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    News and Articles on Journal of Clinical Investigation

    Archives: Journal of Clinical Investigation

    Anti-tumor Effects Are Enhanced By Inhibiting Two Pathways Rather Than One  Aug 26, 2008
    Journal of Clinical Investigation, 2008; DOI ... Journal of Clinical Investigation, 2008; DOI ... 23, 2007) In a study appearing online in the Journal of Clinical Investigation, researchers in China report using mouse models of tuberous sclerosis complex to provide a potential explanation for the fact that. (Science Daily)

    Novel Mechanism That Controls The Development Of Autoimmunity Discovered  Aug 15, 2008
    6, 2004) In the February 2 issue of the Journal of Clinical Investigation Mark Peakman and colleagues from King's College London suggest a mechanism for the specificity of the immune regulation that. (Feb. (Science Daily)

    Protein key to control, growth of blood cells  Aug 14, 2008
    Her study appeared online July 10 in the Journal of Clinical Investigation. Hematopoietic stem cells (HSCs) develop into all types of blood cells: red blood cells, platelets and immune cells. (EurekAlert!)

    New Panel Of Mice Helps Predict How Drugs Are Broken Down In Humans  Aug 5, 2008
    The researchers report their findings in the Aug. 1 issue of the Journal of Clinical Investigation. In the study, four types of mouse were generated: mice that lacked PXR, mice that lacked CAR, mice that expressed human PXR in place of mouse PXR, and mice that expressed human CAR in place of mouse CAR. In addition, breeding these different mice in various combinations led to the generation of mice expressing both human PXR and human CAR and mice lacking both PXR and CAR.. (Science Daily)

    Cigarette smoke worsens flu  Jul 26, 2008
    Ads By Google Indo-Asian News ServiceWashington, July 25, 2008First Published: 17:23 IST(25/7/2008)Last Updated: 17:43 IST(25/7/2008). Cold and flu virus symptoms often mild in non-smokers can seriously hit smokers, according to a study by Yale School of Medicine. (Hindustan Times)

    Smokers Struck by Influenza Face Higher Mortality Rates  Jul 25, 2008
    (SOURCE: Journal of Clinical Investigation, news release, July 24, 2008) ... The study was published in the current issue of the Journal of Clinical Investigation. (Health-Finder)

    Yale study shows why cigarette smoke makes flu, other viral infections worse  Jul 25, 2008
    Published in the Journal of Clinical Investigation, the study also identified the mechanism by which viruses and cigarette smoke interact to increase lung inflammation and damage ... Citation: The Journal of Clinical Investigation, Vol. 118, No. 8 (August 2008). (EurekAlert!)

    Minimally Invasive Treatment Improves Male Fertility  Jul 23, 2008
    2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (Nov. (Science Daily)

    Scientists identify how gastric reflux may trigger asthma  Jul 22, 2008
    "This is the first experimental evidence in a controlled, laboratory setting linking these two very common conditions in humans," says Lin, the senior author of the study published online in the European Journal of Clinical Investigation. "These data suggest that chronic micro-aspiration of gastric fluid can drive the immune system toward an asthmatic response.". (EurekAlert!)

    A Potential Metastatic Disease Target?  Jul 21, 2008
    The study's results were released as a special "highlighted" article in a recent issue of the Journal of Clinical Investigation. Adapted from materials provided by. (Science Daily)

    Bone Marrow Transplants: Cancer Drug Shows Promise Against Graft Vs. Host Disease  Jul 17, 2008
    Journal citation: Journal of Clinical Investigation, Vol. 118, no. 7, July 2008. Funding: National Institutes of Health, Doris Duke Clinical Scientist Development Award, Amy Strelzer Manasevit-National Marrow Donor Program. (Science Daily)

    Overcoming Resistance To A Cancer Drug  Jun 25, 2008
    Journal of Clinical Investigation, 2008; DOI ... Journal of Clinical Investigation, 2008; DOI. (Science Daily)

    Certain anticancer agents could be harmful to patients with heart disease  Jun 24, 2008
    The research was reported June 20, 2008, in advance online publication in the Journal of Clinical Investigation ... Journal of Clinical Investigation June 20, 2008 (advance online publication). (EurekAlert!)

