BIOTECH: Master switch for hunger, reproduction, identified Sep 1, 2008
The switch for these primordial animal instincts likely also is present in humans, said Mark Montminy, a professor at the Salk Institute, in a telephone interview last week. Further research could lead to new obesity and infertility treatments, said Montminy, who took part in a study identifying the molecular switch. (North County Times)
New master switch found in the brain that regulates appetite and reproduction Sep 1, 2008
Now, a master switch has been found in the brain of mice that controls both, and researchers at the Salk Institute for Biological Studies say it may work the same way in humans ... D., both in the Laboratory of Neuronal Structure and Function at the Salk Institute ... The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of future... (EurekAlert!)
Nature conferences Aug 29, 2008
Salk Institute for Biological Studies, La Jolla, California ... Yves Christen (Fondation IPSEN, France), Fred Gage (Salk Institute, USA), Sue Deeley (Nature Publishing Group, USA), Inder Verma (Salk Institute, USA) ... The Salk Institute for Biological Studies, La Jolla, California. (Nature News Service)
Keeping Cells Youthful: How Telomere-building Proteins Get Drawn Into The Fold Aug 27, 2008
Researchers at the Salk Institute for Biological Studies led by Vicki Lundblad, Ph ... (Credit: Courtesy of Edward Mandell, Salk Institute for Biological Studies). (Science Daily)
Cultivating the next Big Idea company Aug 24, 2008
The team submitted some patent applications late last year, and also brought in a Northwestern University researcher, Richard Morimoto, to join Kelley and Andrew Dillin of the Salk Institute as the company's founding scientific trio. Their big round of funding was finalized on Aug. 15. (Boston Globe)
REGION: Young scientists spend a summer in the lab Aug 17, 2008
The boot camp was cosponsored by the Salk Institute, Burnham Institute and life science trade association Biocom. With an average GPA of 4. (North County Times)
Exercise matters Aug 16, 2008
The Salk Institute did not test the prevention of increased risk of chronic disease produced by lifelong physical inactivity and did not test 26 commonly known benefits of exercise. The test studied only one gene; research shows that many genes affect the results of exercise. (Fresno Bee -- Opinion)
John Tierney: Would legal doping level playing field? Aug 13, 2008
Some athletes are already considering new drugs like Aicar and GW1516, which made news recently when researchers at the Salk Institute used them to quickly turn couch-potato mice into treadmill champions with new, strong muscles. "There's a possibility that athletes in this Olympics will be using these drugs," said Ronald Evans, the leader of the team at Salk, who has been fending off inquiries from athletes about these drugs. (International Herald Tribune -- Health)
The downside of a miracle pill Aug 12, 2008
The pill, recently developed by the Salk Institute for Biological Studies, may become the couch potato's dream by providing the benefits of exercise in a once-a-day pill. Ron Evans, one of the study's authors, told MSNBC.com, "We have exercise in a pill. With no exercise, you can take a drug and chemically mimic it.". (The Daily Texan, TX)
Why Gene Therapy Caused Leukemia In Some 'Boy In The Bubble Syndrome' Patients Aug 11, 2008
(May 1, 2006) New animal studies conducted at the Salk Institute for Biological Studies show that the only human gene therapy treatment to date considered to be largely successful, is, in fact, riskier than. (May 1, 2000) French researchers have developed a method of gene therapy to treat human severe combined immunodeficiency (SCID) X1, a life-threatening disease inherited on the X chromosome. (Science Daily)
Multi-tasking Molecule Holds Key To Allergic Reactions Aug 9, 2008
Now, scientists at the Salk Institute for Biological Studies have uncovered the molecular mechanisms behind such allergies, insight they hope will lead to new therapies, both to stop the summer sneezing and treat more severe allergic responses. "These results may allow us to develop acute inhibitors of allergic reactions that do not have the side-effects of current treatments such as drowsiness," says Inder Verma, Ph. (Science Daily)
Distinguishing between 2 birds of a feather Aug 9, 2008
Now, collaboration between researchers at the Salk Institute for Biological Studies and Weill Cornell Medical College has revealed that brain cells processing visual information adjust their filtering properties to make the most sense of incoming information ... The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of future generations... (EurekAlert!)
