Stem Cells from Fat Used to Grow Teen's Missing Facial Bones Oct 16, 2009
To create the new bones, which have become part of the patient's own skull structure and have remained securely in place for four and a half months, the medical team used a combination of , donated bone scaffolds, growth protein, and bone-coating tissue ... For the surgery, Taylor and his team shaped donor bone from cadaver-donated femurs to resemble zygomatic bones and act as a biological scaffold for the bone to grow on ... Mesenchymal stem cells, harvested from Guilkey's fat, and... (Scientific American)
Jaw bone created from stem cells Oct 11, 2009
These were seeded into a tissue scaffold, formed into the precise shape of the human jaw bone by using digital images from a patient. The cells were then cultured using a specially-designed bioreactor which was able to infuse the growing tissue with exactly the level of nutrients found during natural bone development. (BBC News -- Health)
Breakthrough: Bone Graft Grown in Exact Shape of Complex Skull-Jaw Joint Oct 6, 2009
The researchers first used real bone as a scaffold "we know actual bones are ideal because they work in real life," Vunjak-Novakovic says ... They next seeded each scaffold with three million commercially available human , which can give rise to bone, cartilage, fat and other tissues ... The cells, which lined the pores of the scaffold, were regularly fed with streams of nutrients, growth factors and oxygen in a bioreactor. (Scientific American)
Organ grinder Oct 2, 2009
Meanwhile, falling off a scaffold in Cleveland is a construction worker with organs ripe for harvesting ... Meanwhile, falling off a scaffold in Cleveland is a construction worker with organs ripe for harvesting. (New York Post -- Entertainment)
Protein Inhibitor Helps Rid Brain Of Toxic Tau Protein Oct 1, 2009
The normal function of tau is to support the structure of nerve cells, much like the skeleton provides a scaffold to support the body. Tau is inside nerve cells, while another hallmark protein associated with Alzheimer's, beta amyloid, is outside the neurons. (Science Daily)
Specialists weigh in on healthcare reform Sep 18, 2009
The panel of healthcare leaders included Kenneth Buettner, president of York Scaffolding; Alvin Eden, chief of pediatrics at Wyckoff Hospital; Terry Golash, medical director of Aetna; Caryn Schwab, exective director at Mount Sinai Hospital and Michael Rosenblut, president and CEO of Parker Jewish Institute ... As a past president of the Scaffold Industry Association, Buettner s example of a union carpenter showed how expensive health care can be. (Queens Chronicle, NY)
New Rep’s ‘Mister Roberts’ is a solid drama that needs more waves Sep 17, 2009
Cast members also confront an unexpected challenge from the set, a two-level metal scaffold that is visually imposing but that clanks distractingly whenever an actor walks across it. Still, the actors bring some individual strengths to their portrayals. (Boston Globe)
Island Images Sep 15, 2009
Curran, along with fellow Air Force military policeman Bryan Brafford, will be spending three days atop a 14-foot-high scaffold in the parking lot of the Pali Safeway. Brafford and Curran are members of the 15th Security Forces Squadron at Hickam Air Force Base. (Honolulu Star-Bulletin)
Nanoparticle gel heals injured brain and bone Sep 15, 2009
The body's temperature turns the liquid into a gelatin scaffold, spurring the creation of new blood vessels to feed the recovering organ. Over the next three to four weeks the nanoparticles broke apart, releasing their contents. (MSNBC -- Technology)
Petoskey cardiologist is first to place newest heart valve in Paraguay patient Sep 12, 2009
We re putting in a scaffold that will support the artery until it heals. The Cardiac & Vascular Research Center is typically among about 12 hospitals around the country chosen to participate in studies of such medical significance. (Gaylord Herald Times, MI)
Researchers Identify Critical Gene For Brain Development, Mental Retardation Sep 7, 2009
Scientists have thought that the only way for a cell to morph and move is through the action of the cytoskeleton or the scaffold inside the cell, pushing membrane forward or sucking it in, said senior study investigator Franck Polleux, Ph. D., associate professor of pharmacology at the UNC School of Medicine. (Science Daily)
Father: Domestic dispute led to La. murder-suicide Sep 7, 2009
