Ice cream really can control your brain Sep 16, 2009
"VideoSept. 14: The newest Joy Fit Club inductee, Rosemarie Jeanpierre, explains how she lost 110 pounds without surgery. Today showThe researchers also found that one particular type of fat palmitic acid which is found in beef, butter, cheese and milk, is particularly effective at instigating this mechanism.The study was performed on rats and mice but the scientists say their results, published in The Journal of Clinical Investigation, reinforced common dietary recommendations to limit... (MSNBC -- Health)
Scientists Identify Gene For Short-circuiting Excess Mucus In Lung Disease, Common Colds Sep 16, 2009
The discovery was reported in a study posted online Sept. 14 by the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2009; DOI. (Science Daily)
Gene find 'may curb lung mucus' Sep 15, 2009
The Journal of Clinical Investigation study raises hopes of new treatments. Lead researcher Dr Jeffrey Whitsett said a way to combat excessive mucus production would potentially be a significant step forward, as there was currently no effective treatment to remove build-up once it had taken place. (BBC News -- Health)
American Society for Microbiology to launch new open-access journal Sep 12, 2009
He continues to serve on the editorial boards of the Journal of Clinical Investigation and the Journal of Experimental Medicine. "With his deep understanding of microbial processes and his broad research interests, Professor Casadevall was the obvious choice for Editor in Chief of mBio," commented Thomas Shenk, chair of the ASM Publications Board. (EurekAlert! -- Business News)
Overexpressed Protein Converts Noninvasive Breast Cancer Into Invasive Disease Sep 10, 2009
10, 2006) In a study appearing in the January 4, 2006 issue of the Journal of Clinical Investigation, Vincent Cryns and colleagues at Northwestern University report how the protein alpha-basic-crystallin. (July 6, 2009) The recent decline in invasive breast cancer in the US was significantly less pronounced in the poor and those who live in rural areas. (Science Daily)
Aspirin Helps Liver? Sep 5, 2009
The study appears in the Jan. 26 edition of Journal of Clinical Investigation. Distributed by Internet Broadcasting. (KFOXTV.com, TX)
'S' Stands For Surprise: Anticoagulant Plays Unexpected Role In Maintaining Circulatory Integrity Sep 3, 2009
D., a professor in the Salk's Molecular Neurobiology Laboratory, who led the study, which appears in the Sept. 1, 2009, issue of the Journal of Clinical Investigation. "During the course of evolution, it was co-opted from the coagulation cascade for the regulation of inflammation in the immune system.". (Science Daily)
Research Points To New Target For Stopping Colon Cancer Sep 1, 2009
The study is published online August 17 in the Journal of Clinical Investigation. The researchers genetically blocked ERBB3 in a mouse model of colon cancer and in human colon cancer cell lines. (Science Daily)
Human Breast Cancer Hit For Six: Key Role For Six1 In Tumor Development And Metastasis Sep 1, 2009
31, 2009) Heide Ford and colleagues, at the University of Colorado School of Medicine, Aurora, have provided new insight into breast cancer development using mouse models and analysis of human cells, implicating the protein Six1 as central to this process, according to research to be published in the August 24 issue of the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2009; DOI ... Journal of Clinical Investigation, 2009; DOI. (Science Daily)
Abnormal Heartbeats Caused By Changes In Ion Channel Density Aug 29, 2009
28, 2009) Two independent studies have determined how changes in the density of different ion channels in the surface membrane of heart muscle cells can lead to life-threatening abnormal heartbeats, according to research to be published in the August 24 issue of the Journal of Clinical Investigation ... Kruse et al. Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. Journal of Clinical Investigation, 2009; DOI ... Journal of Clinical... (Science Daily)
Bicarbonate Linked To Sticky Mucus In Cystic Fibrosis Aug 28, 2009
However, Paul Quinton and colleagues, at the University of California at San Diego, La Jolla, have now provided insight into this issue by studying mouse small intestine segments ex vivo, according to a paper to be published in the August 24 issue of the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2009; DOI ... Journal of Clinical Investigation, 2009; DOI. (Science Daily)
Prion Protein Identified As Novel Early Pancreatic Cancer Biomarker Aug 19, 2009
They published these findings in the September issue of the Journal of Clinical Investigation. Unlike normal cells, in human pancreatic cancer cells the prion is incompletely processed and binds to a molecule inside the cell known as filamin A. Filamin A is an important regulator of the cell's skeleton and its signaling machineries. (Science Daily)
Mother's immune system may block fetal treatments for blood diseases Aug 17, 2009
The study appeared online August 3 in the Journal of Clinical Investigation. For over 50 years, explained Flake, it has been a fundamental precept of immunology that a fetus tolerates foreign antigens in a window-of-opportunity period before its immune system fully develops the capacity to mount an immune response. (EurekAlert!)
