Mud flies among supervisors Jul 13, 2008
TNF wrote on Jul 11, 2008 1:49 PM:" GET RID OF THEM ALL AND WIPE THE SLATE CLEAN!!!!!!!! ". Erin wrote on Jul 11, 2008 12:31 PM:" Hey, this is odd! Last week the GJ report was flawed, subjective and written by inept fools. This week they are used to defend Wilensky and Claudino's position! Which is it? And why do these Sueprvisors persist in using the newspaper as their personal mouthpiece. At least Tyron does his bidding during the board meetings and in front of the public. ". (San Andreas Calaveras Enterprise, CA)
Mokelumne River still unhealthy, jury complains Jul 4, 2008
tnf wrote on Jul 3, 2008 12:28 PM:" this is absolutely disgusting!! how long have officials known about this, yet this is the first time i have ever seen anything about the contamination in the news? why are the septic tanks and leach lines located in such a bad area? could it have been (again) a building and planning dept slip-up? who allowed them to built in such close proximity to the water? and as for signs not posted to warn people, that is abominable. how many people have let their... (San Andreas Calaveras Enterprise, CA)
Small protein may have big role in making more bone and less fat Jul 2, 2008
It inhibits two key inflammatory molecules, NF-kB and AP-1, which turn on inflammatory genes in response to cytokines, such as TNF- and IL-1, involved in rheumatoid arthritis and other inflammatory diseases, Dr. Shi showed in research published on the cover of the April 15 issue of Journal of Cellular Biochemistry. That study notes GILZ's potential as a novel anti-inflammatory therapy. (EurekAlert!)
Potential New Way To Block Inflammation In Autoimmune Disease Discovered Jun 25, 2008
It is a member of the tumor necrosis factor (TNF) family of receptors, which bind to molecules related to TNF, a cell-signaling protein that promotes inflammation. Many of today's most potent treatments for inflammatory diseases, such as rheumatoid arthritis and psoriasis, interfere with the action of TNF, thereby blocking inflammation ... Since current anti-TNF therapies don't work in all autoimmune diseases, however, the researchers turned to the study of DR3, which is a close relative of... (Science Daily)
Four suspects arraigned Jun 21, 2008
TNF wrote on Jun 12, 2008 9:06 AM:" ... and this is a big part of why the united states needs tougher immigration laws and to crack down on illegal immigrants... we now need to pay to house, feed, cloth, and try these individuals, and to ultimately i'm sure, send them back from whence they came. ". DL wrote on Jun 12, 2008 12:50 AM:" All here illegally, nothing to see here, move along. ". (San Andreas Calaveras Enterprise, CA)
FDA Panel OKs Enbrel for Psoriasis in Children Jun 20, 2008
the FDA announced that it's investigating whether cancers in about 30 children and young adults are linked to the use of Enbrel, Remicade, Humira, and Cimzia, which make up a class of drugs called tumor necrosis factor (TNF) inhibitors. Enbrel got a "black box warning," the FDA's sternest warning, about the risk of serious infections that may lead to hospitalization or death. (WebMD)
New Role Of Inflammatory Protein In Polycycstic Kidney Disease Identified, Could Lead To Treatment Jun 20, 2008
The team showed that a pro-inflammatory cytokine protein tumor necrosis factor- (TNF- ) disrupts the localization of polycystin 2 (the product of a gene mutated in ADPKD) to the plasma membrane and primary cilia in kidney epithelial cells, thus promoting the formation of cysts. The interaction between TNF- and polycystin in the development of cysts is complicated, said Xiaogang Li, Ph ... Additionally, the team found that the drug etanercept, an inhibitor of TNF- currently used to treat... (Science Daily)
On Colitis and Colon Cancer Jun 19, 2008
2 A recent study by Popivanova and colleagues3 sheds light on some of the molecular mechanisms that may underlie this therapeutic effect and suggests a role for anti TNF. antibodies in the prevention of colitis-associated colon. (New England Journal of Medicine)
FDA sees possible J&J psoriasis drug risks Jun 15, 2008
Those drugs work by blocking an inflammation-causing protein called tumor necrosis factor (TNF). Share. (Reuters)
Psoriasis drug may raise cancer risk Jun 15, 2008
If the drug is approved, it will compete with Amgen Inc and Wyeth's Enbrel and Abbott Laboratories Inc's Humira, which block an inflammation-causing protein called tumor necrosis factor (TNF). Prescription information for these drugs includes a warning about a possible elevated risk of cancer. (Food Consumer)
Targeted Genetics Announces Positive Phase 1/2 tgAAC94 Data Presented at Annual European Congress of Rheumatology Jun 12, 2008
SEATTLE and PARIS, June 12 /PRNewswire-FirstCall/ -- Targeted Genetics Corporation (Nasdaq: ) announced today that positive results of a Phase 1/2 clinical study demonstrate that tgAAC94, its investigational agent designed to inhibit activity of tumor necrosis factor-alpha (TNF-alpha), a key mediator of inflammation, is well tolerated and may improve disease symptoms in inflammatory arthritis patients refractory to other therapies, including systemic TNF antagonists ... The Phase 1/2 study... (PR Newswire)