He said Carter Jr. was a scaffold builder; Amber Carter was a secretary at North Oaks Rehabilitation Center in Hammond, where Donna Carter worked as a data entry clerk. Rushing said that state police ballistics experts were conducting tests on a gun found in the senior Carter's car. (Anchorage Daily News)
Biotech firm pioneers knee repair procedure Sep 4, 2009
After about two weeks, the cells cultured with the growth factor are seeded in a biological scaffold, which is then implanted in the patient. The other is that earlier implantation techniques required opening the knee, sewing in a patch of tissue to cover the hole and injecting the newly grown cells into the hole. (Woburn Advocate, MA)
Device firm Prescient Medical gets European OK for heart shield Sep 1, 2009
A traditional stent placed in an artery with hard, calcified plaque needs to be strong and serve as a scaffold in the artery that wants to collapse under the weight of additional tissue, Scheller said. The arteries we deal with are normal. (Philadelphia Business Journal, PA)
Newly Discovered Mechanism In Cell Division Has Implications For Chromosome's Role In Cancer Aug 27, 2009
In the August 14 issue of Developmental Cell, the team reports that a molecular motor protein called Klp9p and the microtubule-associated protein Ase1p form a complex and bind to the midzone of the spindle a sort of molecular scaffold that ensures a critical step: equal division of genetic material between two daughter cells of cell division. They also found that this interaction is regulated by a molecular switch, which is coordinated by two other proteins Cdc2p and Clp1p. (Science Daily)
Researchers Design Patches of Cells to Repair Damaged Hearts Aug 25, 2009
Whereas some scientists are using the stomach to help grow a cardiac patch, others are putting heart cells together on a scaffold where they are keeping a beat on their own ... The patch, initially grown on a mesh scaffold from the heart cells of neonatal rats and a mixture of compounds to aid development, had more blood vessels after spending a week on the rat's omentum compared with patches that were attached immediately onto the damaged hearts ... They have developed a biodegradable scaffold... (Scientific American)
Tension In Axons Is Essential For Synaptic Signaling, Researchers Report Aug 24, 2009
Other researchers have suggested that actin in axon terminals acts as a kind of scaffold that holds the vesicles near the synapse, Saif said ... It appears that actin cannot properly scaffold the vesicles without sufficient tension in the axon terminal. (Science Daily)
Mural gets a facelift Aug 20, 2009
He works on a scaffold, using the photos as a guide ... It s been about 10 years since Young last worked on downtown murals, and he said working high on a scaffold is more difficult today than it was then. (Klamath Falls Herald & News, OR)
Abbott expanding study of its popular Xience stent Aug 16, 2009
The bigger study aims to determine the optimum time people should take blood-thinning medicines after they undergo a common procedure called angioplasty to clear out a blocked artery and implant a stent, a metal-mesh scaffold that props open a blood vessel. That study, announced last November, includes more than 25,000 patients and academic researchers, federal regulators and eight major prescription drug and medical device makers. (Longview Daily News, WA)
Dessert science Aug 16, 2009
These spiny ice crystals form a sort of scaffold, creating stable, non-drippy and slow-melting ice cream ... Protein scaffolds keep all the "goodies" locked into your iced lolly ... "But this (protein scaffold) can stop that coarsening and make the ice more stable.". (BBC News -- Science)
Abbott expanding heart stent study Aug 14, 2009
The bigger study aims to determine the optimum time people should take blood-thinning medicines after they undergo a common procedure called angioplasty to clear out a blocked artery and implant a stent, a metal-mesh scaffold that props open a blood vessel. That study, begun late last year, includes more than 25,000 patients and academic researchers, federal regulators and eight major prescription drug and medical device makers. (Crain's Chicago Business)
Protein Unfolding Is Key For Understanding Blood Clot Mechanics Aug 8, 2009
On the other hand, fibrin provides a scaffold for thrombi, clots that block blood vessels and cause tissue damage, leading to myocardial infarction, ischemic stroke, and other cardiovascular diseases. How does fibrin manage to be so strong and yet so extensible under the stresses of healing and blood flow. (Science Daily)
