SurfWax News Index  |  Track News  |  Save/Exchange Information |  About Us

    News and Articles on RNA

    Archives: RNA

    Triple Helix: Designing a New Molecule of Life  Dec 2, 2008
    Drugs based on PNA would achieve therapeutic effects by binding to specific base sequences of DNA or RNA, repressing or promoting the corresponding gene ... All these organisms are based on nucleic acids DNA and RNA and proteins, working together more or less as described by the so-called central dogma of : DNA stores information that is transcribed into RNA, which then serves as a template for producing a protein ... A molecule that some researchers study in pursuit of this vision is peptide... (Scientific American)

    Discovery Of Virus In Lemur Could Shed Light On AIDS  Dec 2, 2008
    A type of retrovirus, lentiviruses replicate by inserting their RNA into a cell's DNA. Some retroviruses have been known to infect cells that mature into sperm or eggs, incorporating viral DNA into the genome of the host ... In a study published today in the open access journal BMC Evolutionary. (Science Daily)

    Antibiotics: Single largest class of drugs causing liver injury  Dec 1, 2008
    1, 2008) Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute ... DILI remains a diagnosis of exclusion and thus detailed testing should be performed to exclude competing causes of liver disease; importantly, acute hepatitis C virus (HCV) infection should be carefully excluded in patients with suspected DILI by HCV... (EurekAlert!)

    Experimental Drug Blocks Heart Disease in Mice  Dec 1, 2008
    The researchers used a treatment from Regulus Therapeutics -- a joint venture between U.S. biotech companies Alnylam Pharmaceuticals Inc and Isis Pharmaceuticals Inc -- to block or "silence" tiny strands of ribonucleic acid called microRNA.. These genetic fragments regulate the making of genes into proteins, and in this case the researchers discovered how a failing heart had three- to five-times more of a particular microRNA called miR-21. (Newsmax)

    Hemispherx Biopharma Introduces Expense Reduction Program  Nov 29, 2008
    Ampligen(r) and Oragens represent experimental RNA nucleic acids being developed for globally important debilitating diseases and disorders of the immune system. Hemispherx's platform technology includes large and small agent components for potential treatment of various severely debilitating and life threatening diseases. (Primezone Releases)

    European Committee for Human Medicinal Products (CHMP) Issues Positive Opinion for Once-Daily PREZISTA(R) (Darunavir) as Part of Combination Therapy for Treatment-Naive Adults With HIV-1  Nov 28, 2008
    The CHMP's positive opinion is based on 48-week analyses of plasma HIV RNA levels and CD4+ cell counts from the ongoing, randomised, controlled, open-label phase III trial ARTEMIS in antiretroviral treatment-naive HIV-1-infected adults. Patients received 800 mg darunavir once daily with 100 mg ritonavir as part of combination therapy. (PR Newswire)

    Scientists Identify 13 New Tumor-suppressor Genes In Liver Cancer  Nov 28, 2008
    The team used a method honed by Dr. Hannon of introducing stable mutations into mouse cells via RNA interference, or RNAi, a technique in which small RNA molecules are introduced into cells to shut off specific genes. RNA sequences that corresponded to all the 300 or so deleted genes were obtained from an RNAi library compiled by the Hannon lab ... Lowe s team introduced these RNAi tools (known as short-hairpin RNAs, or shRNAs) into progenitor cells that develop into mature liver cells, albeit... (Science Daily)

    SARS Virus Recreated: Opens Door For Potential Defenses Against Future Strains  Nov 28, 2008
    3, 2005) The genome of the SARS virus is a single strand of RNA that folds into regular repeating patterns to form secondary structures such as helices. These then fold and bend in three dimensions to form. (Science Daily)

    Key Advance Toward Treatment For Most Common Adult Form Of Muscular Dystrophy  Nov 27, 2008
    Using a drug-discovery technique in which molecules compete against each other for access to the target the strand of toxic RNA that causes the most common form of muscular dystrophy in adults a team at the University of Rochester Medical Center has identified several compounds that, in the laboratory, block the unwanted coupling of two molecules that is at the root of the disease. The work was published online November 7 by the Journal of the American Chemical Society ... "This discovery gives... (Science Daily)

    Misfolded Proteins Accelerate Yeast Evolution  Nov 27, 2008
    In yeast, the [PSI+] prion is a misfolded version of the Sup35 protein, which plays a key role in how cells translate their messenger RNA molecules into proteins. Earlier studies showed that [PSI+] changes how messenger RNA translation ends, thus uncovering hidden genetic variations by creating altered proteins that change the cell. (Science Daily)

    Controlling Bad Cholesterol: Finding May Herald Scientific Breakthrough  Nov 26, 2008
    11, 2008) Small, specially designed bits of ribonucleic acid (RNA) can interfere with cholesterol metabolism, reducing harmful cholesterol by two-thirds in pre-clinical tests, according to a new study by. . (Science Daily)

