UCLA researchers examine human embryonic stem cell genome Mar 28, 2008
Small defects that could result in big problems later on could be missed using karyotyping for stem cells. Basically, this study shows that the genetic makeup of individual human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility, said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLAs Jonsson Comprehensive Cancer Center. (EurekAlert!)
Chromosomal Abnormalities Play Substantial Role In Autism Jan 23, 2008
In the new study, the researchers examined structural abnormalities in 427 unrelated ASD cases using both microarray analysis and karyotyping ... Karyotyping, in which chromosomes are viewed under the microscope, can identify "balanced" translocations or inversions that might otherwise be missed by microarrays. (Science Daily)
Susan G. Komen for the Cure Announces Recipients of 2007 Komen Brinker Award for Scientific Distinction Dec 13, 2007
He is credited with the development and implementation of many important technologies, including high-speed sorting; flow karyotyping; the first chromosome painting probes; development of interphase fluorescent in situ hybridization (FISH); and the first demonstration using FISH showing ERBB2 amplification and BCR-ABL translocation, both of which are critically important to current patient management. His list of credits also includes brdU/DNA analysis of cell cycle progression; comparative... (PR Newswire)
Minimum telomere length defined for healthy cells Oct 5, 2007
What the Spectral Karyotyping (SKY) analysis revealed. 05 Oct, 2007. (Nature News Service)
Toward A Faster Prenatal Test For Down Syndrome Sep 22, 2007
In a study scheduled for publication in Analytical Chemistry, Stanford University bioengineering professor and Howard Hughes Medical Institute researcher Stephen R. Quake and his graduate student H. Christina Fan point out that most existing pre-natal tests depend on a technique termed karyotyping ... The digital PCR process allowed the researchers to count DNA molecules from the samples, substituting for the two-week cell culture process traditionally needed to produce enough DNA for... (Science Daily)
Test Spots Genetic Damage Done by Smoking Sep 7, 2007
Franklin and his team used two laboratory techniques -- spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) -- to check the chromosomal status of lung tissue among 71 people. Fourteen of the study participants had already been diagnosed with lung cancer, 43 were considered at high-risk for the disease because they were smokers, and another 14 people were healthy men and women who'd never smoked. (MEDLINEplus)
New Technique Detects Specific Chromosomal Damage, May Indicate Lung Cancer Risk Sep 6, 2007
The investigators used a technique called spectral karyotyping (SKY) to examine the bronchial epithelium (BE) of 71 subjects--14 patients with lung cancer, 43 smokers at high risk for developing lung cancer and 14 healthy non-smokers--in the hope of identifying underlying genetic changes that might be hallmarks for cancer. "It is critically important that we thoroughly understand the nature and timing of the cellular and genetic effects of tobacco smoke on BE in order to identify biomarkers and... (Science Daily)
Testing foetus for Down's is now quicker Aug 18, 2007
Unlike conventional methods, such as Karyotyping, which takes up to 21 days to diagnose, the new procedure called FlashFISH (Fluorescent in situ Hybridisation) requires a mere two-hour testing time. Come the year's end, the National University Hospital (NUH) will be the first in the world to offer the novel technique, an "improved" version of the existing Standard FISH, whereby pregnant mothers have to wait for at least 24 to 48 hours for the results. (Channel NewsAsia, Singapore)
Cancer detectors more sophisticated Jan 14, 2007
This examination is called karyotyping. For example, chronic myleogenous leukemia, or CML, displays a characteristic "translocation," or exchange, between chromosomes 9 and 22. (North County Times)