Scaffolding scare calls into question rigging regulation Aug 7, 2009
Questions raised on scaffold regulation ... "I'm angry. I'm a little miffed over this," Kyle Redmond said of his ordeal on the scaffolding ... That scenerio is a frightening and all-too-common occurrence with the type of permanent scaffolding that was housed at the Exchange Place building in the Financial District, said one specialist in scaffolding safety. (Boston Globe)
A lurch and a lifeline 37 floors up Aug 6, 2009
They just wanted to get off the scaffolding as soon as they could ... The metal scaffold underneath Redmond and Ortiz had malfunctioned, causing one side of the platform to drop 20 feet ... Two scaffolding mechanics arrived at the site at about 3:30 p.m. and raised the metal walkway back to its place on the roof, Fire Department spokesman Steve MacDonald said. (Boston Globe)
Worker Dies In 300-Foot Fall From Texas High-Rise Thursday Jul 31, 2009
DALLAS (July 30, 2009)--A construction worker fell 23 stories to his death Thursday after the scaffolding on which he was working gave way at the St. Ann Court high-rise office building project in Dallas. Witnesses said the man was installing hardware on the facade of the 23rd floor of the 26-story, 333-foot structure when the scaffold collapsed at about 2:30 p.m. Thursday ... Dallas fire-rescue spokesman Jason Evans told KDFW-TV of Dallas and Fort Worth reports that the 35-year-old man was the... (KWTX.com, TX)
3-D Scaffold Of Living, Beating Heart Cells May Lead To Viable Strategies Of Transplanting Cells Into Diseased Hearts Jul 24, 2009
Unlike most existing approaches, in which cardiac cells with no supporting structure are injected into heart tissue, Goldman's group uses a patch (Theregen Inc. San Francisco) made from microscopically thin fibers that serve as a scaffold to which the cells can adhere ... "Our work shows that we can put living cells onto a biodegradable, 3-dimensional scaffold in a way that not only allows them to survive, but to spontaneously beat in a coordinated fashion," says Lancaster ... 4, 2008) Broken... (Science Daily)
The Sounds Of Learning: Studying The Impact Of Music On Children With Autism Jul 22, 2009
In fact, he said, participating in musical activities has the potential to scaffold and enhance all other learning and development, from timing and language to social skills. "Beyond these more concrete intellectual benefits, the extraordinary power of music to trigger memories and emotions and join us together as an emotional, empathic and compassionate humanity are invaluable," Molnar-Szakacs said. (Science Daily)
Potential Fix For Damaged Knees Identified Jul 11, 2009
ScienceDaily (July 10, 2009) Investigators from Hospital for Special Surgery have shown that a biodegradable scaffold or plug can be used to treat patients with damaged knee cartilage ... "The data has been encouraging to support further evaluation of this synthetic scaffold as a cartilage repair technique," said Asheesh Bedi, M.D., a fellow in sports medicine and shoulder surgery at Hospital for Special Surgery who was involved with the study ... Dr. Williams believes that there is a role for... (Science Daily)
Gautrain on track Jul 4, 2009
From the track, it's on to Rhodesfield Station and a fear-of-heights challenging climb up a scaffold. In this part of the tour, reporters walk about two kilometres to the station at OR Tambo. (iAfrica.com)
Re-Write The Textbooks: Key Genetic Phenomenon Shown To Be Different Than Believed Jul 3, 2009
These proteins then form a molecular scaffold along the inactive-X chromosome that can stably silence the genes contained within it. The UNC researchers are now actively investigating how this chromosomal remodeling begins in the first place. (Science Daily)
Researchers Publish Comprehensive Model For Medical Device Development Jun 30, 2009
The stent being tested is intended to act as a temporary scaffold to support the blood vessel during the healing process and. (Nov. (Science Daily)
No comments posted. Jun 24, 2009
Study: Equipment failure caused scaffold collapse ... (AP) -- A new federal report says a fatal scaffolding collapse at a Columbia school construction site last year was caused by equipment failure ... A report filed with the Occupational Safety and Health Administration said two parts of the scaffolding failed within 1 to 1 1/2 seconds. (Jefferson City News Tribune, MO)
Crustacean Shell With Polyester Creates Mixed-fiber Material For Nerve Repair Jun 19, 2009
