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    News and Articles on RNA interference

    Archives: RNA interference

    Previous Claims Of SiRNA Therapeutic Effects Called Into Question By Report In Human Gene Therapy  Sep 5, 2008
    23, 2008) RNA interference represents an innovative new strategy for using small RNA molecules to silence specific genes associated with disease processes, and a series of review articles describing the. (May 21, 2007) The use of targeted nanoparticles offers promising techniques for cancer treatment. (Science Daily)

    Landmark Study Opens Door To New Cancer, Aging Treatments  Sep 3, 2008
    (July 15, 2003) Scientists have used a technique called RNA interference to impair cancer cells' ability to produce a key enzyme called telomerase. The enzyme, present in most major types of cancer cells, gives. (Science Daily)

    Bitter-tasting Nectar And Floral Odors Optimize Outcrossing For Plants  Sep 2, 2008
    Apart from control plants that had received only a blind copy of the transgenic DNA fragment, transgenic lines were created (by means of RNA interference) that were unable to produce either nicotine or benzyl acetone; the latter has a sweet odor we know from cocoa beans and is similar to the smell of jasmine and strawberry. A fourth line of transgenic plants could produce neither nicotine nor benzyl acetone. (Science Daily)

    First Gene Associated With Dry Macular Degeneration Found  Aug 29, 2008
    Importantly, this research indicates that individuals with a genetic variant of TLR3 who undergo a new treatment called RNA interference (RNAi) could be at risk. A class of double-stranded RNA (like the genetic information carried by viruses), RNAi is used to turn off or silence other genes related to various diseases. (Science Daily)

    Application Notes  Aug 29, 2008
    A combination of RNA interference (RNAi) with fluorescence microscopy analysis is proving to be a very good solution to this problem. Here we show that the Olympus SZX stereo and upright BX microscopes, both with fluorescence illumination capabilities, are perfect for use in these situations. (Nature News Service)

    Genetics podcast  Aug 29, 2008
    RNA interference (RNAi) is a form of post-transcriptional gene silencing in which double-stranded RNA induces degradation of the homologous endogenous transcripts, mimicking the effect of the reduction, or loss, of gene activity. through the process of RNA interference. (Nature News Service)

    Gene Linked to 'Dry' Macular Degeneration  Aug 29, 2008
    The treatment in question, known as "RNA interference," or RNAi, works by "silencing" genes that bring about wet AMD. Unfortunately, the treatment appears to simultaneously activate TLR3 -- resulting in a 60 percent spike in retinal cell death among mice and humans genetically susceptible to developing dry AMD. The result: RNAi may help protect against wet AMD while boosting the risk for dry AMD, the study authors said. "This raises particular concerns regarding RNAi therapy for wet AMD," Zhang... (MEDLINEplus)

    Gene linked to eye disease  Aug 29, 2008
    These experimental medications, which spur a phenomenon called RNA interference, or RNAi, may suppress a process that helps protect people from dry macular degeneration, Zhang said. Ironically in some individuals, using RNAi to cure wet age-related macular degeneration might actually increase the risk of getting dry macular degeneration, he said. (San Diego Union-Tribune)

    LipidomicNet: New Lipidomics Project Promotes Translational Research Towards Human Disease  Aug 26, 2008
    In combination with advanced proteome and transcriptome analysis tools and novel imaging techniques using RNA interference, it is now possible to unravel the complex network between lipids, genes and proteins in an integrated lipidomics approach. LipidomicNet addresses lipid droplets (LD) as dynamic organelles with regard to composition, metabolism and regulation. (Science Daily)

    Tekmira Pharmaceuticals Publishes Research That Addresses Critical Issue in the RNAi Field  Aug 26, 2008
    VANCOUVER, BRITISH COLUMBIA--(Marketwire - Aug. 26, 2008) - Tekmira Pharmaceuticals Corporation (TSX: - ) announced today that it has published new research that highlights proprietary technology developed by the company to modify small interfering RNA (siRNA) molecules to minimize the immune stimulation effects of siRNA while preserving their RNA interference (RNAi) activity. Tekmira's siRNA modification technology, which the company has filed intellectual property to protect, will be utilized... (CCNMatthews Press Releases)