    How Measles Virus Spreads: Discovery May Rewrite Textbooks  Jun 23, 2008
    Journal of Clinical Investigation, 2008 DOI. Adapted from materials provided by. (Science Daily)

    Hormone may help dieters keep weight off: U.S. study  Jun 21, 2008
    "When you lose weight you've created about the perfect storm for regaining weight," said Michael Rosenbaum of Columbia University Medical Center in New York, whose research appears in the Journal of Clinical Investigation. After weight loss Rosenbaum said the metabolism not only becomes more efficient, so the body needs fewer calories, but the brain becomes more vulnerable to tasty-looking treats. (Scientific American)

    The cause of all hereditary sensory and autonomic neuropathy type II cases has been established  Jun 11, 2008
    A major discovery that details the existence of a neuronal specific form of the WNK1 gene, henceforth referred to as the WNK1/HSN2 isoform, was recently completed by the research group of Dr. Guy A. Rouleau and published in the scientific journal The Journal of Clinical Investigation. The group led by Dr. Rouleau is part of the University of Montreal Hospital Centre (CHUM), the CHUM Research Centre (CRCHUM) and the Sainte-Justine University Hospital Centre. (EurekAlert!)

    Scientists ID Gene Regulating Blood Glucose Levels  Jun 7, 2008
    The study is published in the July issue of The Journal of Clinical Investigation. "Genetics is identifying a whole new set of genes, proteins and pathways that are related to diabetes and blood sugar control. Our next challenge is to figure out how these genes work," study co-author Dr. Thomas A. Buchanan, professor of endocrinology at Keck, said in a prepared statement. (Health-Finder)

    Gene That Regulates Glucose Levels Identified  Jun 4, 2008
    The detailed results will be published in the July issue of the Journal of Clinical Investigation and are currently available online. The research was funded by the American Diabetes Association, the National human Genome Research Institutes, the National Institutes of Diabetes, Digestive and Kidney Diseases, the National Institutes on Aging, the National Heart, Lung and Blood Institute, Medical Research Council of the United Kingdom, the European Union, Lundbeck Foundation Center of Applied... (Science Daily)

    Link Between Inflammation, Cancer Confirmed  Jun 4, 2008
    The researchers published evidence of the long-suspected link in the Journal of Clinical Investigation ... Journal of Clinical Investigation, 2008; DOI. (Science Daily)

    Chronic Stomach Inflammation Boosts Cancer Risk  Jun 3, 2008
    Their findings, confirmed in two studies the researchers did on mice, were published in the June 2 online issue of the Journal of Clinical Investigation. Researchers have long known that inflammation caused by infectious agents, such as Helicobacter pylori and hepatitis C, produces cytokines -- chemicals that can foster cancerous cell proliferation and suppress cell death. (Health-Finder)

    Protein May Be Key To New Therapies For Elevated Triglycerides  May 28, 2008
    Results of their study are published in the June issue of the Journal of Clinical Investigation. Heart disease is the leading cause of death in the United States and is a major cause of disability, according to the Centers for Disease Control and Prevention. (Science Daily)

    Immune system protein could help develop cancer vaccine: study  May 27, 2008
    The research was published Friday in The Journal of Clinical Investigation. Story Tools: | | Text Size. (CBC.ca)

    Cancer vaccine target pinpointed  May 24, 2008
    The research is published in the Journal of Clinical Investigation. The protein is unique to a type of immune cell called a dendritic cell, which is responsible for triggering the body's defence system. (BBC News -- Health)

    Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides  May 24, 2008
    Results of their study are published in the June issue of the Journal of Clinical Investigation. Scientists in the Division of Immunogenetics at Childrens Hospital studied the role of a protein known as Forkhead Box O1 (FoxO1) that mediates the metabolism of glucose and cholesterol. (EurekAlert!)

