A novel use of Nigella sativa on hepatic ischemia-reperfusion injury Sep 20, 2008
Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxidative status (TOS), oxidative stress index (OSI) and myeloperoxidase (MPO) in hepatic tissue were measured. (EurekAlert!)
Unique Bacterium Has Genes For Potent Biofuel Sep 16, 2008
It contained the only copy of a key protein that lets the bugs produce lactate, called lactate dehydrogenase, during fermentation. DNA sequencing revealed the linear chromosome to be 430 kilobases long and contain a cluster of nine genes that code for other enzymes involved in pyruvate metabolism. (Science Daily)
Bone Marrow Alternative: Stem Cells From Umbilical Cord May Be Used To Treat Hepatic Diseases Jul 6, 2008
The scientists explain that the cell transplant carried out in rats caused an improvement both in the histological damage and in the hepatic function, as proved by the enzymatic activities of alanine transaminase, alkaline phosphatase, gama-glutamyl-transpherase and lactate dehydrogenase, as well as the concentrations of total and direct bilirubin. The present treatment for terminal hepatic failure consists of a liver transplant. (Science Daily)
July 2008 highlights Jun 20, 2008
Adding to a growing literature on the role of metabolic enzymes and ATP production in sperm function, it is now shown that one lactate dehydrogenase family member, LDHC, is required for male fertility ... Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility. (EurekAlert!)
Soliris(R) Improved Fatigue Independent of Changes in Anemia in Patients with PNH by Controlling Hemolysis Jun 15, 2008
Anemia was measured by levels of hemoglobin, and hemolysis was measured by levels of lactate dehydrogenase (LDH). Key findings included the following: * While intravascular hemolysis reduction (decreased LDH) and anemia improvement (increased hemoglobin) were both significantly associated with fatigue improvement (odds ratio 1. (PR Newswire)
Chronic Hepatitis E and Organ Transplants Jun 5, 2008
2 Furthermore, it was recently reported that immunosuppression induced by lactate dehydrogenase elevating virus led to increases in the severity and duration of the acute. . (New England Journal of Medicine)
Researchers Identify Genetic Markers That Predict Efficacy Of Novel Cancer Drug May 31, 2008
The drug appeared to work well in a subset of patients who had high levels of serum lactate dehydrogenase (LDH)--one of the major targets of HIF1 ; signaling. Researchers successfully associated genes within this pathway with increased patient benefit from PTK/ZK treatment. (Science Daily)
Pleural Effusions Mar 22, 2008
Tests on the fluid include lactate dehydrogenase (LDH), total protein, cell count and differential, and bacterial cultures. Additional tests for specific diagnoses may also be ordered as necessary. (Suite101.com)
Testicular Cancer Gauge Often Not Used Mar 21, 2008
Those two were used in conjunction with a third tumor marker, LDH or lactate dehydrogenase, 16 percent of the time. The results are reported in Urologic Oncology, Seminars and Original Investigations. (Science Daily)
Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells Feb 6, 2008
46), and lactate dehydrogenase (-121 vs. -15), a marker of hemolysis. There were no differences among the treatment groups in the overall frequency of painful crises, though crises experiences were infrequent in this study. (EurekAlert!)
Promising New Approach To Cadmium Induced Hepatoxicity: Cytoprotective Effect Of Midkine Jan 17, 2008
Midkine treatment prevented apoptosis, lactate dehydrogenase leakage and cytotoxicity caused by cadmium exposure in Hep3B cells. Midkine secretion might be one of the self defense mechanisms of the hepatocytes. (Science Daily)
A Man with Abdominal Pain and Elevated Creatinine Jan 17, 2008
However, several observations remain unexplained: first, the low platelet count; second, the increased serum levels of lactate dehydrogenase; and third, the severe abdominal pain. Of note, the patient was a visitor from a Western European country. (New England Journal of Medicine)
Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line Oct 2, 2007
Cell viability was determined by lactate dehydrogenase (LDH) assay and apoptosis was examined by annexin V and caspase-3 assays. Expression and phosphorylation of mitogen-activated protein kinases (MAPKs; JNK, ERK p44/42, and p38) and nuclear factor-kappa B (NF-kappaB) were investigated by Western immunoblot analysis. (BioMed Central)
Can latent heat safely warm blood? - in vitro testing of a portable prototype blood warmer Aug 1, 2007
To determine the effect of warming on red cell integrity compared to the normal storage lesion of blood, extracellular concentrations of potassium, lactate dehydrogenase and haemoglobin were measured in blood which had been warmed after storage at 2 to 6 degrees C for 1 to 42 days. Results. (BioMed Central)