    Specially Designed RNA Reduces  Aug 20, 2008
    The results showed that the RNA interference, or RNAi, mechanism could provide a new tactic for treating high cholesterol. Similar treatments in four nonhuman primates, conducted off-site by a certified contract research organization, produced an average 56 percent drop in low-density lipoprotein cholesterol levels in the animals' blood. (Oneindia)

    Experiments could lead to new treatments for neuroblastoma  Aug 16, 2008
    Although researchers are discussing the use of short-hairpin RNA and other RNA interference techniques as potential therapies for patients with neuroblastoma and other cancers, Chung said, a compound that blocks the GRP receptor has already been approved by the FDA for adult use. "With the publication of our data, we would like to propose an application involving a number of institutions to move forward with a phase 1 clinical trial using this FDA-approved GRP receptor antagonist for... (EurekAlert!)

    Tekmira Pharmaceuticals Corporation Announces Second Quarter 2008 Operating Results  Aug 14, 2008
    Subsequent to the end of the quarter, Tekmira announced that it had completed a strategic review of its product pipeline and had selected two lead RNA interference (RNAi) product candidates, with plans to advance both into clinical development in 2009. The two lead candidates are ApoB SNALP and PLK1 SNALP.. (CCNMatthews Press Releases)

    Tekmira Pharmaceuticals Announces RNAi Research Collaboration With Bristol-Myers Squibb  Aug 13, 2008
    The relationship between Tekmira and Bristol-Myers Squibb builds upon earlier work conducted at Bristol-Myers Squibb using siRNA delivery technology provided by privately held Protiva Biotherapeutics Inc. In May, Protiva and Tekmira combined their businesses to create a leader in the field of RNAi (RNA interference) therapeutics. Dr. Mark J. Murray, Tekmira's President and CEO, said, "Our relationship with Bristol-Myers Squibb is consistent with our strategy to work with global pharmaceutical... (CCNMatthews Press Releases)

    Designer RNA Fights High Cholesterol, Researchers Find  Aug 12, 2008
    This result indicated that the RNA interference, or RNAi, mechanism could provide a new tactic for treating high cholesterol ... The research focuses on RNA interference, or. (Science Daily)

    RNA stops HIV in its tracks  Aug 11, 2008
    Priti Kumar from the Harvard Medical School in Boston, US, and colleagues from the US, Korea and Germany, used a technique called RNA interference (RNAi) to protect mice possessing a human immune system from infection by HIV. ... Andrew Fire and Craig Mello have won the Nobel prize in physiology or medicine for their discovery of RNA interference. (Chemistry World)

    New Gene Technique Stops HIV In Its Tracks  Aug 10, 2008
    The study researchers discovered that through RNA interference, HIV infection can be suppressed. During RNA interference, where genes are artificially silenced by making use of a natural molecular switch in the cell, can slow down the duplication of HIV in human blood cells ... For the first time, we have used RNA interference to dramatically suppress HIV infection in an organism. (TopNews)

    Hope in HIV battle  Aug 8, 2008
    Today there is better news: in the new issue of Cell, researchers from Harvard Medical School and the Texas Tech University Health Sciences Center announce that a technique called RNA interference can dramatically suppress HIV's spread not just in a petri dish but also in mice carrying human immune cells ... NEWSWEEK: RNA interference is certainly promisingits discoverers won the Nobel Prize two years ago ... Priti Kumar: RNA interference is a mechanism where short molecules of ribonucleic... (MSNBC -- Health)

    AIDS Breakthrough? HIV Halted With RNAi In Mice  Aug 8, 2008
    Working in mice infected with HIV, a team used a method called RNA interference to knock down three genes in T cells, protecting them from the virus. This method seemed to prevent HIV from jumping between cells in the mice. (Science Daily)

    Pfizer setting up key unit in Mission Bay  Aug 7, 2008
    Specifically, Goodman's direct charge from Pfizer CEO Jeff Kindler is to look at emerging technologies like RNA interference, or RNAi, and new ways of delivering vaccines. Nailing down a BBC home could prove a shot in the arm for Pfizer as the world's best-selling drug -- the cholesterol pill Lipitor -- opens to generic competition in 2011. (San Francisco Business Times, CA)

