Gene Therapy Technique Slows Brain Disease ALD Featured In Movie 'Lorenzo's Oil' Nov 6, 2009
Since then he has used RNAi. (May 16, 2006) Researchers from the University of Pennsylvania and NIAID have successfully restored the immune system in basset pups with X-linked severe combined immunodeficiency (the so-called "bubble-boy". (Science Daily)
Genetic 'Co-dependence' Exploited To Kill Treatment-resistant Tumor Cells Oct 22, 2009
Working with scientists in the Broad's RNAi Platform, the team used RNA interference (RNAi) methods to turn off thousands of different genes in 20 laboratory cancer and non-cancer cells. They then sought out genes that, when shut down by short pieces of RNA strands, caused KRAS cells to self-destruct, but had no effect on normal cells. (Science Daily)
Using RNAi-based Technique, Scientists Find New Tumor Suppressor Genes In Lymphoma Oct 15, 2009
The CSHL team s discovery stems from their use of a powerful technology called RNA interference (RNAi), which suppresses gene activity. The scientists employed RNAi to screen hundreds of candidate tumor-suppressors in living mice, using small hairpin-shaped RNA (shRNA) molecules that attach to specific genes with exquisite specificity and switch them off ... The study is one of the few RNAi-based screens that have been carried out in living animals to date. (Science Daily)
Now, a single jab to prevent blindness Oct 13, 2009
Using a technique called RNA interference (RNAI); they could block the production of claudin-5-a protein that normally helps make the blood-retina barrier impermeable ... However, RNAI therapy is not yet safe enough for use in people, as it would breach the blood-brain barrier as well as the blood-retina barrier. (India Times, India)
Gene That Regulates Breast Cancer Metastasis Identified Oct 8, 2009
Through RNA interference (RNAi) technology, they then reduced the expression of a metastasis-suppressor gene in five mice, one of which developed lung metastases in seven weeks. RNA retrieved from the metastasized cells corresponded to KLF17. (Science Daily)
RNA Interference Found In Budding Yeasts Sep 16, 2009
15, 2009) RNAi, a key biochemical pathway in the genetic control networks of most organisms, has now been discovered in Saccharomyces castellii, a close relative of the prototypical budding yeast S. cerevisiae, and in Candida albicans, a common human pathogen ... The ability to study RNAi in yeast and to use RNAi to alter the yeast's protein production may be beneficial for all these fields ... "For a long time, people thought that budding yeast didn't have RNAi at all because Saccharomyces... (Science Daily)
Safe Seed: Researchers Yielding Good Results On Food Cotton In Field Sep 13, 2009
Rathore and his team used a scientific method called RNAi, a process also being used to explore cancer and HIV cures ... 20, 2006) Researchers at the Texas Agricultural Experiment Station used RNAi to reduce the toxic compound gossypol from cottonseed to a level that is considered safe for consumption, but left the compound in. (Science Daily)
Large-scale Study Probes How Cells Fight Pathogens Sep 7, 2009
This was made possible by the use of RNA interference (RNAi), which can reduce or "knock down" the activity of specific genes and can be applied to practically every gene in the mouse genome. "Our use of RNAi was essential," said Hacohen ... "We couldn't have done this work without the efforts of our collaborators in the Broad's RNAi Platform and the tools developed by The RNAi Consortium." The researchers also used a single-molecule technology that enabled them to generate sensitive readouts of... (Science Daily)
Faster, Cheaper Way To Find Disease Genes In Human Genome Passes Initial Test Sep 1, 2009
(July 9, 2008) Researchers have successfully completed a full-genome RNAi screen in neurons, showing what types of genes are necessary for brain. (May 27, 2008) Scientists have developed a new DNA-sequencing method that is much cheaper than those currently in use in laboratories. (Science Daily)
RXi Pharmaceuticals CFO leaving Aug. 28 Aug 21, 2009
RXi Pharmaceuticals Corporation (Nasdaq: RXII), a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today reported results for the quarter ended June 30, 2009 ... D., President and Chief Executive Officer of RXi, commented, RXi continues to make significant progress on its RNAi therapeutic platform with advances in research that have the potential to address multiple large therapeutic markets 00003356 with... (Fresno Bee -- Business)
Stem Cells' 'Suspended' State Preserved By Key Step, Scientists Report Jul 11, 2009
The scientists discovered the pivotal role of Chd1 by using the powerful technique of RNA interference, or RNAi, to screen this gene and 40 other candidate genes. (RNAi is a naturally occurring process in which small RNAs bind to other RNAs to increase or decrease their activity. (Science Daily)
Drug firms' suit against MIT unusual Jul 3, 2009