    Peginterferon-Induced Depression Is Reversible  Nov 26, 2008
    Pre-existing depression and potential biomarkers of depression, such as blood levels of cortisol and the neurotransmitter serotonin, were associated with neurological or psychiatric side effects, the group reports in the American Journal of Gastroenterology ... The 74 patients who had undetectable hepatitis C virus (HCV) RNA at week 20 continued at the same doses to complete 48 weeks of antiviral treatment ... SOURCE: American Journal of Gastroenterology, November 2008. (MEDLINEplus)

    Folic Acid Deficiency  Nov 22, 2008
    RNA continues to form and build up producing excess haemoglobin. The RBC becomes an immature enlarged non-functioning cell often containing excess haemoglobin. (Suite101.com)

    Dangerous 'Two-faced' Protein Crucial To Breast Cancer Spread And Growth Identified  Nov 22, 2008
    This is potentially good news, say the researchers, who published their study in the Nov. 17 issue of the Journal of Cell Biology ... " Dr. Anastasiadis adds that while the discovery was made in breast cancer cells, it has relevance to a number of cancers, including those of the lung, kidneys, and skin, in which p120 plays a role. "These findings have significant implications for our understanding of tumor biology and for improving cancer treatment," he says. This study expands upon a body of... (Science Daily)

    Mechanisms of cardiovascular disease and cancer give clues to new therapies  Nov 22, 2008
    There is also overlap between cardiovascular disease and cancer at the level of gene expression and regulation within cells, and in particular the role of small RNA molecules called micro RNAs. These molecules do not perform the role of RNA as traditionally understood in carrying genetic information from the DNA of genes to the protein factories called ribosomes ... "The future direction is to investigate whether and how the different gene networks regulated by micro RNAs are organized as a... (EurekAlert!)

    New Gene-silencing Pathway Found In Plants  Nov 21, 2008
    RNA polymerases, the enzymes responsible for making RNA from DNA templates, are key players in determining which genes get switched on and which get left off ... D., WUSTL professor of biology in Arts & Sciences, has been investigating the role of two plant-specific RNA polymerases since playing a leading role in their discovery in 2005 ... In a paper published Nov. 14 in Cell, Pikaard and his colleagues explain how these RNA polymerases work together to use the non-coding region of DNA to... (Science Daily)

    Misreading of damaged DNA may spur tumor formation  Nov 21, 2008
    All cells, including non-dividing cells that are not replicating their DNA, continue to transcribe, or make RNA, from some of their genes in order to produce proteins and carry out their normal functions ... By reading the RNA the cells make from the Ras DNA, Saxowsky found that even normal mouse cells misread the damaged DNA about three percent of the time ... It appears that bacterial enzymes that make RNA from DNA are more susceptible to transcriptional mutagenesis than those from mammals,... (EurekAlert!)

    American Chemical Society's Weekly PressPac -- Nov. 19, 2008  Nov 20, 2008
    Here is the latest American Chemical Society (ACS) News Service Weekly PressPac with news from ACS' 36 peer-reviewed journals and Chemical eering News. Please credit the individual journal or the American Chemical Society as the source for this information ... Their study went online November 24 in the premiere issue of ACS Applied Materials faces,a new monthly journal. (EurekAlert!)

    Mexican Department of Public Health to Launch Screening for Human Papillomavirus (HPV), Cause of Cervical Cancer  Nov 19, 2008
    A study published in the Journal of the National Cancer Institute found that about one-third of invasive cervical cancers developed in women whose smears had appeared normal ... Sample technologies are used to isolate and process DNA, RNA and proteins from biological samples such as blood or tissue ... Such uncertainties and risks include, but are not limited to, risks associated with management of growth and international operations (including the effects of currency fluctuations and risks of... (PR Newswire)

    Finding Points to Possible Blood Test for Brain Tumors  Nov 18, 2008
    When Skog analyzed the protein and RNA content of these microvesicles (also called exosomes) in the blood samples of glioblastoma patients, he found that he could obtain a sort of molecular snapshot of the tumor. "By analyzing the RNA in these serum exosomes, we could determine the mutational profile in the tumor without doing a biopsy," explained Skog. (Washington Post)

    Tackling A Hard-to-treat Childhood Cancer By Targeting Epigenetic Changes  Nov 18, 2008
    A pharmaceutical DOT1L inhibitor hasn't yet been found, but when the researchers suppressed DOT1L indirectly through RNA interference techniques, the abnormally activated genes were turned off. "Based on these data, we are searching for small molecules or drugs that inhibit DOT1L," says Armstrong. (Science Daily)

    Conference report highlights new research into drug delivery to treat eye disease  Nov 18, 2008
    Group explores alternatives to surgery and intravitreous injection ... His group is focused on using a family of acid-sensitive polymers to help deliver one of the latest drugs, silencing RNA (siRNA) ... A safer alternative to direct intravitreous injections might be transscleral delivery into the vitreous using subconjunctival injections, said Michael Robinson, MD, adding that researchers needed a clear understanding of the dynamic barriers for the technique to work in treating retinal... (EurekAlert!)