    U.S. researchers uncover West Nile's targets  Aug 7, 2008
    To find out exactly which of those processes were involved in an infection, the research team used a technique called global RNA interference targeting strategy. Using tiny snippets of small interfering RNA, scientists are now able to disable individual genes and thereby assess their function. (Xinhuanet, China)

    Biotech firm MDRNA cuts staff  Aug 5, 2008
    Since then the company has refocused itself on RNA interference research. Reader Comments. (Puget Sound Business Journal, WA)

    Evidence of the role of tick subolesin in gene expression  Aug 3, 2008
    Two subolesin-interacting proteins were identified and characterized by yeast two-hybrid screen, co-affinity purification and RNA interference (RNAi). The effect of subolesin knockdown on the tick gene expression pattern was characterized by microarray analysis and demonstrated that subolesin RNAi affects the expression of genes involved in multiple cellular pathways. (BioMed Central)

    Class of antibiotics can enhance gene-silencing tool  Jul 21, 2008
    Doctors envision the technique, called RNA interference, as a tool to treat a variety of diseases if it can be adapted to humans. Emory University researchers have discovered that antibiotics known as fluoroquinolones can make RNA interference more effective in the laboratory and reduce potential side effects ... The most powerful enhancer of RNA interference was enoxacin, which has been used to treat gonorrhea and urinary tract infections. (EurekAlert!)

    Alfacell Receives NASDAQ Non-Compliance Notification  Jul 19, 2008
    About Alfacell Corporation Alfacell Corporation is the first company to advance a biopharmaceutical product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an RNase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer and other life-threatening diseases. (PR Newswire)

    CSHL scientists correlate enzyme expression levels with chemotherapy drug response  Jul 19, 2008
    The premise of the CSHL team's experiments was to find short RNA molecules that, via a mechanism called RNA interference, or RNAi, could regulate the gene or genes responsible for the effectiveness of chemotherapy treatment. The practical question for the team was which short RNAs, precisely, would have this effect. (EurekAlert!)

    Mass. gets $9.2m as drug maker settles with states  Jul 16, 2008
    extends multiyear alliance with Alnylam Alnylam Pharmaceuticals Inc. plans to disclose today that Swiss drug maker Novartis AG has decided to extend its multiyear alliance with the Cambridge company that specializes in RNA interference, a way to block the expression of key genes linked to diseases. When the deal was initially signed in 2005, the companies said it could ultimately be worth $700 million. (Boston Globe)

    Global catastrophic risks  Jul 15, 2008
    As scientists gain deeper insights into the genetic processes that underlie life, they are able to effectively reprogram human biology through the development of new forms of gene therapies and medications capable of turning on or off enzymes and RNA interference, or gene silencing. "Biology and health and medicine used to be hit or miss," said Kurzweil. (CNN -- International)

    Genes That Control Embryonic Stem Cell Fate Identified  Jul 14, 2008
    The scientists used a powerful technique known as RNA interference, or RNAi, to screen more than 1,000 genes for their role in mouse embryonic stem cells. The technique allows researchers to "knock down" individual genes, reducing their abundance in order to determine the gene's normal role. (Science Daily)

    Researchers reveal types of genes necessary for brain development  Jul 8, 2008
    Dr. Katharine Sepp and her fellow researchers took fresh neuronal cells extracted from embryos of the fruit fly genus Drosophila and screened them using RNA interference techniques. The team tested all genes, one by one in a rapid manner, for their potential role in neuronal development. (EurekAlert!)

    Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro  Jun 30, 2008
    MMP-2 mRNA and protein levels were significantly inhibited by RNA interference (P<0. 05). (BioMed Central)

    Gene Silencer And Quantum Dots Reduce Protein Production To A Whisper  Jun 28, 2008
    The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells ... In the body, RNA interference could be used to treat conditions ranging from breast cancer to deteriorating eyesight. (Science Daily)

    The 21st century tomato  Jun 28, 2008
    In continuing research, Carrari and co-workers are using these methods, as well as RNA interference and transgenesis to map QMLs and to identify and utilize candidate genes that function at network nodes. These systems approaches make it possible to model the whole organism throughout its development. (EurekAlert!)

