Mutant genes 'key to long life' Nov 15, 2009
They found that 86 very old people and their children had higher levels of telomerase which protects the DNA. ... Telomerase can repair the telomeres, preventing them from shrinking ... The team at Einstein found that the centenarians and their offspring had higher levels of telomerase and significantly longer telomeres than the unrelated people in the control group and that the trait was strongly heritable. (BBC News -- Americas)
Longevity Tied to Preserving Chromosome Tips Nov 15, 2009
"Our research was meant to answer two questions: Do people who live long lives tend to have long telomeres? And if so, could variations in their genes that code for telomerase account for their long telomeres?" ... More specifically, the researchers found that participants who have lived to a very old age have inherited mutant genes that make their telomerase-making system extra active and able to maintain telomere length more effectively ... "Our findings suggest that telomere length and... (Science Daily)
Stem Cell Therapy May Offer Hope For Acute Lung Injury Oct 30, 2009
Telomerase is a protein most notable for its connections to aging and. . (Science Daily)
Gene 'Cancer-proofs' Naked Mole Rat's Cells Oct 27, 2009
In 2006, Gorbunova discovered that telomerase -- an enzyme that can lengthen the lives of cells, but can also increase the rate of cancer -- is highly active in small rodents, but not in large ones. Until Gorbunova and Seluanov's research, the prevailing wisdom had assumed that an animal that lived as long as we humans do needed to suppress telomerase activity to guard against cancer ... Telomerase helps cells reproduce, and cancer is essentially runaway cellular reproduction, so an animal... (Science Daily)
Mice Regain Ability To Extend Telomeres Suggesting Potential For Dyskeratosis Congenita Therapy Oct 20, 2009
At the heart of DKC is telomerase, the enzyme that maintains the length of telomeres, the protective caps on the ends of chromosomes. Telomerase has two main components; telomerase reverse transcriptase (TERT) and telomerase RNA. The latter is the template that TERT uses to produce telomere-extending DNA. Patients with DKC have a mutation in one TERT allele and under produce telomerase ... "DKC is one of the few examples in which there is a clear link between a genetic mutation that directly... (Science Daily)
National Science Foundation congratulates Nobel Laureates in medicine/physiology, chemistry and economics Oct 15, 2009
Jack W. Stostak shared the Nobel Prize in Physiology or Medicine with Carol W. Greider and Elizabeth H. Blackburn "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase." ... The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes--the telomeres--and in an enzyme that forms them--telomerase ... Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how... (EurekAlert!)
A first XI doing their country proud Oct 10, 2009
Known as telomerase, it replenishes structures that Blackburn likens to the ''tips of shoelaces'' - protective ''blobs'' of DNA on the end of chromosomes that prevent them fraying. In the right amounts telomerase is a good guy, topping up the telomeres as they wear down with age ... With more than 85 per cent of cancers having high levels of the enzyme, researchers have begun to test anti-cancer drugs that block the action of telomerase. (Sydney Morning Herald -- Australia)
The Nobel Science prizes: Winning ways Oct 9, 2009
These produce an enzyme called telomerase that repairs telomeres after cell division. The problem comes when the telomerase gene is accidentally activated in a cell in which it is supposed to be shut down ... Then you have a cancer cell: 80-90% of cancers produce telomerase in this way. (The Economist)
Yale hails U.S. Nobel Prize in Chemistry laureates Oct 8, 2009
Jack Szostak, another HHMI researcher was awarded Monday the Nobel Prize in Physiology or Medicine for discovery of how chromosomes are protected by telomeres and the enzyme telomerase. "It's fantastic news. I don't think that ever happens before," Robert Tjian, president of HHMI, told Xinhua through telephone. (Xinhuanet, China)
UCSF biologist wins Nobel Prize in medicine Oct 7, 2009
