Studies Differ on Benefits of Aggressive Blood Sugar Control Jun 10, 2008
"There were no clear effects on macrovascular complications such as heart attack or stroke," Patel said. "Most importantly, using the strategy we employed for intensive glucose control, there was no increased risk of death.". (MEDLINEplus)
Backpack Straps Can Decrease Blood Flow In The Shoulder And Arm, And May Result In Loss of Fine Motor Control Apr 9, 2008
The researchers concluded that backpack loads of just 26 pounds decrease upper extremity macrovascular and microvascular blood flows, and may result in a loss of fine motor control and increased fatigue. According to Timothy Neuschwander, MD, the first author of the study and a physician, We surmise that the mechanism of diminished blood flow is likely due to strap compression of the axillary vein. (Science Daily)
Grape Skin Compound Fights The Complications Of Diabetes Mar 21, 2008
The elevated levels of glucose that circulate in the blood of patients with diabetes causes micro- and macrovascular complications by damaging mitochondria, the tiny power plants within cells responsible for generating energy. When they are damaged they can leak electrons and make highly damaging 'free radicals. (Science Daily)
ADVANCE diabetes trial results confirm no evidence of safety risk Feb 29, 2008
Reference: ADVANCE Collaborative Group; Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Heller S, Liu L, Mancia G, Mogensen C, Pan C, Rodgers A, Williams B. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. (EurekAlert!)
Major International Diabetes Study Does Not Confirm Increased Risk Of Death Reported By US Trial Feb 16, 2008
Journal reference: ADVANCE Collaborative Group; Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Heller S, Liu L, Mancia G, Mogensen C, Pan C, Rodgers A, Williams B. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. (Science Daily)
Diabetes dilemma: older people with diabetes face a heavy burden from co-existing health conditions Nov 14, 2007
Meanwhile, 81 percent had at least one of the macrovascular problems that are aggravated or triggered in part by diabetes, including high blood pressure, coronary artery disease, a history of stroke or mini-stroke, or heart failure. The researchers also looked at three unrelated diseases. (EurekAlert!)
The management of diabetes in IndigenousAustralians in the primary care setting Oct 25, 2007
Indigenous Australians with diabetes had high rates of micro- and macrovascular disease ... When compared to non-Indigenous patients, Indigenous patients were more likely to have established macrovascular disease (adjusted Odds ratio 2 ... This cross-sectional study confirms Aboriginal ethnicity as a powerful risk factor for microvascular and macrovascular disease, which practitioners should use to identify candidates for intensive multifactorial intervention. (BioMed Central)
Takeda statement on ACTOS meta-analysis published in the Journal of the American Medical Association Sep 12, 2007
This meta-analysis adds important information to the body of evidence regarding ACTOS and macrovascular ischemic events, and further documents the consistency of data from prospective studies, to meta-analysis, to observational studies. Critical in this body of data is PROactive (PROspective PioglitAzone Clinical Trial In MacroVascular Events), a trial of patients with type 2 diabetes who are at high risk for cardiovascular events ... These data show no increase in mortality or total... (EurekAlert! -- Business News)
Kidneys, eyes and feet are prime targets of the diabetes epidemic Sep 2, 2007
Doctors group diabetes complications into two major categories: microsvascular (affecting small blood vessels) and macrovascular (affecting larger ones) ... Macrovascular complications include heart disease, heart failure and strokes. (Pittsburgh Post-Gazette, PA)
Vitamin B1 Deficiency Key To Vascular Problems For Diabetic Patients, Study Suggests Aug 12, 2007
Diabetes is increasing in incidence in the UK and elsewhere and one of the most significant health problems associated with the condition are vascular complications: microvascular complications, such as damage to the kidney, retina and nerves in arms and legs; and macrovascular complications, such as heart disease and stroke ... The researchers found that the decreased availability of thiamine in vascular cells in diabetes was linked to a marker of microvascular and macrovascular complications. (Science Daily)
Takeda Responds to the FDA Advisory Committee Recommendation Jul 31, 2007
"Critical in this body of data is the PROactive (PROspective PioglitAzone Clinical Trial In MacroVascular Events) study, since the only scientific way to determine a medication's safety is a prospective, long-term trial." About the PROactive Study PROactive was a prospective, randomized, placebo-controlled outcomes trial. The PROactive study included 5,238 patients with type 2 diabetes and a history of macrovascular disease, who were force titrated up to 45 mg daily of either ACTOS or placebo... (PR Newswire)
LCA Announces Sedona Diabetes Wellness Program Jul 4, 2007
Diabetes is a disease in which the body does not properly produce or does not properly use insulin, leading to abnormally high blood sugar which causes microvascular and macrovascular damage. The fifth leading cause of death, it has become epidemic in America, affecting more than 20 million people. (PR Newswire)
Noninvasive Test Assesses Diabetes Vascular Damage Dec 8, 2006
AGE has a deleterious effect on the walls of small and large blood vessels, leading to diabetes-related micro- and macrovascular disease ... Dr. Helen L. Lutgers from University Medical Center Groningen, the Netherlands, and colleagues investigated the association between skin autofluorescence and micro- and macrovascular complications in 973 patients with type 2 diabetes ... Patients with both micro- and macrovascular complications had higher average skin autofluorescence than did patients... (MEDLINEplus)
Anemia Often Develops in Type 2 Diabetics Nov 25, 2006
The rate of Hb decline was fastest in patients with established and progressive renal injury and large blood vessel or "macrovascular" disease at baseline. "These data," Thomas concludes, "are important for developing a rational response to prevention and early management of anemia in individuals with diabetes.". (MEDLINEplus)
ACTOS (pioglitazone HCl) demonstrates significant improvements in cardiovascular outcomes Sep 15, 2006
These results were part of the landmark PROactive (PROspective PioglitAzone Clinical Trial In MacroVascular Events) study ... PROactive (PROspective PioglitAzone Clinical Trial In MacroVascular Events) is a landmark study that prospectively looked at the impact in total mortality and macrovascular morbidity using ACTOS, a glucose-lowering agent ... It was a randomized, double-blind, placebo-controlled outcome study of 5,238 patients with type 2 diabetes and macrovascular disease. (EurekAlert!)
Prognostic value of physicians assessment of compliance regarding all-cause mortality in patients with type 2 diabetes: primary care follow-up study Jul 7, 2006
Among other factors such as patient type (patients presenting at office, nursing home or visited patients), gender, age and a history of macrovascular disease, the physicians assessment of patient compliance was an important predictor of all-cause mortality. Patients whose compliance was assessed by the physician as very bad (6%) were significantly more likely to die during follow-up (OR = 2. (BioMed Central)
Blood Sugar Control Impacts Stroke Risk Jul 6, 2006
"Intensive glucose control in both type 1 and type 2 diabetic patients seems to reduce stroke and other macrovascular events," the authors state. "New secondary prevention trials should be initiated to investigate whether intensive glucose control reduces stroke incidence in these patients.". (MEDLINEplus)