27, 2009) Researchers have developed a technique using spun-sugar filaments to create a scaffold of tiny synthetic tubes that might serve as conduits to regenerate nerves severed in accidents or blood vessels. (Aug. (Science Daily)
Scientists Create Custom 3-dimensional Structures With 'DNA Origami' Jun 16, 2009
Long strands of DNA serving as a "scaffold" are folded back and forth by short strands of DNA serving as "staples" that knit together segments of the scaffold ... Fabricating the desired structure involves mixing the DNA scaffold and staple strands, quickly heating the mixture, and then slowly cooling the sample. (Science Daily)
Broadway: Retro style Jun 5, 2009
It's played out on a scaffold (that resembles a house); it features rock music that would feel at home on a concert stage. And, it relies on the strength of its people to make great lines even better. (Sioux City Journal, IO)
Completely Different Way Of Looking For A New Antibiotic May 30, 2009
"Since the 1960s, drug companies have for, the most part, been tweaking existing molecules, such as building better penicillin with minor changes to the original scaffold. But, you are not very far away from resistance when all you do is a little tweak.". The discovery of a "surprising link" between the three processes involved in cell wall synthesis lets researchers build a method of looking for molecules that will disturb the balance between them. (Science Daily)
Capturing The Birth Of A Synapse: Mechanism Locking Two Neurons Found May 29, 2009
In turn, neuroligins recruit at least two other key proteins (PSD-95 and NMDA receptors) to begin building a scaffold to hold the synapse components in place. The moment of locking is captured in a video (link below) that will appear with the paper's final version at the journal's Web site. (Science Daily)
ATTEMPTED MURDER CHARGE POSSIBLE IN MONDAY INCIDENT May 14, 2009
Pine Bluff Commercial/Ralph Fitzgerald Robert Knott (on scaffold), of Delta Recycling Service, Odell Terry (on ladder) and Jack Reed bring down the crown molding for salvage Tuesday morning out of the historic Bell Mansion on Barraque Street. Deputy Prosecutor Rik Ramsey said the state anticipates charging Steven Anthony Bell, 39, with attempted first-degree murder because store video and witnesses indicate that with the purpose of causing the death of Daniel Spicer, he caused serious physical... (Pine Bluff Commercial, AR)
New Tissue Scaffold Regrows Cartilage And Bone May 14, 2009
ScienceDaily (May 13, 2009) MIT engineers and colleagues have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints ... The scaffold could offer a potential new treatment for sports injuries and other cartilage damage, such as arthritis, says Lorna Gibson, the Matoula S. Salapatas Professor of Materials Science and Engineering and co-leader of the research team with Professor William Bonfield of Cambridge University ... "If... (Science Daily)
MIT: New tissue scaffold regrows cartilage and bone May 12, 2009
--MIT engineers and colleagues have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints. The scaffold could offer a potential new treatment for sports injuries and other cartilage damage, such as arthritis, says Lorna Gibson, the Matoula S. Salapatas Professor of Materials Science and Engineering and co-leader of the research team with Professor William Bonfield of Cambridge University ... "If someone had a damaged region in... (EurekAlert!)
NIST issues first reference material for tissue engineering May 9, 2009
This is an X-ray microcomputed tomograph image of the new NIST reference materials for tissue engineering scaffolds ... The new NIST materials are samples of a typical tissue scaffold material that have been measured and documented by NIST for three different degrees of porosity ... Three-dimensional tissue scaffolds, under development for some years, are biodegradable materials that are meant to be implanted in the body to provide a structurally sound framework for the patients cells to... (EurekAlert! -- Business News)
Tiny Plant Virus May Be Useful As Drug Deliver Agent May 7, 2009
Vimentin is part of the cytoskeleton, the internal scaffold that gives a cell its shape. While the vast majority of vimentin resides inside the cell, a small fraction somehow ends up on the cell's surface. (Science Daily)
May 2009 Geology media highlights May 5, 2009
Instead, they likely represent a structured consortium of protists in a shared collagenous scaffold. These results push back the earliest geologic evidence for animals by around 200 million years. (EurekAlert!)