Potential Risk Identified In Transfusions Of Platelets Before Bone Marrow Transplant Aug 15, 2009
The results are online and scheduled for publication in the September 1 issue of the Journal of Clinical Investigation. Doctors have noticed a pattern in performing bone marrow transplants as a cure for diseases involving bone marrow failure: more transfusions before a bone marrow transplant correlates with a higher likelihood of rejection, says James Zimring, MD, PhD, assistant professor of pathology and laboratory medicine at Emory University School of Medicine. (Science Daily)
Multiple Types Of White Blood Cells Made Directly From Embryonic And Adult Stem Cells Aug 14, 2009
Slukvin's study was published in the Journal of Clinical Investigation. The result included osteoclasts, cells that play a role in osteoporosis, and eosinophils, which are involved in allergy and asthma. (Science Daily)
Estrogen-dependent Switch Tempers Killing Activity Of Immune Cells Aug 14, 2009
Journal of Clinical Investigation, 2009; DOI. Adapted from materials provided by. (Science Daily)
Stem Cell Advance May Further Disease Research Aug 13, 2009
Their study appears in the Aug. 10 online edition of the Journal of Clinical Investigation. "While we now can make almost all types of blood cells from embryonic and adult pluripotent stem cells, the next major challenge is to produce blood stem cells (called hematopoetic stem cells) that might be used in a bone marrow transplant," study leader Igor Slukvin, an assistant professor in the department of pathology and laboratory medicine, said in a university news release. (MEDLINEplus)
New Genetic Link Suspected for Muscular Dystrophy Aug 13, 2009
The study appears in the current issue of the Journal of Clinical Investigation. SOURCE: Journal of Clinical Investigation, news release, Aug. 10, 2009. (MEDLINEplus)
Tumors Feel The Deadly Sting Of Nanobees Aug 11, 2009
The nanobees' effectiveness against cancer in the mice is reported in advance online publication Aug. 10 in the Journal of Clinical Investigation ... Journal of Clinical Investigation, August 10, 2009 (advance online publication). (Science Daily)
Nanocomplexes Program Immune Cells ... Aug 5, 2009
The new research is published in August 2009 in the Journal of Clinical Investigation, by Dr. Jose Conejo-Garcia and colleagues at Dartmouth-Hitchcock's Norris Cotton Cancer Center (Lebanon, New Hampshire), and is entitled Polyethylenimine-based siRNA nanocomplexes reprogram tumor associated dendritic cells via the receptor TLR5 to elicit therapeutic antitumor immunity (Journal of Clinical Investigation, doi 10. 1172/JCI37716). (Suite101.com)
Unlocking The Key To Human Fertility Aug 4, 2009
2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (June 22, 2005) Damage to DNA in sperm is significantly higher in older men than in those who are younger, according to a research presented at the 21st annual conference of the European Society of Human. (Science Daily)
Immune System's Natural Killer Cells Linked To Infant Liver Disease Jul 26, 2009
The study, to be published in the Aug. 3 Journal of Clinical Investigation, is posted online on the journal's website. Adapted from materials provided by , via , a service of AAAS. Email or share this story. (Science Daily)
Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy Jul 23, 2009
Journal of Clinical Investigation, 2009; DOI ... Journal of Clinical Investigation, 2009; DOI. (Science Daily)
New Gene May Signal Aggressive Breast Cancer Jul 22, 2009
They then studied noncancerous, human breast epithelial cells and found that when RCP protein was overproduced, the otherwise healthy cells began to look more like tumor cells, according to the study in the July 20 issue of the Journal of Clinical Investigation ... SOURCE: Journal of Clinical Investigation, news release, July 20, 2009. (MEDLINEplus)
1 gene that contributes to breast cancer's aggressive behavior identified Jul 21, 2009
Singapore research published in Journal of Clinical Investigation ... The research findings are published in the July 20th online issue of Journal of Clinical Investigation (JCI). (EurekAlert!)