Olympics 'farce' Aug 8, 2008
com: Letters To The Editor: Olympics 'farce. Call: (800) 877-3400. (Fresno Bee -- Opinion)
'Exercise Pill' Is No Replacement For Real Exercise, Expert Cautions Aug 7, 2008
6, 2008) Recently, researchers at the Salk Institute for Biological Studies, a research organization focused on biology and its relation to health, published a study in the journal Cell on the results of a substance that increased exercise endurance without daily exertion when tested in mice. Media reports have described this substance as an exercise pill, potentially eliminating the need for exercise. (Science Daily)
Going Going Games Aug 6, 2008
A team of scientists at the Salk Institute in San Diego, USA, had come up with a couple of drugs that transformed ordinary laboratory mice into long-distance runners while simultaneously conferring on them many of exercise's other benefits. When orally administered to untrained mice for a period of only four weeks in an experiment aptly called "couch potato", the animals were able to run an amazing 44 per cent longer than an equal number of untreated, control mice. (India Times, India)
World's Smallest Snake Found In Barbados Aug 5, 2008
(2:19)It may sound far-fetched, but scientists at the Salk Institute for Biological Studies say they've devised a drug that provides all the benefits of exercise. Maggie Rodriguez reports. (CBS News)
Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods Aug 5, 2008
This month's issue of Cold Spring Harbor Protocols () features a pair of protocols from Inder Verma () and colleagues at the Salk Institute describing this method for achieving long-term down-regulation of specific target genes in a wide range of cell types. "Design and Cloning of an shRNA into a Lentiviral Vector" is freely accessible on the website for Cold Spring Harbor Protocols (). (EurekAlert!)
Games cheats pin hopes on tattoo drugs Aug 4, 2008
Professor Ronald Evans, of the Salk Institute in California, said: "We were blown away. This is a drug that is like pharmacological exercise. After four weeks of receiving the drug, the mice were behaving as if they'd been exercised.". Other substances not yet on the banned list but popular among athletes are breast milk and cobalt. (Sydney Morning Herald -- World)
In brief ... Aug 3, 2008
But now researchers at the Salk Institute in La Jolla have discovered a drug that appears to provide in real life many of the benefits of exercise but without the need to exercise. The scientists found that the drug Alcar all by itself significantly boosted the muscle endurance of mice, without the mice ever working out. (San Diego Union-Tribune -- Opinion)
Mighty Mouse in a test tube Aug 3, 2008
Researchers at the Salk Institute in San Diego have found two drugs that greatly increased the athletic endurance of laboratory mice, converting lazy mice and their more athletic brethren into marathon runners. One drug, fed to relatively sedentary mice, increased their endurance on a treadmill by 44 percent after just four weeks of treatment. (International Herald Tribune -- Ed/Op)
Exercise pill Aug 3, 2008
Dr Vihang Narkar and colleagues from the Salk Institute and other research institutes in the US and South Korea carried out the research. The study was funded by the Howard Hughes Medical Institute, Hilblom Foundation, and National Institutes of Health. (NHS Choices)
First performance-enhancing drugs for exercise endurance? Aug 3, 2008
"When we gave the mice a small amount of daily exercise in the presence or not of the drug, all showed an increased ability to run. But those on the drug gained an additional hour," said Ronald Evans of the Salk Institute. Moreover, they found, treatment with another compound endowed mice with greater endurance, even without the exercise. (Hindu)
Drug builds mighty mouse Aug 2, 2008
But lead researcher Ronald Evans, a molecular physiologist at the Salk Institute for Biological Studies in the San Diego community of La Jolla, said he has already been contacted by dozens of athletes and overweight people who have heard about his research from several lectures he has given. Evans said he has notified world anti-doping officials, who are now scrambling to implement a test for it before the Beijing Olympics start next week. (Albany Times Union)
Exercise in a pill? Researchers find two Aug 2, 2008
