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    News and Articles on Randomized

    Archives: Randomized

    Statins do not cause or prevent cancer, researchers find  Aug 21, 2008
    His team did what is known as a meta-analysis, reviewing data from 15 large randomized controlled trials of statins, which included 51,797 patients given statins and 45,043 patients given a placebo and then followed for an average four and a half years. Some studies showed a cancer risk with statins, but on average, there was none, Karas and colleagues report in the Journal of the American College of Cardiology. (Boston Globe)

    Study Outlines Teens' Preferences And Trade-offs For Freedom From Acne  Aug 21, 2008
    "Randomized, blinded, placebo-controlled trials have shown that three to four months of conventional acne therapy, including topical benzoyl peroxide, topical retinoids and oral antibiotics, typically produces reductions in lesion counts in the 40 percent to 60 percent range.". "It has also been suggested that the incidence of scarring from facial acne approaches 95 percent," they continue. (Science Daily)

    Chicken Collagen May Ease Rheumatoid Arthritis  Aug 21, 2008
    Dr. Wei Wei at Anhui Medical University in Hefei and colleagues conducted a randomized 24-week trial comparing chicken collagen (0. 1 milligrams daily in pill form) and methotrexate (10 milligrams per week) in 236 patients with rheumatoid arthritis. (MEDLINEplus)

    Erectile Dysfunction Drug Shows Promise For Relief Of Lower Urinary Tract Symptoms Associated With Benign Prostate Disease  Aug 20, 2008
    Researchers from the University of Texas Southwestern Medical Center at Dallas, Northwestern University and Lilly Research Laboratories report on a randomized, double-blind, placebo-controlled study of over 1000 men in ten countries ... 3, 2006) In the first randomized trial of its kind, Tadalafil, a drug typically prescribed for erectile dysfunction in men, has been proven to increase the sexual function of prostate cancer survivors. (Science Daily)

    B vitamins: no magic bullet against heart disease  Aug 20, 2008
    Earlier this year, the women's antioxidant and folic acid cardiovascular study, a randomized controlled trial involving 5,442 women at high risk for heart disease, found that B vitamins did not lower the risk of cardiovascular events (such as heart attack, stroke and coronary artery bypass surgery) even though the women's homocysteine levels dropped significantly. The findings suggest that lowering homocysteine does not change the course of heart disease. (Globe and Mail)

    The miracle weightloss thatoftenisnt  Aug 19, 2008
    Few randomized, controlled studies (the gold standard of research) have been performed comparing gastric bypass with nonsurgical weight loss therapy. Although initial weight loss can be dramatic gastric-bypass patients typically shed around 70 percent of excess weight patients gradually regain 20 to 25 percent of what they lose. (MSNBC -- Health)

    Chew Gum for Colon Surgery Recovery  Aug 19, 2008
    The researchers call for larger, randomized studies designed specifically to show that postsurgical gum chewing reduces hospital stays following abdominal surgery. In a 2006 study, which was included in the analysis, researchers from Santa Barbara Cottage Hospital estimated that adding postsurgical gum chewing to the colon surgery regimen could save $118 million a year in the U.S.. (WebMD)

    Few Pharmacologic Treatments Of Cancer-Related Fatigue Available To Patients  Aug 19, 2008
    18, 2008) There is limited evidence to support the use of methylphenidate and erythropoietin for the treatment of cancer-related fatigue in some patients, according to a systematic review of randomized controlled trials ... Ollie Minton, M.D., of St. George's University of London and colleagues performed a systematic review and meta-analysis of randomized controlled trials designed to evaluate the impact of a pharmacologic agents on cancer-related fatigue. (Science Daily)

    Tadalafil shows promise for relief of lower urinary tract symptoms associated with BPH  Aug 19, 2008
    Researchers from the University of Texas Southwestern Medical Center at Dallas, Northwestern University and Lilly Research Laboratories report on a randomized, double-blind, placebo-controlled study of over 1000 men in ten countries. Claus G. Roehrborn, MD, Professor of Urology, University of Texas Southwestern Medical Center, states, "Since reports of erectile dysfunction (ED) incidence, pathophysiology and treatment have shown a possible link between BPH LUTS and ED. PDE5 inhibitors like... (EurekAlert!)

