* Is psychiatry turning its back on the facts in favor of drugs? Aug 30, 2008
But, while ECT rarely, if ever, causes clear clinical evidence of brain damage and has not been shown to do so in animal studies, antipsychotic drugs regularly do, in the form of tardive dyskinesia and other syndromes. The same is true of antidepressants. (Taipei Times, Taiwan -- World)
Book recounts woman's ordeal Aug 21, 2008
POCATELLO -- Marcella Enos was diagnosed with tardive dyskinesia about 15 years ago, but recovered from the condition in the fall of 1995. Tardive dyskinesia is a neurological syndrome caused by the long-term use of neuroleptic drugs, according to the National Institute of Neurological Disorders and Stroke ... Enos was using Ritalin to treat a diabetic symptom, but Rod said the doctor was unaware that the drug would cause future side effects resulting into tardive dyskinesia. (Pocatello Idaho State Journal, ID)
Rolfing brings woman relief from muscle disorder Jul 18, 2008
Karen Harkins searched for relief for tardive dyskinesia-dystonia in medicines and traditional and alternative therapies, but it was Rolfing that eventually took her from almost complete disability to a level of comfort and agility she feared she might never have again ... Harkins was told by her doctor that she had a neurological movement disorder called tardive dyskinesia-dystonia ... Tardive dyskinesia is a neurological syndrome caused by long-term, and in cases like Harkins', short-term use... (Scripps Howard News Wire)
State of Alaska and Eli Lilly and Company Reach Agreement to Settle Zyprexa Lawsuit Mar 26, 2008
"A trial always involves significant time and resources, especially a two-phase trial like this one that posed additional legal hurdles. A settlement helps us get back to what we want to focus on as a company: developing important new medications through research and partnerships with doctors and patients. "We appreciate all the time and energy the jury invested over more than three weeks in such a complex case," Armitage added. The agreement involves no admission of wrongdoing on Lilly's part.... (PR Newswire)
A disorder in disguise Mar 26, 2008
For those not detected early, Dr. Kennedy's genetic research aims to minimize the negative side effects of anti-psychotic drugs, such as obesity, diabetes and the involuntary movements known as tardive dyskinesia. A new lab is about to open at CAMH this month to offer this gene-based pharmacological advice to psychiatrists before they prescribe. (Globe and Mail)
FDA Advisory Committee Supports Efficacy and Safety of Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment Feb 7, 2008
Also, as with all antipsychotic treatment, prescribing should be consistent with the need to minimize Tardive Dyskinesia (TD). The risk of developing TD and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic increase. (PR Newswire)
Newer Psychosis Drug Cuts Risk of Movement Problem Feb 2, 2008
NEW YORK (Reuters Health) - Schizophrenic patients treated with aripiprazole (Abilify) have a lower risk of developing tardive dyskinesia, an unpleasant neurological drug side effect, than those given the older anti-psychotic drug haloperidol, according to a report in the Journal of Clinical Psychiatry. Tardive dyskinesia is a serious neurologic condition that can occur after prolonged use of antipsychotic drugs ... Dr. Del D. Miller from the University of Iowa, Iowa City, and colleagues... (MEDLINEplus)
FDA Okays Aripiprazole (Abilify) as Add-On for Major Depression Nov 22, 2007
Other risks and side effects include neuroleptic malignant syndrome, tardive dyskinesia, hyperglycemia and diabetes, hypotension, and seizure. Aripiprazole is not approved for treatment of depressed patients with dementia-related psychosis or pediatric patients with depression. (MedPage Today)
INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients Oct 14, 2007
Treatment should be stopped if the person being treated has NMS. Tardive Dyskinesia (TD) is a serious, sometimes permanent side effect reported with INVEGA and similar medications. TD includes uncontrollable movements of the face, tongue, and other parts of the body. (PR Newswire)
Pfizer Schizophrenia Drug Ad Misleading Aug 15, 2007
The FDA said the Pfizer ad included some information about potential side effects from injectable Geodon but failed to list "other serious warnings and precautions." Specifically, the promotion failed to mention the possibility of neuroleptic malignant syndrome, tardive dyskinesia, hyperglycemia and diabetes. In addition, the ad implied Geodon was more effective than a generic drug, haloperidol, "when this has not been demonstrated by substantial evidence or substantial clinical experience," the... (MEDLINEplus)
Efficacy and safety of Aripiprazole as adjunctive therapy in major depressive disorder May 23, 2007
Tardive dyskinesia (TD)The risk of developing TD and the potential for it to become irreversible may increase as the duration of treatment and the total cumulative dose increase. Prescribing should be consistent with the need to minimize TD. If signs and symptoms appear, discontinuation should be considered since TD may remit, partially or completely. (EurekAlert!)