    In the Arena: Life sciences initiative to become law  Jun 26, 2008
    The bill defines Life sciences as applied sciences that expand the understanding of human physiology and have the potential to lead to medical advances or therapeutic applications, including agricultural biotechnology, biogenerics, biomedical engineering, biopharmaceuticals, chemical synthesis, genomics, medical devices, proteomics, regenerative medicine, RNA interference, stem cell research, and veterinary science. Highlights of the bill are described below. (Lincoln Journal, MA)

    One Gene May Be Key to Myeloma  Jun 25, 2008
    This "Achilles' heel screen" uses RNA interference to spot particularly vulnerable parts of cancer cells. "It allows you to inactivate one gene at a time in a cancer cell and then ask what happens," Staudt explained. (MEDLINEplus)

    Ambrilia Validates its Targeted Delivery Technology for Cancer in Vivo  Jun 19, 2008
    In the past years, a number of oncogenes have been suppressed with RNA interference (RNAi), which can be achieved by siRNAs, showing the potential for therapeutic applications in humans. ADVERTISEMENT. (CCNMatthews Press Releases)

    Stem cell researchers give old muscle new pep  Jun 16, 2008
    For a group of the old mice, the researchers disabled the "aging pathway" that tells stem cells to stop dividing by using an established method of RNA interference that reduced levels of pSmad3. The researchers then examined the muscle of the different groups of mice one to five days after injury to compare how well the tissue repaired itself. (EurekAlert!)

    Shelton resident to study with Nobel Prize winning scientist  Jun 14, 2008
    Mello, along with Dr. Andrew Fire, is responsible for discovering RNA interference, a method of gene silencing using double-stranded RNA in cells. The mechanism may allow scientists to inhibit the expression of certain genes. (Valley News, CT)

    Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion  Jun 13, 2008
    High throughput screens with RNA interference technology enable loss-of-function analyses of gene activities in mammalian cells. While the construction of genome-scale shRNA libraries has been successful, results of large-scale screening of those libraries can be difficult to analyze because of the relatively high noise levels and the fact that not all shRNAs in a library are equally effective in silencing gene expression. (BioMed Central)

    Inhalable Form Of Gene-therapy Takes Aim At Lung Cancer And Inflammatory Lung Disease  Jun 11, 2008
    In the article, Sally-Ann Cryan, Niamh Durcan, and Charlotte Murphy focus on research efforts to develop an inhalable form of RNA interference (RNAi), a gene-therapy technique that interferes with or "silences" genes that make disease-causing proteins. The authors explain that RNAi has advantages over other gene therapies. (Science Daily)

    New Approach To Purifying Drinking Water  Jun 9, 2008
    The relatively new technology, known as RNA interference (RNAi), makes use of short snippets of genetic material that match -- like a lock and key -- a corresponding segment of a gene in the target. When these snippets enter a cell and attach to the corresponding segment, they can inhibit or block the action of the target gene. (Science Daily)

    CSHL scientists trace causal link between a tumor suppressor gene and liver cancer  Jun 4, 2008
    Following the Signaling Pathway Using a mechanism called RNA interference to control the expression of specific genes, the team effectively turned the DLC1 "switch" on and off in living mice cells, and in so doing was able to isolate one particular signaling intermediary whose presence was both necessary and sufficient to set the cell on an uncontrolled growth path. This essential molecular intermediary is called RhoA. When the DLC1 gene is absent in a cell, RhoA is activated, effectively... (EurekAlert!)

    Eating and weight gain not necessarily linked, study shows  Jun 4, 2008
    They took advantage of a powerful and relatively new technique known as RNA interference, or RNAi, which allowed them to inactivate hundreds of genes one at a time to determine the effect of these gene inactivations on serotonin's actions on fat regulation. "Obesity and thinness are not solely determined by feeding behavior," the scientists conclude in their paper. (EurekAlert!)

