NYP/Columbia physician-scientists present at ASCO 44th annual meeting May 31, 2008
Kinesin Spindle Protein (KSP) for Hodgkin's Lymphoma ... A Phase 1 dose-escalation trial of Kinesin Spindle Protein (KSP), a drug that targets a unique aspect of cancer cell division, has been found to be well tolerated and active in select patients with Hodgkin's disease. (EurekAlert!)
Spotlight On A Key Player In The Dance Of Chromosomes May 16, 2008
CENP-E is part of a large class of proteins called kinesins ... The motion of normal kinesin, kinesin-1, is now well known, Selvin said ... I was interested to know whether the normal rules of how kinesin walks apply to these different kinds of kinesins. (Science Daily)
Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway Jan 18, 2008
Differential regulation of dynein and kinesin motor proteins by the microtubule associated protein tau ... Dynein and kinesin proteins transport cellular cargo towards opposite ends of tracks called microtubules ... The transport performed by dynein and kinesin is required for continuously providing new proteins to the axon and synapse to maintain normal cellular function, and is also required to remove old, misfolded, or aggregated proteins for degradation. (EurekAlert!)
Protein-dependent 'Switch' Regulates Intracellular Trafficking In Epithelial Cells Dec 17, 2007
Specifically, the team has discovered a molecular "switch" in developed epithelial cells that selects from a large family of "motor proteins," called kinesins. Each kinesin facilitates the transport of specific surface markers from production sites inside the cell to their ultimate home on the cell's surface ... "Not only are many more kinesins present in cells than previously thought, but their selectivity helps direct which packages of surface proteins are transported, as well as their... (Science Daily)
Molecular Motors And Brakes Work Together In Cells Feb 1, 2007
Green represents the molecular motors, the kinesin proteins klp2, on each microtubule. (Image Credit: Phong Tran, PhD, University of Pennsylvania School of Medicine). (Science Daily)
Molecule Walks In A Straight Line And Carries A Tiny Shopping Bag In Each Hand Jan 23, 2007
(December 8, 2003) -- Biophysicists at Stanford University have finally answered one of the most fundamental questions in molecular biology: How does the tiny motor molecule, known as kinesin, move across a living. . (Science Daily)
Why Biological Loads Do Not Get Caught Up When Being Transported Through Cells Oct 26, 2006
Using an ultra-sensitive microscopy method, the researchers have defined how the motor protein Kinesin-1 interacts with its "transport rails", the microtubules, based on a nanometer scale ... Artist's impression of transport of microtubules on a surface full of kinesin motor proteins ... Motor proteins, of which kinesin-1 is a well-researched example, consist of a head, middle section and tail. (Science Daily)
Scientists Discuss New Frontiers In Single-molecule Research Sep 21, 2006
In 1993, Block and his colleagues were the first to observe the movement of an individual molecule of kinesin, a tiny protein that carries chromosomes, neurotransmitters and other vital cargo along minute tracks called microtubules in living cells. Using a sensitive microscope-based instrument known as an optical trap, the Block team observed that kinesin moves along microtubules in discrete steps that are a mere 8 nanometers long. "Kinesin and other motor molecules are really nature's... (Science Daily)
Researchers Image Molecular Motor Structural Changes Sep 16, 2006
Humans are thought to have approximately 45 different molecular motors -- proteins known as kinesins -- in their bodies. For the study, Endow and her colleagues chose a kinesin found in baker's yeast that closely resembles kinesins found in humans, and which is well understood in terms of structure and biological activity ... But they had not been able to obtain images of the actual structural changes kinesins undergo as they move along microtubules. (Science Daily)
Molecular Motor Helps Cells Tell Which Way Is Up Sep 1, 2006
Chishti's research team, including Kaori Horiguchi and Dr. Toshihiko Hanada, determined that one domain of a molecular motor protein called a kinesin that they had discovered interacted with PIP3 binding protein. They showed that the kinesin and this binding protein motored the PIP3 along microtubules -- the tracks upon which the kinesins move their cargoes ... They also showed that the kinesin-binding adaptor and PIP3 were found together at the tips of the nerve cells and that in one of these... (Science Daily)
Rapid Kala-azar detection kit developed by AIIMS doctors Feb 12, 2006
It is based on novel recombinant kinesin antigen developed by the Department of Laboratory Medicine, AIIMS using plasmid having genes for antigen for protozoa causing Kala Azar and introduced in Escherichia Coli bacteria. It had been patented internationally in 2003 and transferred to Span Diagnostics in June 2005 which developed an immuno filteration rapid test using the patented product and proces reducing the test result to ten minutues. (Webindia123)
A New Way Of Looking At Molecular Motors Feb 10, 2006
All complex organisms use myosin and its relatives, kinesin and dynein, to move substances around inside cells and to help cells move from one place to the other. Myosins also help parasites enter and infect hosts. (Science Daily)