That was followed in 1984 by Blackburn and Greider's Christmas Day discovery of an enzyme they called telomerase, which replenishes those tips, keeping the cells alive. The scientists officially received the Nobel Prize "for the discovery of how chromosomes are protected by telomeres and the telomerase enzyme." ... Subsequent research by scientists worldwide has focused on whether controlling the telomerase could slow or reverse age-related diseases like blindness or cardiovascular disease or... (San Francisco Chronicle)
Chance favoured this prepared mind: our 11th Nobel winner Oct 7, 2009
Dr Blackburn, 60, was recognised with two of her former graduate students, the Americans Jack Szostak and Carol Greider, for their work on telomeres, caps that protect chromosomes in cells, and telomerase, an enzyme that does the protecting ... Telomerase is the enzyme that ensures the job is done ... In cancer, it may be possible to develop drugs that block telomerase. (Sydney Morning Herald -- Australia)
SARS spurs China to act on AIDS Oct 7, 2009
Prize goes to discoverers of telomere caps and telomerase the enzyme that makes them. FEATURE: 13:18 05 October 2009 15 comments. (Yahoo News -- SARS)
Outspoken Australian scientist dropped by Bush wins Nobel Oct 6, 2009
Professor Blackburn, 60, who now works in San Francisco, pioneered the study of telomeres, caps that protect chromosomes in cells, and is a discoverer of telomerase, an enzyme that does the protecting ... Professor Blackburn won with her long-time US collaborators Jack Szostak, who worked on the telemores unique DNA sequence, and Carol Greider, who co-identified the telomerase. (Sydney Morning Herald -- World)
Nobel in Medicine Goes to 3 Americans Oct 6, 2009
Blackburn and Greider discovered the enzyme that builds telomeres - telomerase - and the mechanism by which it adds DNA to the tips of chromosomes to replace genetic material that has eroded away. The prize-winners' work set the stage for research suggesting that cancer cells use telomerase to sustain their uncontrolled growth ... Some inherited diseases are now known to be caused by telomerase defects, including certain forms of congenital aplastic anemia, in which insufficient cell divisions... (CBS News)
Boston geneticist shares Nobel Oct 6, 2009
Later, Blackburn and Greider found an enzyme called telomerase that caused the tips to rebuild, and Szostak discovered a protein fundamental to that enzyme ... The telomerase enzyme appears to be overactive in most human tumor cells, turning the cells immortal and allowing them to grow out of control ... Some efforts are now being made to turn that idea into a cancer therapy, including vaccines against cells with overactive telomerase. (Boston Globe)
Nobel Prize in Medicine shared by three U.S. genetic researchers Oct 6, 2009
Blackburn, Greider and Szostak recognized for research into telomeres--a key chromosome component--and the enzyme telomerase ... Working with Blackburn, Greider helped in 1989 to identify the RNA-based telomerase the enzyme that creates the crucial telomeres in ... "We had no idea when we started this work that telomerase would be involved in cancer, but were simply curious about how chromosomes stayed intact," Greider said in a statement after winning the Lasker Award in 2006 for some of the... (Scientific American)
Telomeres, Telomerase and Cancer Oct 6, 2009
An unusual enzyme called telomerase acts on parts of chromosomes known as telomeres ... In particular, it has led to identification of an extraordinary enzyme named telomerase that acts on telomeres and is thought to be required for the maintenance of many human cancers ... Modern interest in telomeres and telomerase has its roots in experiments carried out in the 1930s by two remarkable geneticists: Barbara McClintock, then at the University of Missouri at Columbia, and Hermann J. Muller, then... (Scientific American)
Nobel prize for chromosome find Oct 6, 2009
The answer lies at the ends of the chromosomes - the telomeres - and in an enzyme that forms them - telomerase ... Joined by Johns Hopkins University's Carol Greider, then a graduate student, Blackburn started to investigate how the teleomeres themselves were made and the pair went on to discover telomerase - the enzyme that enables DNA polymerases to copy the entire length of the chromosome without missing the very end portion ... It is hoped that cancer might be treated by eradicating... (BBC News -- Americas)