New Hope For Rheumatoid Arthritis Sufferers: B Cells As Promising New Therapeutic Targets Jun 10, 2008
In particular, B cell depletion with the anti-CD20 antibody rituximab seems to work for RA patients resistant to standard disease-modifying antirheumatic drugs (DMARDs) and tumor necrosis factor (TNF ) blockers ... The participants, 14 women and 3 men, had a median age of 51 years, a median disease duration of 14 years, and a history of failure to respond to DMARD and/or anti-TNF therapy. (Science Daily)
Understanding Kidney Cell Suicide In Diabetes Patients Jun 10, 2008
Among these genes, the Spanish team identified a protein of the Tumour Necrosis Factor (TNF) family, called TRAIL, as the key to the cell suicide in diabetes affected kidneys. In these kidneys, large quantities of TRAIL can be found that surprisingly do not come from the increased glucose levels that define the disease, but from the inflammation that accompanies the renal damage. (Science Daily)
Breastfed babies lack vitamin D Jun 7, 2008
"At the current time, the FDA believes that the potential benefits of the use of TNF blockers outweigh the potential risks," the agency said in a statement posted on its website. But, it added, "health-care providers, parents and caregivers should be aware of the possible risk of lymphoma and other cancers ... when deciding how best to treat these patients.". (Globe and Mail)
UPDATE 1-FDA panel to discuss Roche arthritis drug July 29 Jun 6, 2008
Roche believes it will become an important alternative treatment to established anti-TNF drugs, helping the company diversify its business and to reduce its reliance on cancer medicines. Drugs that target another protein called tumour necrosis factor, or TNF, have helped revolutionise treatment for rheumatoid arthritis, but up to 40 percent of patients do not get an adequate response. (Reuters)
FDA Starts Safety Review of Autoimmune Disorder Drugs Jun 6, 2008
Reports of increased cancer risk among young users of TNF blockers prompts action ... WEDNESDAY, June 4 (HealthDay News) -- U.S. health officials have started a safety review of a class of drugs known as tumor necrosis factor (TNF) blockers, which are widely prescribed to treat autoimmune disorders such as rheumatoid arthritis, juvenile rheumatoid arthritis and Crohn's disease ... The agency is investigating about 30 reports of cancer in this younger age group submitted between 1998, after the... (MEDLINEplus)
Abbott drugs in FDA risk reviews Jun 5, 2008
The FDA said it is investigating about 30 reports of cancer during the past 10 years in children and young adults taking so-called TNF blockers such as Humira. "The drugs Enbrel, Humira, and Remicade are being reviewed for a possible association between their use and the development of lymphoma and other cancers in children and young adults treated with TNF blockers for juvenile idiopathic arthritis and Crohn's disease," the FDA said. (Chicago Tribune)
Clarification on Press Release Issued Earlier Today: Targeted Genetics Confirms Positive, Interim Phase 1/2 Study Findings May 31, 2008
"We believe the data suggest that tgAAC94 has the potential to improve disease symptoms that are refractory to other therapies, including systemic TNF antagonists." Patients in this Phase 1/2 study continue to be followed for safety and measures aimed to assess functional improvement in treated joints. About Targeted Genetics Corporation Targeted Genetics Corporation is a biotechnology company committed to the development of innovative targeted molecular therapies for the prevention and... (PR Newswire)
Arthritis Drugs May Impair Response to Flu Vaccine May 23, 2008
NEW YORK (Reuters Health) - Drugs known as TNF inhibitors used to treat rheumatoid arthritis modestly impair the immune response to influenza vaccination, which may render people who use these drugs more vulnerable to catching the flu, according to a new study ... "Influenza vaccination is still effective in patients treated with anti-TNF," Dr. Luc B. S. Gelinck from Leiden University Medical Center, the Netherlands, told Reuters Health ... Examples of anti-TNF drugs are Enbrel, Remicade and... (MEDLINEplus)
Tuberculosis not the only risk from new immunological drugs May 21, 2008
Among these drugs are agents that inhibit tumor necrosis factor- (TNF), a cytokine receptor involved in cellular communication. It is known that anti-TNF therapies are associated with an increased risk of tuberculosis ... Kevin Winthrop, MD, of the Oregon Health and Sciences University, said: While much attention has so far focused on tuberculosis cases occurring in patients using anti-TNF therapies, our findings suggest that nontuberculosus mycobacterial infections, histoplasmosis, and... (EurekAlert!)
Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research May 13, 2008
Feldmann and Maini were selected for their role in the discovery of tumor necrosis factor-alpha, or TNF-alpha, as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions afflicting millions worldwide ... Feldmann and Maini investigated the role of cytokines, protein messenger molecules that drive inflammation, and found that a single cytokine, TNF, was capable of driving the disease process ... This led them to seek ways of blocking TNF, and they chose... (PR Newswire)
Gun collection seized, man faces charges May 10, 2008
TNF wrote on May 9, 2008 10:43 AM:" Its about time that Dale Buller be brought forth to face the music for some of his crimes!!! And what about posting some of the money for his bail? Or paying back the county for money they already have spent on him? ". Comments are posted after review by the Web master. (San Andreas Calaveras Enterprise, CA)
Alzheimer's hope over US therapy Apr 11, 2008
It is a widely used treatment for arthritis, blocking a chemical called tumour necrosis factor-alpha, or TNF, which causes pain and swelling in the joints. TNF may also affect communication between brain cells - and could be partly to blame for the advance of Alzheimer's ... The researchers in Los Angeles believe they have discovered a way of delivering etanercept into the brain via an injection in the neck, allowing it to block the disruption caused by TNF.. (BBC News -- Health)
Traffic exhaust can cause asthma, allergies and impaired respiratory function in children Apr 10, 2008
According to new analyses, variants of another asthma gene, TNF (tumour necrosis factor), also affect sensitivity to air pollution. Children with a particular combination of GSTP1 and TNF variants run a considerably higher risk of developing allergies. (EurekAlert!)
New Genetic Links To Psoriasis Uncovered Apr 8, 2008
The researchers also uncovered significant DNA variations on chromosome 13 in a genetic region involved in modifying proteins, and on chromosome 15, in a region responsible for producing a protein that activates TNF alpha (tumor necrosis factor-alpha) in a specialized immune cell known as a dendritic cell. While TNF alpha normally helps fight infections, it is thought to be a major player in psoriasis and psoriatic arthritis ... Several FDA-approved psoriasis medications work by binding to... (Science Daily)
Scientists shine new light on inflammatory diseases Mar 17, 2008
Tumor necrosis factor (TNF) is known to play a role in several important inflammatory diseases including rheumatoid arthritis. While much is known about early signaling pathways activated by TNF, little is known about delayed and chronic TNF responses ... In addition, cells called macrophages produce TNF, but little is known about the effects of TNF on the macrophages themselves. (EurekAlert!)