    Bioniche Phase III Clinical Trial in Bladder Cancer Progressing Well  Aug 18, 2008
    The trial will enrol approximately 800 patients and is a double-blind, randomized trial. About MCC MCC is a sterile mycobacterial cell wall-DNA complex composition that has a dual mode of action: immune stimulation and direct anticancer activity. (Canada Newswire)

    A water-based training program that include perturbation exercises to improve stepping responses in older adults: study protocol for a randomized controlled cross-over trial  Aug 17, 2008
    A prospective, randomized, cross-over trial with concealed allocation, assessor blinding and intention-to-treat analysis will be performed to evaluate the efficacy of the water-based training program. A total of 36 community-dwelling adults (age 65-88) with no recent history of instability or falling will be assigned to either the perturbation-based training or a control group (no training). (BioMed Central)

    First FLEXUS(TM) Interspinous Spacer Surgeries for IDE Clinical Trial  Aug 16, 2008
    said, "The surgical technique and approach was very straightforward. The simplicity of the FLEXUS(TM) design in distracting the stenotic segment may be beneficial in treating this painful condition. We are excited to participate in this IDE." The 340 patient prospective, randomized FLEXUS(TM) IDE study will seek to prove equivalence with the X-Stop device over the two year study period. The study will involve patients that are over 50 years old who may benefit from the decompression provided by... (PR Newswire)

    Hepatitis B Genotypes And Mutants May Influence Liver Cancer Risk  Aug 16, 2008
    When secondary prevention strategies are tested in large randomized trials, patients should be stratified by known risk factors, including viral genotype and mutations. Journal reference. (Science Daily)

    Hope for patients with COPD  Aug 16, 2008
    For the first time, a drug therapy appears to reduce lung function loss in patients with moderate to severe chronic obstructive pulmonary disease (COPD), according to the results of a randomized, double-blind, placebo-controlled trial in 42 countries ... The TORCH study randomized more than 6,000 patients with moderate to severe COPD from 42 countries to receive either salmeterol (SAL; 50 ;g), fluticasone propionate (FP; 500 ;g), the two in combination (SFC; 50/500;g), or placebo ... "The rate... (EurekAlert!)

    India continues to progress in AIDS vaccine development efforts  Aug 16, 2008
    The trial was a double blind, dose-escalation, randomized, placebo-controlled trial, which was initiated after receiving all necessary regulatory and ethical clearances. The objectives of such a Phase I trial are to evaluate the safety of the vaccine candidate and to gather preliminary results of immune responses induced by the candidate. (EurekAlert!)

    To The Moon And Mars: Psychologists Show New Ways To Deal With Health Challenges In Space  Aug 15, 2008
    The system is being evaluated in a set of randomized controlled clinical trials. This interactive program will help astronauts prevent, detect, assess and manage their own psychosocial problems. (Science Daily)

    Prostatectomy Improves Outcome Of Some Men With Prostate Cancer Over Watchful Waiting  Aug 14, 2008
    13, 2008) Men with early prostate cancer who undergo radical prostatectomy have a lower rate of death due to prostate cancer than men who are followed without treatment, known as watchful waiting, according to a randomized controlled trial ... Thus far, this is the only completed randomized trial comparing the two treatment options ... Bill-Axelson et al. Radical Prostatectomy Versus Watchful Waiting in Localized Prostate Cancer: the Scandinavian Prostate Cancer Group-4 Randomized Trial. (Science Daily)

    Coated Film As A Bacteria Killer  Aug 14, 2008
    (May 21, 2008) A silver-coated endotracheal tube may reduce infections with highly resistant bacteria over traditional tubes by nearly half, according to the results of a large randomized. (Sep. (Science Daily)

    Effects of Tibolone in Older Postmenopausal Women  Aug 14, 2008
    Methods In this randomized study, we assigned 4538 women, who were between the ages of 60 and 85 years and had a bone mineral density T score of 2. 5 or less at the hip or spine or a T score of 2. (New England Journal of Medicine)

    BioMS Medical Announces Second Quarter 2008 Results  Aug 13, 2008
    BioMS Medical, in partnership with Eli Lilly and Company (Lilly), is developing MBP8298 (dirucotide), a drug for the treatment of MS undergoing pivotal trials in Canada, Europe and the US. "The three randomized late-stage clinical trials for MBP8298 (dirucotide) continue to progress very well. We recently announced that MAESTRO-03, our U.S. phase III secondary progressive MS trial, was fully recruited with approximately 510 patients," said Kevin Giese, President and CEO of BioMS Medical. "During... (PR Newswire)