    Blood test could help track cancer  Nov 17, 2008
    Inside, they found fragments of ribonucleic acid, or RNA, including messengers related to cell growth and immune response. When they exposed these exosomes to normal cells in the lab, the tumor RNA delivered its genetic message into the cells. (Boston Globe)

    No Clear Answer On Why HIV Vaccine Candidates Did Not Lower Risk Of Acquiring HIV  Nov 17, 2008
    HIV RNA levels approximately 8 to 12 weeks after diagnosis of infection were generally similar in the vaccine and the placebo groups. The geometric means of the HIV RNA levels in the blood of infected individuals, the standard measure of ongoing HIV replication, were approximately 40,000 copies/mL in the 24 volunteers in the vaccine group who developed HIV infection and approximately 26,000 copies/mL in the 21 volunteers in the placebo group who developed infection ... The HVTN is an... (Science Daily)

    Tiny sacs released by brain tumor cells carry information that may guide treatment  Nov 17, 2008
    In their report in the December 2008 Nature Cell Biology, which is receiving early online release, Massachusetts General Hospital (MGH) researchers describe finding tumor-associated RNA and proteins in membrane microvesicles called exosomes in blood samples from glioblastoma patients ... "Glioblastomas release exosomes in sufficient quantities to pass the blood-brain barrier. We were able to isolate them, analyze the RNA transcripts and show how they might be used as biomarkers to guide targeted... (EurekAlert!)

    Eat less, live longer  Nov 16, 2008
    One shows that cutting calorie intake by 20 percent cut damage in DNA and RNA caused by oxidation in half compared to control groups ... "It may be unlikely that it will extend human lifespan significantly," said Jan Vijg, a scientist at the Buck Institute for Age Research who recently co-authored an overview article on ageing in the London-based journal Nature. (iAfrica.com)

    Key contributor to Alzheimer's disease  Nov 16, 2008
    They revealed that a fragment of ribonucleic acid (RNA), once thought to be no more than a by-product, plays a crucial role in regulating inflammation and the development of Alzheimer's disease. The tiny piece of RNA, or microRNA, called miRNA-146a was found in increased amounts in stressed human brain cells and Alzheimer's disease. (India Times, India)

    By Combining Technologies, Researchers Rapidly Hunt Down And Find New Genes That Lead To Cancer  Nov 15, 2008
    Twelve of those genes had never been linked to cancer before, according to the report published online in the journal Cell, a Cell Press publication, on November 13th ... They then identified mouse versions of 301 of those human genes and obtained so-called short hairpin RNAs (shRNA) corresponding to each of those ... shRNA is a sequence of RNA that makes a tight hairpin turn and that can be used to silence genes in a process known as RNA interference. (Science Daily)

    Researchers Say Identification of Women With HPV Types 16, 18 and 45 Could Improve Early Intervention to Stop Cervical Cancer  Nov 14, 2008
    Sample technologies are used to isolate and process DNA, RNA and proteins from biological samples such as blood or tissue, and assays make these isolated molecules visible to facilitate such vital activities as biological research and detection of disease. QIAGEN has developed and markets more than 500 products as well as instruments that make their use more efficient and accurate. (PR Newswire)

    Genetic clues may explain why tumors spread  Nov 14, 2008
    Study: When a bit of RNA goes missing, cancer gets more aggressive ... They found that when a bit of ribonucleic acid or RNA known as microRNA-101 goes missing, a protein called EZH2 starts to proliferate ... "What this study shows is why that protein is elevated in metastatic cancers," said Dr. Arul Chinnaiyan of the University of Michigan, whose study appears in the journal Science. (MSNBC -- Health)

    New Urine Test ID's Prostate Cancer  Nov 14, 2008
    The test, from San Diego-based Gen-Probe, is approved in some European countries but not in the U.S. It detects genetic material -- RNA -- from prostate cancer gene 3 or PCA3 ... Prostate cancer cells express 60 to 100 times more PCA3 RNA than normal cells. (Yahoo News -- Prostate Cancer)

    Epstein-Barr Virus Associated With Inflammatory Diseases Of The Mouth  Nov 14, 2008
    Using a variety of methods, the OHSU team found the Epstein-Barr virus DNA and RNA in significantly higher percentages (43 ... Human cytomegalovirus DNA and RNA were found in measurable numbers in both endodontic patients (15 ... Journal of Endodontics, 03 November 2008. (Science Daily)