    New Drug Reduces One Cause Of Vision Loss  May 20, 2008
    Journal of Clinical Investigation, May 15, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)

    Novel Insight Into Cardiac Arrhythmias, Sudden Cardiac Death  May 12, 2008
    Their findings, published online in the Journal of Clinical Investigation, could pave the way for the development of new, genetically-targeted therapies to treat and prevent fatal arrythmias. See also. (Science Daily)

    Study Offers Clues to Link Between Arrhythmia, Sudden Death  May 10, 2008
    The study was published online Thursday in The Journal of Clinical Investigation. "We are still struggling to understand why arrhythmia causes sudden cardiac death in some patients, but not others, and what underlying molecular mechanisms or abnormalities may be at play," study senior author Dr. Gideon Koren, director of the cardiovascular research center at Rhode Island Hospital and a professor of medicine at Brown University's medical school, said in a prepared statement. (MEDLINEplus)

    Scientists Discover How Stomach Tumors Form  May 2, 2008
    The findings were published online April 22 in The Journal of Clinical Investigation. The study shows that IL-11 promotes chronic inflammation and the formation of tumors in the stomach by increasing activation of the Stat3 protein, a known player in inflammation-associated carcinogenesis. (MEDLINEplus)

    Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia  May 2, 2008
    The surprising findings, published in the April 22 online issue of The Journal of Clinical Investigation, are significant, because individuals with frontotemporal dementia with parkinsonism-17 -- a relatively rare hereditary form of dementia -- are often used as models for studying Alzheimer's disease. Alzheimer's disease and frontotemporal dementia each develop as a result of too many tau proteins accumulating and causing tangled lesions in the brain's neurons. (MEDLINEplus)

    Regenerative Medicine To Repair Wounded Warriors  Apr 23, 2008
    5, 2004) In the February 2 issue of the Journal of Clinical Investigation, Pritinder Kaur and colleagues at the Peter MacCallum Cancer Centre, Australia, demonstrate that both epidermal stems cells and their. (Nov. (Science Daily)

    Scan Detects Oxygen Levels in Tumors  Apr 23, 2008
    April 22, 2008, Journal of Clinical Investigation) ... "If successful, [the trend] will revolutionize the way that we treat cancer," said Dewhirst, who co-wrote a commentary accompanying the new study, published April 22 in the Journal of Clinical Investigation. (Health-Finder)

    World-first Discovery Could Help Treat Life-threatening Tumors  Apr 20, 2008
    19, 2008) WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumours. Western Australian Institute for Medical Research (WAIMR) Associate Professor Ruth Ganss and her team have found that a gene called RGS5 can reverse angiogenesis -- the growth of blood vessels inside the tumour. (Science Daily)

    Hepatitis B Virus Triggers Cell 'Suicide' In Patients With Chronic Infection  Apr 10, 2008
    Their findings are published today in the Journal of Clinical Investigation ... Journal reference: 'Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control hepatitis B virus' is published online ahead of print in the Journal of Clinical Investigation and is embargoed to Tuesday 8th April 2008 at 9pm GMT (5pm Eastern). (Science Daily)

    A Random Analysis  Apr 3, 2008
    Journal of Clinical Investigation 107: 657-662. For genome defense in Neurospora, see Galagan, J. E. and Selker, E. U. 2004. (New York Times)

    Korean scientists find gene promoting liver cancer growth  Mar 24, 2008
    The paper about the research was published in Journal of Clinical Investigation on Friday. "We are now searching for a business partner to conduct clinical research into liver cancer drugs," the daily quoted the team as saying. (Xinhuanet, China)

    Clues To Prevent Spread Of Ovarian Cancer  Mar 19, 2008
    In the April issue of the Journal of Clinical Investigation, the researchers show that an enzyme known as MMP-2 is necessary for ovarian cancer to attach itself to the sites where it tends to spread. Several drugs known as MMP inhibitors (for example, marimastat or prinomastat) inhibit the enzyme, dramatically reducing the tumor's ability to establish itself at sites beyond the ovary. (Science Daily)

    Parkinson's Disease Drug Might Work In Cancer Patients  Mar 19, 2008
    This research was published in the March 13 online issue of The Journal of Clinical Investigation. Other authors include: Chandrani Sarkar, Ph. (Science Daily)

    Pinpointing When A Fetus Develops Male Genitalia, And Birth Defects Related To Male Sex Organs  Mar 18, 2008
    Journal of Clinical Investigation ... 2, 2006) Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows. (Science Daily)

    New Drug Protects Nerve Cells From Damage In Mice  Mar 18, 2008
    Journal of Clinical Investigation. March 12, 2008. (Science Daily)

