Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets Aug 28, 2008
e., daclizumab, tacrolimus, and sirolimus). After the second islet transplantation, the. (New England Journal of Medicine)
Canine Pemphigus Aug 27, 2008
Topical corticosteroids and tacrolimus are also used. In cats, chloramphenicol is used in place of azathioprine. (Suite101.com)
Facial Transplantation Shows Promise for Severe Disfigurement Aug 26, 2008
The subject's immunomodulatory regimen included tacrolimus, mycophenolate mofetil, corticosteroids, and humanized IL-2 receptor monoclonal antibody ... The patient's immunosuppressive regimen included antilymphocyte serum, tacrolimus, mycophenolate mofetil, and prednisone. (RMGH Health News)
Immune Response May Hinder Stem Cell Treatments Aug 19, 2008
Medicating the mice with normal immune systems with a combination of two common anti-rejection compounds -- tacrolimus and sirolimus -- allowed those cells to survive for up to 28 days, the team said. More information. (U.S. News & World Report)
Immune Response To Human Embryonic Stem Cells In Mice Suggests Human Therapy May Face Challenge Aug 19, 2008
They found that a combination of two compounds - tacrolimus and sirolimus - allowed the cells to survive for up to 28 days in the mice with normal immune systems. Wu and his colleagues will continue to investigate whether different combinations can more effectively mitigate the immune response in mice. (Science Daily)
Revolutionary Technique Could Reduce Lifelong Drugs For Transplant Patients Aug 7, 2008
Medical staff were then able to wean six of them down to low-dose tacrolimus monotherapy, which is a much less intrusive drug regime with fewer side effects ... One patient was able to go eight months without any immunosuppression drugs and a further three were successfully weaned from a conventional immunosuppression regime to low-dose tacrolimus monotherapy. (Science Daily)
'Multi-target' immune therapy improves outcomes of severe lupus nephritis Jul 2, 2008
One group of patients received this "multi-target" therapy, consisting of the immunosuppressant drugs tacrolimus and mycophenolate mofetilcommonly used as anti-rejection drugs in transplant patientsplus a steroid. The other group received standard treatment with a single immunosuppressant drug (cyclophosphamide). (EurekAlert!)
Kidney Transplant Patients May Benefit From Going Off Of Certain Immunosuppressive Drugs Jun 25, 2008
Other commonly used regimens include a calcineurin inhibitor such as cyclosporine or tacrolimus, plus mycophenolate mofetil and steroids ... 1% of patients taking tacrolimus plus mycophenolate mofetil and steroids ... 92 for patients in the tacrolimus group. (Science Daily)
A Man with Headache and Visual Changes after Liver Transplantation Jun 12, 2008
Tacrolimus, azathioprine, furosemide, spironolactone, and a short course of corticosteroids were administered postoperatively. The immediate postoperative course was complicated by coagulopathy, intraperitoneal thrombi, and worsening renal function, with ascites and peripheral edema. (New England Journal of Medicine)
No Racial Gap Seen in Liver Transplant Results Jun 7, 2008
The authors believe that much of the credit in equalizing outcomes goes to the introduction of the drug tacrolimus to prevent rejection of transplanted organs. Dr. Johnny C. Hong from the David Geffen School of Medicine at the University of California, Los Angeles, and colleagues analyzed data on 817 patients who underwent transplantation between 1984 and 1993, when cyclosporine was the main anti-rejection agent, and on 1922 patients transplanted between 1994 and 2007 when tacrolimus was the... (MEDLINEplus)
Reduced Exposure to Calcineurin Inhibitors in Renal Transplantation Jun 5, 2008
The authors' putative conclusion is that a quadruple immunosuppressive regimen of daclizumab, "low-dose" tacrolimus, mycophenolate mofetil, and corticosteroids should be considered the standard in renal transplantation. We have concerns, however, about the equipotency of the four immunosuppressive strategies used. (New England Journal of Medicine)
Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients Jun 2, 2008
07) was observed for ELISA-PRA class I. Three different patterns were evident among the renal transplant patients: -- Those in whom the immune function values were in a stable zone (100-300 ng ATP/mL) with or without anti-HLA antibodies -- Those who exhibited diminished levels of immune function ( (1) Tan HP, Donaldson J, Basu A, et al. 411 Living donor kidney transplants using alemtuzumab pre-conditioning and tacrolimus monotherapy: 5 year experience ... (2) Tan HP, Donaldson J, Basu A, et al.... (PR Newswire)
Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function Jun 2, 2008
Baseline characteristics and measured GFR values were similar in the treatment groups and 98 patients in the CellCept-based regimen in combination with SRL were receiving tacrolimus. Graft loss was experienced in 1. (PR Newswire)
Drug may prolong organ life in noncompliant kidney transplant patients May 31, 2008
Co-authors of the study, "Sirolimus (SRL) Blunts Mitogen Response at Trough (C0) Levels More Than Cyclosporin (CSA) or Tacrolimus (TAC): A Safeguard for Our Many Long Term Noncompliant Kidney Transplant Patients (KTPs)" include UC San Diego School of Medicine physicians Nitin Khosla M.D., and Rodolfo Batarse, M.D., assistant professor of medicine. About ATC. (EurekAlert!)
Preventive Treatment Curbs Eczema Flare-Ups May 30, 2008
NEW YORK (Reuters Health) - Among adults with eczema, otherwise known as atopic dermatitis, "proactive" long-term treatment with tacrolimus ointment applied twice-weekly safely reduces exacerbations of the condition, European investigators have shown ... Dr. Andreas Wollenberg, from Ludwig-Maximilian Universitat in Munich, Germany, and members of the European Tacrolimus Ointment Study Group conducted a clinical trial in which 247 adult patients with atopic dermatitis initially applied tacrolimus... (MEDLINEplus)
Isotechnika reports final results of the PROMISE trial May 27, 2008
"PROMISE has shown that the efficacy of voclosporin is statistically non-inferior when compared to the market leader, tacrolimus in all three dose groups," stated Dr. Robert Foster, Isotechnika's Chairman "While matching tacrolimus in efficacy, key safety advantages such as a lower incidence of new onset diabetes mellitus (NODM) and preservation of kidney function were shown. In addition to highlighting these key safety advantages, the wide therapeutic window was confirmed. This window will... (Canada Newswire)
Immunosuppressant Further Linked To Birth Defects, Case Study Suggests Feb 13, 2008
Following the second transplant she took the immunosuppressant drugs tacrolimus and MMF. Two years later she became pregnant and MMF was discontinued at 10 weeks gestation, while tacrolimus, one of the drugs that has been studied in pregnant women, was maintained. She delivered a female infant who had cleft lip and palate, as well as defects of the jaw, eyes and ears, including no external ear canals. (Science Daily)
FDA Approves Additional Indication for Astellas' MYCAMINE(R) Jan 23, 2008
MYCAMINE can be used concomitantly with a number of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus with no alteration in the pharmacokinetics of MYCAMINE. Patients should be monitored for sirolimus, nifedipine or itraconazole toxicity if receiving these drugs in combination with MYCAMINE and their dosage reduced, if necessary. MYCAMINE is available in two sizes, 50mg vial and 100mg vial, offering clinicians convenience of... (PR Newswire)
Grapefruit bad medicine with some drugs Dec 4, 2007
Some of the drugs that fall into this category include: Nimotop (Nimodipine), Nitrendipine, Plendil (Felodipine), Pranidipine and Sular (Nisoldipine) to treat high blood pressure; Statins such as Baycol (Cerivastatin), Mevacor (Lovastatin), Lipitor (Atorvastatin) and Zocor (Simvastatin) to lower cholesterol; Ebastine, an antihistamine (another drug, Seldane (Terfenadine), is no longer available in the United States); Buspar (Buspirone), Halcion (Triazolam), Tegretol (Carbamazepine), Valium... (Scranton Times, PA)
Ugandan Children Are Among the First to Receive Abbott's Lower-Strength Aluvia (lopinavir/ritonavir) Tablet Dec 2, 2007
g., cyclosporin, sirolimus (rapamycin), tacrolimus), various steroids (e. g., dexamethasone, fluticasone propionate, ethinyl oestradiol), other protease inhibitors, certain heart medicines such as calcium channel antagonists, (e. (PR Newswire)
OUR OPINION: State board makes right call on Senate proposal Sep 4, 2007
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Isotechnika reports second quarter results Aug 14, 2007