    Nanoparticles Trigger Cell Death?  Nov 14, 2008
    His research lab has first demonstrated the delivery of RNA using single-walled carbon nanotubes and invented the use of lysophospholipids for obtaining biocompatible nanomaterials. Professor Ilpo Vattulainen: The Biological Physics Group of 26 people located at the Department of Physics at Tampere University of Technology, Finland, is directed by Prof. (Science Daily)

    Plants Can Accumulate Nanoparticles In Tissues  Nov 14, 2008
    The results were published in a cover article in the Journal of Environmental Monitoring and also were highlighted in Chemical Biology, a journal of the Royal Society of Chemistry ... Xiao, who directs the Center for Spintronics and Biodetection at the University of Delaware, noted that the magnetometer used in his physics research is similar to magnetic resonance imaging (MRI), which uses a powerful magnetic field and radio-frequency pulses to produce images of internal structures in the human... (Science Daily)

    AIDS patient is reported cured  Nov 14, 2008
    The case was described last week in The Wall Street Journal ... For example, Irvin S. Y. Chen, director of the AIDS Institute at UCLA , is working on using RNA "hairpin scissors" to cut out the bits of genetic material in blood stem cells that code for the receptors ... 2008 the International Herald Tribune All rights reserved. (International Herald Tribune)

    LSUHSC research identifies key contributor to Alzheimer's disease process  Nov 14, 2008
    Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Center New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's disease. The paper, An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells, will be... (EurekAlert!)

    Novel regulatory step during HIV replication  Nov 14, 2008
    HIV begins its assault by injecting its core that contains a single-stranded RNA into a host cell. Once inside, the viral RNA is converted into double-stranded DNAa process known as reverse transcriptionand the original viral RNA is degraded ... LTRs flank the viral genome and function like "sticky ends", which integrase uses to insert the HIV genome into the host DNA. But they also acts as promoters, regulatory regions that interact with cellular and viral factors to trigger gene expression... (EurekAlert!)

    Tekmira Pharmaceuticals Corporation Announces Third Quarter 2008 Operating Results and Provides Program Update  Nov 13, 2008
    Dr. Mark J. Murray, Tekmira's President and CEO, said, "Our internal product development programs remain on track and we expect to file Investigational New Drug (IND) applications and begin human clinical trials for our two lead proprietary products in 2009. Our partner Alnylam is also proceeding on schedule to file an IND using Tekmira's SNALP technology and we continue to expand the number of pharmaceutical companies using our leading technology." ... "We are continuing to focus on developing... (CCNMatthews Press Releases)

    How much can we blame DNA for who we are?  Nov 13, 2008
    - International Herald Tribune ... It's also about DNA's chemical cousin RNA, doing complicated things it wasn't supposed to do ... Not long ago, RNA was seen as a bureaucrat, the middle molecule between a gene and a protein, as exemplified by the tidy aphorism, "DNA makes RNA makes protein." Now we find cases of short clips of RNA acting like DNA, transmitting genetic secrets to the next generation directly, without bothering to ask permission. (International Herald Tribune)

    Hologic Announces Fourth Quarter and Fiscal 2008 Operating Results  Nov 12, 2008
    -- First Selenia Dimensions "Tomosynthesis/3-D" digital mammography systems installed internationally and recognized as revenue while building a backlog for delivery in future quarters ... When analyzing the Company's operating performance, investors should not consider these non-GAAP measures as a substitute for net (loss) income and (loss) earnings per share prepared in accordance with GAAP. During the fourth quarter, Hologic recognized as revenue the sale of 452 Selenia full-field digital... (PR Newswire)

    The Gene Is Having an Identity Crisis  Nov 12, 2008
    Posted by kdawson on Tuesday November 11, @06:06PM from the more-complicated-than-you-thought dept. writes "New large-scale studies of DNA are causing a . A typical gene is no longer conceived of as a single chunk of DNA encoding a single protein. It turns out, for example, that several different proteins may be produced from a single stretch of DNA. Most of the molecules produced from DNA may not even be proteins, but rather RNA. The familiar double helix of DNA no longer has a monopoly on... (Slashdot)

    Long-term study evaluates boosted PREZISTA* vs. lopinavir/ritonavir as part of HIV combination therapy in treatment-naive adults  Nov 12, 2008
    At 48 weeks, the primary objective of ARTEMIS was reached when PREZISTA demonstrated non-inferiority to lopinavir/r based on the proportion of patients that achieved an undetectable viral load (HIV RNA below 50 copies/mL) ... (2) The main objective of the study was to demonstrate non-inferiority of once-daily PREZISTA/r versus lopinavir/r in proportion of patients achieving virologic response, defined as confirmed HIV-1 RNA (below 50 copies/mL. Non-inferiority of PREZISTA/r vs. lopinavir/r was... (Canada Newswire)

