Ventilation Positions Comparable in Lung Syndrome Patients Nov 13, 2009
"Moreover, prone positioning has been advocated as a rescue maneuver for severe hypoxemia, owing to its positive effects on oxygenation, which have been repeatedly documented since its first description in 1976. However, no randomized clinical trial has yet demonstrated a significant reduction in mortality rate associated with prone positioning," wrote Dr. Paolo Taccone and colleagues. Their study, published in the Nov. 11 issue of the Journal of the American Medical Association, included 342... (MEDLINEplus)
Mood Improves On Low-fat, But Not Low-carb, Diet Plan Nov 13, 2009
D., of Commonwealth Scientific and Industrial Research Organisation-Food and Nutritional Sciences, Adelaide, Australia, and colleagues conducted a randomized clinical trial involving 106 overweight and obese participants who were an average age of 50. Of these, 55 had been randomly assigned to follow a very-low-carbohydrate, high-fat diet and 51 to a high-carbohydrate, low-fat diet for one year. (Science Daily)
Respirator or face mask? Best shield still debated Nov 7, 2009
The only other randomized clinical trial comparing health-care workers' use of respirators and surgical masks was published online in October 2009 in the Journal of the American Medical Association. Canadian researchers reported no difference in influenza rates among nurses using one type of protective device versus the other. (CNN -- Health)
Nicotine Patch Plus Lozenge Most Effective Nov 4, 2009
D., of the University of Wisconsin Center for Tobacco Research and Intervention, Madison, and colleagues conducted a randomized clinical trial of smoking cessation therapies involving 1,504 adults. All had smoked at least 10 cigarettes a day during the previous six months and were motivated to quit. (Newsmax)
Therapeutic Value of Reishi Nov 1, 2009
(Noguchi M, et al. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms. Asian J Androl. (Suite101.com)
Combination Antiretroviral Therapy Effective At Reducing HIV Resistance In Mothers And Babies Following Mother-to-child Transmission Oct 29, 2009
McIntyre et al. Efficacy of Short-Course AZT Plus 3TC to Reduce Nevirapine Resistance in the Prevention of Mother-to-Child HIV Transmission: A Randomized Clinical Trial. PLoS Medicine, 2009; 6 (10): e1000172 DOI. (Science Daily)
People with type 2 diabetes improved muscular strength Sep 23, 2009
Alexandria, VA Physical therapist-directed exercise counseling combined with fitness center-based exercise training can improve muscular strength and exercise capacity in people with type 2 diabetes, with outcomes similar to those of supervised exercise, according to a randomized clinical trial published in the September issue of Physical Therapy, the scientific journal of the American Physical Therapy Association (APTA). Type 2 diabetes is associated with numerous health complications,... (EurekAlert!)
Steroid Injections May Help Restore Vision In Some Patients With Blocked Eye Veins Sep 16, 2009
In one paper, the SCORE (Standard Care vs. Corticosteroid for Retinal Vein Occlusion) Study Research Group reports the results of a randomized clinical trial involving 271 participants with macular edema from central retinal vein occlusion. Of these, 92 were assigned to receive 1 milligram of intravitreal (injected into the eye) triamcinolone, 91 received a 4-milligram dose and 88 were assigned to an observation group that did not receive treatment. (Science Daily)
Immediate Intervention For Patients With Acute Coronary Syndromes Not Always More Beneficial Sep 15, 2009
Immediate vs Delayed Intervention for Acute Coronary Syndromes: A Randomized Clinical Trial. JAMA, 2009; 302 (9): 947-954. (Science Daily)
Reflux Drugs OK with Blood Thinners Sep 3, 2009
"In the end, only a randomized clinical trial can definitively demonstrate the safety of combining these two classes of drugs," she said. SOURCES: Michelle O'Donoghue, M.D., investigator, TIMI Study Group, Brigham and Women's Hospital, Boston; Dirk Sibbing, M.D., Technische Universitat Munchen, Munich, Germany; Sept. 1, 2009, The Lancet, online. (MEDLINEplus)
