Scientists Find Way to Block Weight Gain in Stressed... Jul 3, 2007
Scientists from have found that blocking the pathway that leads stressed people to gain weight is the key to manipulating fat at least in laboratory animals. The findings, published online in on Sunday, explain why people who are chronically stressed often develop "metabolic syndrome," a condition which causes individuals to gain more weight than they should based on the calories they consume. (Fox News)
Scientists Discover Key To Manipulating Fat; Pathway Also Explains Stress-induced Weight Gain Jul 3, 2007
In what they call a "stunning research advance," investigators at Georgetown University Medical Center have been able to use simple, non-toxic chemical injections to add and remove fat in targeted areas on the bodies of laboratory animals ... Investigators at Georgetown University Medical Center have been able to use simple, nontoxic chemical injections to add and remove fat in targeted areas on the bodies of laboratory animals. (Science Daily)
Use of Mice in Biomedical Research Jun 27, 2007
These developments are all reflected in the latest edition (7th ed.) of the Guide for the Care and Use of Laboratory Animals of the National Research Council (NRC) of the United States ... International Committee of the Institute for Laboratory Animal Research ... Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council. (Suite101.com)
Group: Livestock may help treat ailments May 16, 2007
Bruce Friedrich, a vice president of People for the Ethical Treatment of Animals, or PETA, called the technology "Frankenstein science" that leads to the death of many laboratory animals. He said there can be terrifying consequences for humans if diseases cross species barriers. (Herald Online, SC -- Health)
New Stem Cell Method Promises To Repair Severe Blood Vessel Damage May 10, 2007
In what has been described as a breakthrough, US scientists have found a new way to use human embryonic stem cells to produce precursor cells that can repair severely damaged blood vessels in mice and other laboratory animals. They hope this method will one day be used to repair extensive blood vessel damage in humans, for instance diabetics with damaged retinas, people with severe blood vessel damage in limbs (and thereby avoid amputation), and reducing deaths from heart attacks. (Medical News Today)
Scientists Find Gene Linking Lifespan to Calorie Restriction May 5, 2007
" Dillin says that activating the pha-four gene is one of two major ways to lengthen life in laboratory animals. Another is to decrease their sensitivity to insulin, a hormone that regulates blood sugar. But this has unwelcome side effects, such as stunting and reproductive problems. It is a long evolutionary leap from earthworms to people, but Dillin says it is worth determining if the human versions of the pha-four gene operate the same way. The goal would be to develop a drug that could... (Voice of America)
High Doses Of Phytochemicals, Including Flavanoids, In Teas And Supplements Could Be Unhealthy May 2, 2007
The data was from studies done in humans and laboratory animals. The report cites specific examples of toxic effects, including reports of liver, kidney, and intestinal toxicity related to consumption of high doses of green tea-based dietary supplements. (Science Daily)
Pill to boost women's sex drive and help them lose weight Apr 30, 2007
However, in an unexpected short-term side-effect, the laboratory animals also ate significantly less food than usual. In some cases this was one-third less than their usual daily diet. (Scotsman)
FDA advisers get behind new type of HIV drug Apr 25, 2007
The drugs also have been linked to heart rhythm changes in laboratory animals. FDA reviewers noted no increase in lymphomas or infections among patients given Celsentri, but said there was a modest increase in liver problems. (MSNBC -- Health)
'Inherently toxic' chemical faces its future Apr 7, 2007
Some researchers with close-up views of bisphenol A are so shocked by its ability to skew development in their laboratory animals, even at among the lowest doses ever used in experiments, they aren't waiting for the government to ban it. In their personal lives, they can't run away from products containing it fast enough. (Globe and Mail)
First Step In Developing Heart Hormone-based Pill To Control High Blood Pressure Mar 28, 2007
The researchers tested the oral BNP by inducing high blood pressure in laboratory animals, and then giving them the experimental drug ... In this way, the team designed a novel chimeric peptide and defined its heart-kidney action by testing it in laboratory animals. (Science Daily)
Study Citing Antioxidant Vitamin Risks Based On Flawed Methodology, Experts Argue Mar 2, 2007
A study recently published on possible health risks of antioxidant supplements is based on flawed methodology and ignores the broad totality of evidence that comes to largely opposite conclusions, say experts from the Linus Pauling Institute at Oregon State University. The research, which was published in this week s edition of the Journal of the American Medical Association, concluded that antioxidant supplements such as vitamins A and E may significantly increase mortality, and that there was... (Science Daily)
