18, 2008
This measurement could be an early warning system of future reproductive problems in baby boys, the researchers reported in the latest edition of the Journal of Clinical Investigation. "We know from other studies that androgens work during foetal development to programme the reproductive tract. But our assumption was that it would be much later in pregnancy," said the study's lead author, Michelle Welsh. (Times of India)
Male fertility 'set in the womb' Mar 17, 2008
The results are published online in the Journal of Clinical Investigation. Problems with reproductive development such as the testes not descending properly into the scrotum (cryptorchidism) or the urinary tract opening in the wrong place on the penis (hypospadias) are fairly common in young boys. (BBC News -- UK)
Parkinson's Drug May Fight Cancer Mar 15, 2008
The findings were published in the online edition of the Journal of Clinical Investigation. "Researchers can now test this concept in solid tumors where angiogenesis (formation of new blood vessels) plays a critical role in the growth and progression of these cancers," Dr. Sujit Basu, a Mayo Clinic oncologist, said in a prepared statement. (Health-Finder)
Parkinson's Drug May Fight Cancer Mar 15, 2008
A study published in the March 13 online issue of The Journal of Clinical Investigation shows that dopamine, a drug currently used to treat Parkinsons disease and other illnesses, also might work in cancer patients. The study, which was done in mouse and laboratory models, shows that dopamine could possibly prevent new blood vessels from growing and as a result, slow cancer progression. (Newsmax)
Relief for priapism sufferers Mar 15, 2008
The study is published in the Journal of Clinical Investigation. Get personalised news stories on mobile. (India Times, India -- Health/Science)
Rare Syndrome Provides Clues On Obesity, Blood Pressure Mar 5, 2008
The study appeared online March 3 in the Journal of Clinical Investigation. The study was supported in part by grants from the American Heart Association, the National Institutes of Health and the Howard Hughes Medical Institute. (Science Daily)
Hormones could save hearing Mar 5, 2008
Their findings were published in the Journal of Clinical Investigation this week. "The alpha (oestrogen) receptor has no affect on hearing loss when you don't have the beta receptor you get more of a hearing loss. We're seeing the same effect in the males and the females," Canlon told AFP.. (iAfrica.com)
Sticky blood protein yields clues to autism Mar 5, 2008
In an advance online publication in the Journal of Clinical Investigation, Ana Carneiro, Ph. D., and colleagues report that a well-known protein found in blood platelets, integrin beta3, physically associates with and regulates the serotonin transporter (SERT), a protein that controls serotonin availability. (EurekAlert!)
Curry Spice May Thwart Heart Failure Feb 27, 2008
The studies "came to nearly identical conclusions," says an editorial published with the studies in February's edition of The Journal of Clinical Investigation. But editorialist Jonathan Epstein, MD, cautions against counting on curcumin to prevent heart failure in people, since the findings in rodents may not apply to people. (CBS News)
Gene Defect Causes Immune Deficiency And Balance Disorder Feb 26, 2008
The study, published online Feb. 21 in the Journal of Clinical Investigation, examined a specialized strain of Jackson Laboratory mice with a mutation that eliminates the production a protein called p22phox. Disruption of this protein causes a form of chronic granulomatous disease (CGD) -- a severe immune deficiency -- in humans. (Science Daily)
The cat's out of the bag: Felines stave off heart disease Feb 26, 2008
This latest research, published in the Journal of Clinical Investigation, adds to a growing body of medical literature indicating that curcumin has a broad range of biological properties. It is currently being tested as a possible treatment for cancer, Alzheimer's disease and various skin disorders. (Globe and Mail)
Study: genetic defect may produce balance disorders Feb 26, 2008
A study by researchers at the University of Iowa, the Jackson Laboratory in Maine and East Carolina University was funded in part by grants from the National Institutes of Health, and published online Friday in the Journal of Clinical Investigation. The study examined a specialized strain of Jackson Lab mice that eliminates production a protein called p22phox. (Muscatine Journal, IO)
Stimulating Thymus Reactivates T-Cell Production Feb 24, 2008