Congratulations to UCSF Nobel winner Blackburn Oct 6, 2009
Their prize is richly deserved: They discovered telomerase, an enzyme that plays an important role in cell function, aging and cancers ... Their prize is richly deserved: They discovered telomerase, an enzyme that plays an important role in cell function, aging and. (San Francisco Chronicle -- Opinion)
Telomere Copy Protection: Nobel Goes To Scientists Who Solved How Chromosome Ends Work Oct 6, 2009
The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes the telomeres and in an enzyme that forms them telomerase ... Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase ... Conversely, if telomerase activity is high, telomere length is maintained, and cellular senescence is delayed. (Science Daily)
U.S. trio wins medicine Nobel for telomerase Oct 6, 2009
Search Type Choose a search type from the items below. Most Viewed - Top Stories. (Yahoo News -- Top Stories)
Johns Hopkins researcher Greider wins Nobel Prize Oct 6, 2009
Greider and Jack W. Szostak of , and Elizabeth H. Blackburn of the , San Francisco, won "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase," the prize committee wrote in its citation ... The Royal Swedish Academy of Sciences recognized Greider for her 1984 discovery of the enzyme telomerase ... Recently, she and her colleagues developed a model for a rare, inherited disorder related to stem cell failure called dyskeratosis congenita that is caused by... (Baltimore Business Journal, MD)
Nobel Prize in Medicine Awarded for Cracking DNA Puzzle Oct 6, 2009
Later, in 1984, Greider and Blackburn identified telomerase, the enzyme that makes telomere DNA and prevents chromosomes from shortening and becoming unstable ... But when the telomerase enzyme is very active, the telomere length is maintained giving the cell eternal youth ... Inhibiting or interfering with telomerase in cancer cells may kill the cell and someday cure cancer, scientists say. (National Geographic)
Nobel prize-winning medical research long and costly Oct 6, 2009
Elizabeth Blackburn won the Nobel prize for medicine together with Carol Greider and Jack Szostak for work on the existence and nature of telomerase, an enzyme that helps prevent the fraying of chromosomes and is core to new work on aging and cancer. Federal research grants made the work possible, and that money is becoming more important as the California public education system which nurtured the science struggles with budget cuts that will probably reduce the wages of Blackburn and her... (The Star Online, Malaysia)
3 Americans win Nobel for chromosome research Oct 6, 2009
It centers on structures at the end of chromosomes called telomeres and an enzyme that forms them, called telomerase ... Work by the researchers determined that telomeres protect DNA from degradation in the process, and that telomerase maintains the telomeres. (CNN -- Health)
Winning Nobel Prize seen as recognition for entire telomere field Oct 6, 2009
WASHINGTON, Oct. 5 (Xinhua) -- Three Americans won the Nobel prize for medicine on Monday for revealing the existence and nature of telomerase, which one of the laureates, Professor Carol Greider says is a recognition for the entire telomere field. "I really see this as a prize for the entire telomere field. We made the discovery of the enzyme (telomerase) but many other people contribute to really understanding the role of telomere disease. So I really see (it) as a prize recognizing the entire... (Xinhuanet, China)
Three American scientists win 2009 Nobel Prize for Medicine Oct 6, 2009
The trio were awarded the prize for the discovery of "how chromosomes are protected by telomeres and the enzyme telomerase,"the Nobel jury -- the Nobel Assembly announced at a press conference at Karolinska Institute in Stockholm, Sweden ... He added, the solution is to be found in the ends of the chromosomes -- the telomeres -- and in an enzyme that forms them -- telomerase ... "Her co-discovery of the telomerase has revealed a mechanism that plays a key role in determining the lifespan of... (Xinhuanet, China)
Nobel Prize winner Blackburn: warm, special lady Oct 6, 2009
Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak, all from the United States, won the 2009 Nobel Prize in Physiology or Medicine on Monday for revealing the existence and nature of telomerase ... The Nobel Assembly at Karolinska Institute in Stockholm, Sweden, on Monday announced that 60-year-old Blackburn, together with Carol W. Greider and Jack W. Szostak, won this year's Nobel Prize in physiology or medicine for the discovery of "how chromosomes are protected by telomeres and the... (Xinhuanet, China)
Australia's first female Nobel prize winner hailed at home Oct 6, 2009
Blackburn along with two other Americans won the Nobel prize in medicine for discovering and identifying telomerase, the enzymen that renews the little caps on the end of chromosomes whose natural fraying underlies aging and cancer ... In 2007 she was named one of Time magazine's 100 most influential people in the world for her work into the potential of the enzyme telomerase for beating cancer. (Xinhuanet, China)
What's a nice girl like you doing with a Nobel prize? Oct 6, 2009
Dr Blackburn, who is based in San Francisco, pioneered the study of telomeres - caps that protect chromosomes in cells - and is a discoverer of telomerase, an enzyme that does the protecting. Or, as she recently explained it: ''You can think of a chromosome as a shoelace with a telomere as the aglet - the tag or sheath at the end of a shoelace that prevents the end from fraying. (Sydney Morning Herald -- Australia)
Work on DNA earns 3 Americans medicine Nobel Oct 6, 2009
They also discovered telomerase, the enzyme that manufactures telomeres and gives cancer cells their eternal life. The trio's discoveries "have added a new dimension to our understanding of the cell, shed light on disease mechanisms and stimulated the development of potential new therapies," according to the Nobel citation. (AZCentral -- News)
Trio win Nobel Medicine Prize for research into ageing Oct 6, 2009
The trio were honoured for discovering how chromosomes are protected by telomeres and the role of an enzyme called telomerase in maintaining or stripping away this vital shield ... In 1984, Blackburn and her then grad student, Greider, also identified telomerase, the enzyme that makes the telomere DNA. ... But if telomerase levels are high, the telomere length is maintained, and cellular ageing is braked. (Yahoo! Asia News)
Full Story » Oct 6, 2009
U.S. trio wins medicine Nobel for telomerase - Yahoo ... U.S. trio wins medicine Nobel for telomerase. (Yahoo News -- Top Stories)
Breakthrough in stem cell study may fetch Nobel Oct 5, 2009
The trios discovery of the telomerases enzyme set the stage for research suggesting that cancer cells use telomerase to sustain their uncontrolled growth. As usual, the tightlipped award committee is giving no hints about who is in the running before presenting its decision at Stockholms Karolinska institute. (India Times, India -- Health/Science)
MRI, solar cells, aging work are Nobel favorites Sep 26, 2009
Names include Elizabeth Blackburn of the University of California San Francisco, who helped discover telomerase, the enzyme made by the little caps on the end of chromosomes whose natural fraying underlies aging and cancer. advertisement. (MSNBC -- Technology)
Researchers Examine Mechanisms That Help Cancer Cells Proliferate Sep 5, 2009
The researchers also examined an enzyme called telomerase, which "rebuilds" telomeres so they do not get shorter and signals the cell to stop dividing. Normally, telomerase is only active in cells such as stem cells and dividing immune cells, which must reproduce constantly ... But telomerase also has a dark side: When active in cancer cells, it enables unlimited growth, a hallmark of cancer. (Science Daily)
New Therapeutic Target Could Help Patients With Pulmonary Fibrosis Aug 27, 2009
27, 2009) A diagnosis of Idiopathic Pulmonary Fibrosis is not much better than a death sentence: there is no treatment and the survival rate is less than three years. But researchers at the University of Michigan have discovered that targeting of a novel gene utilizing genetic and pharmacologic strategies was successful in treating pulmonary fibrosis in mice and will be developed for future testing in humans. (Science Daily)