Drug being tested to see if it can control diabetes Jan 30, 2007
The drug has already proven to help laboratory animals and people in smaller studies control diabetes and blood pressure. It s not going to be a spectacular drug but it s cheap and it s generic and if we prove that it works it will help control this epidemic of diabetes and maybe even help heart disease, said Tulane Endocrinologist Dr. Vivian Fonseca. (WWLTV.com, LA)
Folic Acid May Prevent Cleft Lip And Palate Jan 27, 2007
"Folic acid deficiency causes facial clefts in laboratory animals, so we had a good reason to focus on folic acid in our clefts study," said Wilcox. "It was one of our main hypotheses.". (Science Daily)
Study claims to solve drug trial mystery Jan 27, 2007
Dr Federica Marelli-Berg, of the Department of Immunology at Imperial College London, presented the findings of research suggesting why the inexperienced immune systems of laboratory animals did not react to the drug ... However the same tests on laboratory animals did not provoke any immune system reaction. (Telegraph.co.uk)
Dog sacrificed for sales demonstration Jan 19, 2007
An institution's policy for animal use is by the institution's IACUC, which is reviewed and approved by the USDA. General guidelines that must be followed are outlined in the federal (in which rats and mice are ) and the on Humane Care and Use of Laboratory Animals ... JK Borchardt, "US debates care standards for small laboratory animals," The Scientist, July16, 2001 ... Public Health Service Policy on Humane Care and Use of Laboratory Animals. (The Scientist)
Amniotic stem cell find could overcome barriers to using embryos Jan 8, 2007
The study also suggests another advantage: unlike embryonic cells, which can form tumours when implanted in laboratory animals, amniotic fluid stem cells do not appear to do so. It is still unclear whether stem cells from amniotic fluid - the liquid that cushions babies in the womb - can give rise to the full range of cell types that embryonic stem cells can produce. (Sydney Morning Herald -- World)
Immune System Cells Linked To Heart Failure Dec 29, 2006
(April 16, 1998) -- Researchers have demonstrated in laboratory animals that tumor necrosis factor alpha, a protein produced in the heart, can lead to congestive heart failure. The finding may pave the way for a. (Science Daily)
Christmas Is Good For You Dec 22, 2006
In research first published in the ACS Journal of Agricultural and Food Chemistry in 2004, scientists at the U.S. Department of Agriculture found that several compounds from cinnamon significantly lower blood sugar levels in laboratory animals. The compounds appeared to mimic the action of insulin, and showed promising results at lowering blood sugar levels in humans with Type 2 diabetes. (Forbes)
Where was the defense? Dec 22, 2006
Where was the defense. A fan's perspective on the Falcons. (Atlanta Journal-Constitution -- Sports)
Experts 'to back monkey testing' Dec 12, 2006
BBC Science Correspondent Pallab Ghosh said research on primates caused particular controversy because they were more sentient than other laboratory animals and so suffered more. The committee, led by Oxford geneticist Professor Sir David Weatherall, heard evidence from 35 people, including representatives from academic organisations, animal welfare groups, the government and patients. (BBC News -- UK)
Experts defend monkey research Dec 12, 2006
1% of the total number of laboratory animals. Some three-quarters of these are macaques, a genus that includes the rhesus monkey and the Barbary macaque, best known as the species found in Gibraltar. (Guardian Unlimited -- UK)
Toward New Medications For Iron-overload Diseases Nov 29, 2006
The researchers report the synthesis and early testing in laboratory animals of a possible new generation of iron chelating drugs, compounds that remove excess iron from the body. In addition to working more efficiently than existing medications, the new compounds target specific organs such as the liver, heart and pancreas that are most vulnerable to iron-overload damage. (Science Daily)
Cover: How We Worry Nov 26, 2006
To probe the risk-assessment mechanisms of the human mind, Joseph LeDoux, a professor of neuroscience at New York University and the author of The Emotional Brain, studies fear pathways in laboratory animals. He explains that the jumpiest part of the brain of mouse and man is the amygdala, a primitive, almond-shaped clump of tissue that sits just above the brainstem. (Time.com)
Tβ4 is essential for coronary vessel development report Nov 18, 2006
In two articles published in the scientific journal, Nature, researchers found that TB4 protects heart tissue following a myocardial infarction (heart attack) and can regenerate coronary vessels in laboratory animals. Abstracts of scientific papers related to TB4's mechanisms of action may be viewed at RegeneRx's web page. (EurekAlert!)