The results are published in the March issue of the Journal of Clinical Investigation. "These results represent new proof-of-principle findings that thymic involution can be reversed in humans," study author Dr. Laura Napolitano, an assistant investigator at Gladstone and an assistant professor of medicine at UCSF, said in a prepared statement. (Health-Finder)
Immune System Reactivated In Adults With HIV Feb 22, 2008
It should be noted that in an accompanying commentary in the Journal of Clinical Investigation, Kiki Tesselaar and Frank Miedema, at University Medical Center Utrecht, The Netherlands, warn that the long-term immunological and clinical benefits of growth hormone administration need to be thoroughly determined before this approach can be used more widely in the clinic ... Journal reference: Growth hormone resurrects adult human thymus during HIV-1 infection, Journal of Clinical Investigation. (Science Daily)
Curcumin May Prevent Heart Failure Feb 22, 2008
In a study entitled, Curcumin prevents and reverses murine cardiac hypertrophy, published in the February edition of the Journal of Clinical Investigation, researchers found when the herb is given orally to a variety of mouse models with enlarged hearts (hypertrophy), it can prevent and reverse hypertrophy, restore heart function and reduce scar formation. The healing properties of turmeric have been well known in eastern cultures for some time. (Newsmax)
Early Detection Of Cerebral Malaria Possible, Animal Study Indicates Feb 20, 2008
Journal reference: A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. Journal of Clinical Investigation. February 14, 2008. (Science Daily)
Transplanted Cells May Hold The Key To Curing Hemophilia A Feb 20, 2008
The study appears online February 14 in the Journal of Clinical Investigation. Daniel Benten and Phyllis Novikoff of Einstein were also involved in this study. (Science Daily)
Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis Feb 19, 2008
Journal article: HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse, Journal of Clinical Investigation. February 14, 2008. (Science Daily)
Role Identified For Glaucoma Gene And Related Signaling Pathway Feb 18, 2008
The study, Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure, appeared online Feb. 14 in the Journal of Clinical Investigation. In addition to Clark, the Alcon scientists involved in this discovery included Wan-Heng Wang, Ph. (Science Daily)
Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests Feb 16, 2008
Their work will appear in the March issue of the Journal of Clinical Investigation and is also available online at the journal website. This research was funded in part by Novartis Institutes for Biomedical Research. (Science Daily)
New Blood Pressure Drug Reduces Clogs Feb 16, 2008
Their work will appear in the March issue of the Journal of Clinical Investigation and is available online beginning today at http://www. jci. (Newsmax)
Transplanted Liver Lining Cells May Cure Hemophilia Feb 15, 2008
(SOURCES: Sanjeev Gupta, M.D., professor, hepatology, Albert Einstein College of Medicine, New York City; Prasad Mathew, M.D., Ted R. Montoya Hemophilia Center, University of New Mexico, Albuquerque; Feb. 14, 2008, Journal of Clinical Investigation, online) ... They transplanted healthy liver endothelial cells into the livers of these mice, according to the report in the Feb. 14 online issue of the Journal of Clinical Investigation. (Health-Finder)
Blood pressure drug may have added benefit Feb 15, 2008
Their work will appear in the March issue of the Journal of Clinical Investigation and is available online beginning today at. Aliskiren, marketed under the brand name Tekturna by pharmaceutical manufacturer Novartis, is the first new class of blood pressure medication approved by the FDA in more than a decade. (EurekAlert!)
Managing Chronic Pain: When Does Morphine Become Less Effective? Feb 8, 2008
The journal article "Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain" was published in the Journal of Clinical Investigation on February 1, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)
Study suggests new therapy for lung disease patients Feb 8, 2008
The investigators worked with rats and human cells for the study, which was published in the February issue of the Journal of Clinical Investigation. "Allowing high levels of CO2 may contribute to the high mortality of patients with diseases like chronic obstructive pulmonary disease (COPD)," said Sznajder, a professor of medicine and of cell and molecular biology at the Feinberg School and a physician at Northwestern Memorial Hospital. (EurekAlert!)