8 mg/kg twice daily) resulting in 3% incidence of acute rejection, as compared to 34 patients treated with tacrolimus, resulting in 9% incidence of acute rejection ... When all three of the ISA247 dosing groups were combined, there was a 7% rate of acute rejection in the ISA247 groups compared to a 9% rate of acute rejection in the tacrolimus group, which is being dosed optimally ... Within the first month post-transplant, kidney function showed improvement across all ISA247 dosing groups... (Canada Newswire)
Health Canada allows Isotechnika to continue patients on ISA247 until commercialization Jun 7, 2007
The primary endpoint of the trial is defined as non-inferiority in biopsy proven acute rejection (BPAR) episodes in patients receiving ISA247 for six months as compared to the tacrolimus control which is currently the North American leading transplant drug in this class ... The overall goal of the trial is to find the most appropriate dose that will result in efficacy (lack of acute rejection) with minimal side effects that are typically seen with other calcineurin inhibitors such as... (Canada Newswire)
LifeCycle Pharma Announces Positive Phase I Clinical Results for its Transplantation Product Candidate, LCP-Tacro May 31, 2007
LifeCycle Pharma's long-term strategy is to concentrate on and commit significant resources to the development of a number of product candidates for organ transplantation as it moves towards becoming a fully integrated specialty pharmaceutical company" added Dr. Ornskov. About the studies: LifeCycle Pharma has conducted a series of Phase I studies in more than 150 healthy volunteers to demonstrate the profile of LCP-Tacro under single-dose and multi-dose (steady-state) conditions. In addition to... (PR Newswire)
LifeCycle Pharma Announces Positive Phase I Clinical Results for its Transplantation Product Candidate, LCP-Tacro Heads into US Phase II Clinical Trials for Organ Transplantation May 31, 2007
Today LifeCycle Pharma A/S (OMX:LCP) announces positive results from its Phase I clinical trial program of LCP-Tacro, a proprietary, once-daily tacrolimus tablet. A series of Phase I trials, involving more than 150 healthy volunteers demonstrate that LCP-Tacro: > "The once-daily profile and significant increase in bioavailability, compared to Prograf(R), that has been demonstrated for our LCP-Tacro product candidate in an extensive Phase I program is encouraging, and provides the foundation to... (Canada Newswire)
Isotechnika announces interim three month data from Phase 2b kidney transplant trial May 7, 2007
8 mg/kg twice daily) resulting in 3% incidence of acute rejection, as compared to 34 patients treated with tacrolimus, resulting in 9% incidence of acute rejection ... When all three of the ISA247 dosing groups are combined, there is a 7% rate of acute rejection in the ISA247 groups compared to a 9% rate of acute rejection in the tacrolimus group, which is being dosed optimally ... Within the first month post-transplant, kidney function showed improvement across all ISA247 dosing groups similar... (Canada Newswire)
EU panel backs Novartis' mock-up pandemic flu vaccine Feb 24, 2007
The regulator also said it has adopted positive opinions for: Advagraf (tacrolimus), from Astellas Pharma GmbH, intended for prevention and treatment of transplant rejection. EMEA review began on 1 March 2006, with an active review time of 201 days. (MarketWatch)
Human Skin Harbors Completely Unknown Bacteria Feb 7, 2007
(October 29, 1998) -- In the first study of its kind in children, tacrolimus, used to fight organ rejection, has been found to combat atopic dermatitis in children. "We've had patients that after four days of treatment ... > (June 16, 2006) -- Our skin not only serves as a physical barrier against infection but skin cells themselves can mount an immune response to kill invading microbes by producing antimicrobial polypeptides. The results ... > (May 21, 2002) -- Scientists have developed... (Science Daily)
Risk factors for diabetes following liver transplant Jan 5, 2007
The risk factors for developing NODM included HCV infection (especially when combined with the immunosuppressant tacrolimus), IFG prior to the transplant, and a history of clinical obesity. In addition, the presence of at least two cardiovascular risk factors and a history of either gestational diabetes or having given birth to a baby weighing over 4 kilograms also increased the risk of NODM. The authors note that since abnormal glucose regulation prior to transplantation has been implicated as... (EurekAlert!)