    Male fertility decided in womb by hormones  Mar 18, 2008
    This measurement could be an early warning system of future reproductive problems in baby boys, the researchers reported in the latest edition of the Journal of Clinical Investigation. "We know from other studies that androgens work during foetal development to programme the reproductive tract. But our assumption was that it would be much later in pregnancy," said the study's lead author, Michelle Welsh. (Times of India)

    Male fertility 'set in the womb'  Mar 17, 2008
    The results are published online in the Journal of Clinical Investigation. Problems with reproductive development such as the testes not descending properly into the scrotum (cryptorchidism) or the urinary tract opening in the wrong place on the penis (hypospadias) are fairly common in young boys. (BBC News -- UK)

    Parkinson's Drug May Fight Cancer  Mar 15, 2008
    The findings were published in the online edition of the Journal of Clinical Investigation. "Researchers can now test this concept in solid tumors where angiogenesis (formation of new blood vessels) plays a critical role in the growth and progression of these cancers," Dr. Sujit Basu, a Mayo Clinic oncologist, said in a prepared statement. (Health-Finder)

    Parkinson's Drug May Fight Cancer  Mar 15, 2008
    A study published in the March 13 online issue of The Journal of Clinical Investigation shows that dopamine, a drug currently used to treat Parkinsons disease and other illnesses, also might work in cancer patients. The study, which was done in mouse and laboratory models, shows that dopamine could possibly prevent new blood vessels from growing and as a result, slow cancer progression. (Newsmax)

    Relief for priapism sufferers  Mar 15, 2008
    The study is published in the Journal of Clinical Investigation. Get personalised news stories on mobile. (India Times, India -- Health/Science)

    Rare Syndrome Provides Clues On Obesity, Blood Pressure  Mar 5, 2008
    The study appeared online March 3 in the Journal of Clinical Investigation. The study was supported in part by grants from the American Heart Association, the National Institutes of Health and the Howard Hughes Medical Institute. (Science Daily)

    Hormones could save hearing  Mar 5, 2008
    Their findings were published in the Journal of Clinical Investigation this week. "The alpha (oestrogen) receptor has no affect on hearing loss when you don't have the beta receptor you get more of a hearing loss. We're seeing the same effect in the males and the females," Canlon told AFP.. (iAfrica.com)

    Sticky blood protein yields clues to autism  Mar 5, 2008
    In an advance online publication in the Journal of Clinical Investigation, Ana Carneiro, Ph. D., and colleagues report that a well-known protein found in blood platelets, integrin beta3, physically associates with and regulates the serotonin transporter (SERT), a protein that controls serotonin availability. (EurekAlert!)

    Curry Spice May Thwart Heart Failure  Feb 27, 2008
    The studies "came to nearly identical conclusions," says an editorial published with the studies in February's edition of The Journal of Clinical Investigation. But editorialist Jonathan Epstein, MD, cautions against counting on curcumin to prevent heart failure in people, since the findings in rodents may not apply to people. (CBS News)

    Gene Defect Causes Immune Deficiency And Balance Disorder  Feb 26, 2008
    The study, published online Feb. 21 in the Journal of Clinical Investigation, examined a specialized strain of Jackson Laboratory mice with a mutation that eliminates the production a protein called p22phox. Disruption of this protein causes a form of chronic granulomatous disease (CGD) -- a severe immune deficiency -- in humans. (Science Daily)

    The cat's out of the bag: Felines stave off heart disease  Feb 26, 2008
    This latest research, published in the Journal of Clinical Investigation, adds to a growing body of medical literature indicating that curcumin has a broad range of biological properties. It is currently being tested as a possible treatment for cancer, Alzheimer's disease and various skin disorders. (Globe and Mail)

    Study: genetic defect may produce balance disorders  Feb 26, 2008
    A study by researchers at the University of Iowa, the Jackson Laboratory in Maine and East Carolina University was funded in part by grants from the National Institutes of Health, and published online Friday in the Journal of Clinical Investigation. The study examined a specialized strain of Jackson Lab mice that eliminates production a protein called p22phox. (Muscatine Journal, IO)