They are fighting over rights in a hot new biotechnology field known as RNA interference, or RNAi in scientific shorthand. RNAi technology could potentially be used to turn off genes responsible for serious diseases ... RNAi may be able to do as much good by turning on helpful but inactive genes. (Boston Globe)
Scientists Kill Cancer Cells with "Trojan Horse" Jul 1, 2009
RNA interference, or RNAi, is designed to silence genes responsible for producing disease-causing proteins and is one of the hottest areas of biotechnology research. RNA was the basis of the 2006 Nobel Prize in medicine. (MEDLINEplus)
The Vulnerable Cancer Cell: New Studies Reveal Broad, Hidden Network That Lets Tumors Thrive May 30, 2009
Independent research teams led by Howard Hughes Medical Institute (HHMI) investigators D. Gary Gilliland of Brigham and Women s Hospital (now senior vice president at Merck Research Laboratories) and Stephen J. Elledge at Harvard Medical School, used RNA interference (RNAi) technology to identify a host of genes that cancer cells depend on for survival ... More than 18 months ago, Elledge and Gilliland decided to see if they could use the powerful RNAi technology to seek out genes that... (Science Daily)
Studies home in on genes that feed tumors May 29, 2009
The studies also point to a quick and effective new way to look for ways to fight cancer, using RNA interference or RNAi, itself a hot area in biotechnology ... To find these compromises, Elledge and Gilliland, who now works at Merck Research Laboratories, used high-throughput RNAi. (MSNBC -- Health)
Fast, Affordable Tool For Finding Gene 'On-off' Switches May 22, 2009
McManus said he plans to make shRNA libraries available through the UCSF Sandler Lentiviral RNAi Core, which he directs. The Core provides essential equipment, training, supervision, and monitoring for researchers working in lentiviral-based research, as well as offering viral packaging and other services for researchers. (Science Daily)
The future of personalized cancer treatment: An entirely new direction for RNAi delivery May 17, 2009
"RNAi has an unbelievable potential to manage cancer and treat it," said Steven Dowdy, PhD, Howard Hughes Medical Institute Investigator and professor of cellular and molecular medicine at UC San Diego School of Medicine ... They found that the entire cellular population underwent a maximum RNAi response ... These RNAi methods can be continually tweaked to combat new mutations a way to overcome a major problem associated with current cancer therapies. (EurekAlert!)
Kinovate Life Sciences, Inc. and Nitto Denko Corporation Announce Successful Development of NittoPhase™ HL High Loading Solid Support for Oligon May 15, 2009
Solid support is the base structure used in the synthesis of oligonucleotides, including diagnostic probes and primers, antisense including RNAi, microRNA, DNA-based and aptamer drugs and represents a substantial portion of the cost to manufacture these oligonucleotides. The market leading loading capacity of NittoPhase HL results in significantly improved yields per gram of material with superior purity, allowing users to realize significant cost savings with no compromise in quality. (Yahoo News -- Press Releases)
Oral Delivery System For RNAi Therapeutics May 6, 2009
Highly specific and highly potent, "RNA interference" or "RNAi" has become both a crucial laboratory technique and widely studied for potential therapeutic applications; the explanation of the mechanism of RNAi was recognized with the 2006 Nobel Prize in Medicine, awarded to UMMS Professor Craig C. Mello, PhD, and collaborator Andrew Z. Fire, PhD, of Stanford University; since the discovery, laboratories around the world have focused on the potential of RNAi to silence genes with high... (Science Daily)
New Understanding Of Dengue Virus Points Way To Possible Therapies For Dengue Fever May 1, 2009
Garcia-Blanco, who is also professor of emerging infectious diseases at the Duke-NUS Graduate Medical School in Singapore, used RNA interference (RNAi) to unlock dengue's secrets ... Garcia-Blanco and colleagues in Duke's RNAi facility were able to knock down gene function in fruit fly cells infected with a strain of the dengue virus known as DENV-2 ... "I like to say that my research is a tale of two islands. I was born in Puerto Rico, where dengue thrives, but Singapore is my classroom. The... (Science Daily)
Gene-laden Bubbles Grow New Blood Vessels Apr 30, 2009
Since then he has used RNAi. (June 24, 2008) Researchers have discovered a new way to limit gene transfer and expression to specific tissues in animals. (Science Daily)
Nobel Laureates to Speak at Keystone Symposia RNA Silencing Conference Apr 18, 2009
Andrew Fire of Stanford University will deliver a keynote address on the evening of April 25 on "Adventures in the Small RNA-ome." On Monday morning, April 27, Craig Mello of the University of Massachusetts Medical School will present on "Complexity of RNA Silencing in C. elegans." Both scientists shared the 2006 Nobel Prize in Medicine for their pioneering work discovering how certain RNA molecules can be used to turn off specific genes in animal cells - a phenomenon known as RNA interference,... (PR Newswire)