Dermatology Team Finds Treatment For Rare 'Life-ruining' Condition Mar 15, 2008
The researchers later teamed up with Dr. Ross to discover the chromosomal site for FCAS. Six years after the discovery, Dr. Ross and a group of UK colleagues pinpointed the specific receptor responsible for FCAS. When triggered, the tumour necrosis factor (TNF) receptor starts the symptoms of FCAS. ... Anakinra (marketed by Amgen Corporation as Kineret) prevents the symptoms of FCAS by stopping the TNF receptor from being triggered. (Science Daily)
Arthritis Medications Reduce Risk Of Heart Attacks And Strokes, Study Suggests Mar 8, 2008
"Our study provides further support of the influence of both traditional and RA specific risk factors in the development of cardiovascular events, especially heart attack" the researchers conclude, "As assessed by this study, the risk was lower with the prolonged use of methotrexate, sulfasalazine, glucocorticoids, leflunomide and TNF-; blockers.". In an accompanying editorial, Dr Ronald van Vollenhoven of Karolinska Institute, Sweden, reviews the research article. (Science Daily)
Arthritis pill may cut heart attack risk Mar 7, 2008
Results also suggested that newer drugs that block an inflammatory protein called tumor necrosis factor, or TNF, were also effective at reducing heart attack and stroke risk, although more research is needed, Sokka said. This class of drugs includes Johnson & Johnson's Remicade, Amgen Inc.'s Enbrel, and Abbott Laboratories Inc's Humira. (MSNBC -- Health)
Watery Pools In Bone Marrow Key To Psoriatic Arthritic Damage Mar 7, 2008
While traditional PsA treatments include NSAIDs or steroids to stop inflammation, the recent focus has been on newer drugs that interfere with tumor necrosis factor (TNF), an inflammatory chemical central to both normal immune function and autoimmune disease ... Going into the study, researchers knew that Enbrel attaches to TNF and removes it from joints and the bloodstream, reducing inflammation, tenderness and pain ... The current study suggests that anti-TNF therapy may work in another way as... (Science Daily)
Arthritis Pill Cuts Heart Attack Risk Mar 7, 2008
Results also suggested that newer drugs that block an inflammatory protein called tumor necrosis factor, or TNF, were also effective at reducing heart attack and stroke risk, although more research is needed, Sokka said. This class of drugs includes Johnson on's Remicade, Amgen Inc's Enbrel, and Abbott Laboratories Inc's Humira. (Newsmax)
Pacemaker tune-up works chemical wonders on damaged hearts in dogs Mar 6, 2008
These included calcium-calmodulin-dependent kinase (CaMKII), which is linked to arrhythmia, and tumor necrosis factor-alpha (TNF), which is also tied to damaging inflammation and cell death. The enzyme Akt, a promoter of cell survival when turned on, was markedly less active in the group whose hearts continued to beat out of sync. (EurekAlert!)
Anti-TNF Therapy Can Help Heart Of Rheumatoid Arthritis Patients, Study Suggests Mar 3, 2008
An inflammatory cytokine known for contributing to the development of RA, tumor necrosis factor a (TNFa) has also been implicated in cardiovascular disorders ... Inhibition of TNFa has opened promising new treatment options for RA patients ... Anti-TNF drugs such as infliximab, etanercept, and adalimumab have been shown to not only diminish signs and symptoms of the disease, but also prevent joint damage. (Science Daily)
Johnson & Johnson Psoriasis Therapy Eases Symptoms With Fewer Injections Feb 3, 2008
Those standard drugs soak up excess amounts of an inflammatory protein, called TNF. J&J's new product is designed to block two different inflammatory proteins, Interleukin-12 and Interleukin- 23, researchers said. Remicade, also approved for rheumatoid arthritis, is taken as an intravenous infusion, making it less convenient for psoriasis patients, doctors say. (Bloomberg -- US)
Recently Discovered Cell Is Unexpected Player In Psoriasis Jan 31, 2008
New research suggests that the psoriasis drug etanercept targets dendritic cells (red), preventing them from producing tumor necrosis factor or TNF (green), a molecule associated with the skin disease. Compared with skin from a pretreatment patient (top), skin from a patient treated with the drug for two weeks has dramatically less TNF. (Credit: Image courtesy of Rockefeller University). (Science Daily)
San Andreas collision creates noontime traffic snarl Jan 31, 2008