Longer Lasting Tumor Blocker May 5, 2009
Most likely, the anti M-CSF treatment had a lasting effect because it resulted in damage to the scaffolding that surrounds cancerous vessels, robbing the tumors of the structural support they need to grow. Meanwhile, the scaffold of mice treated with anti-VEGF remained intact. (Science Daily)
Novel role of protein in generating amyloid-beta peptide Apr 28, 2009
"We discovered that this protein interacts with three components involved in A generation LRP, APP and BACE1 and appears to 'scaffold' them into a structure.". Kang explained that these three components must come together to result in the first cut or cleaving that leads to production of A. (EurekAlert!)
Scientists Synthesize Gold To Shed Light On Cells' Inner Workings Apr 18, 2009
"The protein holds and interacts with gold ions in aqueous solution. We are able to use this protein to provide a scaffold for the formation of gold nanoclusters," explained Yuangang Zheng, Ph ... "We are inspired by nature's ability to create elegant and functional materials. Our process is similar to biomineralization in nature that is found in the formation of bones and shells: where functional proteins mostly interact with sequestered inorganic ions to provide scaffolds for mineral... (Science Daily)
Potential New Target For Treatment Of Hormone Refractory Prostate Cancer Apr 15, 2009
"Our work suggests that ubiquitination of AR, and possibly other transcription factors, may function as the scaffold for cofactor recruitment to modulate transcriptional activity and specificity," concludes Dr. Qiu. "Targeting components of the ubiquitination machinery, such as RNF6, may potentially be effective in treatment of advanced prostate cancer.". (Science Daily)
Study assesses new surgical procedure for regenerating cartilage in damaged knee joints Apr 10, 2009
The procedure, called the Cartilage Autograft Implantation System (CAIS), involves extracting cartilage from the healthy tissue that remains in the knee, breaking it into tiny fragments to enable it to grow and expand, fixing it onto a biologically reabsorbable scaffold, and then implanting the scaffold with the cartilage cells back into the damaged area all in a single surgery. Earlier laboratory studies at Rush had indicated that the procedure can yield the tougher hyaline cartilage that... (EurekAlert! -- Business News)
New malaria drug fights resistance, helps others Apr 9, 2009
"We engineered a new scaffold with both features incorporated into one molecule," the researchers wrote in Nature. It is called by its chemical name for now, T3. (AlertNet)
Why Wall Street needs a Napoleon to shake it up Apr 8, 2009
"No, Madame," said Villefort, "I leave each of them on his own pedestal: Robespierre in the Place Louis XV, on his scaffold, and Napoleon in the Place Vendome, on his column. The difference is that equality with the first was levelling down and with the second a raising up: one of them lowered kings to the level of the guillotine, the other lifted the people to the level of the throne -- which does not mean," Villefort added, laughing, "that they were not both vile revolutionaries...". By the... (Salon)
New medications show promise in treating drug-resistant prostate cancer Apr 8, 2009
Using this molecule as a chemical scaffold, the researchers synthesized nearly 200 slightly different versions of the drug. They tested each one in the lab on prostate cancer cells that had been engineered to produce high levels of androgen receptor. (EurekAlert!)