Key Decision-point At Which Cells With Broken DNA Repair Themselves Or Die Identified Apr 18, 2009
When EYA was experimentally "knocked out" via a technique called RNA interference, or RNAi, damaged cells with double-stranded DNA breaks did not repair themselves; instead, they simply died -- underwent apoptosis. As is often the case in science, multiple labs are engaged on related subjects. (Science Daily)
Advanced search Apr 17, 2009
Search specific journals by selecting from this list, or leave blank to search all of nature. Acta Pharmacologica Sinica. (Nature News Service)
Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research Apr 16, 2009
April 15 /PRNewswire/ -- Cequent Pharmaceuticals, a pioneer in the development of novel products to deliver RNAi-based treatments to prevent and treat human disease, announced that the company's TransKingdom RNA interference (tkRNAi) technology will be the focus of three poster sessions featuring late-breaking research at the American Association for Cancer Research (AACR) meeting. The poster presentation scheduled for Monday afternoon, Safety and Efficacy of a tkRNAi Therapeutic Targeting... (PR Newswire)
Race Is Heating Up For RNAi Leadership Mar 28, 2009
Making it do that is generally called RNA interference, or RNAi ... When RNAi conks out, the body can fall prey to disease ... Harness RNAi and you can create drugs against those illnesses. (Investors Business Daily)
Health & Medicine Mar 28, 2009
Investor's Business Daily: Race Is Heating Up For RNAi Leadership ... Race Is Heating Up For RNAi Leadership ... Making it do that is generally called RNA interference, or RNAi. (Investors Business Daily)
Tekmira Presents Data Demonstrating Further Increases in SNALP Potency Feb 24, 2009
Improvements in therapeutic index have the potential to broaden the therapeutic applications for Tekmira's SNALP technology in the RNA interference (RNAi) field ... Adaptive immune responses, such as the development of antibodies, have the potential to undermine the safety and effectiveness of drugs, such as RNAi therapeutics, that are designed for multiple rounds of administration ... Dr. Mark J. Murray, Tekmira's President and CEO, said "These new improvements have the potential to expand the... (CCNMatthews Press Releases)
A New Gene Silencing Platform -- Silence Is Golden Feb 19, 2009
18, 2009) A team of researchers led by Rutgers' Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over existing RNAi approaches ... "The U1 Adaptor is an oligonucleotide version of this older method and instead targets the 3' end processing step. U1 Adaptors have high activity when used alone and are synergistic when used in combination with RNAi." Gunderson went on to say that the range of possible targets is very broad due to the mechanism of... (Science Daily)
Link Between Control Of Chromosome Duplication And Segregation Discovered Feb 18, 2009
To investigate which of the ORC proteins limit centrosome copying, Stillman and co-investigators Adriana Hemerly, Supriya Prasanth and Khalid Siddiqui, used RNA interference, or RNAi, a technique that uses small pieces of RNA to shut off specific genes. They blocked the production of each of the proteins that combine to form ORC in human cells. (Science Daily)
Nature Reviews Genetics Feb 8, 2009
Click for access to the accompanying RNAi Web Focus, which includes relevant content from across Nature Publishing Group. How will advances in statistics aid genetic analyses. (Nature News Service)
Biopartnering Feb 8, 2009
Patent disputes haven't materialized in the RNAi field yet, but once products near the market, it might be a different story. Charlie Schmidt investigates. (Nature News Service)
Nature Reviews Molecular Cell Biology Feb 8, 2009
From humble beginnings as an obscure phenomenon in plants, RNA interference (RNAi) has evolved into an area of significant impact in numerous fields. The newly launched RNAi Gateway provides a convenient portal into publications relevant to every aspect of RNAi from journals throughout the Nature Publishing Group. (Nature News Service)
Other podcasts Feb 8, 2009
In this special RNAi podcast, we get the low-down on the expanding world of small RNAs: tune in to find out about where we find them, what we know (and don't know) about what they do, how cells process them and even how they evolved. Produced with the support of Alnylam Pharmaceuticals. (Nature News Service)
In Time, Cream Might Prevent Herpes Transmission Feb 7, 2009
The treatment uses RNA interference (RNAi) to fight the virus in two ways: by disabling its ability to replicate and by blocking the host cell's ability to take up the virus. In mice, the treatment is effective when used from one week before to a few hours after exposure to the herpes virus. (MEDLINEplus)
