Chromosomal Abnormalities Jun 14, 2008
If a karyotype reveals a numerical abnormality, it is most likely random ... If, however, a fetal karyotype reveals a structural abnormality, a parental karyotype should be performed to determine or rule out a hereditary condition. (Suite101.com)
Chromosome Analysis Jun 7, 2008
The Karyotype or Comparative Genomic Hybridization of Fetal Matter ... Two techniques, karyotype and comparative genomic hybridization (CGH), are currently used to assess the tissue ... To perform the karyotype, a specialized lab technician will. (Suite101.com)
UCLA researchers examine human embryonic stem cell genome Mar 28, 2008
Clinical specialists commonly generate a karyotype to examine the chromosomes of cancer cells or for amniocentesis in prenatal diagnosis, which has a much lower resolution than Array CGH, said Michael Teitell, a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the senior author of the study ... His team found CNV differences between the two lines in at least seven different chromosome locations below the level of detection using standard... (EurekAlert!)
First Diploid Human Genome Sequence Shows We're Surprisingly Different Sep 5, 2007
Spectral karyotype analysis. (Credit: J. Craig Venter Institute). (Science Daily)
Drug Resistance Argues Against Mutation Theory Of Cancer Jun 29, 2007
The chromosomal fingerprint, or karyotype, of a normal human cell (left), includes 46 paired chromosomes. The distinctive karyotype of an aneuploid breast cancer cell, however, (right) includes duplicates of entire chromosomes, missing chromosomes, and chromosome stubs ... "Why aren't we all getting resistant to any toxic drug we are exposed to" Why does it happen only in cancer cells" Why do cancer cells become resistant and the patients don't""In his experiments, Duesberg and his colleagues... (Science Daily)
Support for chromosomal theory of cancer found in cancers' development of drug resistance Jun 28, 2007
"Why aren't we all getting resistant to any toxic drug we are exposed to" Why does it happen only in cancer cells" Why do cancer cells become resistant and the patients don't"" In his experiments, Duesberg and his colleagues focus on the chromosomal fingerprint of a cell, its karyotype. For decades, physicians have known that cells of a particular cancer have the same set of marker chromosomes, a rogues gallery of normal chromosomes and stumps of chromosomes. Duesberg and UC Berkeley... (EurekAlert!)
When a Person Is Neither XX nor XY: A Q&A with Geneticist Eric Vilain Jun 7, 2007
Now in 1959 when the karyotype of Klinefelter [a male who is XXY] and Turner [a female who has one X] syndromes was discovered, it became clear that in humans it was the presence or the absence of the Y chromosome that's sex determining. Because all Klinefelters that have a Y are male, whereas Turners, who have no Y, are females. (Scientific American)
New Technology Predicted to Revolutionize Genetic Analysis of Preimplantation Embryos Oct 22, 2006
Limitations of these techniques include the inability to test for segregating genetic diseases with no known DNA mutation and the risk of not successfully identifying the genetic makeup of both partners' DNA. Dr. Kearns explains, "The new technology provides an exponential improvement in the quantity and quality of genetic diagnosis for preimplantation embryos. Our optimized and enhanced DNA extraction/amplification protocol and modified microarray platform will permit us to: 1) Perform a... (PR Newswire)
Lenalidomide in the Myelodysplastic Syndrome with Chromosome 5q Deletion Oct 5, 2006
Results Among the 148 patients, 112 had a reduced need for transfusions (76%; 95% confidence interval [CI], 68 to 82) and 99 patients (67%; 95% CI, 59 to 74) no longer required transfusions, regardless of the karyotype complexity. The response to lenalidomide was rapid (median time to response, 4. (New England Journal of Medicine)
Just another child Sep 30, 2006
he nurse did not go into great detail but said the doctor did the karyotype test and would send (it) off to the lab to be certain of the diagnosis, she said. he preliminary results of the test take three days with the final results in three weeks. (Taylor Daily Press, TX)
N.H. Supreme Court overturns DMHC case May 9, 2006
The Dartmouth Online. Tuesday, May 9, 2006. (The Dartmouth Online, NH)
Three New Species Of Lemurs Identified Feb 25, 2006
An international team comprising researchers from Madagascar, Germany, France and Switzerland classified individual lemurs on the basis of either their chromosome profile, called a 'karyotype', or the sequence of the mitochondrial cytochrome b gene. The team analysed the karyotypes of 99 individuals from all currently recognised species of lemur and the cytochrome b gene was sequenced in 68 individuals. (Science Daily)
Scientists discover abnormal chromosomes Feb 17, 2006
Scientists at the Technological Centre for Healthy Birth under the Guangdong Family Planning Research Institute have discovered 39 cases of abnormal chromosomal karyotypes, which are not thought to have been recorded anywhere else in the world ... The new discoveries follow the analysis of 5,000 blood samples since 1996, bringing the number of abnormal chromosomal karyotypes cases first reported by Chinese scientists to 1,838, Zheng said ... Tests showed an abnormal chromosomal karyotype led to... (Xinhuanet, China)