The drugs reproduce many of the biological benefits of exercise, helping cells burn fat better and boosting endurance, said Ronald Evans, a Howard Hughes Medical Institute researcher at the Salk Institute for Biological Studies in California ... In this photo provided by the Salk Institute, Ron Evans is seen holding a vial ... Salk Institute for Biological Studies. (Yahoo News -- Top Stories)
Pop in a Pill Instead of a Work Out? Aug 2, 2008
Salk Institute researchers seem to have made a breakthrough of sorts of narrowing down on two drugs which could actually lull the muscles into feeling the experience of a work out, without actually working out. During their experiments on couch potato mice using the drug named Aicar, researchers found that the endurance of the mice on the treadmill shot up by 44% after subjecting the mice with this drug for one month. (MedIndia)
Pill Could Boost Sports Performance Aug 2, 2008
In 2004, these researchers, from the Salk Institute and the Howard Hughes Medical Institute in La Jolla, Calif. altered the PPAR-delta gene to produce mice with altered muscle composition and increased endurance. (MEDLINEplus)
Biotech: Salk team finds possible 'exercise pill' Aug 2, 2008
Discovery at Salk Institute makes ordinary mice run like marathoners ... Couch potatoes, take heart: A team of scientists at the Salk Institute in La Jolla has made a discovery that might just make your dreams come true. (San Diego Union-Tribune)
Black AIDS Institute Says US Neglects Black People At Home Aug 1, 2008
Researchers at the Salk Institute for Biological Studies in California, led by prominent researcher Dr. Ronald M. Evans, have found two drugs which mimic the effects of exercising on mice, and. Marriage or having a partner halved the risk of developing dementia, a new Swedish research study showed. (eFluxMedia)
Exercise In A Pill? Aug 1, 2008
Back in 2004, the researchers -- who included professor Ronald M. Evans, PhD, of the Salk Institute for Biological Studies and the Howard Hughes Medical Institute in La Jolla, Calif. -- reported that they boosted endurance in mice by tweaking a mouse gene to boost the activity of a protein called PPAR-delta. (CBS News)
Drugs mimic exercise benefits in mice Aug 1, 2008
Now, Evans and his colleagues at the Salk Institute in California think they have found the key ... "Thanks to the much appreciated cooperation of Ron Evans and his team at the Salk Institute, WADA received key information in advance in order to develop and implement ways to detect these molecules," the statement said. (Boston Globe)
'Fitness pill' being developed Aug 1, 2008
With this in mind, lead researcher Professor Ronald Evans, from the Howard Hughes Medical Institute, and the Salk Institute in California, has produced a test which will allow the drugs to be detected in the urine and blood of competitors. He says the drugs could eventually help tackle muscle wasting diseases, or help improve the health benefits of exercise in people at risk of conditions such as diabetes. (BBC News)
'Exercise pill' burns fat -- if you're a mouse Aug 1, 2008
Ron Evans, of the Salk Institute for Biological Studies, displays a drug that helps mice burn fat ... Evans, of the Salk Institute for Biological Studies in La Jolla, California, and the Howard Hughes Medical Institute, reports the work with colleagues in a paper published online Thursday by the journal Cell. (CNN)
Drugs offer promise of fitness without effort Aug 1, 2008
Researchers at the Salk Institute report they have found two drugs that do wonders for the athletic endurance of couch potato mice. One drug, known as Aicar, increased the mice's endurance on a treadmill by 44 percent after just four weeks of treatment. (International Herald Tribune)
AICAR: Scientists say they've put exercise in a pill Aug 1, 2008
Salk Institute for Biological Studies Ronald Evans holds a vial of a drug that boosts the effects of exercise in mice. Evans works at the Salk Institute for Biological Studies in La Jolla, Calif ... Salk Institute for Biological Studies Ronald Evans holds a vial of a drug that boosts the effects of exercise in mice. (Los Angeles Times)
Rejoice, couch potatoes! It's exercise in a pill Aug 1, 2008