Anemia Treatment May Improve or Worsen Disease, Based on Timing Feb 3, 2008
This research was published in the February issue of the Journal of Clinical Investigation (online January 24). The research was funded by the V. Kann Rasmussen Foundation, the NIH, Children's Hospital Boston, the Juvenile Diabetes Foundation, and the Research to Prevent Blindness organization. (Science Daily)
T cell immunity enhanced by timing of interleukin-7 therapy Feb 2, 2008
1, 2008) of the Journal of Clinical Investigation, a team led by UW-Madison School of Veterinary Medicine Professor of pathobiological sciences Marulasiddappa Suresh reports that therapeutic administration of interleukin-7 can be linked to a stage of early infection to effectively increase the number of a type of killer cell that recognizes and selectively assassinates virus-infected cells. "These cells need to get interleukin-7 for their survival," explains Suresh, of the killer immune cell... (EurekAlert!)
TNF-alpha Antagonist Stops Inflammation-induced Colon Cancer In Its Tracks Jan 29, 2008
The article "Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis" was recently published in the Journal of Clinical Investigation. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)
Adult Stem Cell Application Effective In Treatment Of Peripheric Vascular Disease Jan 29, 2008
The research work published in The Journal of Clinical Investigation analysed the role and potential of two different types of cell-based treatments for peripheric vascular disease ... The results of the study have been recently published as an article in The Journal of Clinical Investigation the main author of which is doctor in Biology at the University Hospital of the University of Navarra and CIMA, Xabier L;pez Aranguren. (Science Daily)
Possible progress on Gehrig's disease Jan 29, 2008
The report was published online last week in the Journal of Clinical Investigation. "It transfers to the quality of life," said lead scientist John Engelhardt, a UI professor and the head of the anatomy/cell-biology department. (Daily Iowan, IA)
Genetic Link To One Form Of Common Pediatric Illness -- Inflammation Of The Middle Ear Jan 27, 2008
The article "Eya4-deficient mice are a model for heritable otitis media" is published in the Journal of Clinical Investigation January 24, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)
Cancer treatment may also help osteoporosis Jan 27, 2008
Tests in mice showed it apparently helps regenerate bone tissue and be may be a potential treatment for osteoporosis, a team at Massachusetts General Hospital and the Harvard Stem Cell Institute reported in the Journal of Clinical Investigation. Harvard stem cell expert Dr. David Scadden said scientists have been hoping to find ways to use drugs to stimulate stem cells, which are the body's master cells. (Reuters UK)
Unexpected Protein Interaction Suggests New Lou Gehrig's Disease Drug Target Jan 26, 2008
25, 2008) Discovery of an unexpected protein-protein interaction has led University of Iowa scientists and colleagues to identify a drug that slows the progression of Amyotrophic Lateral Sclerosis (ALS) in mice and nearly doubles the animals' lifespan. The UI findings may lead to a treatment for some forms of ALS, and the research also reveals a biological mechanism that might represent a new drug target for ALS and other neurological diseases. (Science Daily)
Spice up your love life with the great sex diet Jan 24, 2008
The International Journal of Cardiovascular Interventions published a report noting that supplemental arginine may improve blood flow in coronary arteries, and an article in The Journal of Clinical Investigation showed arginine significantly improved circulation in young adults with high cholesterol. Although this research is not the definitive word on dietary arginine, Edlen-Nezin claims that adding it to your diet will improve your sex life. (MSNBC -- Health)
Altering Brain's Lipid Metabolism Reduces Alzheimer's Plaques In Mice Jan 23, 2008
Journal of Clinical Investigation, February 2008 (online January 17). Adapted from materials provided by. (Science Daily)
Molecule That Facilitates Cancer Spread In Both Cells And Their Surroundings Found Jan 22, 2008