Astellas Pharma US, Inc. Submits Supplemental New Drug Application For Antifungal Product MYCAMINE(R) Dec 27, 2006
MYCAMINE can be used concomitantly with a variety of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus. Important Safety Information MYCAMINE is contraindicated in patients with hypersensitivity to any component of this product. (PR Newswire)
Glucocorticoid Plays Key Role In Skin Abnormalities Induced By Psychological Stress Dec 6, 2006
(October 29, 1998) -- In the first study of its kind in children, tacrolimus, used to fight organ rejection, has been found to combat atopic dermatitis in children. "We've had patients that after four days of treatment ... > (October 14, 2002) -- Researchers at National Jewish Medical and Research Center report in the October 10 issue of the New England Journal of Medicine that patients with atopic dermatitis, also known as eczema, are ... > (October 15, 2004) -- Dutch researcher Manon Franssen... (Science Daily)
Drug Reduces Kidney Transplant Rejection Rates Nov 10, 2006
"Most studies, including this one, use cyclosporine-based immunosuppression, but tacrolimus is more commonly used by most centers today. Also, a lot of centers are using prednisone-free immunosuppression, and prednisone was used in this study. So, I'm not sure how uniformly applicable these results are given current immunosuppression trends," she explained. However, Josephson added that anything that can be done to reduce the risk of rejection is helpful. (MEDLINEplus)
Noxafil(R) (Posaconazole) Oral Suspension Approved in European Union for Prevention of Invasive Fungal Infections Nov 9, 2006
Serious and rare fatal toxicity from cyclosporine has occurred when taken in combination with NOXAFIL and therefore reduction of the dose of drugs like cyclosporine, tacrolimus or sirolimus and frequent monitoring of drug levels of these medications is necessary when taking them in combination with NOXAFIL. The safety and effectiveness of NOXAFIL for prophylaxis in patients below the age of 13 years old have not been established. In the EU, NOXAFIL is recommended for use in patients 18 years of... (PR Newswire)
Infants Targeted In The Fight Against Skin Disease Oct 10, 2006
Residents and researchers in the Top End are fighting back against skin disease by targeting the prevention and treatment of scabies, tinea and skin sores in infants living in remote indigenous communities. Often the disease of poverty and poor housing, scabies and skin sores is rife in many remote indigenous communities. (Science Daily)
Organ transplants reclaim lives (Goody L. Solomon) Oct 8, 2006
One called Neoral, may increase the risk of infection but has been connected to fewer incidents of diabetes in kidney transplant patients compared to Prograf (also called tacrolimus). Diabetes is a leading heart disease risk in transplant patients. (Washington Times, DC)
New ray of hope for Type 1 diabetics Oct 1, 2006
The cells are infused into the patient via the portal vein, and are then kept from being destroyed by the recipient's immune system through the use of two immunosuppressants, sirolimus and tacrolimus as well as a monoclonal antibody drug used in transplant patients called daclizumab. It was in 2000 that the procedure made headlines, when eight Canadian Type 1 diabetics were freed from daily insulin injections after the transplantation. (The Money Times)
New Findings Back Eczema Gene Link Sep 27, 2006
(October 29, 1998) -- In the first study of its kind in children, tacrolimus, used to fight organ rejection, has been found to combat atopic dermatitis in children. "We've had patients that after four days of treatment ... > (June 16, 2005) -- Wet work and its health effects attracted much attention at the conference "Occupational and Environmental Exposures of Skin to Chemicals - 2005", which was held in Stockholm, Sweden 12-15 June 2005. ... > (October 29, 1997) -- Between cold air, reduced... (Science Daily)
