Coordinated prophylactic surgical management for women with hereditary breast-ovarian cancer syndrome Apr 15, 2008
Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed to assess the feasibility of coordinated PM and BSO in hereditary breast-ovarian cancer syndrome. (BioMed Central)
MRI's High False Positive Rate Has Little Impact On Women's Choice Of Preventive Mastectomy Mar 28, 2008
Once the women had discovered that they carried a BRCA mutation (which gives a lifetime risk of breast cancer of up to 85 per cent and for ovarian cancer of up to 60 per cent) they made six-monthly visits to hospital to be examined by an experienced medical specialist and to have a mammography and, whenever possible, MRI. During their first surveillance visit, the researchers recorded whether the women had a preference for ongoing surveillance, or prophylactic mastectomy and/or a prophylactic... (Science Daily)
Benefit Of Cancer Prevention Surgery Differs Between Women With BRCA1 And BRCA2 Mutations Feb 15, 2008
According to the research, the surgery -- called risk-reducing salpingo-oophorectomy (RRSO) -- may confer different benefits for women at inherited risk for breast and ovarian cancer depending upon whether BRCA1 or BRCA2 is abnormal. The efficacy of this procedure for the prevention of breast and gynecologic cancer had never been evaluated in groups of women stratified according to mutation type, despite 17 percent to 39 percent of all BRCA mutation carriers having a mutation in the BRCA2 gene. (Science Daily)
Cancer Gene Carriers Cut Risk with Ovarian Surgery May 29, 2007
Dr. Fatima Laki and colleagues at the Institut Curie in Paris analyzed the survival rates of 89 women with BRCA1 and/or BRCA2 mutations who has their ovaries removed, a procedure also referred to as salpingo-oophorectomy, between 1994 and 2004 at their institution. The women were an average of 51 years old when they underwent salpingo-oophorectomy ... One died of breast cancer 12 months after salpingo-oophorectomy. (MEDLINEplus)
Removal of ovaries decreases risk of certain cancers for women at high-risk Jul 12, 2006
Steven A. Narod, M.D., of the Toronto-Sunnybrook Regional Cancer Center, Toronto, Ontario, and colleagues conducted a study to determine the absolute risks for developing ovarian, fallopian tube, and peritoneal cancers in a group of BRCA1 and BRCA2 mutation carriers and estimated the risk reduction associated with salpingo-oophorectomy (surgical removal of the ovaries and fallopian tubes) ... "Women who carry a mutation in the BRCA1 gene are asked to consider prophylactic bilateral... (EurekAlert!)
Cancer-reducing Benefits Of Preventive Surgery May Be Specific To Gene Mutation Jun 6, 2006
Of this group, 561 opted to have their ovaries and fallopian tubes surgically removed -- a procedure called risk-reducing salpingo-oophorectomy -- while 325 chose to participate in ovarian surveillance. The women were followed for 40 months via questionnaire or medical review. (Science Daily)
Summary for Patients Mar 21, 2006
Interventions to prevent cancer include oral contraceptives to reduce ovarian cancer risk, the drug tamoxifen to reduce breast cancer risk, and surgical removal of the ovaries (bilateral salpingo-oophorectomy) or the breasts (bilateral mastectomy) ... They also collected information about the benefits, harms, and costs of 6 different strategies: oral contraceptives, tamoxifen, bilateral salpingo-oophorectomy, bilateral mastectomy, both surgeries, or surveillance. (Annals of Internal Medicine)