Anti-Aging Pill Targets Telomeres at Ends of Chromosomes Aug 18, 2009
TA-65 is produced at very low levels in the astragalus plant, but the company purifies and concentrates the substance, which is thought to "turn on" the enzyme telomerase (hTERT) that acts to maintain or lengthen telomeres ... He is the chief executive officer of , a rival company that is screening for chemicals to activate telomerase, but also a T.A. Sciences client for the past two-and-a-half years ... He thinks that "taking a telomerase inducer is safer than driving my car to work" but... (Scientific American)
Handle With Care: Telomeres Resemble DNA Fragile Sites Jul 18, 2009
The only other known replication problem posed by telomeres was solved in 1985 when it was shown that the enzyme telomerase elongates telomeres, which shorten during every cell division. The second problem posed by telomeres, the so-called end-protection problem, was solved by de Lange and her colleagues when they found that shelterin protects the ends of linear chromosomes, which look like damaged DNA, from unnecessary repair. (Science Daily)
Click to read:Sotomayor Dodges Abortion Questions Jul 16, 2009
You're slippin dude" Lemmie get up to speed, Gravy! by bannednancy July 15, 2009 1:52 PM EDT It's "lemme" not "lemmie"... ya ignorant Texan. by spiritwalk July 15, 2009 2:13 PM EDT And Burris never talked about a payoff to Blago for his appointment. Thats my story and I am sticking to it. by joule18 July 15, 2009 10:06 PM EDT Obama doesn't do much except travel, issue orders his Czar's to do the work, and lie to us all. How's that no taxes for people who earn less than $250K going? Bet you... (CBS News)
Variations in 5 genes raise risk for most common brain tumors Jul 6, 2009
CCDC26, located on chromosome 8, modulates retinoic acid, which in turn increases programmed cell death in glioblastoma cells and reduces telomerase activity (see next). TERT, found on chromosome 5, is essential for telomerase activity that preserves telomeres, which are found on the ends of chromosomes and prevent them from unraveling. (EurekAlert!)
New Connection Between Cancer Cells, Stem Cells Jul 3, 2009
ScienceDaily (July 2, 2009) A molecule called telomerase, best known for enabling unlimited cell division of stem cells and cancer cells, has a surprising additional role in the expression of genes in an important stem cell regulatory pathway, say researchers at the Stanford University School of Medicine ... "Telomerase is the factor that accounts for the unlimited division of cancer cells," said Steven Artandi, MD, PhD, associate professor of hematology, "and we're very excited about what this... (Science Daily)
Protein May Be Strongest Indicator Of Rare Lung Disease, Study Shows Jun 18, 2009
ScienceDaily (June 17, 2009) Researchers at the University of Cincinnati (UC) have discovered a protein in the lungs that can help in determining progression of the rare lung disease Idiopathic Pulmonary Fibrosis (IPF). Researchers say the protein Serum surfactant protein A is superior to other IPF predictors and could lead to better decisions about treatment and timing of lung transplantation. (Science Daily)
The New Age Intervention Regeneration Booster by Jan Marini available at www.lavandou.com Mar 19, 2009
Keeping these two factors in mind, the brand new Age Intervention Regeneration Booster combines both topical and anti-inflammatory agents, along with Telomerase Enzyme and other skin-restoring ingredients. Designed to help reduce and prevent wrinkles, discoloration or dark circles around the eyes, and other skin blemishes, while at the same time improving skin texture, tone, and firmness, the Age Innovation Regeneration Booster promises to give any woman that youthful look no matter what her age... (Yahoo News -- Press Releases)
Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes Mar 5, 2009
They found the answer in telomerase, the enzyme that renews telomeres and is necessary to prevent loss of genetic information after repeated cell division. Telomerase adds short repeated DNA sequences to the ends of chromosomes to protect them ... T cells are some of the very few cells in adults that can turn on telomerase when stimulated, probably because they have to divide many times and stay alive for decades. (EurekAlert!)