European Union's CHMP Adopts Positive Opinion for NOXAFIL(R) (posaconazole) Oral Suspension for Prevention of Invasive Fungal Infections Sep 22, 2006
Dose reduction and more frequent clinical monitoring of cyclosporine, tacrolimus and sirolimus should be performed when NOXAFIL therapy is initiated. In the EU, NOXAFIL is recommended for use in patients 18 years of age and above. (PR Newswire)
[extra: Further details] Aug 19, 2006
Lebowohl M, Freeman AK, Chapman MS, Feldman SR, Hartle JE, Henning A. Tacrolimus ointment is effective for facial and intertriginous psoriasis. J Am Acad Dermatol 2004; 51(5):723-730. (British Medical Journal)
Protopic Effective for Nickel-Induced Allergy Aug 1, 2006
NEW YORK (Reuters Health) - Protopic, also known as tacrolimus 0 ... "Theoretically, since the mechanism of action is the same," tacrolimus ointment would be effective in allergic contact dermatitis induced by other compounds, Dr. Donald Belsito from the University of Missouri in Kansas City told Reuters Health ... In the Journal of the American Academy of Dermatology, Belsito and colleagues from several other U.S. institutions report the results of tacrolimus 0. (MEDLINEplus)
FDA Approves SPRYCEL(TM) (dasatinib) With Two Indications Jun 29, 2006
g., alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot alkaloids [ergotamine, dihydroergotamine]) should be administered with caution. Long-term suppression of gastric acid secretion by use of H2 blockers or proton pump inhibitors (e. (PR Newswire)
Basilea Presents Compelling Clinical and Preclinical Data on Its Novel Broad-Spectrum Antifungal BAL8557 Jun 27, 2006
Ciclosporin and tacrolimus are frequently used and important immunosuppressant drugs in transplant medicine. BAL8557 had no significant impact on the pharmacokinetics of ciclosporin and a relatively modest effect on tacrolimus ... Schmitt-Hoffmann A, Roos B, Sauer J, Maares J, Spickermann J, Iersel MP, Heep M. -- P-0320 / Effect of BAL8557, a Water-soluble Azole Pro-drug (WSA), on the Pharmacokinetics of Tacrolimus. (Primezone Releases)
Kaneka Obtains Positive Results in Preclinical Trials of Drug Eluting Stent Jun 17, 2006
Kaneka's DES, which uses cobalt chromium alloy for a stent, consists of tacrolimus, an immunosuppressant by Astellas Pharma, and biodegradable polymer. By , JCN Staff Writer. (JCN Network, Japan)
Flaking on scalp can be controlled Jun 13, 2006
Two other new agents, pimecrolimus (Elidel) and tacrolimus (Protopic), happen to be controversial. These anti-inflammatories do not contain corticosteroids (which, if used over long periods, can cause thinning of the skin). (Newsday -- Health)
Astellas Announces Application for the Immunosuppressant FK506 Modified Release Formulation in Japan May 30, 2006
Tokyo, Japan, May 30, 2006 - (JCN Newswire) - Astellas Pharma Inc. (TSE: 4503) today announced that it has submitted an application for the market authorization for the immunosuppressant FK506 Modified Release Formulation (generic name: tacrolimus) to the Pharmaceuticals and Medical Devices Agency (PMDA) with the proposed indication of "suppression of organ rejection in organ transplantation" and "suppression of graft rejection and GVHD in bone marrow transplantation" on May 29, 2006 in Japan.... (JCN Network, Japan)
Sorin Group: Six Month Clinical Results of e-Janus Registry May 25, 2006
Sorin Group, Europe's largest medical technology company specialising in the treatment of cardiovascular diseases, presented last week during the annual Paris Course on Revascularization (EuroPCR), six-month clinical results from its e-Janus international "real-world" registry, providing additional clinical evidence of the strong benefits of the Janus Tacrolimus-eluting Carbostent in the high-risk subgroup of patients with Acute Myocardial Infarction ... About Janus stent Sorin's... (Canada Newswire)