    Surgery Helps With Prostate Cancer, Sometimes  Aug 13, 2008
    But it wasn't a randomized, controlled trial -- the gold standard for medical research. "Basically, I don't think we know the right answer about what to do," she said. (Washington Post)

    Adherex Reports Second Quarter 2008 Financial Results  Aug 13, 2008
    The additional patient enrollment is expected to provide a more robust estimate of the response rate, and provide ancillary information potentially valuable for the design and conduct of a prospective, randomized trial. - Eniluracil has continued to enroll patients in the Phase I and Phase I/II trials intended to determine the maximum tolerated dose (MTD) of oral 5-FU in combination with eniluracil. (CCNMatthews Press Releases)

    Cell Therapeutics Announces that the European Organization for Research and Treatment of Cancer Completes Enrollment in Phase II Clinical Trial of Brostallicin as First Line Therapy for Advanced or Metastatic Soft Tissue Sarcoma  Aug 12, 2008
    Potential for data analysis early 2009 SEATTLE, Aug. 12 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc.'s (CTI) (Nasdaq: ; MTA) subsidiary Systems Medicine (SM) announced today that planned enrollment is complete in the European Organization for Research and Treatment of Cancer (EORTC) randomized phase II clinical trial of brostallicin in patients with newly diagnosed advanced or metastatic soft tissue sarcoma who have had no prior chemotherapy ... Patients are randomized in a 2:1 ratio either... (PR Newswire)

    Genital herpes treatment does not prevent HIV  Aug 12, 2008
    In a randomized multicenter trial, Dr. C. Celum of the University of Washington, Seattle, and colleagues evaluated the effects of acyclovir in 1,814 gay men who have sex with men from the United States and Peru, and in 1,358 women from Zimbabwe, Zambia and South Africa. All were infected with HSV-2 but not with HIV, the virus that causes AIDS.. (Reuters)

    Pharmacokinetics Study Confirms Therapeutic-Enabling Quantities of Allon's Drugs AL-108 and AL-208 in Human Cerebrospinal Fluid  Aug 12, 2008
    - The Company expects to release top-line results during the Third Quarter from the randomized portion of a Phase II clinical trial evaluating the safety, tolerability and effect of AL-208 as a prevention for the mild cognitive impairment resulting from ischemic damage during coronary artery bypass graft surgery. Pharmacokinetic study results. (CCNMatthews Press Releases)

    Key clinical studies of Regeneron's ARCALYST (rilonacept) for treatment of CAPS published  Aug 12, 2008
    In the pivotal, randomized, double-blind clinical study, 47 patients with FCAS or MWS were randomized to receive either ARCALYST or placebo for six weeks ... Patients were then re-randomized to either ARCALYST or placebo and evaluated over a subsequent nine-week period ... "In this case, recognizing that IL-1 is an active mediator of inflammatory disease, we developed ARCALYST to potently inhibit IL-1 in the bloodstream before it can bind to its receptors. Once it was recognized that the genetic... (EurekAlert!)

    Experimental chemotherapy regimen shows promise in treating advanced lung cancer  Aug 12, 2008
    "This is a promising alternative, but needs further testing in randomized trials," he said. . (EurekAlert!)

    HEALTH BLOG: Are fruit drinks or soda worse for diabetics?  Aug 11, 2008
    In 2003, Montori and his collaborators reported that only about one in five "randomized trials" of diabetes drugs answered questions about quality of life and risk of dying. (In randomized trials, patients are randomly assigned to take a new drug or a sugar pill or the standard treatment for their condition, if there is one. (USA Today -- Life)

    Medicinal Marijuana Effective For Neuropathic Pain In HIV, Study Finds  Aug 8, 2008
    Ellis et al. Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial ... 13, 2007) In a randomized placebo-controlled trial, patients smoking cannabis experienced a 34 percent reduction in intense foot pain associated with HIV -- twice the rate experienced by patients who smoked. (Science Daily)

    Growth Hormone Treatment For HIV Patients Improves Abdominal Fat, But Worsens Glucose Level  Aug 7, 2008
    "Data from our randomized, placebo-controlled trial involving a long duration of observation inject a note of caution into the debate regarding the use of GH therapy in the HIV population," the authors write ... Lo et al. Low-Dose Physiological Growth Hormone in Patients With HIV and Abdominal Fat Accumulation: A Randomized Controlled Trial ... (June 7, 2005) A randomized UCLA study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature... (Science Daily)