21, 2008) The discovery that a molecule drives local tumor growth, as well as its ability to flourish and spread, opens a new window for understanding and treating cancer by taking aim at both cancer cells and their surrounding environment. A Dartmouth Medical School team led by Dr. Murray Korc found that a member of a common molecular family plays a role in the progress of a particularly resilient and aggressive pancreatic cancer, and that its influence is not restricted to that cancer. (Science Daily)
Molecule May Trigger Psoriasis Jan 19, 2008
(SOURCE: Journal of Clinical Investigation, news release, Jan. 17, 2008) ... These findings, published in the Jan. 17 issue of the Journal of Clinical Investigation, suggest that targeting IL-22 may provide a new approach to treating people with psoriasis, the study authors said. (Health-Finder)
Genetic Breakthrough Offers Promise In Tackling Kidney Tumors Jan 14, 2008
23, 2007) In a study appearing online in the Journal of Clinical Investigation, researchers in China report using mouse models of tuberous sclerosis complex to provide a potential explanation for the fact that. (May 1, 2006) Percutaneous cryoablation, a relatively non-invasive technique that destroys tumors by freezing them, is a safe method for treating kidney tumors in selected patients who are not considered. (Science Daily)
Important Clue To The Cause Of Parkinson's Disease Discovered Jan 7, 2008
This research appears in the January 2 advance online issue of The Journal of Clinical Investigation. Other Einstein scientists involved in the research were lead author Marta Martinez-Vicente, Susmita Kaushik, Ashish Massey and Dr. Antonia Follenzi. (Science Daily)
Possible Parkinsons trigger identified Jan 3, 2008
In the study in The Journal of Clinical Investigation on Wednesday, the team showed how in the majority of patients dopamine modifies normal proteins to act like the mutated ones to trigger tremors and other symptoms. "What we have found is dopamine modifies alpha-synuclein that really resembles the mutation," Cuervo said. (MSNBC -- Health)
How cells digest protein could trigger Parkinson's Jan 3, 2008
In the study in The Journal of Clinical Investigation on Wednesday, the team showed how in the majority of patients dopamine modifies normal proteins to act like the mutated ones to trigger tremors and other symptoms. Cuervo said a drug to fix the breakdown in Parkinson's patients was years away because it would take researchers time to understand fully how the process worked. (Xinhuanet, China)
Your Health: Holiday sweets can be health hazards Dec 28, 2007
The results of their study, published in the November 2007 issue of the Journal of Clinical Investigation, showed that when eaten in excess, sugars like fructose and glucose can wreak havoc with testosterone and estrogen levels. Fructose and glucose aren t always easy to sidestep since they re exceedingly abundant in the American diet, both individually and in a combined state. (Green Valley News & Sun, AZ)
Hormone May Be New Drug Target For Preventing Lymphedema, Tumor Spread Dec 28, 2007
The study is published Dec. 20, 2007, in the Journal of Clinical Investigation. Study co-authors are Kimberly L. Fritz-Six, William P. Dunworth and Manyu Li, all of the UNC School of Medicine. (Science Daily)
Cell-death receptor links cancer susceptibility and inflammation Dec 28, 2007
Most recently, El-Deiry and colleagues demonstrated for the first time a link between TRAILs receptor and cancer susceptibility, as reported online December 13, 2007 in the Journal of Clinical Investigation in advance of the January 2008 print issue. Unexpectedly, they also found a connection via Trail between inflammation and cancer susceptibility. (EurekAlert!)
What AM I? AM Is A Regulator Of Vascular System Functionality Dec 21, 2007
New data reported in two studies in the Journal of Clinical Investigation has identified signaling by a peptide known as AM in the development of both the blood and lymphatic vascular systems in mice ... Journal of Clinical Investigation. (Science Daily)
Chronic Kidney Disease Linked To Oxygen-deprived Tissue Dec 21, 2007
The findings appear in a December issue of the Journal of Clinical Investigation. This study was carried out by D. F. Higgins PhD, N. Shrimanker BA and Y. Akai, MD- PhD of the University of Pennsylvania; K. Kimura MD, Y. Akai MD, Y. Saito MD and M. Iwano MD of Nara Medical University, Japan; W. M. Bernhardt MD, B. Hohenstein MD and K-U. Eckardt MD of Friedrich-Alexander University, Germany; R. S. Johnson PhD of UCSD; M. Kretzler MD of University of Michigan; and C. D. Cohen MD of University of... (Science Daily)