May 1, 1960: Caen on capital punishment Apr 2, 2009
Suddenly the door behind the scaffold swung open and the nightmare scene was enacted in a flash: the murderer, his arms bound, was hustled roughly onto the trapdoor, the noose was slammed around his neck, a black mask dropped over his unbelieving face, the trapdoor clanged open, the body shot through and stopped with a sickening crack. For an eternity, the victim twitched in spasm after spasm, and one by one the witnesses began fainting around me. (San Francisco Chronicle)
Transforming Medical Diagnosis With New Scanning Technology Apr 1, 2009
Researchers have taken parahydrogen and, through a reversible interaction with a specially designed molecular scaffold, transferred its magnetism to a range of molecules. The resulting molecules are much more easily detected than was previously possible. (Science Daily)
Laureate league Apr 1, 2009
McGough was also a member of the pop group The Scaffold between 1963 and 1973, with whom he reached number one in the singles chart with Lily The Pink. He also presents the BBC Radio 4 programme Poetry Please and continues to perform his own poetry. (BBC News -- Entertainment)
Getting down to cancer basics Mar 30, 2009
The composite DNAprotein structure, called chromatin, is not simply a scaffold, but plays an active role in controlling gene activity. The UTX protein alters a key organising subunit component of chromatin, called a histone. (EurekAlert!)
New Protein Important In Breast Cancer Gene's Role In DNA Repair Identified Mar 29, 2009
MERIT40 not only recruits BRCA1 and RAP80 to the sites of DNA damage and signals for DNA repairman to the site, but also acts as the molecular scaffold for the BRCA1-RAP80 complex. The BRCA1-RAP80 protein complex works as machine. (Science Daily)
Proteins By Design: Biochemists Create New Protein From Scratch Mar 28, 2009
Currently, protein engineers take an existing biochemical scaffold from nature and tweak it a bit structurally to make it do something else. This research demonstrates how we used a set of simple design principles, which challenge the kind of approaches that have been used to date in reproducing natural protein functions, says Dutton. (Science Daily)
Alarm 'failed' on ditched chopper Mar 26, 2009
Page last updated at 00:01 GMT, Thursday, 26 March 2009. The missing tail section was eventually recovered and brought ashore. (BBC News -- UK)
Stem Cells Yield New Clues To Glut Of Glial Cells In Down's Syndrome, Glioblastoma, And Alzheimer's Disease Mar 23, 2009
(May 6, 2002) Researchers have discovered that astrocytes -- brain cells once thought to be little more than a component of the supportive scaffold for neurons -- may actually play a starring role in triggering. (July 15, 2004) Adult stem cells in the brains of mice possess a broader differentiation potential than previously thought and may be capable of developing into other cell types including those involved in the. (Science Daily)
Lab-grown Nerves Promote Nerve Regeneration Mar 20, 2009
20, 2009) Researchers at the University of Pennsylvania School of Medicine have engineered transplantable living nerve tissue that encourages and guides regeneration in an animal model. Results were published in March in the journal Tissue Engineering Part A.. (Science Daily)
Research yields potential target for cancer, wound healing and fibrosis Mar 19, 2009
This study advances earlier research on the beta-1 integrin tail, that revealed the ability of this integrin tail to provide a scaffold for signaling proteins that control cell survival. The extracellular matrix is a complex mixture containing proteins such as fibronectin and collagen that provide structural support to cells and traction for cell movement. (EurekAlert!)
No hiding place for infecting bacteria Mar 16, 2009
P. aeruginosa uses these cell proteins as a scaffold to build a protective biofilm making these infections very difficult to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic fibrosis patients. (EurekAlert!)
Fireman transforms pickup paramedics Mar 14, 2009
GUATEMALA CITY, Guatemala (CNN) -- When Guatemalan laborer Faustino Morales fell from a scaffold in February, the response from volunteer firefighters was immediate. Within minutes, the "bomberos" reached the accident site with advanced rescue equipment, an ambulance and a thorough knowledge of how to treat his injuries. (CNN -- US)
Misplaced Metamorphosis Mar 13, 2009
13, 2009) Researchers at the University of Pennsylvania School of Medicine and the University of Connecticut have pinpointed the source of immature cells that spur misplaced bone growth. Unexpectedly, the major repository of bone-forming cells originates in blood vessels deep within skeletal muscle and other connective tissues, not from muscle stem cells themselves. (Science Daily)
'Civilians die' in S Lanka battle Mar 9, 2009
Stem cell 'scaffold' for stroke. Girl aged 6 among five crash dead. (BBC News -- South Asia)