Lead researcher Ronald Evans, a molecular physiologist at the Salk Institute for Biological Studies in the San Diego community of La Jolla, said he has already been contacted by dozens of athletes and overweight people who have heard about his research from several lectures he has given on the subject. Evans said he has notified world anti-doping officials, who are now scrambling to implement a test for it before the Beijing Olympics start next week. (News & Observer)
Couch potatoes: A fitness pill for you? Aug 1, 2008
AP / Salk Institute Ron Evans holds a vial of GW1516 at his lab in the Salk Institute for Biological Studies in La Jolla. Scientists at the Salk Institute in La Jolla have chemically switched on a gene in mice and triggered a process that increased their endurance levels without requiring exercise, according to an article published Thursday in the online edition of the journal Cell. (San Diego Union-Tribune)
Naps Can Give Boost, If They Stay Short Jul 23, 2008
Dr. Sara Mednick, a researcher from the Salk Institute for Biological Studies, improved heart function, hormonal maintenance and cell repair as some of the benefits of power napping. Her research also indicates that power naps can lift your moods, lower stress and improve memory and learning. (Click2Houston, TX)
Stem cell chicken and egg debate moves to unlikely arena: the testes Jul 21, 2008
A team of scientists at the Salk Institute for Biological Studies led by Leanne Jones, Ph ... The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of future generations of researchers. (EurekAlert!)
Can You Hear Me Now? Primitive Single-Celled Microbe Expert In Cellular Communication Networks Jul 13, 2008
It commands a signaling network more elaborate and diverse than found in any multicellular organism higher up on the evolutionary tree, researchers at the Salk Institute for Biological Studies have discovered ... D. from the Salk Institute, Susan L. Young, Ph ... (Credit: Graphic: Courtesy of Dr. Gerard Manning, Salk Institute for Biological Studies. (Science Daily)
Grant review upsets some Jul 7, 2008
In one instance, reviewers questioned the expertise that Salk Institute scientists had in the field of hemophilia when, in fact, one of the scientists is a leader in that area ... Gage, from the Salk Institute, bypassed the institute's scientific staff and sent a letter directly to the board rebutting what he thought were factual errors in his review. (San Diego Union-Tribune)
In sleep, we are birds of a feather Jul 1, 2008
Philip Steven Low of the Salk Institute for Biological Studies in San Diego, California, and colleagues report in The Proceedings of the National Academy of Sciences that electroencephalograms of the songbirds show they have episodes of rapid-eye-movement sleep and slow-wave sleep as well as transition stages and quick spikes, all reminiscent of mammalian sleep patterns. It's the first time that this complete group of sleep characteristics has been found outside of mammals a surprising finding,... (International Herald Tribune -- Health)
Adult Stem Cells Reprogrammed In Brain Jul 1, 2008
Now, researchers at the Salk Institute for Biological Studies achieved the same feat with adult neural stem cells still in place in the brain. They successfully coaxed mouse brain stem cells bound to join the neuronal network to differentiate into support cells instead. (Science Daily)
Biotech: Repairing damage to brain may be nearer Jun 26, 2008
Researchers from the Salk Institute and University of California San Diego also contributed to the project, which was funded by the National Institutes of Health. The work Lipton's team has done more recently, which involves human embryonic stem cells, was funded by the California Institute for Regenerative Medicine through a four-year grant. (San Diego Union-Tribune)
It's all a matter of a shapely brain Jun 25, 2008
When Simon LeVay, formerly at the Salk Institute in La Jolla, California, published work in 1991 showing that a minuscule part of the brain is as small in gay men as it is in women, he was catapulted into a maelstrom of criticism and misinterpretation. Some accused him of "biological bigotry" while others said he was "pathologising" gay men, and even expressing an internalised homophobia. (Sydney Morning Herald -- World)
Striving To Break The Link Between Obesity And Diabetes Jun 23, 2008