Spectrum Laboratory Products, Inc. Issues Nationwide Recall of Tacrolimus Active Pharmaceutical Ingredient May 18, 2006
Spectrum Laboratory Products, Inc. Issues Nationwide Recall of Tacrolimus Active Pharmaceutical Ingredient ... Spectrum Laboratory Products, Inc. Issues Nationwide Recall of Tacrolimus Active Pharmaceutical Ingredient ... FOR IMMEDIATE RELEASE -- Gardena, CA -- May 11, 2006 -- Spectrum Laboratory Products, Inc, (Spectrum), Gardena, California, is initiating a voluntary nationwide recall of the active pharmaceutical ingredient (API) tacrolimus after learning some lots are sub-potent. (U.S. Food and Drug Administration -- Alerts)
Autoimmune Hepatitis Ii Apr 17, 2006
Other immunosuppressant medications used in AIH include azathioprine, which is considered a mainstay along with prednisone, and also 6-mercaptopurine, cyclosporine, mycophenylate mofetil, and tacrolimus. Patients with suspected viral hepatitis who are treated with interferon typically have a worsening of AIH symptoms. (Suite101.com)
Topical Therapies Show Promise for the Treatment of Psoriasis Mar 3, 2006
"With the emergence of several new therapies, more people with psoriasis are experiencing substantial improvements and reporting a greatly enhanced quality of life." New Treatments in Topical Therapy Recent research has shown that calcineurin inhibitors (TCIs), such as tacrolimus ointment and pimecrolimus cream, may be effective in treating psoriasis, although they are currently only approved by the U.S. Food and Drug Administration (FDA) for the treatment of atopic dermatitis, another chronic... (PR Newswire)
New Cancer Warnings Added to Two Eczema Creams Jan 24, 2006
The creams, Novartis AG's Elidel (pimecrolimus) and Astellas Pharma Inc.'s Protopic (tacrolimus), will come with a "black-box" warning -- the strongest type used in the United States -- 10 months after the agency first called for them. Food and Drug Administration officials said while a clear link between the drugs and cancer risk had not been found, there have been enough cancer reports to warrant the change. (MEDLINEplus)
News nuggests: University of Pittsburgh health sciences research roundup Jan 24, 2006
Both groups were given a six-day course of the anti-rejection drug tacrolimus. Although carbon monoxide is toxic at high concentrations, at low concentrations it appears to function as a signaling molecule that protects cells against bombardment by the inflammatory immune response, says senior author Noriko Murase, M.D., associate professor of surgery at the Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine. (EurekAlert!)
FDA Warns of Two Eczema Agents' Possible Cancer Risks Jan 21, 2006
Jan. 20 - The FDA said black box warnings about the possible risks of skin cancer and lymphoma have been added to the labels of Elidel Cream (pimecrolimus) and Protopic Ointment (tacrolimus), two popular eczema drugs. Although no causal link between cancer and the two drugs has been established, the FDA said it has received reports of 78 cases of cancer among patients using the drugs. (CNN)
Cyclosporine Inhibits Hepatitis C Virus In Vitro Jan 7, 2006
The most commonly used anti-rejection medication is Tacrolimus, although Cyclosporine is also used ... They found that Cyclosporine reduced HCV replication by 20 percent, compared to no reduction with Tacrolimus ... After 48 weeks, 46 percent of the patients taking Cyclosporine had achieved a sustained virological response, compared with just 27 percent of the patients taking Tacrolimus. (Science Daily)