TNF wrote on Jan 30, 2008 11:52 AM:" and this is EXACTLY why teenage drivers are given provisional licences!! Hopefully that driver whom caused the accident was issued a citation by CHP. ". Name. (San Andreas Calaveras Enterprise, CA)
Repeat Rituximab Safe for Rheumatoid Arthritis Jan 30, 2008
NEW YORK (Reuters Health) - Additional courses of rituximab in rheumatoid arthritis patients who continue to experience symptoms after they finish an initial course of treatment with this tumor necrosis factor (TNF) inhibitor can induce a sustained and safe clinical response, an international team of researchers reports. The findings of this study of rituximab, marketed in the U.S. as Rituxan, appear in the journal Arthritis and Rheumatism. (MEDLINEplus)
Newer Rheumatoid Arthritis Drugs Lower Production of B Cells Jan 26, 2008
They found that drugs known as anti-TNF compounds -- including Enbrel, Humira and Remicade -- help reduce the activity of abnormal B cells that play a role in autoimmune diseases such as RA and lupus. TNF is a chemical messenger that fires up the immune system ... Anti-TNF drugs inhibit TNF.. (Forbes)
Ambulance service cut draws scrutiny Jan 24, 2008
TNF wrote on Jan 23, 2008 12:32 PM:" I firmly believe that the service contract that ALA promised this county has been broken. The response time to residents homes are sometimes ridiculous, and I cannot believe that they are further cutting this county's coverage. Yes, they may be receiving less calls for service - BUT - coverage is needed in these rural areas nonetheless; due to the incredible response times it will require for ambulances to come from San Andreas or even Valley Springs for... (San Andreas Calaveras Enterprise, CA)
Lupus in women: New genetic risk factors identified Jan 21, 2008
In our previous study, we identified that a gene called TNFSF4, important for the communication between different cells of the immune system, is also involved in the susceptibility to systemic lupus, said Dr Rioux ... Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus Deborah S Cunninghame Graham, Robert R Graham, Harinder Manku, Andrew K Wong,John C Whittaker, Patrick M Gaffney, Kathy L Moser, John D Rioux, David Altshuler,Timothy W Behrens... (EurekAlert!)
A new view of drugs used to treat rheumatoid arthritis Jan 21, 2008
A team of physicians and scientists at the University of Rochester Medical Center reports that drugs known as anti-TNF compounds which include drugs such as Enbrel, Humira and Remicade affect our B cells, which play a role in many autoimmune diseases. In a study published in the cutting-edge section of the Jan. 15 issue of the Journal of Immunology, the team found that anti-TNF compounds help eliminate abnormal B cell activity in patients, raising the possibility that the drugs improve the... (EurekAlert!)
Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis Jan 19, 2008
Important Safety Information Serious infections, sepsis, tuberculosis (TB) and opportunistic infections, including fatalities, have been reported with the use of TNF-blocking agents, including HUMIRA. Many of these serious infections have occurred in patients also taking other immunosuppressive agents that in addition to their underlying disease could predispose them to infections ... TNF-blocking agents, including HUMIRA, have been associated with reactivation of hepatitis B (HBV) in patients... (PR Newswire)
Psoriasis Drug Effective In Children And Adults, Study Suggests Jan 18, 2008
Etanercept is a type of protein that blocks the action of a substance produced by the immune system called tumor necrosis factor (TNF). People with immune diseases such as plaque psoriasis have too much TNF in their bodies. (Science Daily)
Adult Drug Effective in Treating Psoriasis in Children Jan 17, 2008
Etanercept is a tumor necrosis factor receptor (TNF). People with psoriasis have too much TNF, and entaercept reduces the amount of TNF. But, it can also lower the immune system's ability to fight infections. (U.S. News & World Report)
An emerging candidate for protecting patients from liver injury after abdomen surgery Jan 17, 2008
Finally, blood is collected for detecting the expression of adhesion molecules in leukocyte and the activity of hepatic enzymes, including LDH, ALT, and AST, and the concentration of pro-inflammatory mediators such as TNF-, IL-6 and monocyte chemotactic protein-1 (MCP-1). After careful evaluation, the researchers concluded R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury by inhibition of leukocyte rolling and adhesion, through depressing the expression of... (EurekAlert!)