    The promise and power of RNA  Nov 11, 2008
    RNA turns out to be far more important than previously thought. Left, messenger RNA, active in protein production; right, silencing RNA turns off the gene that makes the purple pigment in this petunia ... But a powerful new approach, called RNA interference, may surmount that obstacle. (International Herald Tribune)

    Now: The rest of the genome  Nov 11, 2008
    It turns out, for example, that several different proteins may be produced from a single stretch of DNA. Most of the molecules produced from DNA may not even be proteins, but another chemical known as RNA. The familiar double helix of DNA no longer has a monopoly on heredity ... Graphic: A bestiary of RNA ... To make a protein from a gene, a cell had to read it and build a single-stranded copy known as a transcript out of RNA. This RNA was then grabbed by a cluster of molecules called a... (International Herald Tribune)

    Without enzyme, biological reaction essential to life takes 2.3 billion years  Nov 11, 2008
    In 1995, Wolfenden reported that without a particular enzyme, a biological transformation he deemed "absolutely essential" in creating the building blocks of DNA and RNA would take 78 million years. "Now we've found a reaction that again, in the absence of an enzyme is almost 30 times slower than that," Wolfenden said. (EurekAlert!)

    OHSU finds association between Epstein-Barr virus, inflammatory diseases of the mouth  Nov 11, 2008
    A new study, published in the Journal of Endodontics, finds a link between Epstein-Barr virus and the microorganisms that cause irreversible pulpitis and apical periodontitis ... The findings are published online () in the Journal of Endodontics, one of the leading peer-reviewed endodontology journals ... The study also is expected to be published in the December 2008 (volume 34, issue 12) issue of the Journal of Endodontics. (EurekAlert!)

    Herpes drug inhibits HIV replication  Nov 8, 2008
    The drug specifically targeted RT, the key HIV enzyme that converts the virus' RNA into DNA so it can be replicated ... These findings appeared in Journal of Biological Chemistry online Friday. (India Times, India -- Health/Science)

    Study Finds Fears Of HIV Transmission In Families With Infected Parent  Nov 7, 2008
    The findings will be published in the November issue of the peer-reviewed journal Pediatrics ... 3, 2005) A genetic analysis of viral RNA from 10 heterosexual couples, in which one partner has sexually transmitted HIV to the other, provides the first documentation of some differences in how the virus. (Science Daily)

    Bird flu dupes our bodies  Nov 6, 2008
    Pieces of protein inside the virus form tube-like structures that obscure strands of RNA formed as host cells are attacked, according to the study ... Images from a cryo-electron microscope revealed that the proteins interact to create tiny tubes, hiding the RNA generated during infection that would normally prompt the body's immune system activate ... The study was published in the London-based science journal Nature. (iAfrica.com)

    Protein 'tubules' free avian flu virus from immune recognition  Nov 6, 2008
    A protein found in the virulent avian influenza virus strain called H5N1 forms tiny tubules in which it "hides" the pieces of double-stranded RNA formed during viral infection, which otherwise would prompt an antiviral immune response from infected cells, said Baylor College of Medicine researchers in an online report in the journal Nature. Two domains or portions of the protein NS1 combine to form tiny tubules where double-stranded RNA is hidden from the immune system, said Dr. B. V. Venkataram... (EurekAlert!)

    Human Genes: Alternative Splicing Far More Common Than Thought  Nov 4, 2008
    4, 2008) Scientists have long known that it's possible for one gene to produce slightly different forms of the same protein by skipping or including certain sequences from the messenger RNA. Now, an MIT team has shown that this phenomenon, known as alternative splicing, is both far more prevalent and varies more between tissues than was previously believed ... "A decade ago, alternative splicing of a gene was considered unusual, exotic ; but it turns out that's not true at all it's a nearly... (Science Daily)

    Former Telomolecular CEO Clarifies SEC Settlement  Nov 3, 2008
    With the help of his partners, the company established internal manufacturing capacity and began to sell nanotechnology based cosmetic goods just before his departure ... The company had also made advances in the delivery of intact RNA to cells through a process known as RNA protein shielding, it had recently begun to work on the development of therapeutics for diseases of the mitochondria, and it had developed new kinds of biodegradable nanoparticle based gene delivery technologies ... Business... (Yahoo News -- Press Releases)

    New method provides panoramic view of protein-RNA interactions in living cells  Nov 3, 2008
    Forced to look elsewhere, scientists turned to RNA, a direct yet more complex transcript of DNA. But methodological problems have historically plagued the study of RNA regulation in living cells, limiting not only the accuracy of results but also our understanding of RNA's role in human disease ... By adapting techniques mastered in the test tube and combining them with high throughput technology, the team has developed a genome-wide platform to study how specialized proteins regulate RNA in... (EurekAlert!)