As a postdoctoral fellow at the Salk Institute for Biological Studies in La Jolla, Calif. before he joined the Cornell faculty last summer, Qi found that some of the mice in his lab became obese on a Western-diet regimen while others did not. (Science Daily)
Mechanism Contributing To Appropriate Formation Of The Spine Discovered Jun 20, 2008
(May 13, 2005) In this week's journal Nature, scientists at the Salk Institute for Biological Studies report that they have solved one of the "holy grail" puzzles of developmental biology: the existence of a. (July 27, 2004) In studying the way groups of cells are patterned or arranged to form segments in the developing embryo, researchers have identified a developmental "rule" followed by centipedes and thereby. (Science Daily)
Read more... Jun 19, 2008
com, Ruben H. Fleet Science Center, The Scripps Research Institute, Salk Institute for Biological Sciences, San Diego Mensa, San Diego Museum of Art, San Diego Science Educators Association, San Diego Regional Economic Development Corporation, San Diego Science Alliance, San Diego State University, San Diego Supercomputer Center, San Diego Zoo, ScholarNexus, The Bishop's School, UC San Diego Division of Biological Sciences, UC San Diego Division of Physical Sciences, UC San Diego Jacobs School... (PNN Online)
Perfect Vision But Blind To Light Jun 18, 2008
However, researchers at the Salk Institute for Biological Studies have found that eliminating a third sensor -- cells expressing a photopigment called melanopsin that measures the intensity of incoming light --makes the circadian clock blind to light, yet leaves normal vision intact ... (Credit: Courtesy of Dr. Megumi Hatori, Salk Institute for Biological Studies). (Science Daily)
Biology reborn Jun 17, 2008
Meanwhile, scores of other biotechs have been spawned from the science out of UCSD, the Salk Institute, the Burnham Institute for Medical Research, the Scripps Research Institute and other small, local research facilities. In fact, San Diego has become a case study for cities around the globe that are investing millions of dollars to foster the creation of a biotechnology cluster and the industry's well paying jobs. (San Diego Union-Tribune -- Business)
Biotech breakthroughs Jun 15, 2008
Scientific discoveries out of respected research institutions, such as the University of California San Diego, the Salk Institute for Biological Studies and the Scripps Research Institute on Torrey Pines Mesa, , have been spun into hundreds of biotechnology companies. The first San Diego company, Hybritech, developed a simple but effective prostate-specific antigen test to detect prostate cancer in 1985. (San Diego Union-Tribune -- Business)
Mixing And Matching Genes To Keep Nerve Cells Straight Jun 12, 2008
Others who took part in this work include Seunghee Lee, Bora Lee, Kaumudi Joshi and Jae W. Lee, all of BCM and Samuel L. Pfaff of the Salk Institute in La Jolla, California. The research was funded by the National Institute of Neurological Disorders and Stroke, PEW, March of Dimes Foundations and the Mental Retardation/Developmental Disabilities Research Center. (Science Daily)
Top architects wowed by city's designs Jun 10, 2008
Jurors stopped by the Salk Institute, an iconic masterpiece from the 1960s by the late Louis Kahn. When they couldn't gain access to the Stonehenge-like courtyard, Griffin took off her shoes and peeked over the western edge to get a look something a pair of young visiting Spanish architects were doing at the same time. (San Diego Union-Tribune)
30-year mortgage rates hit 11-week high Jun 6, 2008
The consortium is made up of the University of California San Diego, Burnham Institute for Medical Research, Scripps Research Institute and Salk Institute. The consortium recently received a $43 million grant to help create the research center. (San Diego Union-Tribune -- Business)
Plant Biologists Discover Unexpected Proteins Affecting Small RNAs May 21, 2008
A study by Salk Institute for Biological Studies investigator Joseph Ecker, Ph ... Ecker, a professor in the Plant Biology Laboratory and director of the Salk Institute Genomic Analysis Laboratory, started by posing a simple genetic question. (Science Daily)
University Research and Science Parks Create Sustainable Innovation May 13, 2008