    'Exercise Pill' Is No Replacement For Real Exercise, Expert Cautions  Aug 7, 2008
    18, 2007) In a new randomized controlled trial, both aerobic and resistance exercise improved glycemic/blood sugar control in people with type 2 diabetes. The greatest improvements came from combined aerobic. (Science Daily)

    Is Stretching All It's Cracked Up to Be?  Aug 7, 2008
    Those who are randomized to stretch are asked to do a 10-minute program before and after exercise, stretching muscles in their legs, hips and back. Those randomly assigned not to stretch must continue their normal exercise routine but refrain from stretching for 13 weeks. (Atlanta Journal-Constitution -- Health)

    Estrogen Relieves Psychotic Symptoms In Women With Schizophrenia  Aug 6, 2008
    D., of The Alfred and Monash University and The Alfred Hospital, Melbourne, Australia, and colleagues conducted a randomized, double-blind study involving 102 women of child-bearing age with schizophrenia. For 28 days, 56 women were randomly assigned to receive 100 micrograms of estradiol daily via a skin patch and 46 women received a placebo skin patch in addition to their regular medications. (Science Daily)

    Q&A: What to take from new prostate screening guide  Aug 6, 2008
    A: Actually, doctors in the USA and Europe are conducting massive randomized trials to determine whether prostate screening saves lives, Kramer says. The American study involving 75,000 men began in 1992. (USA Today -- News)

    Erectile Dysfunction May Be "Normal" with Age  Aug 6, 2008
    Using data from more than 3,800 participants in the European Randomized Study on Screening for Prostate Cancer, Korfage and her colleagues assessed whether urinary, bowel, and sexual dysfunction "and the associated bother" were part of the "normal" aging process. As described in the medical journal Urology, the men -- all of whom were cancer-free -- were divided into five groups by age: 58-61, 62-64, 65-67, 68-70, and 71 years and older. (MEDLINEplus)

    BELLUS Health moves forward on nutraceutical and pharmaceutical fronts - Reports Results for First Half of 2008  Aug 5, 2008
    It will be an international, double-blind, randomized, placebo-controlled and parallel design study of approximately 190 patients to be followed for a period of 24 months ... The study is a 26-week, double-blind, placebo-controlled, randomized study ... The study is a 26-week, double-blind, placebo-controlled, randomized study. (Canada Newswire)

    Researcher: Booze battles heart disease  Aug 5, 2008
    None of the studies were "randomized controlled trials" -- the gold standard of scientific research, whereby people are randomly assigned to an intervention, such as exercising or consuming alcohol. There are lots of observational data to support moderate drinking, said Dr. Robert A. Vogel, professor of medicine and director of clinical vascular biology at the University of Maryland School of Medicine. (Florida Today)

    New Male Circumcision Device For HIV Prevention  Aug 5, 2008
    "Circumcision is the only new HIV prevention method to demonstrate consistent efficacy in randomized controlled trials," notes co-principal investigator Dr. Philip S. Li, associate research professor of urology and reproductive medicine and director of microsurgical research and training at the Center for Male Reproductive Medicine and Microsurgery at Weill Cornell Medical College. Three randomized controlled trials in Kenya, Uganda and South Africa reported a protective effect (up to 60... (Science Daily)

    Same Dose Of Anthracycline Is Not Safe For Everyone, Study Finds  Aug 5, 2008
    Neither randomized clinical trials nor studies that rely on large administrative databases are adequate for addressing the issue. Therefore, Ryberg's study is an important step to helping physicians personalize cancer care for their patients. (Science Daily)

    Psychotic Symptoms Relieved With Estrogen Treatment  Aug 5, 2008
    " Estradiol is the member of the estrogen family best represented in the human body. While it is usually associated with female secondary sex characteristics, both males and females maintain levels of estradiol. To explore this association, Jayashri Kulkarni, M.B.B.S., M.P.M., F.R.A.N.Z.C.P., Ph.D., of The Alfred and Monash University and The Alfred Hospital, Melbourne, Australia, and colleagues performed a randomized, double blind study in women of child-bearing age with schizophrenia. A total... (Medical News Today)

    Male circumcision efforts lag in Africa despite evidence of dramatic impact in preventing HIV  Aug 5, 2008
    Randomized control trials, including in Uganda, Kenya and South Africa, have shown that circumcision can reduce the transmission of HIV in heterosexual men by as much as 65 percent ... " ### PSI is a nonprofit organization based in Washington, D.C. that harnesses the vitality of the private sector to address the health problems of low-income and vulnerable populations in more than 60 developing countries. With programs in malaria, reproductive health, child survival and HIV, PSI promotes... (EurekAlert!)

