Overdose deaths spark call for action Nov 15, 2009
Cities nationwide, including Baltimore, New York, Chicago and San Francisco, started programs to distribute naloxone to likely victims, along with instructions on how to administer it in an emergency. Naloxone is a drug used by paramedics to restore normal breathing and heart rate in opiate drug users mid-overdose. (The Palm Beach Post)
Nanoparticle-based Battlefield Pain Treatment Moves A Step Closer Sep 26, 2009
In this case, they wanted one that could convert to Naloxone, a drug now used to counter morphine s effects, but would activate only when blood oxygen levels drop too low ... When respiratory distress is too severe, that will trigger release of Naloxone, the antagonist (morphine-suppressing) drug ... Baohua Huang, Shengzhuang Tang, Ankur Desai, Xue-min Cheng, Alina Kotlyar, Abraham Van Der Spek, Thommey P. Thomas, James R. Baker Jr. Human plasma-mediated hypoxic activation of indolequinone-based... (Science Daily)
Infant pain, adult repercussions Sep 26, 2009
To test this hypothesis, LaPrairie and Murphy gave adult animals that were injured at the time of birth a drug called naloxone ... After animals received an injection of naloxone, they behaved just like an uninjured animal. (EurekAlert!)
Nektar Presents Data Demonstrating Favorable Oral Bioavailability and Drug-Drug Interaction Profile for NKTR-118 Sep 14, 2009
Oral NKTR-118 combines Nektar's advanced small molecule polymer conjugate technology platform with naloxol, a derivative of the opioid-antagonist drug, naloxone ... In vitro studies demonstrated the high metabolic stability of NKTR-118 compared to naloxone. (PR Newswire)
It's Not All In Your Head: Descending Neural Mechanisms Of Placebo-induced Pain Control Aug 30, 2009
Eippert and colleagues employed sophisticated brain imaging techniques to examine both higher cortical and lower brainstem responses in two groups of subjects: one receiving a drug called naloxone, which blocks opioid signaling, and one group with a natural opioid state ... The researchers found that naloxone reduced behavioral placebo effects as well as placebo-induced decreases in pain-related brain responses. (Science Daily)
Runners high can turn into a real addiction Aug 27, 2009
Finally, all groups were given Naloxone, a drug used to counteract an opiate overdose and produce immediate withdrawal symptoms ... Also, the active rats that were only allowed food for one hour per day exercised the most and showed the most intense reaction to Naloxone. (MSNBC -- Health)
Using Heroin to Treat Heroin Addiction Aug 24, 2009
The drug is less likely to be abused, he said, because the naloxone would block the opiate effect of bupronorphine if the drug were injected. 1. (ABC News)
Excessive exercise can be addicting, new study says Aug 18, 2009
Rats in all four groups were then given naloxone, a medicine for heroin overdose that produces immediate withdrawal symptoms. Active and inactive rats responded very differently to naloxone, which was given in proportion to their weight ... Additionally, the more a given rat had run, the worse its withdrawal symptoms after naloxone. (EurekAlert!)
Weymouth mayor declares war on drug abuse Aug 12, 2009
Attempts to help people who abuse opiate drugs by Kay s task force include an attempt to distribute naxal naloxone to the families of drug abusers. Nasal naloxone is a drug that blocks the flow of opiate substances by a user who is suffering an overdose ... Frano said that the Rev. William Salmon of Immaculate Conception Church has expressed an interest in having parents trained to administer nasal naloxone at the parish. (Weymouth News, MA)
Did Drugs Kill Michael Jackson? Jun 27, 2009
It is not known what measures the emergency workers took to save Jackson, but if they had determined that he suffered from cardiac arrest triggered by an overdose of narcotics, they would have likely used a shot of naloxone, a drug that counteracts opioid overdose, to get the brain back online and the heart beating again, says Connie Meyer, an EMS captain in Johnson County, Kans. In cases where it's not clear whether narcotics are involved cardiac arrest may be caused by a wide range of factors,... (Time.com)
FRIEND: Michael Jackson Had Demerol Addiction Jun 27, 2009
" An overdose can be "reversible," he said, by administering mouth-to-mouth rescusitation and then an antidote -- Naloxone. Schaffel, who produced Jackson's "Private Home Movies" in 2003, said his friend's addiction to Demerol began as early as 1984, when the pop star suffered burns when his hair caught fire filming a Pepsi commercial. He was later was treated at the Betty Ford Clinic. In 2002, Jackson was ordered to undergo a medical examination after he failed to show up in a California court... (ABC News)
Do-It-Yourself Anti-Overdose Kits: Do They Help? May 30, 2009
The kits, which include vials of the drug naloxone (brand name Narcan), commonly used in hospitals and ambulances to reverse opiate overdose, have led to at least 1,000 successful overdose reversals in the city since 2001, according to Bigg ... Project Lazarus will hand out naloxone kits and offer training, including instruction on rescue breathing, to patients who are starting methadone treatment for pain methadone is stronger and lasts longer than other painkillers, which puts users at a... (Time.com)
Anti-Nausea Drug May Combat Opiate Addiction Feb 24, 2009
"The jumping behavior displayed by morphine-dependent mice after administration of (the anti-opiate drug naloxone) is a commonly used measure of physical dependence." ... Then the mice were given naloxone, and the researchers counted how many times the animals jumped in 15 minutes as a measure of physical dependence ... Eight healthy male volunteers were pretreated with inactive "placebo" or ondansetron before receiving morphine followed by naloxone. (MEDLINEplus)