Treatment May Limit Graft-Versus-Host Disease Aug 21, 2009
"This is the first randomized clinical trial to show that ATG-F can reduce severe acute and clinically relevant chronic GVHD without compromising disease-free survival or overall survival," Dr. Jurgen Finke, of Universitatsklinikum Freiburg in Germany, and fellow researchers said in a news release from The Lancet Oncology, which is publishing the study online Aug. 19 and in its September print issue. "The use of ATG-F is safe for patients who are going to receive transplantation from matched... (MEDLINEplus)
Novel Treatment Reduces Swollen Livers Aug 18, 2009
Drenth, from Radboud University Nijmegen Medical Centre, commented: "In Nijmegen, we had experience with the administration of synthetic gastrointestinal hormones in two polycystic liver patients. This treatment resulted in significantly smaller liver cysts. This stimulated us to proceed to a randomized clinical trial in 54 polycystic liver patients from Nijmegen (The Netherlands) and Leuven (Belgium). Computer tomography indicated that the size of the average liver was 4.6 liters, at least... (Science Daily)
Men with Angina Do Worse Than Women Aug 8, 2009
"You need a randomized clinical trial to get definitive results.". But the difference in outcome between men and women appears real, although the reasons for it remain unknown, Fonarow said. (MEDLINEplus)
NHLBI stops study of pulmonary hypertension treatment in sickle cell patients Jul 29, 2009
Known as walk-PHaSST, the study was the first multicenter, randomized clinical trial to test the safety and effectiveness of sildenafil for pulmonary hypertension in patients with sickle cell disease, one of the most common genetic blood disorders in the United States ... "Walk-PHaSST emphasizes the importance of multi-site, blinded, randomized clinical trials to increase our understanding of both the benefits and the potential risks of specific treatments," noted Jonathan C. Goldsmith, M.D.,... (EurekAlert!)
Improving Impaired Attention May Help Patients Recover From Stroke Jul 26, 2009
In the first full-scale single-blinded, randomized clinical trial using Attention Process Training (APT), 78 stroke survivors were randomized to receive APT or standard rehabilitation care. APT is designed to improve the ability to maintain attention, as well as to shift attention (such as when having a conversation with more than one person) and to attend to more than one thing at a time. (Science Daily)
The Vibrators of the Future Jul 22, 2009
The company also describes a randomized clinical trial for menstrual pain in which patients who used the active patch for five days reported a significantly greater reduction in pain than patients given a sham alternative. If this data were to be peer-reviewed and published, it might give the product a credibility boost. (Slate)
Sugar Substitute Appears To Prevent Early-childhood Cavities Jul 8, 2009
Xylitol Pediatric Topical Oral Syrup to Prevent Dental Caries A Double-blind Randomized Clinical Trial of Efficacy. Arch Pediatr Adolesc Med. (Science Daily)
Intensive In-hospital Support Doubles Likelihood Of Smoking Cessation In Heart Patients Jun 30, 2009
The study, a randomized clinical trial, compared intensive intervention with minimal intervention and found that patients admitted for open heart surgery (coronary artery bypass grafts) had significantly higher long-term abstinence rates at 1 year compared with those admitted for heart attacks (acute myocardial infarctions. . (Science Daily)
Study suggests obese women should not gain weight May 30, 2009
Dr. Thornton's paper, "Perinatal Outcomes in Nutritionally Monitored Obese Pregnant Women: A Randomized Clinical Trial," was published in the June issue of the Journal of the National Medical Association. Her co-authors include Claudia Smarkola, PhD, Sharon M. Kopacz, MD, and Sabriya B. Ishoof, MD.. (EurekAlert!)
AGA Institute presents cutting-edge research during DDW May 29, 2009
OPT-80 versus vancomycin in Clostridium difficile infection: Results of a randomized clinical trial. M. Miller et al. (2:15 p.m.). (EurekAlert!)