    Stimulating Thymus Reactivates T-Cell Production  Feb 24, 2008
    The results are published in the March issue of the Journal of Clinical Investigation. "These results represent new proof-of-principle findings that thymic involution can be reversed in humans," study author Dr. Laura Napolitano, an assistant investigator at Gladstone and an assistant professor of medicine at UCSF, said in a prepared statement. (Health-Finder)

    Immune System Reactivated In Adults With HIV  Feb 22, 2008
    It should be noted that in an accompanying commentary in the Journal of Clinical Investigation, Kiki Tesselaar and Frank Miedema, at University Medical Center Utrecht, The Netherlands, warn that the long-term immunological and clinical benefits of growth hormone administration need to be thoroughly determined before this approach can be used more widely in the clinic ... Journal reference: Growth hormone resurrects adult human thymus during HIV-1 infection, Journal of Clinical Investigation. (Science Daily)

    Curcumin May Prevent Heart Failure  Feb 22, 2008
    In a study entitled, Curcumin prevents and reverses murine cardiac hypertrophy, published in the February edition of the Journal of Clinical Investigation, researchers found when the herb is given orally to a variety of mouse models with enlarged hearts (hypertrophy), it can prevent and reverse hypertrophy, restore heart function and reduce scar formation. The healing properties of turmeric have been well known in eastern cultures for some time. (Newsmax)

    Early Detection Of Cerebral Malaria Possible, Animal Study Indicates  Feb 20, 2008
    Journal reference: A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. Journal of Clinical Investigation. February 14, 2008. (Science Daily)

    Transplanted Cells May Hold The Key To Curing Hemophilia A  Feb 20, 2008
    The study appears online February 14 in the Journal of Clinical Investigation. Daniel Benten and Phyllis Novikoff of Einstein were also involved in this study. (Science Daily)

    Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis  Feb 19, 2008
    Journal article: HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse, Journal of Clinical Investigation. February 14, 2008. (Science Daily)

    Role Identified For Glaucoma Gene And Related Signaling Pathway  Feb 18, 2008
    The study, Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure, appeared online Feb. 14 in the Journal of Clinical Investigation. In addition to Clark, the Alcon scientists involved in this discovery included Wan-Heng Wang, Ph. (Science Daily)

    Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests  Feb 16, 2008
    Their work will appear in the March issue of the Journal of Clinical Investigation and is also available online at the journal website. This research was funded in part by Novartis Institutes for Biomedical Research. (Science Daily)

    New Blood Pressure Drug Reduces Clogs  Feb 16, 2008
    Their work will appear in the March issue of the Journal of Clinical Investigation and is available online beginning today at http://www. jci. (Newsmax)

    Transplanted Liver Lining Cells May Cure Hemophilia  Feb 15, 2008
    (SOURCES: Sanjeev Gupta, M.D., professor, hepatology, Albert Einstein College of Medicine, New York City; Prasad Mathew, M.D., Ted R. Montoya Hemophilia Center, University of New Mexico, Albuquerque; Feb. 14, 2008, Journal of Clinical Investigation, online) ... They transplanted healthy liver endothelial cells into the livers of these mice, according to the report in the Feb. 14 online issue of the Journal of Clinical Investigation. (Health-Finder)

    Blood pressure drug may have added benefit  Feb 15, 2008
    Their work will appear in the March issue of the Journal of Clinical Investigation and is available online beginning today at. Aliskiren, marketed under the brand name Tekturna by pharmaceutical manufacturer Novartis, is the first new class of blood pressure medication approved by the FDA in more than a decade. (EurekAlert!)

    Managing Chronic Pain: When Does Morphine Become Less Effective?  Feb 8, 2008
    The journal article "Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain" was published in the Journal of Clinical Investigation on February 1, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)

    Study suggests new therapy for lung disease patients  Feb 8, 2008
    The investigators worked with rats and human cells for the study, which was published in the February issue of the Journal of Clinical Investigation. "Allowing high levels of CO2 may contribute to the high mortality of patients with diseases like chronic obstructive pulmonary disease (COPD)," said Sznajder, a professor of medicine and of cell and molecular biology at the Feinberg School and a physician at Northwestern Memorial Hospital. (EurekAlert!)