    Startup uses video games to heal young people  Aug 4, 2008
    So HopeLab tested Re-Mission very much the way pharmaceutical companies test their drugs - in a randomized, controlled clinical trial with hundreds of subjects. The results, published in the scientific journal Pediatrics today, were encouraging. (San Francisco Chronicle -- Business)

    Top Pediatrics Journal Publishes Positive Safety Results of First Children's Trial Involving COLD-fX(R)  Aug 4, 2008
    Pediatrics - the official journal of the American Academy of Pediatrics and a prestigious medical journal - has published safety results of a children's randomized, double-blind, placebo-controlled clinical trial involving COLD-fX. The trial, designed to measure safety and tolerability, showed COLD-fX is safe for children. (CCNMatthews Press Releases)

    Growth Hormone Reduces Fat In HIV Patients With Abdominal Obesity  Aug 4, 2008
    " Low-Dose Physiological Growth Hormone in Patients With HIV and Abdominal Fat Accumulation: A Randomized Controlled Trial Janet Lo; Sung Min You; Bridget Canavan; James Liebau; Greg Beltrani; Polyxeni Koutkia; Linda Hemphill; Hang Lee; Steven Grinspoon JAMA(2008). 300[5]: pp. 509 - 519. Written by: Peter M Crosta Copyright: Medical News Today Not to be reproduced without permission of Medical News Today Please rate this article: (Hover over the stars then click to rate) Patient / Public: or... (Medical News Today)

    Canadian study of colds and kids: Positive safety results for ginseng extract  Aug 4, 2008
    The randomized, double-blind, placebo controlled Canadian trial which was conducted in collaboration with the University of Alberta in Canada was designed to measure the safety and tolerability of COLD-fX for treatment of cold and flu in children. Acute three-day doses of COLD-fX were well tolerated with no serious adverse events, or differences in adverse events versus the placebo group. (EurekAlert!)

    Epilepsy drug may help alcoholics recover from dependence, small study suggests  Aug 4, 2008
    Although the study involved only 21 insomniacs in recovery from alcohol dependence, and did not provide long-term gabapentin treatment or long-term follow-up on their sleep or their alcohol recovery, it was randomized, placebo-controlled, and double-blinded. In all, 30 percent of the patients who received gabapentin during alcohol recovery relapsed to drinking, compared with 80 percent of those who received a placebo. (EurekAlert!)

    OSU engineer: Hydrogen system in autos a scam  Aug 2, 2008
    senojjones wrote on Jul 31, 2008 5:06 AM:" Having spent my lifetime studying science, chemistry in my case, it is frustrating to see scams like hydrogen boosting becoming popular. Also frustrating that many news outlets cover this stuff without bothering to cross check their story with someone with at least a modocum of training.There is no way that you can significantly increase gas mileage by using hydrogen generated from "excess" energy.The usual answer is that critics and every car company... (Corvallis Gazette Times, OR)

    Eradicating Gut Bacteria Improves Stomach Cancer Outcomes  Aug 2, 2008
    noted that colonoscopy is widely used to screen for colorectal cancer even though there are no published randomized trials of benefits versus risks. "Yet, worldwide, gastric cancer kills more people, and there is better evidence that H. pylori eradication can prevent mortality than there is for colonoscopy screening. Preventing gastric cancer by eradicating H. pylori in high-risk regions should be a priority," Talley wrote. (MEDLINEplus)

    BioMS Medical completes patient recruitment in phase III U.S. multiple sclerosis trial  Aug 1, 2008
    QUICK SEARCH BY ORGANIZATION. FREE SUBSCRIPTION SERVICES. (Canada Newswire)

    Frankincense Provides Relief To Arthritis Sufferers  Aug 1, 2008
    A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin(R) for treatment of osteoarthritis of the knee. Arthritis Research & Therapy, In Press. (Science Daily)

    Evotec Announces Initiation of Phase I Clinical Trial of VR1 Antagonist Under Partnership With Pfizer Inc.  Aug 1, 2008
    The Phase I study is a randomized, double-blind and placebo-controlled single ascending dose study in healthy volunteers to evaluate the compound's safety, tolerability and pharmacokinetic profile after oral administration. ADVERTISEMENT. (Primezone Releases)

