Stem Cell Marker For Aggressive Bowel Cancer Aug 23, 2008
They found that patients who had the most aggressive forms of the disease also had a stem cell marker protein called Lamin A in their tissue ... But based on their findings, the researchers estimated that one third of patients with early stage bowel cancer are likely to be expressing the Lamin A stem cell marker, indicating that they have an aggressive form of the disease ... "Lamin A/C Is a Risk Biomarker in Colorectal Cancer." Willis ND, Cox TR, Rahman-Casas SF, Smits K, Przyborski SA, et... (Medical News Today)
Stem Cell Indicator For Bowel Cancer Should Lead To Better Survival Rates Aug 21, 2008
They found that patients who had a stem cell marker protein called Lamin A present in their tissue were more likely to have an aggressive form of the disease ... However, the new study suggests that around one third of these patients will express the Lamin A stem cell marker, which indicates a more serious form of the cancer. (Science Daily)
New stem-cell breakthrough in bowel cancer fight Aug 20, 2008
A study by Durham University and Stem-Cell Institute discovered people with a stem-cell protein called Lamin A were more likely to have an aggressive form of the disease ... But one third of these will have the Lamin A protein showing an aggressive cancer and need chemotherapy urgently. (Glasgow Daily Record)
New Test Helps Treat Colon Cancer Aug 20, 2008
British researchers said on Wednesday those with the most aggressive kind of cancer could be identified early by testing for a stem cell marker protein called Lamin A.. The team concluded that patients testing positive for Lamin A should be given chemotherapy, in addition to surgery, to increase their chances of survival ... The new research, however, suggests that around one third of these early-stage patients will have the Lamin A stem cell marker, indicating a more serious form of disease,... (Newsmax)
Baby stalked by rare 'aging' disease Mar 19, 2008
They believe it is caused by a mutation in the gene called LMNA, which makes the Lamin A protein. The defective Lamin A protein renders the nucleus of a cell unstable and that cellular instability appears to lead to the process of premature aging. (India Times, India -- Health/Science)
Phenotype and Course of Hutchinson–Gilford Progeria Syndrome Feb 7, 2008
The genetic basis of most cases of this syndrome is a change from glycine GGC to glycine GGT in codon 608 of the lamin A (LMNA) gene, which activates a cryptic splice donor site to produce abnormal lamin A; this disrupts the nuclear membrane and alters transcription ... Abnormal lamin A (progerin) appears to accumulate with aging in normal cells. (New England Journal of Medicine)
Sierra Leone: Different Kind of Battle [analysis] Dec 20, 2007
com: Sierra Leone: Different Kind of Battle (Page 1 of 2). Use our pull-down menus to find more stories. (allAfrica.com)
HIV Protease Inhibitor Drugs May Adversely Affect The Scaffolding Of The Cell Nucleus, Study Finds Jul 21, 2007
They found that the inhibition of ZMPSTE24 by the HIV protease inhibitor drugs led to an accumulation of prelamin A, which is a precursor to mature lamin A -- a key molecule in the structural scaffolding for the cell nucleus. ZMPSTE24 is a membrane-bound intracellular zinc metalloproteinase that is required for the conversion of prelamin A to mature lamin A. ... Interestingly, researchers found that the accumulation of prelamin A was exaggerated in cells that contained half the normal amount of... (Science Daily)
A fly lamin gene is both like and unlike human genes Jun 13, 2007
Mutations in the gene coding for human lamin A cause a range of diseases collectively called laminopathies, including forms of muscular dystrophy and premature aging diseases ... found that mutations in the ubiquitously expressed Drosophila lamin gene cause larvae to move less and show subtle muscle defects, while surviving lamin adults walk poorly and can't fly like aged wild type flies. (EurekAlert!)
New clues for treatment of disease that causes accelerated aging May 3, 2007
But the infants' unusual mutations caused them to make many more bad copies of the gene's primary protein, lamin A, than progeria patients ... "Our success in treating these cells, which had unusually high levels of bad lamin A, suggest that progeria treatment may not be as distant as we thought," says senior author Jeffrey Miner, Ph ... "If physicians can reduce production of bad lamin A by as little as half in progeria patients, we might see significant improvement.". (EurekAlert!)