    Anemia Treatment May Improve or Worsen Disease, Based on Timing  Feb 3, 2008
    This research was published in the February issue of the Journal of Clinical Investigation (online January 24). The research was funded by the V. Kann Rasmussen Foundation, the NIH, Children's Hospital Boston, the Juvenile Diabetes Foundation, and the Research to Prevent Blindness organization. (Science Daily)

    T cell immunity enhanced by timing of interleukin-7 therapy  Feb 2, 2008
    1, 2008) of the Journal of Clinical Investigation, a team led by UW-Madison School of Veterinary Medicine Professor of pathobiological sciences Marulasiddappa Suresh reports that therapeutic administration of interleukin-7 can be linked to a stage of early infection to effectively increase the number of a type of killer cell that recognizes and selectively assassinates virus-infected cells. "These cells need to get interleukin-7 for their survival," explains Suresh, of the killer immune cell... (EurekAlert!)

    TNF-alpha Antagonist Stops Inflammation-induced Colon Cancer In Its Tracks  Jan 29, 2008
    The article "Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis" was recently published in the Journal of Clinical Investigation. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)

    Adult Stem Cell Application Effective In Treatment Of Peripheric Vascular Disease  Jan 29, 2008
    The research work published in The Journal of Clinical Investigation analysed the role and potential of two different types of cell-based treatments for peripheric vascular disease ... The results of the study have been recently published as an article in The Journal of Clinical Investigation the main author of which is doctor in Biology at the University Hospital of the University of Navarra and CIMA, Xabier L;pez Aranguren. (Science Daily)

    Possible progress on Gehrig's disease  Jan 29, 2008
    The report was published online last week in the Journal of Clinical Investigation. "It transfers to the quality of life," said lead scientist John Engelhardt, a UI professor and the head of the anatomy/cell-biology department. (Daily Iowan, IA)

    Genetic Link To One Form Of Common Pediatric Illness -- Inflammation Of The Middle Ear  Jan 27, 2008
    The article "Eya4-deficient mice are a model for heritable otitis media" is published in the Journal of Clinical Investigation January 24, 2008. Adapted from materials provided by , via , a service of AAAS.. (Science Daily)

    Cancer treatment may also help osteoporosis  Jan 27, 2008
    Tests in mice showed it apparently helps regenerate bone tissue and be may be a potential treatment for osteoporosis, a team at Massachusetts General Hospital and the Harvard Stem Cell Institute reported in the Journal of Clinical Investigation. Harvard stem cell expert Dr. David Scadden said scientists have been hoping to find ways to use drugs to stimulate stem cells, which are the body's master cells. (Reuters UK)

    Unexpected Protein Interaction Suggests New Lou Gehrig's Disease Drug Target  Jan 26, 2008
    25, 2008) Discovery of an unexpected protein-protein interaction has led University of Iowa scientists and colleagues to identify a drug that slows the progression of Amyotrophic Lateral Sclerosis (ALS) in mice and nearly doubles the animals' lifespan. The UI findings may lead to a treatment for some forms of ALS, and the research also reveals a biological mechanism that might represent a new drug target for ALS and other neurological diseases. (Science Daily)

    Spice up your love life with the great sex diet  Jan 24, 2008
    The International Journal of Cardiovascular Interventions published a report noting that supplemental arginine may improve blood flow in coronary arteries, and an article in The Journal of Clinical Investigation showed arginine significantly improved circulation in young adults with high cholesterol. Although this research is not the definitive word on dietary arginine, Edlen-Nezin claims that adding it to your diet will improve your sex life. (MSNBC -- Health)

    Altering Brain's Lipid Metabolism Reduces Alzheimer's Plaques In Mice  Jan 23, 2008
    Journal of Clinical Investigation, February 2008 (online January 17). Adapted from materials provided by. (Science Daily)

    Molecule That Facilitates Cancer Spread In Both Cells And Their Surroundings Found  Jan 22, 2008
    21, 2008) The discovery that a molecule drives local tumor growth, as well as its ability to flourish and spread, opens a new window for understanding and treating cancer by taking aim at both cancer cells and their surrounding environment. A Dartmouth Medical School team led by Dr. Murray Korc found that a member of a common molecular family plays a role in the progress of a particularly resilient and aggressive pancreatic cancer, and that its influence is not restricted to that cancer. (Science Daily)

