New Old Drug Fights Colon Cancer Oct 14, 2009
In diseases like cystic fibrosis (CF) and muscular dystrophy, antibiotics from the aminiglycoside family can repair damaged or mutated DNA. For her new study, Dr. Rosin-Arbesfeld looked at a closely-related but less toxic family of antibiotics from the Macrolide family that achieves the same therapeutic results. Dr. Rosin-Arbesfeld focused on a gene associated with colorectal cancer, the APC gene, and noticed that the mutation types in colorectal cancer are similar to those in the CF gene. (Science Daily)
Triple Therapy Halves Exacerbations In Moderate-to-severe COPD, Study Suggests Oct 10, 2009
8, 2008) Long-term use of a macrolide antibiotic may reduce the frequency of exacerbations in patients with moderate to severe chronic obstructive pulmonary disease by as much as 35 percent, according to a. (Feb. (Science Daily)
Overall Antibiotic Prescription Rates For Respiratory Tract Infections Decreasing Aug 22, 2009
"Overall, ARTI-associated prescription rates for penicillin, cephalosporin, and sulfonamide/tetracycline decreased. Prescription rates for azithromycin increased and it became the most commonly prescribed macrolide [a type of antibiotic] for ARTI and OM (10 percent of OM visits). Among adults, quinolone prescriptions increased," the authors write. "Our results indicate that overall antibiotic prescription rates have decreased significantly. These changes coincided with efforts to reduce... (Science Daily)
Advanced Life Sciences Receives Complete Response Letter From FDA for Restanza(TM) (Cethromycin) in Community Acquired Pneumonia Aug 1, 2009
Restanza is a novel, once-a-day, oral antibiotic that is in development for the treatment of CAP. It has shown higher in vitro potency and a broader range of activity than macrolides against Gram-positive bacteria associated with respiratory tract infections, and, again in in vitro tests, it appears to be effective against penicillin-, macrolide- and fluoroquinolone-resistant bacteria ... Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as... (PR Newswire)
Bill would restrict antibiotics in food animals Jul 31, 2009
Currently, livestock feeds mixed with antibiotics such as Tylosin, a macrolide; and Chlortetracycline are sold over the counter ... The legislation proposes that "in the absence of any clinical sign of disease" farmers be forbidden from using any of seven classes of antibiotics, including penicillin, tetracycline and macrolide for routine infection prevention. (San Francisco Chronicle -- Politics)
Lijun International Pharmaceutical Announcement of Profit Growth Jul 17, 2009
Mr. Wu added that: "Looking into the second half of the year, the Group is to continue to consolidate its leading role of macrolides antibiotics, strengthen intravenous infusion segment, boost the sales of general medicines and privileged brands, speed up the launches and enhance the sales of OTC and healthcare products. The Group will leverage on every chance to strengthen our development by focusing on the response to the new medical reform, keeping our eye on any possible market terminal... (JCN Network, Japan)
Advanced Life Sciences Announces Outcome of FDA's Anti-Infective Drugs Advisory Committee Review of Restanza(TM) (cethromycin) Jun 3, 2009
Restanza is a novel, once-a-day, oral antibiotic that is under review for approval by the FDA for the treatment of CAP. It has shown higher in vitro potency and a broader range of activity than macrolides against Gram-positive bacteria associated with respiratory tract infections, and, again in in vitro tests, it appears to be effective against penicillin-, macrolide-, and fluoroquinolone-resistant bacteria ... Macrolides and penicillins are currently the front-line treatments for respiratory... (PR Newswire)
UTSA, Health Science Center collaborate with Merck & Co. to develop chlamydia vaccine Apr 28, 2009
Macrolide (erythromycin-like) antibiotics can successfully eradicate the pathogen in most patients, but treated individuals are highly susceptible to re-infection if exposed via unprotected sex with an infected partner. Consequently, chlamydia remains present and stable in a high percentage of sexually active individuals. (EurekAlert! -- Business News)
Exacerbations In COPD: One Thing Leads To Another Mar 3, 2009
8, 2008) Long-term use of a macrolide antibiotic may reduce the frequency of exacerbations in patients with moderate to severe chronic obstructive pulmonary disease by as much as 35 percent, according to a. (May 21, 2008) A new study has found that patients with chronic obstructive pulmonary disease who are at high risk for hospitalization or emergency room visits from exacerbations or complications benefit from. (Science Daily)
