Amanda's gift of courageAt journey's end, brave teen never let illness get best of her Aug 10, 2008
HER SPIRIT WILL LIVE ON Amanda Beckett Callagy, pictured with her brother Michael, suffered from Sandhoff Disease until she died on Aug. 3 due to complications ... During her three years battling the very rare Juvenile-Onset Sandhoff Disease, 16-year-old Amanda, a Weehawken native, continued to learn, make friends, and treasure the good in life until she passed away early Sunday morning, Aug. 3 ... Juvenile-Onset Sandhoff Disease is a disorder where waste products build in cells until they... (West New York Reporter, NJ)
Human stem cells stalled brain disease in mice Mar 14, 2007
Dr. Evan Snyder of the Burnham Institute for Medical Research in La Jolla, California, who led the study, says his team hopes to move quickly to test their method in children with a fatal and incurable brain disease called Sandhoff disease ... For their study, Snyder and colleagues used mice bred with the equivalent of Sandhoff disease ... They also boosted the brains supply of the enzyme hex, which is lacking in Sandhoff disease. (MSNBC -- Health)
Mouse tests show stem cells treat brain disease Mar 14, 2007
Dr Evan Snyder of the Burnham Institute for Medical Research California, who led the study, says his team hopes to move quickly to test their method in children with a fatal and incurable brain disease called Sandhoff disease. They also said their approach could lead to ways to treat a range of neurodegenerative diseases such as Parkinson's, Alzheimer's and amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease. (India Times, India -- Health/Science)
Study on mice is successful, Burnham says Mar 12, 2007
In a peer-reviewed article in the journal Nature Medicine, published online yesterday, the La Jolla-based scientists write that they implanted two types of stem cells human neural stem cells taken from a developing brain and human embryonic stem cells coaxed to become neural stem cells into mice with Sandhoff disease, a deadly degenerative childhood affliction ... The Burnham scientists hope their work with Sandhoff disease, for which there is no cure, lays the groundwork for clinical trials ...... (San Diego Union-Tribune -- Business)
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease Mar 12, 2007
"Dr. Snyder's team has extended the promise of stem cell therapies to children with special-needs, including those with Sandhoff disease." said Fia Richmond, founder of Children's Neurobiological Solutions Foundation and mother of a brain-injured child. "The CNS Foundation is proud to have contributed major funding for this research along with A-T Children's Project on behalf of the 14 million special-needs children in this country alone.". (EurekAlert!)