Turmeric Extract Suppresses Fat Tissue Growth In Rodent Models May 24, 2009
ScienceDaily (May 23, 2009) Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed high fat diets supplemented with curcumin and cell cultures incubated with curcumin. (Science Daily)
Drug That Targets Vasculature Growth Attacks Aggressive Thyroid Cancer May 17, 2009
Dr. Bible says plans are also under way to test pazopanib in a larger, controlled and randomized clinical trial of patients with advanced differentiated thyroid cancer. Researchers want to more accurately assess benefits and risks. (Science Daily)
Real And Simulated Acupuncture Appear More Effective Than Usual Care For Back Pain May 16, 2009
D., of Group Health Center for Health Studies, Seattle, and colleagues compared four different types of treatment in a randomized clinical trial involving 638 adults (average age 47) with chronic low back pain at Group Health in Seattle and Kaiser Permanente Northern California in Oakland. During the seven-week treatment period, 157 participants received 10 acupuncture treatments in a manner individually prescribed by a diagnostic acupuncturist; 158 underwent a standardized course of acupuncture... (Science Daily)
Help on chemo from the spice rack May 15, 2009
Simply adding a teaspoon of ginger to food consumed in the days before, during, and after chemotherapy can reduce the often debilitating side effects of nausea and vomiting, a large, randomized clinical trial has found. And a newer type of antinausea drug, when added to standard medications, can help prevent such side effects as well. (Boston Globe)
Fast, Simple Treatment Option For Patients Too Sick For Open-heart Surgery? May 9, 2009
If approved, this would enable a pivotal randomized clinical trial to be launched later this year. The Carillon Mitral Contour System was recently granted CE Mark approval, which allows the device to be sold in Europe. (Science Daily)
Vitamin E, Selenium and Soy Won't Prevent Prostate Cancer May 5, 2009
"Men should include these things as part of a healthy lifestyle and integrated approach to preventive medicine. However non-pharmacologic dietary preventions, whole foods, extracts and herbs' influence on the development of cancer is complex and may not be appropriately tested using a randomized clinical trial.". HealthDay. (MEDLINEplus)
Hormone Therapy Offers Potential Protective Effect Against Colon Cancer In Older Women Apr 28, 2009
The largest randomized clinical trial was the 16,000-participant Women's Health Initiative, which concluded in 2004 that combination hormone therapy (estrogen and progestin) reduced a woman's risk of colorectal cancer by about 40 percent, he says. "But few studies have delved deeper to see how these hormones work at the molecular level," Dr. Limsui says. (Science Daily)
Cognitive Behavior Therapy Helps Older Adults With Anxiety Reduce Worry, Improve Mental Health Apr 10, 2009
D., of the Baylor College of Medicine, Houston, and colleagues conducted the first randomized clinical trial of CBT for late-life GAD in primary care to examine whether CBT would improve outcomes relative to enhanced usual care (EUC) ... Stanley et al. Cognitive Behavior Therapy for Generalized Anxiety Disorder Among Older Adults in Primary Care: A Randomized Clinical Trial. (Science Daily)
Ovarian Cancers Detected Early May Be Less Aggressive, Questioning Effectiveness Of Screening Mar 28, 2009
27, 2005) Almost half of lung cancers detected by a chest x-ray were early-stage cancers, according to baseline results of a large, randomized clinical trial that is testing the efficacy of a chest x-ray as a. (June 25, 2003) Scientists at the Pacific Northwest Research Institute (PNRI) in Seattle announced a new biomarker for ovarian cancer today. (Science Daily)
Circumcision Is Found To Curb Two S.T.D.s Mar 27, 2009
The study, a randomized clinical trial published Thursday in The New England Journal of Medicine, assigned more than 3,000 uncircumcised Ugandan men who were not infected with H.S.V.-2 to undergo immediate circumcision or to be circumcised 24 months from the start of the investigation. A subgroup was similarly evaluated for H.P.V. infection. (Ghana Web, Ghana)
Green, Black Tea Can Reduce Stroke Risk, Research Suggests Mar 5, 2009
4, 2009) Drinking at least three cups of green or black tea a day can significantly reduce the risk of stroke, a new UCLA study has found. And the more you drink, the better your odds of staving off a stroke. (Science Daily)
Medicines do best with regular use Feb 24, 2009
To answer this question, a randomized clinical trial called CAMP (Childhood Asthma Management Program) was started in the mid-1990s. Children were placed into three groups: one took an inhaled steroid regularly, the second took a nonsteroid medication regularly, and a third took medications only on an as-needed basis. (Boston Globe)
Tea Reduces Stroke Risk Feb 24, 2009
On a Handheld Device. SIGN UP FOR FREE NEWS ALERTS. (Newsmax)
High-flux hemodialysis prolongs survival in many patients with CKD Feb 21, 2009
In a randomized clinical trial called the Membrane Permeability Outcome (MPO) study, they enrolled 738 hemodialysis patients and assigned them to either low-flux or high-flux hemodialysis. Patients were followed for 3 to 7. (EurekAlert!)