Fast-Acting Alzheimer's Therapy Excites Researchers Jan 14, 2008
"It is imperative that the medical and scientific communities immediately undertake to further investigate and characterize the physiologic mechanisms involved. "This gives all of us in Alzheimer's research a tremendous new clue about new avenues of research, which is so exciting and so needed in the field of Alzheimer's," she said. The study focuses on one of these cytokines, tumor necrosis factor-alpha (TNF), a critical component of the brain's immune system. Normally, TNF finely regulates the... (Consumer Affairs)
Dementia drug instant hit claim Jan 10, 2008
" Neil Hunt, of the Alzheimer's Society, echoed that view: "It is crucial more research is carried out, before any conclusions are drawn on TNF alpha and the development of Alzheimer's disease. " Bookmark with: SEE ALSO 06 Dec 07 | Health 24 Oct 07 | Wales 14 May 07 | Health RELATED INTERNET LINKS The BBC is not responsible for the content of external internet sites MOST E-MAILED Tata Motors unveils bargain car Dementia drug instant hit claim Secondary schools in Trafford Scotland's Property... (BBC News -- Health)
Reversal Of Alzheimer's Symptoms Within Minutes In Human Study Jan 10, 2008
The study focuses on one of these cytokines, tumor necrosis factor-alpha(TNF), a critical component of the brain s immune system. Normally, TNF finely regulates the transmission of neural impulses in the brain ... The authors hypothesized that elevated levels of TNF in Alzheimer s disease interfere with this regulation. (Science Daily)
Arthritis drug offers hope to ease dementia Jan 10, 2008
The rationale for the treatment is that etanercept is an antibody-based drug that acts against a compound called tumour necrosis factor (TNF) that is active in causing inflammation in rheumatoid arthritis. The authors believe that TNF is also involved in the processes in Alzheimer s disease that disrupt brain functioning. (Times Online)
Symptoms of Alzheimer's Reversed in Minutes Jan 10, 2008
The study focuses on one of these cytokines, tumor necrosis factor-alpha(TNF), a critical component of the brains immune system. Normally, TNF finely regulates the transmission of neural impulses in the brain ... The authors hypothesized that elevated levels of TNF in Alzheimers disease interfere with this regulation. (Newsmax)
Fighting Diseases Of Aging By Wasting Energy, Rather Than Dieting -- Works For Mice Dec 7, 2007
29, 2006) Recent studies show promise for significantly reducing vascular aging by inactivating TNF;, which has been linked to blood vessel dysfunction and cell death. The related report by Csiszar et. (Science Daily)
Promising New Therapy Being Studied to Treat Rheumatoid Arthritis Nov 16, 2007
A unique aspect of certolizumab pegol is the rapid attainment of the high hurdle ACR50 and ACR70 responses by 12-16 weeks, compared to other TNF inhibitors which achieve these responses by about 24 weeks or more, said Edward Keystone, MD, University of Toronto, and lead investigator in the study. Whether this is a reflection of the rapid entry of the pegylated molecule in the joint, remains unclear. (Science Daily)
Molecule Makes Cancer Cells Commit Suicide Nov 13, 2007
But they found that the cancer cells are only killed when the mimetic molecule is introduced in conjunction with another component of the apoptotic machinery known as TNF ... The researchers' studies revealed that the sensitive cell lines produced their own TNF;, so they were already "primed" for apoptosis ... The paradox, said Wang, is that TNF; signaling is also part of a complex pathway that gives cancer cells a "survival" signal, offering them a growth advantage. (Science Daily)
REMICADE becomes first anti-TNF biologic therapy to treat 1 million patients worldwide Nov 7, 2007
HORSHAM, PA and KENILWORTH, NJ, NOVEMBER 6, 2007Centocor, Inc., Schering-Plough Corporation, and Mitsubishi Tanabe Pharma Corporation announced today that an estimated one million patients have now been treated with REMICADE (infliximab), the leading anti-tumor necrosis factor (TNF)-alpha therapy worldwide. In fact, REMICADE has been used to treat more patients worldwide than all other anti-TNF-alpha agents combined ... REMICADE was the first anti-TNF-alpha treatment approved by the U.S. Food... (EurekAlert! -- Business News)
Avigen's AV411 Shows Promising Initial Results for Neuropathic Pain Nov 4, 2007
AV411 is a first-in-class orally bioavailable small molecule, a glial attenuator that suppresses pro-inflammatory cytokines IL-1 beta, TNF alpha, and IL-6, and may upregulate the anti-inflammatory cytokine IL-10. While considered a New Molecular Entity (NME) in the United States and Europe, the drug was first approved in Japan over 15 years ago. (Primezone Releases)
Pneumocystis Pneumonia Associated with Infliximab in Japan Nov 1, 2007
Strict postmarketing surveillance of infliximab and etanercept, a drug that blocks the action of TNF, revealed incidences of pneumocystis pneumonia in Japanese patients with rheumatoid arthritis that were higher (0. 4% and 0. (New England Journal of Medicine)
Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients Oct 16, 2007
REMICADE is the global market leader among anti-tumor necrosis factor alpha (TNF-alpha) therapies and is the only anti-TNF-alpha treatment approved in three different therapeutic areas: gastroenterology, rheumatology and dermatology ... REMICADE is unique among available anti-TNF biologic therapies ... Unlike self-administered therapies that require patients to inject themselves frequently, REMICADE is the only anti-TNF biologic administered directly by caregivers in the clinic or office... (EurekAlert!)
