This is your brain on fatty acids Oct 31, 2009
The Hopkins team, reporting Oct. 29 in Neuron, reveals how palmitate, a fatty acid, marks certain brain proteins NMDA receptors that need to be activated for long-term memory and learning to take place ... "Before now, no one knew that NMDA receptors change in response to the addition of palmitate," says Richard Huganir, Ph ... The discovery emerged from work with live neurons in a dish, to which the scientists first fed radioactive palmitate, then separated out the NMDA receptors. (EurekAlert!)
Sustained-Release Antipsychotic Approved for Schizophrenia Aug 5, 2009
MONDAY, Aug. 3 (HealthDay News) -- Invega Sustenna (paliperidone palmitate) has been approved by the U.S. Food and Drug Administration to treat schizophrenia, drug maker Janssen said in a news release. The longer-acting version of the previously approved drug should help prevent relapses commonly caused when schizophrenia patients fail to take a more frequent dose, the company said. (MEDLINEplus)
FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia Aug 1, 2009
TITUSVILLE, N.J., July 31 /PRNewswire/ -- The U.S. Food and Drug Administration today approved INVEGA(R) SUSTENNA(TM) (paliperidone palmitate) extended-release injectable suspension for the acute and maintenance treatment of schizophrenia in adults ... It is the first once-monthly, long-acting, injectable atypical antipsychotic approved for this use in the U.S. INVEGA SUSTENNA is available in milligrams (mg) of paliperidone palmitate in dose strengths of 39 mg, 78 mg, 117 mg, 156 mg and 234 mg.... (PR Newswire)
Newsweek: The next blockbuster drugs Jul 23, 2009
The Potential Blockbusters: There are a number of seemingly promising antipsychotic drug candidates, but one at the top of the list is paliperidone palmitate for treating schizophrenia ... The main advantage of paliperidone palmitate could be in its delivery. (MSNBC -- Health)
Dynamic Molecular Mechanism To Keep Brain Activity Stable Jul 18, 2009
Protein palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating synaptic proteins in neurons. Here, the research group found that DHHC3 is located in the cell body of neurons to palmitoylate newly synthesized synaptic proteins such as PSD-95, and move out them into dendrites of neurons. (Science Daily)
'Proof' face creams beat wrinkles Apr 29, 2009
Half received the Boots cream and half received a moisturiser with none of the "anti-ageing" ingredients - peptides, retinyl palmitate and white lupin extract. The volunteers applied the cream each night to the face, wrists and forearms. (BBC News)