Six-Week Investigational Study In Adults With Major Depressive Disorder Evaluates The Effectiveness of Adjunctive Aripiprazole Therapy With Antidepressants May 22, 2007
If signs and symptoms appear, immediate discontinuation is recommended - Tardive dyskinesia (TD)-The risk of developing TD and the potential for it to become irreversible may increase as the duration of treatment and the total cumulative dose increase. Prescribing should be consistent with the need to minimize TD. If signs and symptoms appear, discontinuation should be considered since TD may remit, partially or completely - Cerebrovascular adverse events (eg, stroke, transient ischemic attack),... (PR Newswire)
FDA Approves Astrazeneca's Once-Daily Seroquel XR(TM) Extended-Release Tablets for the Treatment of Schizophrenia May 18, 2007
Tardive dyskinesia (TD), a potentially irreversible syndrome of involuntary dyskinetic movements, may develop in patients treated with antipsychotic drugs. The risk of developing TD and likelihood that it will become irreversible are believed to increase as the duration of treatment and total cumulative dose of antipsychotic drugs administered to the patient increase. (PR Newswire)
Lilly Responds to the Cost-Effectiveness Analysis of the CATIE Schizophrenia Trial Dec 1, 2006
According to the CATIE CEA, perphenazine, a first-generation typical, was found to be the most cost-effective treatment when used in modest doses in the treatment of patients without pre-existing Tardive Dyskinesia (TD), followed closely by Zyprexa(R) (olanzapine) ... Cherri Miner, MD, Lilly U.S. Medical Director for Zyprexa said, "Lilly supports studies such as CATIE that add to the body of knowledge for enhancing the treatment of schizophrenia. However, as in every study or analysis, there are... (PR Newswire)
Older medication may be more cost-effective for some patients with schizophrenia Dec 1, 2006
In addition, the study lasted 18 monthslong enough to determine how patients respond to and initially tolerate the drugs, but not long enough to consider some serious long-term side effects, such as development of the movement disorder tardive dyskinesia (TD), diabetes, cardiovascular problems, or other medical conditions that can develop even years after a patient with chronic schizophrenia starts taking an antipsychotic medication. Despite these caveats, the study results suggest new ways of... (EurekAlert!)
FDA Approves RISPERDAL(R) for Treatment of Irritability Associated with Autistic Disorder Oct 7, 2006
You may have heard the term "tardive dyskinesia." These are usually persistent, uncontrollable, slow or jerky facial or body movements that can be caused by all medications of this type. If you have these symptoms, talk to your healthcare professional. (PR Newswire)
Bad science: Ben Goldacre Aug 12, 2006
Tardive dyskinesia is a horrible and disabling movement disorder, a side-effect of schizophrenia treatment. A 1996 review looked at 500 studies of 90 treatments for it: not one provided useful data, they all either had too few patients or were too brief. (Guardian Unlimited)
Eli Lilly Posts 2Q Profit of $822 Million Jul 22, 2006
Of course the 50 year old Thorazine didn't cause diabetes and is many times cheaper but it could cause tardive dyskinesia. Where Eli Lilly's negligence comes in,is their KNOWING and not informing consumers (black box warning) until the FDA demanded it. (ABC 7 News, DC)
Schizophrenia - what it is, how it feels and why we should care May 27, 2006
Many patients, they said, are troubled by muscle spasms, tremors, blurred vision, drowsiness and restlessness, and if you have to be prescribed the medication for long periods of time Tardive Dyskinesia comes around. TD as they call it, is characterized by involuntary movements. (Black Hills Pioneer, SD)
Drugs caused scary side effects May 2, 2006
Studies in adults suggested they were less likely to cause tremors, painful muscle contractions and tardive dyskinesia, a potentially disabling neurological disorder ... By then, Evans says, she had read up on tardive dyskinesia (TD), a neurological disorder that can be caused by anti-psychotics. (USA Today -- News)
Adult atypicals not for kids May 2, 2006
USATODAY.com - Adult anti-psychotics can worsen troubles. Sign up to receive our free Daily Briefing e-newsletter and get the top news of the day in your inbox. (USA Today -- News)
Medicines can cause problems May 2, 2006
Rex has a movement disorder called tardive dyskinesia which causes him to grimace and make involuntary movements ... Rex now has a serious case of tardive dyskinesia (TD), suffering daily episodes of involuntary jerking movements and facial grimacing, says Erin Evans, his mother. (USA Today)
New Dosages of RISPERDAL(R) (Risperidone) Now Available Mar 25, 2006
Some people may have heard the term "tardive dyskinesia." These are usually persistent, uncontrollable, slow or jerky facial or body movements that can be caused by all medications of this type. A rare but serious side effect that has been reported with this kind of medicine, including RISPERDAL(R), is known as NMS or neuroleptic malignant syndrome. (PR Newswire)
AstraZeneca Submits sNDA for SEROQUEL(R) for Bipolar Depression Treatment Jan 1, 2006
Prescribing should be consistent with the need to minimize the risk of tardive dyskinesia. A rare condition referred to as neuroleptic malignant syndrome has been reported with this class of medications, including SEROQUEL. Hyperglycemia, in some cases extreme and associated with ketoacidosis, hyperosmolar coma, or death, has been reported in patients treated with atypical antipsychotics, including SEROQUEL(R) (quetiapine fumarate). (PR Newswire)