    Flu Vaccine Doesn't Protect Seniors From Pneumonia  Aug 1, 2008
    "There have been good randomized trials that show, at least in healthy seniors, that the vaccine reduces the risk of influenza," he said. "However, earlier studies have overestimated how well the vaccine works in reducing complications of influenza. So, the vaccine may not reduce the risk of complications as much as previously thought," he said. (Health-Finder)

    Give children more calcium  Aug 1, 2008
    To determine how the intake of dietary calcium affects bone mineral content (BMC) - a marker for bone strength - in children, researchers used an evidence-based approach to assess data from 21 randomized clinical trials with more than 3,800 children. Statistically pooled data revealed that those kids who had inadequate calcium consumption prior to the start of these studies experienced a substantial increase in their total body BMC that was approximately 25 times greater than children who... (MSN India)

    Flu Vaccine May Not Protect Seniors Well  Aug 1, 2008
    But she said that researchers should work to understand better how well the current flu vaccines work in seniorsand to explore other options for controlling flu in the "old old." Examples include bigger doses or stronger types of vaccines, and conducting randomized controlled trials comparing them. . (Newsmax)

    An online hoax becomes a source about Karadzic  Jul 31, 2008
    The hoaxer identified himself as Tristan Dare, and described himself as a "media artist who specializes in masterminding viral 'guerrilla style' interactive online performances," who is a "citizen of the world, and currently resides in the global village." He agreed to be interviewed, but only via e-mail, after being reached at the randomized e-mail address assigned to the person who registered the site. His identity could not be confirmed. (International Herald Tribune)

    Ivivi Technologies' PEMF Signals Reduce Post Surgical Pain in Breast Augmentation Patients by 87 Percent, Study Reports  Jul 31, 2008
    In a randomized double-blind, placebo-controlled pilot study of 40 healthy women undergoing breast augmentation surgery with silicon breast implants, 12 received bilateral PEMF therapy (a coil delivered PEMF signal for each breast); 14 received sham therapy (neither coil delivered signal); and 14 received contralateral therapy (each patient had one active and one sham treatment in each breast). For each patient, two battery powered coils (either delivering PEMF signals or no signal) were placed... (Primezone Releases)

    Study: Indian herb reduces osteoarthritis symptoms  Jul 31, 2008
    This randomized, double-blinded, placebo-controlled trial of 70 patients will be of great interest to sufferers, especially those who don't get adequate relief from existing treatments. B. serrata has been used for thousands of years in the Indian system of traditional medicine known as 'Ayurveda. (Xinhuanet, China)

    Gastric Cancer in Japan — Honing Treatment, Seeking Causes  Jul 31, 2008
    In this issue of the Journal, Sasako and colleagues (pages 453 462) present results from a randomized trial of surgery for gastric cancer conducted in 24 specialized hospitals in Japan. The 523 enrolled patients all had a diagnosis of curable gastric cancer and were randomly assigned to receive either Japan's standard surgical treatment gastrectomy plus extensive removal of regional lymph nodes or the same procedure plus para-aortic nodal dissection. (New England Journal of Medicine)

    D2 Lymphadenectomy plus PAND for Gastric Cancer  Jul 31, 2008
    We conducted a randomized, controlled trial at 24 hospitals in Japan to compare D2 lymphadenectomy alone with D2 lymphadenectomy plus PAND in patients undergoing gastrectomy for curable gastric cancer. Methods Between July 1995 and April 2001, 523 patients with curable stage T2b, T3, or T4 gastric cancer were randomly assigned during surgery to D2 lymphadenectomy alone (263 patients) or to D2 lymphadenectomy plus PAND (260 patients). (New England Journal of Medicine)

    New study shows calcium significantly improves children's bone health  Jul 31, 2008
    Researchers used an evidence-based approach to assess data from 21 randomized clinical trials with more than 3,800 children to determine how the intake of dietary calcium affects bone mineral content (BMC), a marker for bone strength, in children ... "The evaluation of randomized controlled trials was critical to understand the effects of calcium and dairy on children's bone health," noted Joshua Muscat, Ph. (EurekAlert!)

    Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation  Jul 30, 2008
    In the randomized, double-blind, placebo-controlled trial, 1,649 individuals with mild Alzheimer's (mean MMSE in both groups = 23. 3) were randomized 1:1 to receive tarenflurbil 800 mg twice-a-day or placebo for 18 months ... 9) were randomized to receive placebo (n=29), PBT2 50mg (n=20) or PBT2 250mg (n=29) capsules orally, once per day for 12 weeks. (PR Newswire)

    Allon Therapeutics AL-108 Human Efficacy Data Presented to Two ICAD 2008 Scientific Workshops  Jul 30, 2008
    The Phase IIa trial was a double-blind, randomized, placebo-controlled, multiple-dose study to evaluate the safety, tolerability and effect on cognitive function of AL-108 after 12 weeks of intranasal administration in patients with aMCI. Clinically, patients with aMCI demonstrate memory impairment with otherwise normal cognition. Several aspects of cognitive function were evaluated. (CCNMatthews Press Releases)

    More Exercise Helps Heavy Women Keep Weight Off  Jul 30, 2008
    To better understand how much exercise overweight women really need to maintain a healthy weight, the researchers randomized 201 overweight and obese women to four different exercise intensity groups: burning 1,000 calories weekly in moderate exercise; burning 1,000 calories a week by exercising vigorously; burning 2,000 calories with moderate exercise; or burning 2,000 calories with vigorous exercise. Study participants cut their calorie intake to 1,200 or 1,500 daily depending on their weight... (MEDLINEplus)

    Cholesterol-Lowering Drugs Might Help Prevent Alzheimer's  Jul 30, 2008
    "We need a randomized trial, a primary prevention trial," she said. But the controlled trials that have been done, in the United States and elsewhere, have had mixed results, Wolozin said. (MEDLINEplus)

    Newsweek: Statins may reduce dementia risk  Jul 29, 2008
    While epidemiological studies like Haan's have been generally positive, randomized clinical trialsthe benchmark of clinical researchhave, for the most part, failed to show any cognitive benefits ... On the other hand, epidemiological studies are not randomized and those who wind up taking statins in such studies may be resistant to cognitive decline for reasons other than statin use. (MSNBC -- Health)

    Health Canada approves ORENCIA(R) (abatacept) for the treatment of moderate-to-severe juvenile idiopathic arthritis (JIA) in patients six years and older  Jul 29, 2008
    Patients entering Period B (n=122) were randomized to remain on ORENCIA (n=60) or receive placebo (n=62) for six months. The primary endpoint of the study was time to occurrence of disease flare. (Canada Newswire)

    A Hormone That Enhances One’s Memory Of Happy Faces  Jul 29, 2008
    They recruited healthy male volunteers and in a double-blind, randomized design, administered either oxytocin or a placebo. They then presented a series of happy, angry and neutral human faces to the volunteers on a computer screen. (Science Daily)

    Antimicrobial Sutures Reduce Infections In Brain Shunt Surgery, Study Finds  Jul 29, 2008
    "Unfortunately, none of these studies were prospective, randomized and double-blinded. "In animal trials sutures coated with the antimicrobial triclosan have been shown to reduce the number of bacteria adhering to sutures, but only one study has been published to date on their effect in preventing surgical site infection, so we decided to conduct our own trial," he said. "Our results showed that using antimicrobial sutures reduced infection risk by 16 percent. " Antibiotic-impregnated shunts,... (Science Daily)

    Gummy Bears That Fight Plaque  Jul 29, 2008
    Xylitol gummy bear snacks: a school-based randomized clinical trial. BMC Oral Health, (in press). (Science Daily)

    Statins May Protect Against Memory Loss  Jul 29, 2008
    Haan hopes the study will help fuel randomized trials to test statins and their ability to prevent dementia. Of 1,674 participants who were free of dementia at the start of the study, 27 percent, or 452 people, took statins at some point in the study. (Newsmax)

    The Myth of Moderation  Jul 29, 2008
    Participants were also asked to restrict their food intake to between 1,200 and 1,500 calories per day, and were randomized to one of four physical activity intervention groups based on energy expenditure (either 1,000 calories or 2,000 calories burned per week) and exercise intensity (high versus moderate). By the end of the 24-month intervention, the women who managed to lose at least 10% of their starting body weight (which was, on average, about 193 lbs. (Time.com)

    The NTI-tss device for the therapy of bruxism, temporomandibular disorders, and headache: where do we stand? A qualitative systematic review of the literature  Jul 29, 2008
    Reporting quality of articles about randomized controlled trials (RCTs) was evaluated using the Jadad score. To identify adverse events, we searched in the identified publications and in the MAUDE database. (BioMed Central)

    Valens Pharma reports top-line results from voluntary Phase II trial  Jul 28, 2008
    The Phase II trial encompassing 83 patients, was a randomized, double blind, placebo controlled trial, conducted at the University of Alberta, in Edmonton. Patients in the study group received a bolus infusion of DCA i.v. immediately post surgery followed by a continuous infusion of DCA i.v. for a 24 hour period. (Canada Newswire)