Study reveals a key to blood vessel growth and possible drug target Oct 15, 2007
In the current study, the UCSF team determined that two well known signaling molecules, birc2 and TNF, are crucial to the survival of endothelial cells -- which line the blood vessels and maintain the integrity of the blood vessel wall during vascular development -- in zebrafish embryos ... Next, through a series of genomic analyses and biochemical studies, the team discovered the critical role of birc2 and TNF in blood vessel health in the zebrafish embryo. (EurekAlert!)
Abbott drug maintains psoriasis relief in trial Oct 2, 2007
Two leading approved psoriasis drugs, Amgen Inc's Enbrel and Johnson & Johnson's Remicade, work instead by blocking another inflammation-causing protein called tumor necrosis factor (TNF). Abbott's own Humira, a blockbuster treatment for rheumatoid arthritis that is awaiting U.S. approval for psoriasis, also blocks TNF.. (San Diego Union-Tribune -- Business)
Some arthritis drugs may protect the heart Sep 28, 2007
Most antirheumatic biologic agents block TNF, a mediator previously shown to interfere with the lining of blood vessels, promote plaque rupture, and induce an unhealthy "prothrombotic state" - that is, prone to blood clot formation. We now must study "whether biologicals have the capacity of reversing the cardiovascular effects of TNF in a sustained way," he added. (Scientific American)
Closing In On Genes Involved With Rheumatoid Arthritis Sep 21, 2007
They found a consistent association with one specific region of the genome -- a region on chromosome 9 that includes the two genes, complement component 5 (C5) of the complement system (a primitive system within the body that is involved in the defense against foreign molecules) and a gene involved in the inflammatory response, TNF receptor-associated factor 1(TRAF1). Rheumatoid arthritis is a very common chronic illness that affects around 1% of people in developed countries. (Science Daily)
Diamyd Medical: Further Evidence for Lasting Immunological Efficacy of Diamyd Diabetes Vaccine Sep 19, 2007
Upon in vitro stimulation with GAD65, 15 months after vaccination, the immune system of Diamyd-treated patients showed a highly statistically significant increase in the secretion of several immunomodulatory substances, dominated by regulatory cytokines, including IL5, IL13, IL10, IL17, IFN- and TNF. The same immunological fingerprint was observed in virtually all Diamyd treated patients (fig 1). (BusinessWire)
Genome Area Linked to Rheumatoid Arthritis Sep 19, 2007
This region, on chromosome 9, includes two genes called complement component 5 (C5) and TNF receptor-associated factor 1 (TRAF1). TRAF1 is involved in inflammatory response, and C5 plays a role in the complement system, involved in defending the body against foreign molecules, the researchers said. (Health-Finder)
Panel reports on gene therapy death Sep 18, 2007
comment:TNF-alpha deficiency symptoms - per Janeway Pg 485 ... Mice lacking TNF alpha or the TNF p55 receptor gene are susceptible to intracellular bacterial/mycobacterial infection ... This leads one to believe that the problem is exactly due to the adenovirus therapy, in cases where it interferes too successfully with TNF-alpha. (The Scientist)
Potential New Way to Treat Inflammatory Disease Found Sep 14, 2007
These cells are activated by a chemical compound called tumor necrosis factor (TNF) released by the neutrophils. Although there are several ways by which neutrophils release TNF, Kettritz and colleagues found that neutrophils can be stimulated to produce TNF in a totally new and different way ... Usually, TNF is produced when specific chemicals bind to proteins called receptors on the surface of a neutrophil, which tells the cell that it should make TNF, Kettritz says. (Newsmax)