    Molecule May Trigger Psoriasis  Jan 19, 2008
    (SOURCE: Journal of Clinical Investigation, news release, Jan. 17, 2008) ... These findings, published in the Jan. 17 issue of the Journal of Clinical Investigation, suggest that targeting IL-22 may provide a new approach to treating people with psoriasis, the study authors said. (Health-Finder)

    Genetic Breakthrough Offers Promise In Tackling Kidney Tumors  Jan 14, 2008
    23, 2007) In a study appearing online in the Journal of Clinical Investigation, researchers in China report using mouse models of tuberous sclerosis complex to provide a potential explanation for the fact that. (May 1, 2006) Percutaneous cryoablation, a relatively non-invasive technique that destroys tumors by freezing them, is a safe method for treating kidney tumors in selected patients who are not considered. (Science Daily)

    Important Clue To The Cause Of Parkinson's Disease Discovered  Jan 7, 2008
    This research appears in the January 2 advance online issue of The Journal of Clinical Investigation. Other Einstein scientists involved in the research were lead author Marta Martinez-Vicente, Susmita Kaushik, Ashish Massey and Dr. Antonia Follenzi. (Science Daily)

    Possible Parkinsons trigger identified  Jan 3, 2008
    In the study in The Journal of Clinical Investigation on Wednesday, the team showed how in the majority of patients dopamine modifies normal proteins to act like the mutated ones to trigger tremors and other symptoms. "What we have found is dopamine modifies alpha-synuclein that really resembles the mutation," Cuervo said. (MSNBC -- Health)

    How cells digest protein could trigger Parkinson's  Jan 3, 2008
    In the study in The Journal of Clinical Investigation on Wednesday, the team showed how in the majority of patients dopamine modifies normal proteins to act like the mutated ones to trigger tremors and other symptoms. Cuervo said a drug to fix the breakdown in Parkinson's patients was years away because it would take researchers time to understand fully how the process worked. (Xinhuanet, China)

    Your Health: Holiday sweets can be health hazards  Dec 28, 2007
    The results of their study, published in the November 2007 issue of the Journal of Clinical Investigation, showed that when eaten in excess, sugars like fructose and glucose can wreak havoc with testosterone and estrogen levels. Fructose and glucose aren t always easy to sidestep since they re exceedingly abundant in the American diet, both individually and in a combined state. (Green Valley News & Sun, AZ)

    Hormone May Be New Drug Target For Preventing Lymphedema, Tumor Spread  Dec 28, 2007
    The study is published Dec. 20, 2007, in the Journal of Clinical Investigation. Study co-authors are Kimberly L. Fritz-Six, William P. Dunworth and Manyu Li, all of the UNC School of Medicine. (Science Daily)

    Cell-death receptor links cancer susceptibility and inflammation  Dec 28, 2007
    Most recently, El-Deiry and colleagues demonstrated for the first time a link between TRAILs receptor and cancer susceptibility, as reported online December 13, 2007 in the Journal of Clinical Investigation in advance of the January 2008 print issue. Unexpectedly, they also found a connection via Trail between inflammation and cancer susceptibility. (EurekAlert!)

    What AM I? AM Is A Regulator Of Vascular System Functionality  Dec 21, 2007
    New data reported in two studies in the Journal of Clinical Investigation has identified signaling by a peptide known as AM in the development of both the blood and lymphatic vascular systems in mice ... Journal of Clinical Investigation. (Science Daily)

    Chronic Kidney Disease Linked To Oxygen-deprived Tissue  Dec 21, 2007
    The findings appear in a December issue of the Journal of Clinical Investigation. This study was carried out by D. F. Higgins PhD, N. Shrimanker BA and Y. Akai, MD- PhD of the University of Pennsylvania; K. Kimura MD, Y. Akai MD, Y. Saito MD and M. Iwano MD of Nara Medical University, Japan; W. M. Bernhardt MD, B. Hohenstein MD and K-U. Eckardt MD of Friedrich-Alexander University, Germany; R. S. Johnson PhD of UCSD; M. Kretzler MD of University of Michigan; and C. D. Cohen MD of University of... (Science Daily)

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