    Substance tackles skin cancer from 2 sides  Nov 3, 2008
    It was created and tested by an international team of researchers led by the University of Bonn ... A close relative of the nuclear DNA, known as RNA, served them as therapy ... It has only been known for a few years that small RNA molecules can basically be used to target certain genes and switch them off. (EurekAlert!)

    Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers  Nov 2, 2008
    Data will also be presented demonstrating synergy between ANA598 and cytokines induced by ANA773, Anadys' TLR7 agonist oral prodrug, also in development for hepatitis C. These data strongly support the potential for ANA598 to be used in combination with multiple other agents approved or under investigation for hepatitis C. -- In a poster titled "Antiviral Efficacy of the HCV RNA Polymerase Inhibitor ANA598 in the Chimpanzee Model of HCV Infection", Anadys will present data showing that ANA598... (PR Newswire)

    Motor Protein Found That Rewinds DNA  Nov 2, 2008
    The two molecular biologists initially discovered that this motor protein burns energy in the same way as enzymes called helicases and, like helicases, attached to the dividing sections of DNA. But while helicases use their energy to separate two annealed nucleic acid strands such as two strands of DNA, two strands of RNA or the strands of a RNA-DNA hybrid the scientists found to their surprise that this protein did the opposite; that is, it rewinds sections of defective DNA and thus seals the... (Science Daily)

    By Imaging Live Cells, Researchers Show How Hepatitis C Replicates  Nov 1, 2008
    What the researchers discovered in the hepatitis C virus may also prove to be true for related single-strand RNA viruses in the Flaviviridae family, W ... Journal of Virology, 2008; 82 (21): 10519 DOI. (Science Daily)

    Roche Receives FDA Approval for Hepatitis C Viral Load Test on Its Fully Automated Real-Time PCR Platform  Oct 31, 2008
    The test uses Roche's proprietary real-time PCR technology to quantify the amount of Hepatitis C RNA in a patient's blood ... "We are pleased to offer this new solution for laboratories and physicians to optimize their turnaround time, workflow and patient care with simultaneous processing of HIV and HCV patient samples." The new test offers a broad dynamic range from high levels of virus in a patients blood to the "undetectable" low levels of viremia -- the goal of therapy. (PR Newswire)

    Pervasive Network Discovered Driving Protein Production And Placement In Cells  Oct 31, 2008
    In a study to be published on Oct. 27 in the journal Public Library of Science-Biology, investigators led by Pat Brown, PhD, professor of biochemistry and a Howard Hughes Medical Institute investigator, and Dan Hogan, a graduate student in Brown's lab, have accumulated persuasive evidence that certain proteins guide the fates of the molecules conveying genetic instructions from cells' nuclei to the diverse intracellular destinations where these instructions are to be carried out ... It's been... (Science Daily)

    UC Davis researchers discover a key to aggressive breast cancer  Oct 31, 2008
    The researchers next conducted a series of laboratory experiments using human breast cancer cell lines and a technique called RNA interference that allows for selective depletion of cellular proteins. Interestingly, they found the same results in the human breast cancers that they found in mice. (EurekAlert!)

    Scientists Identify Single MicroRNA That Controls How Heart Chambers Form  Oct 30, 2008
    The discovery of the role of a microRNA called miR-138, could offer strategies for the treatment of congenital heart defects ... MicroRNAs are very small RNAs of 20 to 25 nucleotides that regulate numerous gene functions ... Approximately 650 human miRNAs are known, but only a few have yet been studied to determine what they actually do in a cell. (Science Daily)

    Novel Genetic Screens Provide Panoramic Views Of Cellular Systems  Oct 29, 2008
    They even use cutting-edge RNA interference (RNAi) technology to knock down one gene at a time ... Now, researchers at Harvard Medical School, the Institute for Cancer Research, and the Institut de Biologia Molecular de Barcelona have widened the lens, using RNAi to systematically knock down pairs of genes in fruit fly cells ... "Data from our novel double RNAi screens provide panoramic views of cellular processes," says senior author Norbert Perrimon, who is an HMS professor of genetics and an... (Science Daily)

    Newly Discovered Mechanism Can Explain Beckwith-Wiedemann Syndrome  Oct 28, 2008
    The findings, published in the journal Molecular Cell, have implications in understanding the human disorder Beckwith-Wiedemann syndrome ... If a gene is active on the maternal chromosome, the corresponding gene is usually active also on paternal chromosome ... When part of this domain is transcribed a long RNA molecule, Kcnq1ot1-RNA, is formed. (Science Daily)

    Novel Marker Of Colon Cancer  Oct 28, 2008
    A research article to be published on October 14, 2008 in the World Journal of Gastroenterology addresses this question. In this research, by using the combined methods of laser microdissection (LMD), P27-based RNA amplification, and polypeptide, They evaluated differentially expressed genes between early carcinoma and lymph node metastatic patients ... The results were confirmed at the level of RNA and gene expression. (Science Daily)