    Little Evidence That Treating Varicoceles In Men Boosts Pregnancy Rates  Jul 28, 2008
    However, high-quality, randomized trials were not able to confirm these positive conclusions. The review included eight studies involving 607 men. (Science Daily)

    Q&A: Trans fat  Jul 28, 2008
    Many randomized and controlled dietary trials have already found that consumption of trans-fat can more than raise bad cholesterol. It can promote inflammation that is implicated in many chronic diseases such as heart disease, heart attacks, diabetes and other chronic diseases such as infertility. (Food Consumer)

    'Statins' Linked To Improved Survival In Kidney Transplant Recipients  Jul 26, 2008
    However, he emphasizes that the observational study does not permit any cause-and-effect conclusions: "The proof that statin use prolongs life can only be accomplished in a randomized controlled trial.". Journal reference. (Science Daily)

    WEX Announces Presentation at Scientific Conference  Jul 26, 2008
    This clinical trial (TEC-006) is a multicentre, randomized, double-blind and placebo-controlled trial comparing the efficacy and safety of TTX to placebo in approximately 120 patients with moderate to severe inadequately controlled cancer-related pain. Market Opportunity. (CCNMatthews Press Releases)

    Gummy bears good for children's teeth  Jul 26, 2008
    Xylitol gummy bears snacks: a school-based randomized clinical trial ... Children, first to fifth grade (n=154), from two elementary schools in rural Washington State, USA, were randomized to xylitol 15. (BioMed Central)

    Viagra Works For Antidepressant-related Sexual Dysfunction In Women, Study Suggests  Jul 24, 2008
    It is believed no randomized controlled trial has demonstrated an effective treatment for women experiencing sexual dysfunction associated with SRIs ... The randomized controlled clinical trial was conducted between Sept. 2003 and Jan. 2007 at seven U.S. research centers ... Sildenafil Treatment of Women With Antidepressant-Associated Sexual Dysfunction: A Randomized Controlled Trial. (Science Daily)

    Targeted Drug Boosts Survival Among Liver Cancer Patients  Jul 24, 2008
    The current study was a randomized, placebo-controlled study that included 602 people with advanced liver cancer. Despite that, however, the study volunteers still retained liver function. (Health-Finder)

    Sorafenib in Advanced Hepatocellular Carcinoma  Jul 24, 2008
    The affiliations of the authors and the names of the investigators in the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) Investigators Study Group are listed in the Appendix. Address reprint requests to Dr. Llovet or Dr. Bruix at the Barcelona Cl;nic Liver Cancer Group, Liver Unit, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain, or at jmllovet{at}clinic. (New England Journal of Medicine)

    Bradmer initiates enrollment in Phase III GLASS-ART Trial in primary glioblastoma multiforme  Jul 23, 2008
    The randomized trial will enroll up to 760 patients at leading treatment centers across the United States. Additional information on the trial can be found at or at and then by searching the term "Bradmer" or the study identifier NCT00615186. (Canada Newswire)

    Viagra May Help Women  Jul 23, 2008
    The JAMA article said it is "believed no randomized controlled trial has demonstrated an effective treatment for women experiencing sexual dysfunction" from antidepressant drugs. But researchers found that only 28% of women taking Viagra showed no improvement, as opposed to 73% of women taking a placebo. (Wall Street Journal)

    Can Indoor Tanning Prevent Cancer?  Jul 23, 2008
    "It is true that there is some evidence that higher vitamin D levels may reduce cancer risk, particularly of colorectal cancer, and possibly some other cancer types. The data a relatively strong, but not considered definitive by everyone."A meta-analysis of randomized trials of vitamin D vs. placebo found an overall 8 percent lower total mortality in those who got vitamin D. Thus, overall, there is strong evidence that more vitamin D may have some important health benefits, perhaps even beyond... (Click2Houston, TX)

    Vytorin misses primary end point in SEAS study  Jul 22, 2008
    Kenilworth and Whitehouse Station, NJ - Merck and Schering-Plough presented interim results of the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study today, a randomized, multicenter, placebo-controlled study evaluating the effects of combination ezetimibe/simvastatin (Vytorin) on clinical outcomes in roughly 1800 patients with aortic stenosis, and the results showed that the controversial cholesterol-lowering medication was no better than placebo in reducing the primary composite end... (TheHeart.Org)

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