    Tekmira Pharmaceuticals and Protiva Biotherapeutics Announce Completion of Business Combination  Jun 2, 2008
    The combined company, which will retain the name Tekmira, will be a global leader in the field of RNA interference ("RNAi") therapeutics. ADVERTISEMENT. (CCNMatthews Press Releases)

    New Insights Into Cellular Reprogramming Revealed By Genomic Analysis  May 30, 2008
    By identifying characteristic differences in the epigenetic maps and expression profiles of these partially reprogrammed cells, the researchers designed treatments using chemicals or RNA interference (RNAi) that were sufficient to drive them to a fully reprogrammed state. One of these treatments, involving the chemotherapeutic 5-azacytidine, could improve the overall efficiency of the reprogramming process by several hundred percent. (Science Daily)

    Alnylam and Takeda strike $150m drug-licensing deal  May 28, 2008
    Alnylam, which made a similar deal with Swiss drug company Roche last summer, has attracted attention from major drug makers and investors alike for its early efforts to develop drugs through RNA interference technology, a way to "silence" nettlesome genes in the body that are thought to be associated with disease. In addition, Alnylam has smaller partnerships with , AG, and Cambridge-based Idec Inc.. (Boston Globe)

    Alnylam May Gain $1 Billion From Takeda for Technology Licenses  May 28, 2008
    The agreement gives Takeda a foothold in RNA interference, a technique developed over the past 15 years for blocking human genes from making protein ... to form Regulus Therapeutics LLC. Regulus is developing drugs using another kind of RNA interference technology, called microRNAs, that can control several genes simultaneously. (Bloomberg)

    New Treatments For Viral And Other Diseases By Blocking Genes  May 28, 2008
    However there is now the possibility of developing treatments potentially against all viral diseases through drugs based on the recently discovered phenomenon of RNA interference (RNAi), as was discussed at the ESF conference ... Although the basic mechanisms of RNA interference are now quite well understood, significant challenges remain in applying the technique in treatment of disease. (Science Daily)

    Daily Briefing  May 28, 2008
    There is growing interest in development of so-called RNA interference technology from traditional pharmaceutical companies eager to supplement their slow-growing pipelines of drugs. Chemtura starts buyout talks. (Atlanta Journal-Constitution -- Business)

    Another potential $1B deal for RNAi drug technology  May 28, 2008
    There is growing interest in development of so-called RNA interference technology from traditional pharmaceutical companies eager to supplement their slow-growing pipelines of drugs. The most recent deal by Alnylam may quiet critics who thought Roche would be the only pharmaceutical willing to dig that deep into its pocket for yet another large upfront fee, Broadpoint Capital analyst Simos Simeonidis said in a research note. (San Diego Union-Tribune -- Business)

    Biotech Reigns At Wharton's Business Plan Contest  May 26, 2008
    To prevent the gene from causing blindness, iTherapeutics' drug would harness a biological mechanism called RNA interference, also known as RNAi or gene silencing. (Two American scientists won the Nobel Prize in 2006 for their discovery of RNAi. (Forbes)

    RNA Toxicity Contributes To Neurodegenerative Disease, Scientists Say  May 23, 2008
    10, 2005) Scientists at the Ecole Polytechnique F;d;rale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of. (Nov. (Science Daily)

    Former CMS Administrator: "'Blunt Instrument' Policies an Increasingly Bad Fit in Era of Personalized Health Care"  May 17, 2008
    McClellan commented on additional issues facing the current and future health care landscape: -- Recent rapid advancements in gene-based care such as proteomics and genomics, RNA interference, regenerative medicine and epigenetics are ushering in the "Biomedical Century" and introducing a sea change in personalized medicine that makes "all the spending worth it." -- A key driver of cost is not rising prices or an aging population; in fact, the key driver is simply more people getting more... (PR Newswire)

    New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit  Apr 14, 2008
    RNA interference is an experimental technique that allows for the targeted reductions of gene expression. A systematic evaluation of 7,000 genes was conducted in a cisplatin resistant variant of the ovarian cancer cell line A2780. (PR Newswire)