    New Antibiotic Target And Antibiotic Mechanism Identified; Discoveries Hold Promise For Drug-Resistant Tuberculosis  Oct 28, 2008
    The researchers showed how three antibiotics myxopyronin, corallopyronin and ripostatin block the action of bacterial RNA polymerase (RNAP). RNAP is the enzyme that transcribes genetic information from DNA into RNA, which, in turn, directs the assembly of proteins, the building blocks of all biological systems ... Blocking bacterial RNAP kills bacterial cells. (Science Daily)

    Chinese scientists win Gates grants  Oct 28, 2008
    Gao Qian, at Fudan's medical college, said two of his students came up with the ideas focusing on researching the role of MicroRNA - a short single-stranded RNA molecule that is now recognized as playing an important role in gene regulation - in the transition from latent to activated tuberculosis. Chen Zhiwei, director of the AIDS Institute at the University of Hong Kong Li Ka Shing Faculty of Medicine, is aiming for an AIDS vaccine capable of inducing neutralizing antibodies against HIV-1... (Xinhuanet, China)

    Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults  Oct 27, 2008
    About the ARTEMIS study ARTEMIS (AntiRetroviral Therapy with TMC114 examined in naive subjects) is an international ongoing, randomized, controlled, open-label non-inferiority phase 3 trial that compares the efficacy and safety of PREZISTA/r with lopinavir/r in treatment-naive HIV-1-infected adult patients with viral load greater than 5,000 copies/mL. Patients were randomized to receive PREZISTA/r 800 mg/100 mg once daily or, based on approved dosing in each country, either lopinavir/r 800... (PR Newswire)

    Analysis of Long-Term Vicriviroc Data Provides Evidence of Sustained Viral Suppression, Increased CD4 Cell Counts and Tolerability in Treatment-Experienced HIV-Infected Patients  Oct 27, 2008
    Virologic response to regimens containing vicriviroc was evidenced within 12 weeks by a significant decrease in virus (HIV RNA) detectable in the blood and was sustained long-term. Median change from baseline viral load (HIV RNA) was -2 ... References (1) Coakley E, et al. Second International Workshop Targeting HIV Entry. (PR Newswire)

    Why Binge Drinking Is Bad For Your Bones  Oct 26, 2008
    Callaci is co-author of the study, published recently in the journal Alcoholism: Clinical and Experimental Research ... They found that alcohol affected the amounts of RNA associated with these genes ... (RNA serves as the template for making proteins, the building blocks of bones and other tissue. (Science Daily)

    Study Shows How Antibiotic Sets Up Road Block To Kill Bacteria  Oct 26, 2008
    Scientists already knew that this antibiotic inhibited the actions of an enzyme called RNA polymerase, which sets gene expression in motion and is essential to the life of any cell ... In the case of myxopyronin, the antibiotic binds to RNA polymerase in a way that interferes with the enzyme's ability to use DNA to start the process of activating genes so they can make proteins ... "This is the first antibiotic that we know that inhibits polymerase before it even starts RNA synthesis," said... (Science Daily)

    Binge drinking 'bad for bones'  Oct 26, 2008
    And, according to the researchers, the findings could help in the development of new drugs to minimise bone loss in alcohol abusers, the 'Alcoholism: Clinical and Experimental Research' journal reported ... The researchers focused on genes responsible for bone health -- they found that alcohol affected the amounts of RNA, which serves as the template for making proteins, the building blocks of bones and tissue, associated with these genes ... With some genes, alcohol increased the amount of RNA.... (Times of India)

    Cause Of Weakness In Marine Animal Hybrids Discovered  Oct 25, 2008
    They further pinned the problem area to a single enzyme, called "RNA polymerase," for the failed trigger. "In hybrids we found that these genes don't turn on in response to stress, which means the animals don't have enough energy, and that leads to low survivorship," said Burton. (Science Daily)

    Merck's Free Radical  Oct 24, 2008
    The first fruits of Rosetta's technology began to emerge with a 2002 article in the New England Journal of Medicine ... 1 billion in cash to buy tiny Sirna Therapeutics, a leader in a field called RNA silencing, which uses small molecules to shut off genes. (Forbes -- Business)

    Common Respiratory Syncytial Virus May Hide In The Lungs, Lead To Asthma, Researchers Report  Oct 23, 2008
    Dr. Ramilo said the team's findings contradict the current thinking that ribonucleic acid viruses like RSV are easily destroyed. "Whether RSV persists in children remains to be seen, but the fact that the virus persists in mice is amazingly powerful," he said. (Science Daily)

