Researchers identify mechanism that helps bacteria avoid destruction in cells Oct 10, 2009
Intracellular pathogens include Chlamydia, which causes infertility in women, and Legionella, which causes Legionnaire's disease ... Intracellular pathogens, like Chlamydia and Legionella, must contend with vesicular trafficking and membrane fusion in the host cell ... The Chlamydia bacteria expressed a SNARE-like protein called IncA and the Legionella expressed a SNARE-like protein called IcmG/DotF, both of which inhibit SNARE-protein-mediated fusion. (EurekAlert!)
How To Improve Vaccines To Trigger T Cell As Well As Antibody Response Sep 19, 2009
Intracellular pathogens exhibit a wide variety of behaviors that the immune system has learned to recognize, such as lurking in the endosome (salmonella), the endoplasmic reticulum and Golgi bodies (Legionella), the lysozyme (Q fever) and the cytosol (Listeria). Effective vaccines must mimic this behavior in order to stimulate a complete immune response. (Science Daily)
Trius' Torezolid Antibiotic for the Treatment of Severe Skin Infections Featured at ICAAC Meeting Sep 13, 2009
A1-1934/7: Torezolid (TR-700), a novel methyltetrazolyl-oxazolidinone, accumulates markedly within human THP-1 macrophages and shows activity towards intraphagocytic Legionella pneumophila: comparison with linezolid. Copies of these posters will be available on the Trius Web site following the ICAAC meeting. (PR Newswire)
Stress Signals Link Pre-existing Sickness With Susceptibility To Bacterial Infection Aug 4, 2009
A new study published in Disease Models & Mechanisms, shows that infection with the pneumonia causing bacteria Legionella, is facilitated by an increased amount of a signaling protein that is associated with mitochondrial disease ... Researchers now show that the stress-signal associated with mitochondrial disease facilitates the growth and reproduction of the lung-infecting bacteria, Legionella ... Infectious bacteria, like Legionella, target the mitochondria and might use them to supplement... (Science Daily)
Sanctions sought against The Dillard House Jul 3, 2009
" James Orlando, a paralegal for the plaintiff, noted such action was odd since the TRO ordered the status quo of the environment would be maintained.Orlando had checked into the cottage Aug. 28 and obtained samples of the water tub, 20 days after the death of Stuart Hecht. According to the report provided by PathCon Laboratories, water from the spa tub had an "extremely high amount" of legionella bacteria, measured at 3,690 colony forming units per milliliter. PathCon, which was founded by two... (Clayton Tribune, GA)
Bioinformatics Sheds Light On Evolutionary Origin Of Rickettsia Virulence Genes Mar 20, 2009
Once introduced, these virulence factors compromise the host and may result in harmful disease, for example Legionnaires' disease (Legionella pneumophila) and Q fever (Coxiella burnetii). However, these secretion systems have not been implicated in human diseases caused by Rickettsia, including epidemic typhus (R. prowazekii) and Rocky Mountain spotted fever (R. rickettsii). (Science Daily)
Hospital Rooms Reopen After Legionnaire's Detected Mar 3, 2009
Last month, lab tests showed legionella bacteria in water samples taken from the two areas, where four patients came down with the disease since Jan. 1. All were treated and released. (13WMAZ.com, GA)
Atlanta hospital finds Legionnaire's bacteria Feb 13, 2009
Lab tests showed legionella bacteria in water samples taken from Grady Memorial Hospital rooms on two floors where the patients came down with the disease since Jan. 1, said Dr. Leon Haley, the hospital's deputy chief of staff. Legionnaire's can be deadly, but was not in these cases. (Yahoo News)
Legionnaires' patients recovering; Grady may be source Feb 9, 2009
In those cases, the Legionella bacteria is often found in the plumbing ... Legionella bacteria are common in the environment, particularly in warm, stagnant water. (Atlanta Journal-Constitution -- Health)
Legionnaires' disease found in 4 Grady patients Feb 8, 2009
Infection with Legionella occurs when someone breathes a contaminated water mist, the Web notice explains. The bacteria can be present in plumbing systems. (Atlanta Journal-Constitution -- Health)