    Should Genetic Modification And RNA Interference Be Used On Farm Animals?  Apr 12, 2008
    Should Genetic Modification And RNA Interference Be Used On Farm Animals ... Should Genetic Modification And RNA Interference Be Used On Farm Animals ... 11, 2008) A range of new technologies including genetic modification (GM) and RNA Interference are being deployed to improve the health of farm animals in a series of European and global initiatives. (Science Daily)

    Development of patatin knockdown potato tubers using RNA interference (RNAi) technology, for the production of human-therapeutic glycoproteins  Apr 3, 2008
    In the present study, potato patatins were eliminated almost completely via RNA interference (RNAi) technology to develop potato tubers as a more efficient protein expression system ... The effects of RNA interference were characterized at both the protein and mRNA levels using 1D and 2D SDS/PAGE and quantitative real-time RT-PCR analysis. (BioMed Central)

    New study raises doubts over favored biotechnology method  Apr 2, 2008
    That field, called RNA interference, is supposed to provide a way to precisely turn off specific disease-causing genes ... Shares of Alnylam, a start-up specializing in RNA interference, are down more than 8 percent since then ... RNA interference is a natural mechanism used by organisms to render genes inactive - presumably the genes of invading pathogens. (International Herald Tribune -- Business)

    Tekmira shares up 25 per cent after company prepares to merge with ...  Apr 1, 2008
    The two Vancouver-based companies will merge under the name Tekmira to develop novel delivery technology and nucleic acid drugs, including RNA interference (RNAi) therapeutics ... The suit claims rights of certain drug delivery technology for small interfering RNA, the molecules that mediate RNA interference. (680 News)

    Gene Silencing Therapies Could Have Harmful Side Effects, Research Suggests  Mar 29, 2008
    Ambati, professor and vice chair of ophthalmology and visual sciences at the University of Kentucky College of Medicine, and his colleagues have made a critical discovery that challenges the view that siRNA's therapeutic effects are imparted solely through RNA interference ... "RNA interference does, of course, exist," said Ambati, a University Research Professor and the Dr. E. Vernon Smith & Eloise C. Smith Endowed Chair in Macular Degeneration Research ... "It is just that siRNA functions... (Science Daily)

    Tekmira Pharmaceuticals Presents Data on Improved Drug Delivery Technology at International RNAi Conference  Mar 29, 2008
    VANCOUVER, BRITISH COLUMBIA--(Marketwire - March 28, 2008) - Tekmira Pharmaceuticals Corporation ("Tekmira") (TSX: - ) announced today that a new second-generation formulation of the Company's liposomal drug delivery technology has the potential to bring a 10-fold increase in potency to RNA interference (RNAi) drugs that are administered intravenously. ADVERTISEMENT. (CCNMatthews Press Releases)

    Triumphs and tribulations for RNA interference  Mar 27, 2008
    But another study of how RNA interference (RNAi) works this time in mice casts some doubt over how well researchers understand the process, and suggests caution in pursuing the technique in people ... The miRNA molecule he and his team silenced, called miR-122, also plays a part in hepatitis C. They say they hope to start clinical trials of miRNA interference against this infection later this year. (Nature News Service)

    Neuronal Regulators Offer Potential Targets For Cancer  Mar 22, 2008
    After uncovering this role, Westbrook used a technique called RNA interference (RNAi) to search for proteins that reduce REST levels. He reasoned that these proteins might promote tumor formation if expressed outside the nervous system. (Science Daily)

    Can Cancer Causing Compounds Be Cut From Tobacco? Gene 'Knockout' Floors Tobacco Carcinogen  Mar 20, 2008
    To get initial lines of plants with the troublesome gene silenced, the NC State researchers used a technique called RNA interference in which genetic engineering was used to introduce a gene that inhibits the demethylase gene function into the tobacco plant ... Journal reference: Ramsey S. Lewis and Ralph E. Dewey, North Carolina State University; Anne M. Jack, Lily Gavilano, Balazs Siminszky and Lowell Bush, University of Kentucky; Jerry Morris, Vincent Robert and Alec Hayes, Philip Morris... (Science Daily)