Potent cancer drug hopes raised Jul 21, 2009
But the Journal of Clinical Investigation study found they can also kill cancer cells directly themselves. The discovery of the unique pathway used by antibody therapies to kill cancer cells has for the first time revealed why they are more effective than chemotherapy. (BBC News -- Health)
Genetic Factors That Hold Promise For Treatment Of Vascular Diseases Jul 20, 2009
18, 2005) In the March 1 issue of the Journal of Clinical Investigation, Shahin Rafii and Barbara Hempstead along with colleagues from Cornell University, delve into the mechanisms underlying the angiogenic. (July 17, 2008) New findings could lead to future treatments to prevent lower limb amputations in diabetes. (Science Daily)
Trojan horse for ovarian cancer -- nanoparticles turn immune system soldiers against tumor cells Jul 16, 2009
Their research, published online July 13 for the August Journal of Clinical Investigation, offers a promising approach to orchestrate an attack against a cancer whose survival rates have barely budged over the last three decades. "We have modulated elements of the tumor microenvironment that are not cancer cells, reversing their role as accomplices in tumor growth to attackers that boost responses against the tumor," said Dr. Jose Conejo-Garcia, assistant professor of microbiology and immunology... (EurekAlert!)
New Role Discovered For Molecule Important In Development Of The Pancreas Jul 15, 2009
The findings appear in the July 2009 issue of the Journal of Clinical Investigation. The protein, Pdx1, is a pivotal molecule in the regulation of beta-cell development and we hope this type of information could help in efforts to generate beta-cell replacements for the treatment of diabetes," says senior author Doris Stoffers, MD, PhD, Associate Professor of Medicine at the University of Pennsylvania School of Medicine. Stoffers is also a member of the Institute for Diabetes, Obesity, and... (Science Daily)
Clocking Salt Levels In The Blood: Link Between The Circadian Rhythm And Salt Balance Jul 6, 2009
Journal of Clinical Investigation, DOI. Adapted from materials provided by , via , a service of AAAS. Email or share this story. (Science Daily)
Enzyme Doesn't Act Alone In Atrial Fibrillation Jul 1, 2009
The findings can be found online in the current edition of the Journal of Clinical Investigation. Others who took part in the study include Drs. (Science Daily)
Protein That Protects Sperm, Reduces Miscarriage Rates Identified Jun 27, 2009
2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (July 7, 2008) Pregnancy rates decrease and miscarriages were found to increase when a father is over 35 years of age. (Science Daily)
How Viral Infection Can Protect From Type 1 Diabetes May 29, 2009
Journal of Clinical Investigation, May 26, 2009 ... Journal of Clinical Investigation, May 26, 2009. (Science Daily)
Potential New Way To Protect Kidneys Threatened By Insufficient Blood Or Toxins May 23, 2009
ScienceDaily (May 22, 2009) Better treatments for acute renal failure may be possible by blocking the mitochondrial fragmentation that occurs when kidneys don't get enough blood or are exposed to toxins, researchers at the Medical College of Georgia report in the may issue of The Journal of Clinical Investigation. See also. (Science Daily)
Gene signature helps predict breast cancer prognosis May 20, 2009
In the Journal of Clinical Investigation, Harold (Hal) Moses, M.D., and colleagues report that this gene signature which is associated with the transforming growth factor-beta (TGF- ) signaling pathway correlates with reduced relapse-free survival in patients with breast cancer, especially in those with estrogen receptor (ER) positive tumors. The results suggest that assessing TGF- signaling may be a useful aid in determining breast cancer prognosis and in guiding treatment. (EurekAlert!)
Pepsi-Cola throwback May 17, 2009
Last week, the Journal of Clinical Investigation reported that consuming drinks sweetened with fructose could raise blood levels of LDL, or bad cholesterol, and triglycerides in overweight people ... The Journal of Clinical Investigation report addressed the harmful traits of pure fructose, which high-fructose corn syrup isn't. (Montana Standard, MT)
Breakthrough In The Treatment Of Bacterial Meningitis May 16, 2009
Their findings, published May 13 in The Journal of Clinical Investigation, suggest that disruption or modulation of this interaction of bacterial adhesins with the receptor might offer unexpectedly broad protection against bacterial meningitis and may provide a therapeutic target for the prevention and treatment of disease. Professor Ala Aldeen, who has been studying meningitis and its causes for over 20 years, said: This is a significant breakthrough which will help us design novel strategies... (Science Daily)
Pepsi going old school in products - 'Throwback’ uses sugar from regional supplier in Wyoming May 12, 2009
Last week, the Journal of Clinical Investigation reported that consuming drinks sweetened with fructose could raise blood levels of LDL, or bad cholesterol, and triglycerides in overweight people ... The Journal of Clinical Investigation report addressed the harmful traits of pure fructose, which high-fructose corn syrup isn t.. (Missoulian, MT)
Lithium may help radiation target cancer, spare healthy tissue May 5, 2009
In the May 1 issue of the Journal of Clinical Investigation, Fen Xia, M.D., Ph. D., and colleagues show that lithium promotes DNA repair in healthy cells but not in brain tumor cells. (EurekAlert!)
