Analysis of Long-Term Vicriviroc Data Provides Evidence of Sustained Viral Suppression, Increased CD4 Cell Counts and Tolerability in Treatment-Experienced HIV-Infected Patients Oct 27, 2008
This novel nucleoside-sparing vicriviroc regimen is designed to help avoid the risk of toxicities associated with the nucleoside class of HIV drugs, which can include neuropathy, myopathy, renal toxicity, hepatic steatosis, lactic acidosis, bone marrow suppression, fat atrophy and, with certain agents, increased risk of myocardial infarction. (8-10) This approach represents a potential opportunity to preserve nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs, NNRTIs),... (PR Newswire)
Durability of Stavudine, Lamivudine and Nevirapine among Advanced HIV-1 Infected Patients with/without Prior Co-administration of Rifampicin: A 144-week Prospective Study Oct 14, 2008
8%) patients discontinued d4T due to neuropathy and/or symptomatic lactic acidosis. Conclusions. (BioMed Central)
Giuseppe Attardi; unveiled how the engines of cells work Apr 10, 2008
In this way, he was able to show that a rare form of dementia now known as MELAS syndrome - or mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes - was caused solely by mutations in mtDNA.. Other researchers have subsequently used the same technique to prove that a variety of other congenital disorders are produced by mutations in mtDNA.. (Boston Globe)
BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients Mar 25, 2008
People taking BARACLUDE should tell their healthcare provider right away if they feel very weak or tired, have unusual muscle pain, have trouble breathing, have stomach pain with nausea and vomiting, feel cold -- especially in their arms and legs, feel dizzy or lightheaded, or have a fast or irregular heartbeat, as they may be signs of a serious condition called lactic acidosis (buildup of an acid in the blood). Lactic acidosis is a medical emergency and must be treated in the hospital ...... (EurekAlert!)
Cheyanne Coxen gets her Disneyland wish granted Dec 12, 2007
The initials stand for mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke. It s very progressive, Angie said. (Missoulian, MT)
Mitochondria Defects Linked To Social Behavior And Spatial Memory Dec 6, 2007
Previous studies have shown that mitochondrial "cytopathies" can underlie conditions as diverse as muscle weakness, lactic acidosis, mental retardation, stroke, diabetes, or heart disease. Significant mitochondrial genetic defects have been found in patients diagnosed with neurodegenerative diseases like Alzheimer's and Parkinson's. (Science Daily)
Health Differences In Newborn Girls And Boys Aug 15, 2007
more rapid lactic acidosis in newborn female livers may result in greater metabolic damage during ischemia. According to Quaglietta, the lead researcher, These findings may offer a potential explanation for pediatric studies reporting worse outcome of recipients receiving livers from female donors. (Science Daily)
Keep diabetes drug Avandia on the market, FDA advised Jul 31, 2007
Lactic acidosis; should not be given to people with kidney problems. Alpha-glucosidase inhibitors. (USA Today -- News)
For Type 2 Diabetes, Older Drugs Seem Tried and True Jul 18, 2007
26 mmol/L [10 mg/dL])," they wrote. Metformin, in contrast, was associated with a decrease in LDL levels of by about 0.26 mmol/L. Other oral agents had no apparent effects on LDL levels. There was also moderately good evidence that thiazolidinediones, second-generation sulfonylureas, and metformin had similar, minimally positive effects on systolic blood pressure. But when it came to weight gain, only metformin was neutral, compared with all other agents, which were associated with an increase... (MedPage Today)
Analysis: Older, cheaper diabetes... Jul 18, 2007
But it can cause a rare but dangerous side effect called lactic acidosis, the buildup of lactic acid in the blood. It also should not be given to diabetics who have moderate kidney disease or heart failure. (CNN -- Specials)
Iron Overload Jul 17, 2007
Reactive Iron Species. Read about the effect of iron overdose on the outcome of pregnancy. (Suite101.com)
A Woman with Headaches, Weakness, and Strokelike Episodes Jul 12, 2007
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes. Migraine. (New England Journal of Medicine)
Avandia: Getting the Facts May 23, 2007
Metformin hydrochloride can cause a rare but serious side effect called lactic acidosis, which is a build-up of lactic acid in the blood that can cause death. What is GlaxoSmithKline's reaction to these findings. (Fox News -- Views)
Sebivo(R) (Telbivudine) Approved in European Union as a New Treatment for Chronic Hepatitis B Patients Apr 30, 2007
Important Safety Information about Telbivudine Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination with antiretrovirals. Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued anti-hepatitis B therapy, including telbivudine. (PR Newswire)
Four-Year Data Demonstrate Continued Low Incidence of BARACLUDE(R) (entecavir) Resistance in Nucleoside-naive Chronic Hepatitis B Patients Apr 15, 2007
People taking BARACLUDE should tell their healthcare provider right away if they feel very weak or tired, have unusual muscle pain, have trouble breathing, have stomach pain with nausea and vomiting, feel cold - especially in their arms and legs, feel dizzy or lightheaded, or have a fast or irregular heartbeat, as they may be signs of a serious condition called lactic acidosis (buildup of an acid in the blood). Lactic acidosis is a medical emergency and must be treated in the hospital ... Lactic... (PR Newswire)
FDA Approves JANUMET for Type 2 Diabetes Apr 3, 2007
Consistent with the labeling for metformin alone, the labeling for JANUMET contains a boxed warning for lactic acidosis, a rare, but serious, metabolic complication that can occur due to metformin accumulation during treatment with JANUMET.. Patients treated with JANUMET experienced weight loss comparable to metformin alone, with no increased risk of hypoglycemia, edema, or GI disturbances beyond metformin alone. (Playfuls.com)
DCA: Cancer Breakthrough or Urban Legend? Feb 7, 2007
The basic gist of the research report is that cancer cells rely on certain energy pathways that are different from normal cells, similar to the situation that occurs in what we medically call lactic acidosis. Lactic acidosis, in very simple terms, occurs in our bodies when we are very ill or may be suddenly severely traumatized. (ABC News)
Long-used drug shows new promise for cancer Jan 18, 2007
While this type of research in laboratory animals does not generally generate a lot of enthusiasm, in this case the findings are creating a stir because DCA has actually been used safely in humans for decades -- in treating rare inherited metabolic disorders such as lactic acidosis, not cancer. "One of the big concerns about drugs is that they can harm people but we already know this drug is safe. It doesn't even affect normal cells," Dr. Michelakis said. (Globe and Mail)