Why these foods help you prolong life Nov 17, 2006
By mimicking the effects of drastic calorie restriction which has been shown to prolong the lives of laboratory animals by up to one third resveratrol can do much the same. Leading the study, David Sinclair, at the Harvard Medical School, and Rafael de Cabo, at the National Institute on Aging, fed one group of mice a high-fat diet from the age of one year (their middle age), a second group was fed high-fat foods but with a large daily dose of resveratrol. (TimesOnline)
Red wine substance appears to counter bad health in fat mice Nov 2, 2006
Previous research has shown that laboratory animals fed very low-calorie diets live significantly longer. In the hope of finding a drug that could harness the natural life-extending capabilities activated by caloric restriction, Sinclair and his colleagues identified a number of promising compounds, including resveratrol, which is found in red wine, grape skins and other plants. (FOX59, IN)
Red Wine Compound Promotes Health, Study Finds Nov 2, 2006
Previous research has shown that laboratory animals fed very-low-calorie diets live significantly longer, which has prompted some people to try arduous "caloric restriction" diets as a possible fountain of youth, even though their effectiveness in humans remains unproven. In the hope of finding a drug that could harness the natural life-extending capabilities activated by caloric restriction, Sinclair and his colleagues identified a number of promising compounds, including resveratrol, which is... (Washington Post)
Wine stops obesity's ills in mice Nov 2, 2006
Previous research has shown laboratory animals fed very low-calorie diets live significantly longer, which has prompted some people to try strenuous "caloric restriction" diets as a possible fountain of youth, even though its effectiveness remains unproven. To examine for the first time whether resveratrol could also extend longevity in mammals, Sinclair and his colleagues studied year-old mice, the equivalent of middle-aged humans. (Toronto Star -- World)
Obesity drug may help Type 2 diabetes Oct 30, 2006
When the receptor is blocked in laboratory animals, they eat less and lose weight. Regulators in Europe licensed the drug as a weight-loss pill in June, in combination with diet and exercise, for people who are obese and at risk for diabetes. (CBC News)
Passion over Covance runs high at session Oct 28, 2006
"25, 26 So, contrary to the propaganda put forward by the medical establishment to justify its work, animal experimentation does not save human lives. As the industry's own evidence proves, it does just the opposite. -------------------------------------------------------------------------------- Author's Note: This article is based on information contained in Sacred Cows and Golden Geese: The Human Cost of Animal Experimentation, by C. Ray Greek, MD, and Jean Swingle Greek (Continuum... (AZCentral -- Business)
New Tool Can Help Predict Diabetes Complications Oct 25, 2006
Studies in laboratory animals revealed that caffeine stimulates the body's metabolism and may induce a mechanism that helps to reduce obesity, which is also strongly linked to type 2 diabetes. Other research suggests that a reduction in risk for diabetes may be due to compounds in coffee other than caffeine. (PR Newswire)
Is it a bird, is it a plane, is it Superdave? Oct 2, 2006
In the past month alone he has met Nelson Mandela and repudiated Margaret Thatcher s ambivalence over the ANC two decades ago, laid a wreath at Gandhi s grave in India and, in another foreign trip, visited Scotland to lament that the poll tax was imposed there as if its people were mere laboratory animals. Further, in an underreported speech, he condemned the English caricature of Glaswegians as aggressive alcoholics. (TimesOnline)
Possible Health Risks For Children Born To Overeating Mothers Sep 23, 2006
The ONPRC also participates in the voluntary accreditation program overseen by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC). Can't find it. (Science Daily)
John Cassidy on neuroeconomics Sep 15, 2006
Unfortunately, this is an invasive procedure, and its experimental use has generally been restricted to laboratory animals. There is also a more fundamental objection to neuroeconomics and the Platonic view of decision-making. (New Yorker)
Extremists target legitimate research Aug 22, 2006
The university's Animal Research Committee ensures that research strictly adheres not only to the federal Animal Welfare Act but also the "Guide for the Care and Use of Laboratory Animals" issued by the National Institutes of Health and guidelines issued by the National Research Council ... Laboratory animals are a critical component of modern research because they serve as effective models for the study of human disease ... Research involving laboratory animals has served as a vital cornerstone... (The Daily Bruin, CA)