Could Genetics Improve Warfarin Dosing? New Research Says Yes -- Now For The Clinical Trial Feb 20, 2009
In an important step toward putting these findings into clinical practice, NIH is launching the largest prospective, multi-center, randomized clinical trial in the United States to test whether a gene-based strategy for prescribing the initial warfarin dose will improve patient outcomes ... Although genetic tests are now available for doctors to use to help determine the initial dose of warfarin, a large, randomized clinical trial the gold standard for testing medical therapies is needed to... (Science Daily)
GlideScope(R) Ranger Video Laryngoscope by Verathon(R) Awarded Airworthiness Certification by U.S. Army Feb 19, 2009
The GlideScope Video Laryngoscope: randomized clinical trial in 200 patients. British Journal of Anesthesia 2005; 94: 381-384. (PR Newswire)
Stroma Genomic Signature Predicts Resistance To Anthracyclin-based Chemotherapy In Breast Cancer Feb 12, 2009
To help find an answer to this question, a collaborative study was set-up within the framework of a large randomized clinical trial that involved more than 40 different hospitals throughout Europe, including those in the UK, France, Belgium, Netherlands, Poland, Sweden and Switzerland. It was led by Professor Herv; Bonnefoi of the European Organization for Research and Treatment of Cancer (EORTC) in collaboration with the Swedish Breast Cancer Group (SBCG), the Swiss Cancer Group (SAKK) and the... (Science Daily)
FDA Approves First Atrial Fibrillation Ablation Catheters Feb 10, 2009
"In this randomized clinical trial, catheter ablation was shown to significantly outperform anti-arrhythmic drug (AAD) therapy for the treatment of drug refractory recurrent symptomatic paroxysmal AFib. These data were first presented in November 2008 at the American Heart Association's Annual Scientific Sessions.". The EZ Steer ThermoCool Nav is a bi-directional verson of the NaviStar ThermoCool. (Medical News Today)
Breast Cancer after Estrogen plus Progestin Feb 8, 2009
Methods We analyzed the results of the WHI randomized clinical trial in which one study group received 0. 625 mg of conjugated equine estrogens plus 2. (New England Journal of Medicine)
Brain & Nervous System Feb 7, 2009
Often touted as a way to preserve aging memories, no large-scale, randomized clinical trial -- until now -- has thoroughly evaluated the safety and effectiveness of ginkgo biloba extract as a way to prevent dementia. Retired Army Spc. (CNN -- Health)
Boomer's Health Feb 7, 2009
Often touted as a way to preserve aging memories, no large-scale, randomized clinical trial -- until now -- has thoroughly evaluated the safety and effectiveness of ginkgo biloba extract as a way to prevent dementia. Peppermint oil, soluble fiber, and antispasmodic drugs can indeed help people with irritable bowel syndrome, according to an analysis of 25 years of research on the condition, which is characterized by bouts of diarrhea and constipation. (CNN -- Health)