The conference is being hosted by the University of California San Diego Science Research Park and will be held at the Salk Institute for Biological Studies in La Jolla. Alexandria Real Estate Equities, Inc., is the lead sponsor for the conference. (PR Newswire)
Chromosome 'Lassoing': A New Key Mechanism In Cell Division May 12, 2008
24, 2005) Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes. This finding. (Science Daily)
Humans And Fruit Flies Have Same Insulin-regulated Molecular Pathway To Maintain Energy Balance When Starved May 9, 2008
Both rely on the same insulin-regulated molecular pathway to maintain their energy balance when starved for food, reports a team of researchers at the Salk Institute for Biological Studies. See also. (Science Daily)
$271 million in stem cell grants OKd May 8, 2008
The grantees in Southern California are UCLA, UC Irvine, the University of Southern California, UC Santa Barbara and the San Diego Consortium for Regenerative Medicine - a collaboration that includes UC San Diego, the Scripps Research Institute, the Burnham Institute for Medical Research and the Salk Institute. Also winning a grant is UC Merced, which will build the lab at the former Castle Air Force base, where it has other facilities. (San Francisco Chronicle -- Science)
Stem cell group gets its first building block May 8, 2008
The consortium, which includes University of California San Diego, the Burnham Institute for Medical Research, the Salk Institute for Biological Studies and The Scripps Research Institute, had asked for $50 million. The group was one of 12 that were awarded $271 million in construction funding yesterday by the stem cell institute's board. (San Diego Union-Tribune -- Business)
Stem cell grants awarded May 8, 2008
The San Diego consortium, which includes University of California San Diego, the Burnham Institute for Medical Research, the Scripps Research Institute and the Salk Institute, plan to build a four-story building, with a basement, full of research equipment, on a 7 -acre parcel at North Torrey Pines Road and Torrey Pines Scenic Drive. The land, owned by UCSD, is valued at about $15 million and is within walking distance of all four member campuses. (San Diego Union-Tribune)
Diabetes Link To Alzheimer's Disease Explained May 3, 2008
Now, researchers at the Salk Institute for Biological Studies identified the probable molecular basis for the diabetes -- Alzheimer's interaction ... The research has been supported by grants to the Salk Institute from the Bundy and the Shiley Foundations. (Science Daily)
Area March of Dimes Ambassador named May 2, 2008
March of Dimes establishes The Salk Institute for Biological Studies in La Jolla, Calif. 1961. (Demotte Kankakee Valley Post News, IN)
Salk Study Links Diabetes To Alzheimer's May 2, 2008
SAN DIEGO -- A new study from researchers at the Salk Institute and the University of California, San Diego, may have figured out why diabetics are up to 65 percent more likely than non-diabetics to get Alzheimer's. According to the study published in the journal Neurobiology of Aging, the brains of diabetic mice were unable to process insulin effectively, leading to swelling of the brain and faster death of brain and nerve cells. (NBCSandiego.com, CA)
Salk gets $20M gift May 2, 2008
K.C. ALFRED / Union-Tribune Martin Hetzer, an assistant professor of cell biology, looked at bone cancer cells yesterday at the Salk Institute ... That's what researchers at the Salk Institute in La Jolla hope to accomplish with the dynamic human cell a stadium filled with millions of busy molecules thanks to a five-year, $20 million donation from the Waitt Family Foundation and its president, Gateway computer company co-founder Ted Waitt ... Also, several researchers at the Salk Institute and... (San Diego Union-Tribune)
Charting The Epigenome: Zooming In On Genome-wide DNA At Single Base Resolution Apr 23, 2008
But new high-throughput DNA sequencing technology has enabled researchers at the Salk Institute for Biological Studies to map the precise position of these individual DNA modifications throughout the genome of the plant Arabidopsis thaliana, and chart its effect on the activity of any of Arabidopsis' roughly 26,000 genes ... D., a professor in the Plant Biology laboratory and director of the Salk Institute Genomic Analysis Laboratory ... (Credit: Courtesy of Dr. Ryan Lister, Salk Institute). (Science Daily)