    Evolution Of Genes That Trigger The Body's Immune Response To Viral Infection  Oct 23, 2008
    22, 2008) Virginia Commonwealth University Institute of Molecular Medicine researchers have traced the evolutionary origin of two genes that serve as primary cellular sensors of infection with RNA viruses, such as influenza, poliovirus, West Nile virus, and HIV, which may ultimately provide researchers with insight into a possible new pathway for the development of innate immunity. See also. (Science Daily)

    Nobel Laureate Confirms Importance of Adjuvants in Controlling Devastating Diseases  Oct 23, 2008
    Luc Montagnier, a winner of the 2008 Nobel Prize in Physiology and Medicine, confirms the importance of adjuvants in a current article in the Wall Street Journal (Oct ... Ampligen(r) and Oragens represent experimental RNA nucleic acids being developed for globally important debilitating diseases and disorders of the immune system. (Primezone Releases)

    Palo Alto-based Intradigm targets cancer's genetic switch  Oct 23, 2008
    Intradigm targets cancer's genetic switch - Silicon Valley / San Jose Business Journal ... Subscribe to Silicon Valley / San Jose Business Journal ... Silicon Valley / San Jose Business Journal - by. (San Jose Business Journal, CA)

    Mapping a clan of mobile selfish genes  Oct 23, 2008
    " As mutations gradually blur the features of older Alu elements, some become unable to make copies of themselves. To identify the Alu retrotransposons that are still capable of moving around, Devine and graduate student E. Andrew Bennett, who is first author, divided them into families and tested a representative of each family in the laboratory. The results are published online and are scheduled to appear in the December issue of the journal Genome Research. Laboratories at Emory, the... (EurekAlert!)

    Alternative methods to analyse the impact of HIV mutations on virological response to antiviral therapy  Oct 23, 2008
    We used a subset of 87 patients with a complete baseline genotype and plasma HIV-1 RNA available at baseline and at week 12. PCA and PLS components were determined with all mutations that had prevalences >0. (BioMed Central)

    New Urine Test ID's Prostate Cancer  Oct 22, 2008
    The test, from San Diego-based Gen-Probe, is approved in some European countries but not in the U.S. It detects genetic material -- RNA -- from prostate cancer gene 3 or PCA3 ... Prostate cancer cells express 60 to 100 times more PCA3 RNA than normal cells. (Yahoo News -- Prostate Cancer)

    'Junk' DNA May Have Important Role In Gene Regulation  Oct 21, 2008
    The findings, which increase understanding of how humans differ from other animals, including non-human primates, appear Oct. 17 in the open-access journal PLoS Genetics ... A type of transposon called retrotransposons are transcribed into RNA and then reintegrated into the genomic DNA. The most common form of retrotransposons in the human genome are Alu elements, which have more than one million copies and occupy approximately 10 percent of the human genome ... D., assistant professor of... (Science Daily)

    New Natural Products Act Against Antibiotic-resistant Bacteria  Oct 21, 2008
    Today, the scientists publish their results in the distinguished journal "Cell" ... The origin of the current success story is outlined by HZI biologist Dr. Herbert Irschik: "In our fundus we have three substances myxopyronin, corallopyronin and ripostatin which were isolated and characterised chemically and biologically. Already many years ago we recognized their unusual antibiotic effect. It was directed in an unknown manner against the bacterial RNA polymerase, i.e. the enzyme that reads the... (Science Daily)

    Hemispherx Biopharma to Present At 48th Annual ICAAC Conference  Oct 21, 2008
    Ampligen(r) and Oragens(r) represent experimental RNA nucleic acids being developed for globally important debilitating diseases and disorders of the immune system. Hemispherx's platform technology includes large and small agent components for potential treatment of various severely debilitating and life threatening diseases. (Primezone Releases)

    A molecule with a momentous effect  Oct 20, 2008
    Now, the tiny genetic thermostats first discovered in the Peter Pan worms, molecules called microRNAs, are seen as having a crucial role to play in everything from stem cells to cancer. "This was a form of regulation of gene expression that we simply hadn't known existed until recently, and that has the power to modify cellular processes in really quite profound ways," said David Baltimore, a Nobel laureate and professor of biology at the California Institute of Technology who works with... (Boston Globe)

    Evolution Of Virulence Regulation In Staphylococcus Aureus  Oct 19, 2008
    The research, published by Cell Press in the October 10th issue of the journal Molecular Cell, may lead to strategies for developing more effective therapeutics against the human pathogen responsible for most of the antibiotic-resistant infections contracted in the community ... The agr system initiates rapid target gene expression when bacterial cell density reaches a threshold level, exerting its effect through RNAIII. Phenol-soluble modulins (PSMs), which play an important role in the ability... (Science Daily)

    Archives: RNA

    Back to Health News

[ Terms Of Use | Privacy | About ]
©1998-2008 SurfWax, Inc.
All rights reserved. Patents pending.



Copyright SurfWax, Inc. 2008