Researchers report the cloning of a key group of human genes, the protein kinases May 3, 2008
They further used the kinome collection in several high-throughput screens, including a screen which identified two novel kinases regulating the Hedgehog signaling pathway a key pathway linked to multiple types of human cancer ... Application of active and kinase-deficient kinome collection for identification of kinases regulating Hedgehog signaling, Cell 133, May 2nd, 2008. (EurekAlert!)
Master Switch That Regulates Blood Pressure Identified Nov 3, 2007
There are 518 of them -- referred to as the human kinome -- and they coordinate a wide variety of complex biological functions. The WNK kinases, which were discovered in 2000, have been a subject of intense interest among medical researchers since 2001 when a group at the Yale University School of Medicine found a link between this class of kinases and FHHt. (Science Daily)
Ireland Cancer Center researchers advance lung cancer treatment Apr 24, 2007
Dr. Ma's team conducted further study on the mutation and identified the mutation to occupy a location that constitutes a highly conserved salt bridge structure across the whole human kinome (more than 300 protein kinases with many of which as "druggable" therapeutic targets). His findings suggest that genetic mutations altering the salt bridge structure in the kinome proteins may affect cancer cell signaling, drug inhibitor binding and drug sensitivity. (EurekAlert!)
Ocean home to new proteins, families Mar 15, 2007
N. Kannan et al., "Structural and Functional Diversity of the Microbial Kinome," PLoS Biology, March 2007. 1986-2007 The Scientist. (The Scientist)
Millions Of New Genes, Thousands Of New Protein Families Found In Ocean Sampling Expedition Mar 15, 2007
Structural and Functional Diversity of the Microbial Kinome. The availability of the GOS metagenomic data along with other large microbial genome data sets is enabling more research into specific kinds of protein families. (Science Daily)
