Undergraduates Forge New Area Of Bioinformatics Jul 6, 2008
"As the efficiency of high-throughput mass spectrometry improves, it is likely that proteomics will be used increasingly in genome annotation. As well as improving the accuracy of annotation, proteomics can provide information that other annotation methods are blind to, such as RNA editing and novel protein modifications," writes Patrick Goymer in Nature Reviews Genetics. Battling Floods of Genomic Data. (Science Daily)
Molecular adaptation and expression evolution following duplication of genes for organellar ribosomal protein S13 in rosids Jan 27, 2008
To determine if partitioning of expression takes place between numt rps13 and mt rps13, expression of both copies and RNA editing of mt rps13 were examined by RT-PCR, qRT-PCR, and sequencing from 14 different organ types plus seedlings subjected to five different abiotic stresses. Co-expression of numt rps13 and mt rps13 was observed in all the organs and various stress treatments. (BioMed Central)
Surprises in fly genome Nov 8, 2007
The comparative analyses uncovered new microRNA genes, RNA genes, and RNA structures involved in post-transcriptional processes such as messenger RNA editing and translational control. They also revealed many new gene regulators, including several found at higher levels in specific tissues than regulators already known to be important in these tissues. (The Scientist)
A population study of Trypanosoma cruzi minicircles: predicting guide RNAs in the absence of empirical RNA editing May 25, 2007
The structurally complex network of minicircles and maxicircles comprising the mitochondrial DNA of kinetoplastids mirrors the intricate RNA editing process that is required for faithful expression of encrypted maxicircle genes. Although a few of the guide RNAs that direct this editing process have been discovered on maxicircles, guide RNAs are found mostly on the minicircles. (BioMed Central)
Killing The Messenger RNA: Small Gene-Silencing Molecules Subject To Redirection By Editing Feb 28, 2007
"Using bioinformatics tools to compare the unedited and edited versions of only one species of microRNA against data banks of known gene sequences, the scientists identified two different groups of about 80 genes each likely to be targeted by the two versions of the molecule. They then selected three genes from each group for a closer look, testing to see whether their expression was in fact altered, up or down, by the microRNAs. It was.Then they chose one potentially affected gene at random to... (Science Daily)
Drug Strategy Makes Cancer Genes Get Lost In Translation Jan 27, 2007
(December 7, 2000) -- In a new study, scientists at The Wistar Institute report the first direct evidence that RNA editing is essential to mammalian embryo development. RNA editing is a normal but not yet fully understood. (Science Daily)