Parental Cigarette Use Is 'Double Whammy' For Children Aug 11, 2006
(October 18, 2000) -- Scientists at the National Institute on Drug Abuse (NIDA) have demonstrated that laboratory animals will self-administer marijuana's psychoactive component, THC (delta-9-tetrahydrocannabinol), in. . (Science Daily)
City Honors Native Son With Special Day Jul 6, 2006
Crudup began a six-month training regimen learning more than 101 instruments of the surgical profession by performing exploratory surgery on laboratory animals. It wasn't much longer before medical students and surgical residents were watching Crudup's work when professors would send them over, saying, "go see Jimmy." Students from Japan, China, Canada and the United States were watching Crudup and then participating in their own surgical research under his supervision. (Forest Scott County Times, MS)
Findings Reveal Possible Strategy Against Obesity, Diabetes And Infertility Jul 6, 2006
To learn whether STAT3 mediates some of leptin s activities, we devised a technique for inactivating STAT3 with pinpoint accuracy in the hypothalamus and observing the results in laboratory animals when we administered leptin, says Dr. Rossetti. Our tool for rapidly inactivating STAT3 was a cell-permeable peptide (short protein) that we infused into specific areas of the hypothalamus using fine needles. (Science Daily)
Brain Research Breakthrough May Lead to Parkinson's Cure Jun 23, 2006
In experiments with laboratory animals, researchers were able to use this discovery to rescue the dying cells, repair the affected pathway, and improve neurological function, which could lead to better treatments for humans with Parkinson s disease. "For the first time we've been able to repair dopaminergic neurons, the specific cells that are damaged in Parkinson's disease," says researcher Susan Lindquist of Howard Hughes Medical Institute, in a news release. (Fox News)
Good Hygeine May Be Cause of High Allergy Rates Jun 20, 2006
The study showed that wild rats and mice had higher levels of two types of antibodies normally associated with triggering allergies and autoimmune diseases in laboratory animals ... "While the production of these two antibody types lead to autoimmune disease and allergy, respectively, in the laboratory animals, their production seemed to represent a nonpathogenic, protective response to the environment by the wild rodents.". (Fox News)
Microbes Transform 'Safest' PBDEs Into More Harmful Compounds Jun 15, 2006
In laboratory animals, high blood levels of PBDE are associated with cancer, lowered immunity, thyroid problems, and learning and memory difficulties. Although PBDE levels in people haven t reached the levels of laboratory animals, Alvarez-Cohen says scientists are concerned because they are rising in humans at an exponential rate, doubling every two to five years. (Science Daily)
Soil-bound Prions That Cause CWD Remain Infectious Apr 15, 2006
To ascertain whether prions remain infectious in soil, the researchers also injected clay-bound prions into laboratory animals. The animals began to show TSE symptoms at approximately the same time as animals injected with only prions. (Science Daily)
Studies Can't Prove Soy Formula Risks Mar 18, 2006
A variety of toxic effects, including stunted growth, sexual organ abnormalities, and decreased fertilization, have all been observed in laboratory animals ... Human infants consume much lower genistein doses than laboratory animals, and most of the chemical is not absorbed into the human bloodstream, says Karl Rozman, PhD, a University of Kansas toxicologist who led NIH panel. (Fox News)
Blood Levels Of Suspected Carcinogen Vary By Race, Ethnicity Mar 10, 2006
Environmental Science ology. The study, by scientists at the Centers for Disease Control and Prevention (CDC) in Atlanta, is the first to detect racial or ethnic differences in levels of PFCs among humans. (Science Daily)
Tysabri Waltzes through FDA Advisory Panel by 12-0 Vote Mar 10, 2006
Anita Smith was a human being and not a laboratory animal that belonged to Biogen. Thus, her records cannot be withheld at the companys direction. (Newsinferno.com)
Soy Might Worsen Heart Condition Jan 7, 2006
As laboratory animals are routinely fed soy diets, and soy contains plant estrogens, the scientists took the mice off the soy and put them on milk-protein diets to better compensate for the differing male and female hormones. Their discovery of the significant improvement in the heart function of those male mice with HCM who had been switched to the milk-protein diet prompted them to change the focus of their work. (Forbes)