    Aedes aegypti uses RNA interference in defense against Sindbis virus infection  Mar 18, 2008
    RNA interference (RNAi) is an important anti-viral defense mechanism. The Aedes aegypti genome encodes RNAi component orthologs, however, most populations of this mosquito are readily infected by, and subsequently transmit flaviviruses and alphaviruses. (BioMed Central)

    RNA Interference (RNAi)  Mar 16, 2008
    What is the Mechanism of RNA interference. One of the places where this form of gene regulation occurs naturally is in cellular defenses against infection by specific classes of viruses. (Suite101.com)

    A protein that makes breast cancer spread  Mar 15, 2008
    To show that SATB1 was both necessary and sufficient for breast cancer metastasis, the team used a technique called RNA interference to remove it from highly aggressive cancer cells in mice. This inhibited tumour growth. (Nature News Service)

    Alnylam says gene-blocker cut infection rate 38%  Mar 1, 2008
    Alnylam holds rights to make drugs using RNA interference, or RNAi, that can stop harmful genes from making proteins. (Bloomberg). (Boston Globe)

    Data show a decline in cystic fibrosis since introduction of ...  Feb 28, 2008
    The work of UMMS researcher Craig Mello, PhD, an investigator of the prestigious Howard Hughes Medical Institute (HHMI), and his colleague Andrew Fire, PhD, then of the Carnegie Institution of Washington, toward the discovery of RNA interference was awarded the 2006 Nobel Prize in Physiology or Medicine and has spawned a new and promising field of research, the global impact of which may prove astounding. UMMS is the academic partner of UMass Memorial Health Care, the largest health care... (EurekAlert (press release))

    Technology's Grand Challenges for Engineering  Feb 18, 2008
    Breakthroughs in technologies such as RNA interference, involving inhibiting the functioning of genes, and gene therapy will allow us to flick genetic switches on and off and add new ones - putting an end to many illnesses and expanding lifespans, he added ... "We are rapidly learning the software programs called genes that underlie biology. We are understanding disease and aging processes as information processes, and are gaining the tools to reprogram them."RNA interference, for example,... (Telegraph.co.uk)

    'Comps will beat human IQ by 2030'  Feb 18, 2008
    "We are understanding disease and ageing processes as information processes, and are gaining the tools to reprogramme them. RNA interference, for example, allows us to turn selected genes off, and new forms of gene therapy are enabling us to effectively add new genes. Within two decades, we will be in a position to stop and reverse the progression of disease and ageing resulting in dramatic gains in health and longevity," he added. Get personalised news stories on mobile. (Times of India)

    Slow Calif. science plan a lesson for Mass.  Feb 11, 2008
    Another $500 million would support public research and education facilities, including a stem cell bank to be housed at the University of Massachusetts Medical School in Worcester and a research center focused on RNA interference, an area pioneered by UMass researcher Craig Mello. Unlike the Massachusetts proposal, California's stem cell plan didn't come from politicians. (Boston Globe)

    2 Postdoctoral Positions  Feb 8, 2008
    We are also interested in possible infection-induced RNA interference processes on the eukaryotic host side. For further information about the RNA biology group visit. (Nature News Service)

    State channels investment to biotech startup Sirnaomics Inc.  Feb 8, 2008
    The $50,000 will be used to help the year-old company develop drugs using RNA interference technology. RNA interference technology gives researchers the ability to switch disease-causing genes on and off. (Baltimore Business Journal, MD)

    Unsuspected Protein Determines Resistance To Breast Cancer Treatment  Feb 6, 2008
    Ashworth, Dr. Christopher J. Lord and colleagues used a sophisticated and highly selective loss-of-function RNA interference screening method to identify genes that, when silenced, cause tamoxifen resistance. The researchers identified Cyclin-Dependent Kinase 10 (CDK10) as a critical component of the response to tamoxifen and other therapies that target estrogen signaling. (Science Daily)