Chemical Found In Medical Devices Impairs Heart Function May 4, 2009
5, 2005) In their study appearing online on February 3 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation, Michael Otto and colleagues from Rocky Mountain. (Oct. (Science Daily)
Lupus Kidney Damage Linked To Malfunction Of Immune Cells Apr 28, 2009
In the second study, published in the April issue of The Journal of Clinical Investigation, the researchers found that some members of a family of genes called kallikreins offered a degree of protection in both mice and humans against a type of kidney damage caused by a different mechanism ... Journal of Clinical Investigation, 2009; 119 (4): 911 DOI. (Science Daily)
Fructose-Sweetened Drinks Up Metabolic Syndrome Risk Apr 28, 2009
The study was published in the Journal of Clinical Investigation. Decreased sensitivity to insulin and dyslipidemia are signs of metabolic syndrome, which increases the risk of heart attack. (MEDLINEplus)
Therapeutic effect of imatinib improved with addition of chloroquine Apr 14, 2009
(PHILADELPHIA) The therapeutic effects of the blockbuster leukemia drug imatinib may be enhanced when given along with a drug that inhibits a cell process called autophagy, researchers from the Kimmel Cancer Center at Jefferson reported in the Journal of Clinical Investigation. The cell-death effect of imatinib (Gleevec) was potentiated when chloroquine, an autophagy inhibitor, was given with imatinib for the in vitro treatment of chronic myeloid leukemia (CML) cells including the CML stem... (EurekAlert!)
Gene Discovery Could Lead To Male Contraceptive Apr 11, 2009
2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (Aug. (Science Daily)
Biology Of Flushing Could Renew Niacin As Cholesterol Drug Apr 11, 2009
Journal of Clinical Investigation, May 1, 2009. Adapted from materials provided by. (Science Daily)
Fiber helps kill bad cells Apr 7, 2009
In an unrelated paper published online today in the Journal of Clinical Investigation, a team at Duke University Medical Center is looking at how to enhance the same cell surface protein's effect on lowering bad cholesterol and increasing good cholesterol through niacin, or vitamin B3. That team might turn its attention to potential cancer protective effects after seeing MCG's work. (The Augusta Chronicle)
* World News Quick Take Apr 4, 2009
The research, which appears in the April edition of US-published Journal of Clinical Investigation, demonstrates that THC and related cannabinoids appear to be a new family of potential antitumoral agent. . (Taipei Times, Taiwan -- Sports)
How infection may spark leukaemia Apr 1, 2009
The Institute of Cancer Research study appears in the Journal of Clinical Investigation. While infection is clearly only one factor in triggering progression, this study greatly increases the strength of evidence for its role in the commonest form of childhood leukaemia. (BBC News -- Health)
Licorice compound offers new cancer prevention strategy Mar 24, 2009
In the study published in the Journal of Clinical Investigation, Raymond Harris, M.D., Ming-Zhi Zhang, M.D., and colleagues show that inhibiting the enzyme 11 -hydroxysteroid dehydrogenase type 2 (11 HSD2) either by treatment with a natural compound found in licorice or by silencing the 11 HSD2 gene prevents colorectal cancer progression in mice predisposed to the disease. Colorectal cancer is the second leading cause of cancer deaths in the United States. (EurekAlert!)
