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News and Articles on Oligodendrocyte
Why Repair Of Brain's Wiring Fails Aug 25, 2009
The investigation, conducted in mice and in human tissue, showed that repair of nerve fibers is hampered by biochemical signals that inhibit the development of cells known as oligodendrocytes, which function as repair workers in the brain. Oligodendrocytes form a protective sheath, known as myelin, that insulates the fibrous cables, or axons, radiating from nerve cells ... In multiple sclerosis, the immune system's T cells and B cells attack oligodendrocytes, ultimately damaging the myelin... (Science Daily)
Statins May Have A Negative Impact In Multiple Sclerosis Patients May 29, 2009
MS is an autoimmune disease of the central nervous system (CNS), in which immune cells attack the myelin sheath (the protective insulation of nerve fibres), and the myelin-producing cells of the CNS (oligodendrocytes), causing demyelination ... In the early stages of MS, following an immune system attack on myelin, oligodendrocyte progenitor cells or stem cells in the CNS are recruited to the lesion ... "The mechanism of statin action in these studies was not determined. That is, does statin... (Science Daily)
Stem Cell Breakthrough May Lead to Multiple Sclerosis Treatments Apr 11, 2009
The researchers pushed the stem cells to grow into critical nervous system support cells called oligodendrocytes, according to a report released Thursday. Oligodendrocytes produce the myelin sheath that surrounds nerve fibers like wire insulation ... For years, researchers using mouse embryonic stem cells (ESCs) knew that if they added one of two proteins, FGF2 or SHH, to the cells' growth media, they could reliably induce those cells to become oligodendrocytes. (MEDLINEplus)
Human ES cells progress slowly in myelin's direction Apr 9, 2009
The cells the researchers made are called oligodendrocytes, which are responsible for making myelin in the central nervous system ... Unlike human embryonic stem (ES) cells, it's relatively easy to persuade mouse ES cells to turn into oligodendrocytes; it's often done by exposing these cells to a protein called Sonic Hedgehog, which produces oligodendrocytes in the spinal cord of developing embryos ... Now Su-Chun Zhang and his co-workers show in the May issue of Development () that treating... (EurekAlert!)
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