    New iPhones, iPods introduced  Feb 6, 2008
    The company is focusing on RNA interference, a process of inhibiting the expression of genes associated with particular diseases. Amira Pharmaceuticals and GlaxoSmithKline said they will collaborate on the development and commercialization of FLAP 5-lipoxygenase activating protein inhibitors for the treatment of respiratory and cardiovascular disease. (San Diego Union-Tribune -- Business)

    Genes Linked To Parkinson's Protection Identified  Jan 26, 2008
    Using a revolutionary technique known as RNA interference, or RNAi, Hamamichi removed, one at a time, the functions of each of the 867 genes from the tiny nematodes. This, Caldwell said, enabled the research team to investigate the impact the missing function would have on cellular processes. (Science Daily)

    The RNA Drug Revolution: A New Approach To Gene Therapy  Jan 24, 2008
    23, 2008) RNA interference (RNAi) represents an innovative new strategy for using small RNA molecules to silence specific genes associated with disease processes, and a series of review articles describing the state-of-the-art and potential therapeutic applications of RNAi and microRNAs will begin with two review papers in the January 2008 issue of Human Gene Therapy ... At least six clinical trials using RNA interference (RNAi) have been approved, with many more coming down the pipeline,... (Science Daily)

    RNA Biology Finding Makes Waves By Challenging Current Thinking  Jan 23, 2008
    19, 2000) Using genetically altered strains of the roundworm C. elegans, scientists have revealed some of the genetic components responsible for a still-mysterious cellular process called RNA interference. (Apr. (Science Daily)

    Gene Responsible For Debilitating Blood Cell Disorder Discovered  Jan 23, 2008
    To explore this unconventional idea, the researchers used a powerful technique known as RNA interference, which partially eliminates, or knocks down , the activity of specific genes ... Another implication of the research is that the RNA interference-based approach used by Ebert and his colleagues can be readily adapted to a variety of other diseases ... Indeed, a broader application of RNA interference may lead to the discovery that other diseases, particularly cancers, stem from subtle, single... (Science Daily)

    Study uncovers method for repressing deadly parasite  Jan 21, 2008
    Next, according to Petri, Linford used a new molecular technique called RNA interference, to block the protein. As a result, the parasite could not eat the dead cells and was unable to colonize and infect the colon. (The Cavalier Daily, VA)

    Means Of Controlling A Parasite That Kills And Eats Human Cells Identified  Jan 21, 2008
    The team identified a particular protein on the surface of the ameba called a kinase, PATMK. Using a special technique called RNA interference to inhibit the actions of this kinase, they prevented the ameba from eating dead cells. "By blocking this kinase, we have for the first time prevented the ameba from colonizing and invading the gut," said Dr. Petri. (Science Daily)

    Tracking down HIV propagation  Jan 19, 2008
    Using RNA interference (RNAi) to screen thousands of genes, researchers from Harvard Medical School have identified 273 human proteins required for HIV propagation. The vast majority had not been connected to the virus by previous studies. (Australian Life Scientist)

    Cells That Promote Formation Of Lethal Lung Metastases Identified  Jan 16, 2008
    By using a technique called RNA interference, or RNAi, to block the expression of Id-1 in living animals, the team was able to prevent mobilization of EPCs to the site of metastasis, and thereby inhibit the angiogenic switch. This, in turn, interrupted the process in mice by which micrometastases are converted into lethal macrometastases. (Science Daily)

    Proteins found that AIDS targets  Jan 12, 2008
    Led by geneticist Stephen Elledge of Brigham and Womens Hospital, the team used a technique called RNA interference that can disrupt a genes ability to do its job and make a protein. One by one, they disrupted thousands of human genes in test tubes, dropped in some HIV, and watched what happened. (MSNBC -- Health)

    Reseachers Identify New Targets to Disrupt HIV Lifecycle  Jan 12, 2008
    " To find the 273 proteins that are part of the HIV life cycle, Elledge and his colleagues screened thousands of possibilities using a technique honored with a Nobel Prize a year ago, RNA interference, which can be used to effectively shut down one gene at a time within a cell. Then the researchers infected the cell with HIV to see if the virus could reproduce. "And we did this for over 20,000 human proteins, all the known, currently known proteins to figure out which ones might be important,"... (Voice of America)

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