New Role For Immune System Pathway In Post-heart Attack Inflammation Mar 17, 2009
The study, published online March 9 in the Journal of Clinical Investigation, suggests that CaM kinase II inhibition could be a therapeutic target in heart disease, but by previously unknown pathways. CaM kinase II is a pivotal enzyme that registers changes in calcium levels and oxidative stress and translates these signals into cellular effects, including changes in heart rate, cell proliferation and cell death. (Science Daily)
Transcriptional Factor SOX9 Renders Melanomas Sensitive To Retinoic Acid And Stops Tumor Growth Mar 11, 2009
Journal of Clinical Investigation, 2009; DOI. Adapted from materials provided by , via , a service of AAAS. Email or share this story. (Science Daily)
Take 2: What Protein And Where It Is Located Are Important For Drug Design Mar 6, 2009
The research is published Feb. 23, 2009, in the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2009; DOI. (Science Daily)
Protein Complex Linked To Parkinson Disease Mar 5, 2009
The research is published Feb. 23, 2009, in the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2009; DOI ... Journal of Clinical Investigation, 2009. (Science Daily)
Prenatal Molecular Diagnosis For Tuberous Sclerosis Complex Mar 4, 2009
23, 2007) In a study appearing online in the Journal of Clinical Investigation, researchers in China report using mouse models of tuberous sclerosis complex to provide a potential explanation for the fact that. . (Science Daily)
Muscular Dystrophy And Exercise-induced Muscle Fatigue Have More In Common Than You Might Think Mar 4, 2009
The research is published Feb. 23, 2009, in the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2009; DOI ... Journal of Clinical Investigation, 2009; DOI. (Science Daily)
Muscular dystrophy mystery solved; Mizzou scientist moves closer to MD solution Feb 27, 2009
In his most recent study, published Monday in The Journal of Clinical Investigation, Duan and his team identified the location of genetic material responsible for the production of nNOS.. Following the identification of the genetic material, Duan and his team created a series of new dystrophin genes. (EurekAlert!)
Key To Regenerative Therapies? Process For Expansion And Division Of Heart Cells Identified Feb 24, 2009
5, 2004) In the February 2 issue of the Journal of Clinical Investigation, Pritinder Kaur and colleagues at the Peter MacCallum Cancer Centre, Australia, demonstrate that both epidermal stems cells and their. . (Science Daily)
Gene Linked To Aggressive Progression Of Liver Cancer Identified Feb 19, 2009
In the study, published online in the February issue of the Journal of Clinical Investigation, researchers reported that the astrocyte elevated gene-1, AEG-1, plays a key role in regulating HCC in series of cellular models ... Journal of Clinical Investigation, Feb 16, 2009; DOI. (Science Daily)
Body's Defenses May Worsen Chronic Lung Diseases In Smokers Feb 19, 2009
Borchers and his team report their findings in the March 2009 issue of the Journal of Clinical Investigation. The study appears online ahead of print Feb. 9, 2009. (Science Daily)
Monkey study links fat, fetal toxicity Feb 8, 2009
The federally funded study appears in the online edition of the Journal of Clinical Investigation. Human and monkey fetuses are vulnerable to fat overload, Grove said, because they don't develop a fat storage system until very late in pregnancy. (OregonLive, OR -- Business)
Viagra May Shield Heart from Blood Pressure Damage Feb 7, 2009
The findings, published online Monday in The Journal of Clinical Investigation, suggest that sildenafil may prove useful in the treatment or prevention of heart damage due to chronic high blood pressure. "Sildenafil clearly prolongs the protective effects of RGS2 in mouse hearts," senior investigator Dr. David Kass, a cardiologist and professor of medicine at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute in Baltimore, said in a Hopkins news release. (MEDLINEplus)
Team led by Scripps Scientists increases understanding of two types of blindness Feb 7, 2009
D., was reported in an advance, online edition of the Journal of Clinical Investigation on February 2, 2009. The research is also likely to apply to a range of other neurodegenerative conditions, including vision loss from Huntington's and Alzheimer's diseases and inherited retinal degenerations, such as retinitis pigmentosa. (EurekAlert!)
New treatment hope for prostate cancer Feb 7, 2009
An article, which described the invention, has recently been published in the prestigious international journal The Journal of Clinical Investigation. Head of the Burnet Institute's Cancer Immunotherapy Laboratory, Associate Professor Pei Xiang Xing said his group has produced a monoclonal antibody to a unique tumour marker for the treatment of prostate cancer. (EurekAlert!)
Estrogen May Explain Why Women with Cystic Fibrosis Suffer More Feb 7, 2009
The authors of the study, published in the Nov. 20 issue of the Journal of Clinical Investigation, suggest that drugs that reduce estrogen levels, such as tamoxifen, might be helpful in fighting this devastating disease. The evidence is still preliminary, however. (MEDLINEplus)
